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Degeneration 2018

February 10, 2018

Bascom Palmer Eye Institute

Sponsored by theUniversity of Miami Miller School of Medicine

BASCOM PALMER EYE INSTITUTE

Angiogenesis, Exudation, and Degeneration 2018February 10, 2018

Bascom Palmer Eye Institute invites you to join us in February 2018 for our fifteenth annual angiogenesis meeting. This unique and exciting symposium entitled Angiogenesis, Exudation, and Degeneration 2018 will be held February 10, 2018 at the Mandarin Oriental Hotel in Miami, Florida. The meeting will feature an exceptional gathering of basic scientists, clinicians, and healthcare experts, all focused on understanding and treating neovascular and exudative diseases of the eye. The meeting will highlight the revolutionary pharmacotherapies now in development and clinical practice for the management of neovascular AMD, macular edema, diabetic retinopathy, and retinopathy of prematurity with a special emphasis on the present and future financial impact of these drugs on clinical practices and Medicare.

Mandarin Oriental Hotel, Miami

COURSE CO-DIRECTORS

Thomas A. Albini, MD Associate Professor of Clinical OphthalmologyBascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine

Philip J. Rosenfeld, MD, PhDProfessor of OphthalmologyBascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine

Harry W. Flynn, Jr., MDProfessor of Ophthalmology

The J. Donald M. Gass Distinguished Chair in Ophthalmology

Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine

COURSE DESCRIPTIONAngiogenesis 2018 follows the tradition of excellence established by Bascom Palmer’s widely acclaimed Angiogenesis programs between 2004 and 2017. Designed for retina specialists, general ophthalmologists and researchers, the current program will review the latest in translational research and clinical trials with an emphasis on how these results will impact clinical ophthalmology. We will emphasize recently completed studies for treatment of a broad spectrum of retinal diseases with special emphasis on age-related macular degeneration, diabetic retinopathy, and retinal vein occlusions.

COURSE OBJECTIVESUpon completion of this program, participants should be able to:• Enhance patient care by evaluating the current global use of anti-VEGF drugs for exudative ocular diseases• Improve management skills by evaluating all the risks associated with injections of anti-VEGF drugs• Analyze the rationale for emerging treatments for different macular and retinal degenerative conditions• Analyze results of clinical trials in exudative and non- exudative macular diseases and apply to clinical practice• Evaluate the benefits and limitations of combination therapies for exudative macular diseases• Evaluate the benefits and limitations of different imaging strategies for macular diseases• Evaluate the emerging imaging technology known as OCT angiography• Enhance patient care by analyzing the genetic basis for different macular and retinal degenerative conditions

PROGRAM

Subject to change

7:00 am Registration and Continental Breakfast

7:55 Welcome and Overview Philip J. Rosenfeld, MD, PhD, Harry W. Flynn, Jr., MD and Thomas A. Albini, MD

SESSION I: Age-Related Macular Degeneration Moderators: Philip J. Rosenfeld, MD, PhD and Thomas A. Albini, MD

8:00 Top Innovations in Retina – A VC’s Perspective Emmett T. Cunningham, Jr., MD, PhD, MPH

8:10 Rare and High Impact Genetic Variants Related to Macular Degeneration Johanna M. Seddon, MD, SCM

8:20 Risk Factors for Progression to Advanced Age-Related Macular Degeneration: 5-year Follow-up of Patients with Early AMD Forms Carel B. Hoyng, MD

8:30 Oil Spill Strategies for AMD - Proof-of-Concept Studies Christine A. Curcio, PhD, FARVO

8:40 The Gut Feeling in AMD: Analysis of the Intestinal Microbiome in Exudative AMD Sebastian Wolf, MD, PhD

8:50 Drusenoid Detachment of the Retinal Pigment Epithelium: Life Cycle Lawrence A. Yannuzzi, MD

9:00 Computational Models of the Choroid and Outer Retina: Insights into Aging and Disease Philip Luthert, MBBS

9:10 OCTA Imaging of the Choriocapillaris Ruikang Wang, PhD

9:20 Ultrahigh Speed OCT for Assessing Vascular Impairment James Fujimoto, PhD

9:30 OCTA Based Clinical Trial Endpoints in AMD Nadia Waheed, MD

9:40 Geographic Atrophy Secondary to AMD: Baseline Data from Proxima A Nancy M. Holekamp, MD

SESSION II: Non-Exudative AMD Moderators: Harry W. Flynn, Jr. MD and Jaclyn L. Kovach, MD

9:50 Gap Junction (Connexin Channel) Therapy Colin Green, BSc, MSc, PhD, DSc

10:00 Kamuvudine for Macular Degeneration Jayakrishna Ambati, MD

10:10 Novel Anti-Oxidants in the Treatment of Intermediate Age-Related Macular Degeneration: The TRIAD Trial Karl G. Csaky, MD

SATURDAY, FEBRUARY 10, 2018

10:20 Efficacy of Elamipretide, a Mitochondrial-Targeted Drug, in the Treatment of Vision Loss in Drusen and Noncentral GA Scott W. Cousins, MD

10:30 Macrophage Modulation as Therapeutic Target in Dry AMD Shelley Romayne Boyd, MD, FRCS(C), DABO, BSc 10:40 HMR59 -Gene Therapy for Dry AMD – Background and Pre-Clinical Studies Jay S. Duker, MD

10:50 HMR59 – Gene Therapy for Dry AMD – Initial Results of the Phase 1b Study Elias Reichel, MD

11:00 C3 Inhibition for Geographic Atrophy in AMD Cedric G. Francois, MD, PhD

11:10 Increased Exudation after C3 Inhibition: Why SS-OCTA is Necessary for Non-Exudative AMD Clinical Trials Philip J. Rosenfeld, MD, PhD

SESSION III: Macular Neovascularization: Imaging and Emerging Therapies Moderators: Philip J. Rosenfeld, MD, PhD and Ninel Z. Gregori, MD

11:20 Understanding Aneurysmal Type 1 Neovascularization, aka Polypoidal Choroidal Vasculopathy K. Bailey Freund, MD

11:30 Nascent Type 3 Neovascularization in Age-Related Macular Degeneration Giuseppe Querques, MD, PhD

11:40 Second Generation Gene Therapy for Neovascular AMD Allen C. Ho, MD

11:50 Squalamine Combination Therapy for Exudative AMD – Results of a Randomized Clinical Trial Jason S. Slakter, MD

12:00 pm Evaluation of Binding Affinity, Stability and Sterility of Aflibercept and Ziv-Aflibercept after Compounding Method Michel E. Farah, MD

12:10 Ang2 Inhibition in Neovascular AMD David M. Brown, MD, FACS

12:20 Delayed Intraocular Inflammatory Response Following Intravitreal Injections Stephan Michels, MD, MBA

12:30 Lunch

SESSION IV: Macular Neovascularization and Anti-VEGF Therapy Moderators: Thomas A. Albini, MD and Harry W. Flynn, Jr., MD

1:20 IVAN Study: 5-year Follow up Results Usha Chakravarthy, MD

1:30 CNV Long-Term Evolution after Treatment Bruno Lumbroso, MD

1:40 Impact of Injection Frequency on Visual Outcomes: a Real-world Analysis Andrew A. Moshfeghi, MD

1:50 Geographic Atrophy Secondary to Anti VEGF Treatment: Data from Real Live Clinical Trials Giovanni Staurenghi, MD

2:00 Outcomes in Patients with Neovascular Age-related Macular Degeneration Based on Dosing Intervals in the Second Year of the VIEW Studies W. Lloyd Clark, MD

2:10 Prognostic Factors for Visual Outcomes in Eyes Treated with Ranibizumab for Myopic Choroidal Neovascularization Diana V. Do, MD

SESSION V: Brolucizumab Symposium Moderators: Philip J. Rosenfeld, MD, PhD and Lawrence J. Singerman, MD, FACS

2:20 The Science Behind Brolucizumab Carl D. Regillo, MD, FACS

2:30 Brolucizumab Phase 3 Study Design Rishi P. Singh, MD

2:40 Brolucizumab Phase 3 Top Line Results David M. Brown, MD, FACS

2:50 Brolucizumab Phase 3 Analysis of Images and Cases Glenn J. Jaffe, MD

3:00 Brolucizumab Phase 3 Additional Analyses Pravin U. Dugel, MD

3:10 Panel Discussion

SESSION VI: Retinal Vascular Diseases: Imaging and Anti-VEGF Therapy Moderators: Harry W. Flynn, Jr., MD and Justin Townsend, MD

3:20 Suspended Scattering Particles in Motion: A Novel OCTA Finding in Exudative Maculopathy Amir H. Kashani, MD, PhD

3:30 Wide Field SS OCT-A: Why We need it for Diabetic Retinopathy Professor Jean-Francois Korobelnik

3:40 Precise Detection of Macular Capillary Nonperfusion Using SS-OCT Angiography in Macular Edema Second- ary to Diabetic Retinopathy and Retinal Vein Occlusion Toshinori Murata, MD, PhD

3:50 OCT Angiography and Diabetic Retinopathy Harry W. Flynn, Jr., MD

4:00 Diabetic Retinopathy, Capillary Perfusion and Anti-VEGF Therapy Ramin Tadayoni, MD, PhD

4:10 Mechanism by which VEGF Suppression Improves Retinal Vessel Closure in DME and RVO Peter A. Campochiaro, MD

4:20 Circulating VEGF Levels after Anti-VEGF Therapy in Diabetics Lee M. Jampol, MD

4:30 Intravitreal Aflibercept for Retinal Non-Perfusion in Proliferative Diabetic Retinopathy: 6-Month Outcomes of the Prospective, Randomized RECOVERY Trial Charles C. Wykoff, MD, PhD

4:40 Ranibizumab Treatment Resulted in Disease Modification of Central Retinal Vein Occlusion in the CRUISE Clinical Trial Michael S. Ip, MD

4:50 Anti-VEGF in ROP: Safety and Managing Expectations Darius M. Moshfeghi, MD

SESSION VII: Diabetes, Retinal Degenerations, and Uveitis Moderators: Thomas A. Albini, MD and Philip J. Rosenfeld, MD, PhD

5:00 Pharmacotherapy in Development for Diabetic Macular Edema: What May Be Coming to the Clinics? Quan Nguyen, MD, MSc

5:10 Topical Therapy for Diabetic Macular Edema David S. Boyer, MD

5:20 Integrin Antagonism and DME Peter K. Kaiser, MD

5:30 Ang2 Inhibition in Diabetic Macular Edema Philip J. Rosenfeld, MD, PhD

5:40 MacTel Phase 2 Trial with CNTF Emily Y. Chew, MD

5:50 Update on Clinical Trials for Retinal Degenerations Byron L. Lam, MD

6:00 Retinal Progenitors Cells for RP: The jCyte Experience Baruch D. Kuppermann, MD, PhD

6:10 Novel Therapies in the Management of Uveitis Sunil Srivastava, MD

6:20 Ocular Histopathologic Features of Congenital Zika Syndrome Sander R. Dubovy, MD

6:30 Adjourn/Cocktail Reception

Jayakrishna Ambati, MDDuPont Guerry, III, Professor of OphthalmologyProfessor & Vice Chair for Research, OphthalmologyFounding Director Center for Advanced Vision ScienceUniversity of VirginiaCharlottesville, VA

David S. Boyer, MDClinical Professor of OphthalmologyKeck School of MedicineUniversity of Southern California Senior Partner Retina-Vitreous Associates Medical GroupLos Angeles, CA

David M. Brown, MD, FACSClinical Professor of OphthalmologyBaylor College of Medicine Director of Clinical ResearchRetina Consultants of HoustonHouston, TX

Peter A. Campochiaro, MDGeorge S. and Dolores Dore Eccles Professor of Ophthalmology and NeuroscienceWilmer Eye InstituteThe Johns Hopkins University School of MedicineBaltimore, MD

Usha Chakravarthy, MDProfessor of Ophthalmology and Vision SciencesRoyal Victoria Hospital (The Belfast Trust)Northern Ireland, United Kingdom

Emily Y. Chew, MDDirector, Division of Epidemiology and Clinical Applications National Eye Institute/National Institutes of HealthBethesda, MD

W. Lloyd Clark, MDPalmetto Retina CenterWest Columbia, SC

Scott W. Cousins, MDRobert Machemer, MD, Professor of Ophthalmology and ImmunologyVice Chair for ResearchDirector, Duke Center for Macular DiseasesDuke Eye CenterDuke University Durham, NC

Karl G. Csaky, MD, PhDT. Boone Pickens DirectorClinical Center of Innovation for Macular DegenerationManaging and Medical DirectorRetina Foundation of the SouthwestDallas, TX

Emmett T. Cunningham, Jr., MD, PhD, MPHAdjunct Professor of OphthalmologyCalifornia Pacific Medical CenterStanford University School of Medicine The Francis I. Proctor Foundation, UCSFHillsborough, CA

Christine A. Curcio, PhD, FARVOProfessor of Ophthalmology Director, Age-related Maculopathy Histopathology LaboratoryUniversity of Alabama at Birmingham School of Medicine Birmingham, AL

Diana V. Do, MDProfessor of OphthalmologyByers Eye InstituteStanford University School of MedicinePalo Alto, CA

Sander R. Dubovy, MDProfessor of PathologyBascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineMiami, FL

Pravin U. Dugel, MDClinical Professor of OphthalmologyKeck School of MedicineUniversity of Southern CaliforniaLos Angeles, CA Managing Partner, Retinal Consultants of ArizonaRetinal Research Institute LLCPhoenix, AZ

Jay S. Duker, MDProfessor and Chairman of OphthalmologyDirector, New England Eye CenterTufts Medical CenterTufts University School of MedicineNew England Eye CenterBoston, MA

Michel E. Farah, MDProfessor of OphthalmologyPaulista School of MedicineSão Paulo Federal University - UNIFESPSao Paulo, Brazil

Cedric G. Francois, MD, PhDApellis PharmaceuticalsCrestwood, KY

K. Bailey Freund, MDVitreous Retina Macula Consultants of New YorkClinical Professor of Ophthalmology NYU School of MedicineNew York, NY

James G. Fujimoto, PhDElihu Thomson Professor of Electrical EngineeringDept. of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge, MA

Colin Green, BSc, MSc, PhD, DScProfessor of OphthalmologyFaculty of Medical and Health SciencesThe University of AucklandNew Zealand

Ninel Z. Gregori, MDAssociate Professor of Clinical OphthalmologyBascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineMiami, FL

Allen C. Ho, MDAttending Surgeon and Director of Retina Research Wills Eye HospitalProfessor of Ophthalmology Thomas Jefferson UniversityMid Atlantic RetinaPlymouth Meeting, PA

Nancy M. Holekamp, MDDirector, Retina ServicesPepose Vision InstituteProfessor of Clinical OphthalmologyWashington University School of MedicineSaint Louis, MO

Carel B. Hoyng, MDProfessor of OphthalmologyRadboud University CenterNijmegen, Netherlands

Michael S. Ip, MDAssociate Professor of OphthalmologyUniversity of Wisconsin School of Medicine and Public HealthMadison, WI

Glenn J. Jaffe, MDRobert Machemer Professor of OphthalmologyChief, Vitreoretinal DivisionDirector, Duke Reading CenterDuke Eye CenterDuke UniversityDurham, NC

Lee M. Jampol, MDLouis Feinberg, MD, Professor of OphthalmologyNorthwestern MedicineFeinberg School of MedicineNorthwestern UniversityChicago, IL

SPEAKERS

Peter K. Kaiser, MDProfessor of OphthalmologyChaney Family Endowed Chair of Ophthalmology ResearchCole Eye InstituteCleveland ClinicCleveland, OH

Amir H. Kashani, MD, PhDAssistant Professor of Clinical OphthalmologyUSC Roski Eye InstituteUniversity of Southern CaliforniaLos Angeles, CA

Professor Jean-François KorobelnikHead of Ophthalmology DepartmentBordeaux University HospitalPlace Amélie Raba Léon Bordeaux, France

Jaclyn L. Kovach, MDAssociate Professor of Clinical OphthalmologyBascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineNaples, FL

Baruch D. Kuppermann, MD, PhDRoger F. Steinert Professor and Chair, Department of OphthalmologyDirector, Gavin Herbert Eye InstituteUniversity of CaliforniaIrvine, CA

Byron L. Lam, MDProfessor of OphthalmologyBascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineMiami, FL

Bruno Lumbroso, MDCentro Italiano MaculaRome, Italy

Philip Luthert, MBBSProfessor and Honorary ConsultantMoorfields Eye HospitalUniversity College LondonLondon, UK

Stephan Michels, MD, MBAProfessor and Vice Chair Department of OphthalmologyCity Hospital TriemliZurich, Switzerland

Andrew A. Moshfeghi, MD, MBAAssociate Professor of Clinical OphthalmologyUSC Roski Eye InstituteUniversity of Southern CaliforniaLos Angeles, CA

Darius M. Moshfeghi, MDProfessor of OphthalmologyChief, Retina DivisionByers Eye Institute at Stanford/Horngren Family Vitreoretinal CenterStanford University School of MedicinePalo Alto, CA

Toshinori Murata, MD, PhDProfessor and Chairman of OphthalmologyShinshu UniversityMatsumoto, Japan

Quan Dong Nguyen, MD, MSc, FAAOProfessor of OphthalmologyByers Eye InstituteStanford University School of MedicineStanford, CA

Giuseppe Querques, MD, PhDAssociate ProfessorUniversitá Vita-Salute San RaffaeleInstituto Scientifico San RaffaeleMilano, Italy

Carl D. Regillo, MD, FACSDirector, Retina ServiceWills Eye HospitalProfessor of OphthalmologyThomas Jefferson UniversityPhiladelphia, PA

Elias Reichel, MDProfessor and Vice Chair of OphthalmologyDirector, Vitreoretinal ServiceNew England Eye CenterTufts Medical CenterTufts University School of MedicineBoston, MA

Shelley Romayne Boyd, MD, FRCS(C), DABO, BSc St. Michael HospitalUniversity of TorontoToronto, Ontario, Canada

Johanna M. Seddon, MD, ScMProfessor of OphthalmologyTufts University School of MedicineDirector, Ophthalmic Epidemiology and Genetics ServiceTufts Medical CenterBoston, MA

Lawrence J. Singerman, MD, FACSVoluntary Professor of OphthalmologyBascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine Clinical Professor of OphthalmologyCase Western Reserve University Retina Associates of Cleveland, Inc.Cleveland, OH

Rishi P. Singh, MDAssociate Professor of Ophthalmology Case Western Reserve UniversityStaff Physician, Cole Eye Institute Cleveland ClinicCleveland, OH

Jason S. Slakter, MDClinical Professor of OphthalmologyNew York University School of MedicinePartner, Vitreous-Retina Macula Consultants of New YorkNew York, NY

Sunil K. Srivastava, MDStaff Physician, Cole Eye Institute Cleveland ClinicCleveland, OH

Giovanni Staurenghi, MDProfessor of OphthalmologyUniversity of MilanLuigi Sacco Hospital University of MilanMilano, Italy

Ramin Tadayoni, MD, PhDProfessor and Chairman of OphthalmologyUniversité Paris Hôpital LariboisièreParis, France

Justin Townsend, MDAssistant Professor of Clinical OphthalmologyBascom Palmer Eye InstituteUniversity of Miami School of MedicineMiami, FL

Nadia Waheed, MDAssistant Professor of OphthalmologyTufts Medical SchoolTufts New England Eye CenterBoston, MA

Ruikang (Ricky) Wang, PhDProfessor, Bioengineering & OphthalmologyUniversity of WashingtonSeattle, WA

Sebastian Wolf, MD, PhDProfessor and ChairmanDepartment of OphthalmologyInselspital, Universitätsspital BernBern, Switzerland

Charles C. Wykoff, MD, PhDRetina Consultants of HoustonBlanton Eye Institute, Houston Methodist HospitalHouston, TX

Lawrence A. Yannuzzi, MD Professor of Clinical OphthalmologyCollege of Physicians and SurgeonsColumbia University School of MedicineManhattan Eye and Ear HospitalNew York City, NY

DATESaturday, February 10, 2018: 7:55 am to 6:30 pm

LOCATIONMandarin Oriental Miami, Miami, Florida500 Brickell Key Drive, Miami, FL 33131Reservations: (800) 526-6566, Direct: (305) 913-8288

Mandarin Oriental Miami is one of America’s finest hotels and recently voted Best Urban Hotel by Miami Herald’s Readers Choice South Florida’s Finest survey-Best of South Florida. Ideally located on prestigious Brickell Key, its deluxe, waterfront location perfectly befits the opulence you’ll find within. The rooms are luxurious, the award-winning restaurants are some of the finest in Miami and the spa is one of the most beautiful in the world. The hotel’s extensive leisure facilities make it the perfect choice for a conference or a holiday in Miami.

HOTEL RESERVATIONSFor hotel information and reservations, please call 305-913-8288 or 800-526-6566.

The special hotel rate for conference attendees is $419 per night for single or double plus tax. The Mandarin Oriental will extend the special group rate for three days prior and three days after the main program dates, subject to availability. Check-in time is 3:00 pm; Check-out time is 12:00 noon.

We suggest you make your hotel reservations as soon as possible as the winter months are the height of South Florida’s tourist season. Bascom Palmer’s preferred room rate will be released after January 10, 2018. Reservations and deposits received after that time are subject to current rates and availability. Please contact the Mandarin Oriental Miami for hotel cancellation policies. For additional information visit: www.mandarinoriental.com/miami

CONFERENCE FEESRegistration rate is $475.Conference fees include course materials, opening reception, continental breakfast, lunch and refreshment breaks.

CANCELLATION POLICYConference tuition, less a $50 cancellation fee, is refundable if notice is received by January 26, 2018. No refunds shall be considered after January 26, 2018 or after sixty (60) days following payment.

INFORMATION

Bascom Palmer Eye InstituteAngiogenesis, Exudation, and Degeneration 2018

ACCREDITATION:The University of Miami Leonard M. Miller School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

CREDIT DESIGNATION:The University of Miami Leonard M. Miller School of Medicine designates this live activity for a maximum of 9.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

DISCLOSURE AND CONFLICT OF INTEREST RESOLUTION:All conflicts of interest of any individual(s) in a position to control the content of this CME activity will be identified and resolved prior to this educational activity being provided. Disclosure about provider and faculty relationships, or the lack thereof, will be provided to learners.

SERVICES FOR THE DISABLEDIf special arrangements are required for an individual with a disability to attend this conference, please contact Karen Davila at (305) 326-6110 on or before January 26, 2018.

REGISTRATIONSpace is limited. Please register early.

To register by internet: Please visit: http://bascompalmer.org/cme/angiogenesis/registration

To register by mail: Please complete the registration form and return with your check or credit card payment to:Bascom Palmer Eye InstituteDepartment of Continuing Medical Education1400 NW 10th Ave., Suite 508Miami, FL 33136 (Att: Karen Davila)

To register by fax: Please complete the registration form and return with your credit card payment to (305) 326-6518.

For more information contact:Bascom Palmer Eye InstituteDepartment of Continuing Medical Education at(305) 326-6110 / Email: bascompalmercme@miami.edu

www.bascompalmer.org

Bascom Palmer Eye Institute

REGISTRATION FORM

Bascom Palmer Eye InstituteAngiogenesis, Exudation, and Degeneration 2018

REGISTRATION: $475

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Saturday, February 10, 2018Registration is limited, so please register early.

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