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    Drug StudyDrug Study

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    Ampicillin Ampicillin

    Classifica tion: Anti-infective

    Me chanisms of Ac tion:Interferes with cell wall synthesis of susceptibleorganism, preventing bacterial multiplication

    Deactivated by beta-lactamase, an enzymeproduced by resistant bacteria.

    Classifica tion: Anti-infective

    Me chanisms of Ac tion:Interferes with cell wall synthesis of susceptibleorganism, preventing bacterial multiplication

    Deactivated by beta-lactamase, an enzymeproduced by resistant bacteria.

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    In d ica tion:T reatment of respiratory tract and soft tissueinfection, bacterial meningitis, septicemiaand gonococal infections caused bysusceptible microorganisms

    Con tr ain d ica tion:Hypersensitivity to penicillins,cephalosporins or imipenemOral form not used to treat severepneumonia, bacteremia, pericarditis,purulent or septic arthritis during acutestage

    In d ica tion:T reatment of respiratory tract and soft tissueinfection, bacterial meningitis, septicemiaand gonococal infections caused bysusceptible microorganisms

    Con tr ain d ica tion:Hypersensitivity to penicillins,cephalosporins or imipenemOral form not used to treat severepneumonia, bacteremia, pericarditis,purulent or septic arthritis during acutestage

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    Adv e r s e Eff e c ts:

    T hrombophlebitis at injection siteIrritabilitySkin rashes

    Itchy eyesLaryngospasmLaryngeal edemaDiarrhea

    Adv e r s e Eff e c ts:

    T hrombophlebitis at injection siteIrritabilitySkin rashes

    Itchy eyesLaryngospasmLaryngeal edemaDiarrhea

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    N ur sin g R e sponsibili tie s:Obtain patient history of infection before and during therapy to

    assess responseAssess patient for signs and symptoms of infection, fever,

    characteristics of wounds, sputum, urine, stool, ear ache, and WBCcount

    Obtain CNS before drug therapy to identify if correct treatmenthas been initiated

    Assess for allergic or hypersensitivity reactions: chills, fever,joint pain, pruritus and rash.

    Monitor renal function: urine output, urinalysis: protein andblood.

    Assess for over growth of infection: perineal itching, fever,malaise, redness, pain, swelling, drainage, rash, diarrhea, or changein character of cough and sputum.

    N ur sin g R e sponsibili tie s:Obtain patient history of infection before and during therapy to

    assess responseAssess patient for signs and symptoms of infection, fever,

    characteristics of wounds, sputum, urine, stool, ear ache, and WBCcount

    Obtain CNS before drug therapy to identify if correct treatmenthas been initiated

    Assess for allergic or hypersensitivity reactions: chills, fever,joint pain, pruritus and rash.

    Monitor renal function: urine output, urinalysis: protein andblood.

    Assess for over growth of infection: perineal itching, fever,malaise, redness, pain, swelling, drainage, rash, diarrhea, or changein character of cough and sputum.

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    G e n tamicinG e n tamicin

    Classification:

    Anti-infective

    Me chanisms of Ac tion:Interferes with protein synthesis in bacterial cellby binding to ribosomal subunit, causing

    misreading of genetic code; inaccurate peptidesequence forms in protein chain, causingbacterial death

    Classification:

    Anti-infective

    Me chanisms of Ac tion:Interferes with protein synthesis in bacterial cellby binding to ribosomal subunit, causing

    misreading of genetic code; inaccurate peptidesequence forms in protein chain, causingbacterial death

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    In d ica tion:

    Interferes with protein synthesis in bacterial cellby binding to ribosomal subunit, causingmisreading of genetic code; inaccurate peptidesequence forms in protein chain, causing bacterial

    death

    Con tr ain d ica tion:Hypersensitivity to gentamicin Injury and

    ulceration of the cornea, viral infection or mycosis

    In d ica tion:

    Interferes with protein synthesis in bacterial cellby binding to ribosomal subunit, causingmisreading of genetic code; inaccurate peptidesequence forms in protein chain, causing bacterial

    death

    Con tr ain d ica tion:Hypersensitivity to gentamicin Injury and

    ulceration of the cornea, viral infection or mycosis

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    Adv e r s e Eff e c ts:HeadacheFever Muscle weakness and twitchingAcute organic brain syndromeRashItchingAnaphylaxisApneaAnemia

    Adv e r s e Eff e c ts:HeadacheFever Muscle weakness and twitchingAcute organic brain syndromeRashItchingAnaphylaxisApneaAnemia

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    V itamin KV itamin KClassifica tion:Clotting vitamin/agent

    Me chanisms of Ac tion:Vitamin K is fat soluble vitamin that plays an important role in bloodclotting

    In d ica tion:For those with vitamin K deficiency

    Con tr ain d ica tion:In patients receiving anticoagulants as vitamin K decreas theeffects of the drugs

    Classifica tion:Clotting vitamin/agent

    Me chanisms of Ac tion:Vitamin K is fat soluble vitamin that plays an important role in bloodclotting

    In d ica tion:For those with vitamin K deficiency

    Con tr ain d ica tion:In patients receiving anticoagulants as vitamin K decreas theeffects of the drugs

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    Adver s e e ff e cts:

    Decreased appetite, decreases movement or activity; difficult in

    breathing, enlarged liver, general body swimming, muscle stiffness,yellow eyes or skin.Difficulty in swallowing; fast or irregular breathing;

    lightheadedness or fainting; shortness of breath; skin rash or itching;swelling of eyelids, face, or lips

    N ur sin g R e sponsibili tie s:

    If you take warfarin(a blood thinner, you should know that vitamin kor food containing vitami k can affect the the drug

    Vitamin K deficiency is very rare. It occurs when the cody cantproperl absorb the vitamihn from the intestinal tract

    Vitamin k deficiency can also occur after long term treatment withantibiotics

    If you are taking anticoagulant medicines(bloodthinners), the amountof vitamin k in your diet may affect how well these these medicinework.

    Adver s e e ff e cts:

    Decreased appetite, decreases movement or activity; difficult in

    breathing, enlarged liver, general body swimming, muscle stiffness,yellow eyes or skin.Difficulty in swallowing; fast or irregular breathing;

    lightheadedness or fainting; shortness of breath; skin rash or itching;swelling of eyelids, face, or lips

    N ur sin g R e sponsibili tie s:

    If you take warfarin(a blood thinner, you should know that vitamin kor food containing vitami k can affect the the drug

    Vitamin K deficiency is very rare. It occurs when the cody cantproperl absorb the vitamihn from the intestinal tract

    Vitamin k deficiency can also occur after long term treatment withantibiotics

    If you are taking anticoagulant medicines(bloodthinners), the amountof vitamin k in your diet may affect how well these these medicinework.

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    F u si d ic aci dF u si d ic aci d

    Classifica t ion:Opthalmic Prparations

    Me chanisms of Ac tion:Inhibits bacterial photosynthesis; it does not bindto the bacterial ribosomes but inhibits the factor necessary for translocation of peptide subunitsand elongation of the peptide chain; bacteriostaticor bactericidal

    Classifica t ion:Opthalmic Prparations

    Me chanisms of Ac tion:Inhibits bacterial photosynthesis; it does not bindto the bacterial ribosomes but inhibits the factor necessary for translocation of peptide subunitsand elongation of the peptide chain; bacteriostaticor bactericidal

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    In d ica tion:T

    reatment of staphylococcal infections, often inconjunction with other drugs

    Con tr ain d ica tion:

    Hypersensitivity

    Adv e r s e Eff e c ts:Hypersensitivity reactions in the form of rashes and

    irritation may occur after the topical administrationof fusidates; rash is rare after systemicadministration

    In d ica tion:T

    reatment of staphylococcal infections, often inconjunction with other drugs

    Con tr ain d ica tion:

    Hypersensitivity

    Adv e r s e Eff e c ts:Hypersensitivity reactions in the form of rashes and

    irritation may occur after the topical administrationof fusidates; rash is rare after systemicadministration

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    N ur sin g R e sponsibili tie s:Obtain patients history including hypersensitivity

    Assess the patient for signs and symptoms of infection including characteristics of wounds,urine, stool, ear ache, fever; obtain baselineinformation before and during treatmentPerform periodic monitoring of liver function testMonitor hypocalcaemia

    N ur sin g R e sponsibili tie s:Obtain patients history including hypersensitivity

    Assess the patient for signs and symptoms of infection including characteristics of wounds,urine, stool, ear ache, fever; obtain baselineinformation before and during treatmentPerform periodic monitoring of liver function testMonitor hypocalcaemia