uicc hpv and cervical cancer curriculum chapter 6.c.2. methods of treatment - surgery prof. achim...

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UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

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Page 1: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

CURRICULUM

VPH y Cancer CervicalUICC

Page 2: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

01 Capítulo 6.c.2

Métodos de tratamiento – cirugía

Prof. Achim Schneider, MD, MPHCharité Universitätsmedizin Berlin, Germany

Page 3: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

02 Cáncer del cuello uterino • Diagnóstico

• Estadío

• Tratamiento

- Cirugía

- Radioterapia

- Quimioterapia

• Seguimiento

Page 4: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

03 Sistema de Estadificación FIGO

Estadío I Estadío II

Estadío III Estadío IV

Page 5: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

04 Opciones de tratamiento primario

TRATAMIENTO PRIMARIO

Cirugía

Cirugía Radio-quimioterapia

Radioterapia

Radio-quimioterapia

Radio-quimioterapia Cirugía

Quimioterapia

Quimioterapia Cirugía

Page 6: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

05 Éxito Terapéutico

Source: Informe Anual de FIGO

Radioterapia Cirugía

Estadío FIGO

Haza

rd R

ati

o

Page 7: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

06Comparación de cirugía y radioterapia en pacientes con estadío FIGO IBCirugía Radioterapia

Supervivencia 85% 85%

Complicaciones severas

Fístula urológica 1 - 2%Fístula intestinal o urológica

1.4 – 5.3%

Vagina Encortecimiento pequeñoFibrosis o posible estenosis, particularmente en mujeres

postmenopáusicas

Ovario Se puede preservar

Castración, el traslado quirúrgico de los ovarios

fuera de la pelvis solamente preserva la función de los

ovarios en 50% de las mujeres

Efectos crónicos Atonía de vejiga 3%Fibrosis de los intestinos y/o

de la vejiga 6 – 8%

AplicabilidadMejores candidatas < 70

años, < 100 kg y en buena condición física

Toda paciente es candidata potencialmente

Mortalidad quirúrgica

1%

< 1% (primordialmente el resultado de embolismo

pulmonar durante el tratamiento intracavitario)

Page 8: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

07 Histerectomía extendida o radical

Page 9: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

08 Tratamiento quirúrgico para cancer cervical estadío IA2 - IIB

Friedrich Schauta 1849 - 1919

Ernst Wertheim 1864 - 1920

Page 10: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

09 Linfadenectomía

Infrarenal izquierda

Infra-mesentérica izquierda

Para-aortica derecha

Pelvisparametrio

Cysterna chyli

Page 11: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

10 Histerectomía radical (1)

Vejiga

Recto

Page 12: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

11 Histerectomía radical (2)

Page 13: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

12 Resección parametrial

Page 14: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

13 Plexo hipógastrico

Page 15: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

14 Histerectomía radical vaginal tipo III – Conservadora de nervios

Sensitividad(+)

Función motora (+)

Ute rusBla se

Ure te rBe c ke nb o d e n

Re ktumRecto

VejigaÚtero

Suelo pélvico

Page 16: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

15 Tasa de supervivencia despues de una histerectomía radical vaginal• Estadío IA - IB1, ganglios linfáticos libres de tumor (pN0),

sin afectación tumoral de los vasos sanguíneos y linfáticos (L+V=0)

• Sin factores de riesgo independientes

• n = 110 patients

• Tiempo de seguimiento: 44 (1-89) meses

• Supervivencia

>36 meses: n = 70 (64%)

>60 meses: n = 36 (33%)

Page 17: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

16 Complicaciones luego de una histerectomía radical• Temprano

- Hemorragia

- Formación de fístula

- Estenosis del ureter

- Embolismo pulmonar

- Infección

- Íleo

Page 18: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

17

• Tardía

- Linfocele

- Control de vejiga

- Obstipación

- Sensibilidad

Complicaciones luego de una histerectomía radical

Page 19: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

18 Traquelectomía radical (1)

Daniel Dargent

Page 20: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

19 Traquelectomía radical (2)

Page 21: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

20 Traquelectomía radical (3)• Precondiciónes

- Deséan mantener fertilidad

- Estadío pT1A1 L1

- pT1A2

- pT1B1 < 2 cm

- Sin afectación tumoral de vasos sanguíneos

- Ganglios linfáticos libre de tumor(pN0)

- Margen de resección endocervical ≥ 0.5cm

- Longitud cervical residual de 1 cm

Page 22: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH CURRICULUM VPH y Cancer Cervical UICC

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

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Gracias!

Esta presentación se encuentra disponible en: www.uicc.org/curriculum