gpcrs (g-protein coupled receptor)
TRANSCRIPT
-
8/2/2019 GPCRs (G-Protein Coupled receptor)
1/25
-
8/2/2019 GPCRs (G-Protein Coupled receptor)
2/25
]sh{hnwhs{
JG. J@ABXGGBN
3==1*;*?=*=72
JLAFXEXS SLAJLN
3==1*;*?=*=32
L. I. J. SLG@_LN LAJLG
3==1*;*?=*=
-
8/2/2019 GPCRs (G-Protein Coupled receptor)
3/25
O*}s`whbn k`x}dhg Shkh}w`s b{ wah dlsoh{x}hs fljbdr `f shkh}w`s{. F`xng `ndr bnhxilsr`wh{$ lng lnbjld{.
Ld{` in`n l{ {hvhn*wsln{jhjcslnh
g`jlbn shkh}w`s{$ ?WJ shkh}w`s{$ah}wlahdbkld shkh}w`s{ lng O }s`whbn*dbnihgshkh}w`s{ !O]DS"$ O]KS{.
Wah{h wr}h `f shkh}w`s k`nwlbn gb{wbnkwahwhs`wsbjhsbk OW]*cbngbno shoxdlw`sr}s`whbn{ in`n l{ O*}s`whbn{.
-
8/2/2019 GPCRs (G-Protein Coupled receptor)
4/25
O }s`whbn*k`x}dhg shkh}w`s{ lsh bnv`dvhg bnjlnr gb{hl{h{$ lng lsh ld{` wah wlsohw `f
l}}s`qbjlwhdr ;=( `f ldd j`ghsnjhgbkbnld gsxo{.
O]KS{ bnkdxgh5
Cb`ohnbk ljbnh{Hbk`{ln`bg{
]h}wbgh a`sj`nh{
@}b`bg{
Ljbn` lkbg{ {xka l{ OLCL
$*lgshnhsobk shkh}w`s }s`whbn{
@wahs }h}wbgh lng ]s`whbn dbolng{
-
8/2/2019 GPCRs (G-Protein Coupled receptor)
5/25
O*}s`whbn shoxdlwhg hffhkw`s{bnkdxgh5
Lghnrdrd krkdl{h
]a`{}a`db}l{h K]a`{}a`gbh{whsl{h{
Kl3) kalnnhd{
I) kalnnhd{
-
8/2/2019 GPCRs (G-Protein Coupled receptor)
6/25
-
8/2/2019 GPCRs (G-Protein Coupled receptor)
7/25
Gbvbghg bnw` washh jlbn kdl{{h{ `f fljbdr
Kdl{{ L5 Wah dlsoh{w kdl{{ cr fls$ k`nwlbnnhlsdr 18( `f wah O]KS ohnh{. Aldf `fwah{h lsh }shgbkwhg w` hnk`gh `dflkw`sr
shkh}w`s{$ wah shjlbnbno lsh kdl{{bfbhg l{`s}aln shkh}w`s{.
Kdl{{ C5 [hkshwbno shkh}w`s fljbdr. L}s`whbn fljbdr abkab{ l os`x} `fhv`dxwb`nlsbdr*shdlwhg }s`whbn{. Jlnr{hkshwbno shkh}w`s{ lsh shoxdlwhg cr}h}wbgh a`sj`nh{.
Kdl{{ K5 L wr}h `f odxwljlwh shkh}w`s{abka lsh lkwbvh was`x a ln bngbshkw
-
8/2/2019 GPCRs (G-Protein Coupled receptor)
8/25
-
8/2/2019 GPCRs (G-Protein Coupled receptor)
9/25
O{5 Wah fbs{w O*}s`whbn ld}al {xcxnbw w` ch bghnwbfbhg l{
O{. wab{ b{ sh{}`n{bcdh f`s {wbjxdlwbno lghnrdlwh krkdl{h
lng b{ LG]*sbc`{rdlwhg lng lkwbvlwhg cr KWq. [`jhhvbghnkh {a`{ walw wab{ {xcxnbw kln ld{` hnalnkh wahlkwbvbwr `f wah klsgblk D*wr}h Kl b`n kalnnhd{$bngh}hnghnwdr `f wahbs }a`{}a`srdlwb`n cr kLJ]
{wbjxdlwhg }s`whbn ibnl{h L.O`df5 O`dfb{ l krkdl{h*{wbjxdlwbno a`j`d`o bn wah `dflkw`sr
h}bwahdbxj$ lkwbvlwhg cr wah dlsoh fljbdr `f `dflkw`srshkh}w`s{.
Ob5 Ob b{ wah O*}s`whbn sh{}`n{bcdh f`s bnabcbwbno lghnrdlwhkrkdl{h. Wah bnabcbwb`n b{ jhgblwhg cr wah ld}al {xcxnbwlng b{ LG]*sbc`{rdlwhg lng lkwbvlwhg cr ]Wq. Bw ld{`lkwbvlwh{ bnlsg shkwbfbhs I b`n kalnnhd{ lng wab{lkwbvlwb`n b{ jhgblwhg cr {xcxnbw{. Bw al{ washh
b{`jhs{
-
8/2/2019 GPCRs (G-Protein Coupled receptor)
10/25
O`5 O`{ jlbn fxnkwb`n b{ w` shgxkh wah `}hnbno}s`clcbdbwr `f wa`{h v`dwloh olwhg Kl b`nkalnnhd{ bnv`dvh bn nhxs`wsln{jbwwhs shdhl{h.
Ahnkh$ bw b{ dlsoh sh{}`n{bcdh f`s wahbgh{}shlg lxw` bnabcbwb`n `f wsln{jbwwhs{hkshwb`n cr }sh*{rnl}wbk shkh}w`s{ lng wab{hffhkw b{ jhgblwhg was`xoa shdhl{hg {xcxnbw{. Wahsh lsh w` jlbn b{`jhs{ `f wab{5O`