PHARMACOLOGYPHARMACOLOGYScience dealing with

interactions between living systems and molecules,

especially chemicals from outside the body.

Science dealing with interactions between living

systems and molecules, especially chemicals from

outside the body.Drugs will be different in:

Size--most smallShape--to fit receptorChemical nature--acid/base

Drugs will be different in:Size--most smallShape--to fit receptorChemical nature--acid/base

Drug-body interactionDrug-body interactionPharmacodynamic:What drug does to youa) mimic or inhibit normal physiological/biochemical

processes or inhibit pathological processes in animals or(b) inhibit vital processes of endo- or ectoparasites and microbial organisms.

Pharmacokinetic:What you do to drug(absorb, distribute,

metabolize,eliminate)

Pharmacodynamic:What drug does to youa) mimic or inhibit normal physiological/biochemical

processes or inhibit pathological processes in animals or(b) inhibit vital processes of endo- or ectoparasites and microbial organisms.

Pharmacokinetic:What you do to drug(absorb, distribute,

metabolize,eliminate)

Get the drug in:Get the drug in:

OralInhaleTopicalTransdermalSubcutaneousIntramuscularBuccalSublingualRectal

Parenteral---must skip the GI tract to avoid stomach acid(some penicllins and insulin)

OralInhaleTopicalTransdermalSubcutaneousIntramuscularBuccalSublingualRectal

Parenteral---must skip the GI tract to avoid stomach acid(some penicllins and insulin)

DRUG GROUPSDRUG GROUPSAntibioticsAntifungalsAntiviralsAntiretroviralsAffective disordersInsomniaCNS disordersRespiratory agentsGastrointestinal agentsUrinary systemCardiovascularAnticoagulantHyperlipidemiaNarcotic and opoid analgesicsNon-narcotic analgesicsThyroid

AntibioticsAntifungalsAntiviralsAntiretroviralsAffective disordersInsomniaCNS disordersRespiratory agentsGastrointestinal agentsUrinary systemCardiovascularAnticoagulantHyperlipidemiaNarcotic and opoid analgesicsNon-narcotic analgesicsThyroid

DRUG GROUPS CONTDRUG GROUPS CONT

Hormone replacementBone diseaseCorticosteroidsHypoglycemicTopicalchemotherapy

Hormone replacementBone diseaseCorticosteroidsHypoglycemicTopicalchemotherapy

drug interactionsdrug interactions drug-drug interactions--- addition--combined effect of 2 drugs antagonism---drugs work against each

other potentiation----one drug increase effect of

the other synergism----combined effect is more

intense or longer

drug-disease interaction-some diseases may inhibit effects of drugs.

drug nutrient interaction--poor nutrition may affect metabolism

drug-drug interactions--- addition--combined effect of 2 drugs antagonism---drugs work against each

other potentiation----one drug increase effect of

the other synergism----combined effect is more

intense or longer

drug-disease interaction-some diseases may inhibit effects of drugs.

drug nutrient interaction--poor nutrition may affect metabolism

drug interactionsdrug interactions drug-food interaction----some drugs have

better absorption with fatty meal some drugs have decreased absorption

with food grapefruit juice may affect some drugs warfarin interacts with vitK foods. newborns---organs not developed until

1yoa geriatric---pharmacokinetics changes with

age due to GI, cardiac,ect changes.

drug-food interaction----some drugs have better absorption with fatty meal

some drugs have decreased absorption with food

grapefruit juice may affect some drugs warfarin interacts with vitK foods. newborns---organs not developed until

1yoa geriatric---pharmacokinetics changes with

age due to GI, cardiac,ect changes.