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g protein–coupled receptor 21 (gpr21)

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THE DISTILLERY SciBX: Science–Business eXchange Copyright © 2012 Nature Publishing Group 1 This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine/metabolic disease Diabetes G protein–coupled receptor 21 (GPR21) Mouse studies suggest inhibiting GPR21 could help treat or prevent type 2 diabetes. Gpr21 knockout mice had greater insulin and glucose tolerance and lower hepatic glucose production, proinflammatory cytokines and macrophages in adipose tissue than wild-type mice. Next steps include identifying GPR21 inhibitors. SciBX 5(25); doi:10.1038/scibx.2012.654 Published online June 21, 2012 Findings unpatented; unlicensed Osborn, O. et al. J. Clin. Invest.; published online June 1, 2012; doi:10.1172/JCI61953 Contact: Jerrold M. Olefsky, University of California, San Diego, La Jolla, Calif. e-mail: [email protected]

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Page 1: G protein–coupled receptor 21 (GPR21)

the distillery

SciBX: Science–Business eXchange Copyright © 2012 Nature Publishing Group 1

This week in therapeutics

Indication Target/marker/pathway Summary Licensing statusPublication and contact information

Endocrine/metabolic disease

Diabetes G protein–coupled receptor 21 (GPR21)

Mouse studies suggest inhibiting GPR21 could help treat or prevent type 2 diabetes. Gpr21 knockout mice had greater insulin and glucose tolerance and lower hepatic glucose production, proinflammatory cytokines and macrophages in adipose tissue than wild-type mice. Next steps include identifying GPR21 inhibitors.

SciBX 5(25); doi:10.1038/scibx.2012.654 Published online June 21, 2012

Findings unpatented; unlicensed

Osborn, O. et al. J. Clin. Invest.; published online June 1, 2012; doi:10.1172/JCI61953 Contact: Jerrold M. Olefsky, University of California, San Diego, La Jolla, Calif. e-mail: [email protected]

http://www.biocentury.com/targets/gpr21?utm_source=nature
mailto:[email protected]

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