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  • 52 | March+april 201 1 positivelyaware.coM

    2011 HIV Drug guide

    Drug interactions

    For DetaIls, reaD tHe Drugs page

    in the Drug Guide, or refer to the manufac-turers package insert for a full compre-hensive list of potential drug interactions. Also, make your pharmacist and health care providers aware of any drug that you add. Some interactions are more serious

    than others; some drugs may only require a dose adjustment, while others may either render the drug completely ineffective, or worse, lead to a potentially fatal reaction.

    Discuss any changes, however minor, with your health care providers, including your pharmacist, since small reactions

    may become serious. Look up your drugs with Check my meds at www.aidsmeds.com/cmm, which lists the effect of food as well as interactions for medications. The University of Liverpool also has an interac-tive database that allows you to look up antiretroviral drug interactions and has PDF charts of interactions between anti-retrovirals and other drugs. Remember, brand names are usually capitalized, while generic names are not. Go to www.hiv-druginteractions.org.

    Do your meDsplay well with others?

    NucleosIDe reVerse traNscrIptase INHIbItorsalso called nucleoside analogs, NRTIs, or nukes

    Potential drug class interactions None.

    Combivir(Retrovir and Epivir)

    See Epivir and Retrovir (zidovudine). Do not take Atripla, Emtriva, Epivir, Epivir-HBV, Epzicom, Retrovir (zidovudine), rilpivirine/Truvada, Trizivir, or Truvada, since all or part of these medications are already in Combivir or have equivalent medications.

    Emtriva(emtricitabine, or FTC)

    No significant drug interactions. Do not take Emtriva with Atripla, Combivir, Epivir, Epivir-HBV, Epzicom, rilpivirine/Truvada, Trizivir, or Truvada, since they contain Emtriva or medication equivalent to Emtriva.

    Epivir(lamivudine, or 3TC)

    No significant drug interactions. Do not take Atripla, Combicir, Emtriva, Epivir-HBV, Epzicom, Trizivir, or Truvada, while taking Epivir, since they contain Epivir or medication equivalent to it.

    Epzicom(Epivir and Ziagen)

    See Epivir and Ziagen. Do not take Atripla, Combivir, Emtriva, Epivir, Epivir-HBV, rilpivirine/Truvada Trizivir, or Truvada, while taking Epzicom, since all or part of these medications are already in Epzicom or have equivalent medications.

    Retrovir(zidovudine, or AZT)

    Do not take with Combivir or Trizivir, since zidovudine is already in these medications. Amphotericin B, Benemid, Biaxin, dapsone, Depakote, doxorubicin, flucytosine, ganci-clovir, hydroxyurea, interferon-alpha, methadone, pentamidine, phenytoin (Dilantin), ribavirin, rifampin, sulfadiazine, Valcyte, and Zerit.

    Trizivir(Epivir, Retrovir, and Ziagen)

    See Epivir, Retrovir, and Ziagen. Do not take Atripla, Emtriva, Epivir, Epivir-HBV, Epzicom, Ziagen, Retrovir (zidovudine), or Truvada while taking Trizivir, since all or part of these medications are already in Trizivir or have equivalent medications.

    Truvada(Viread and Emtriva)

    See Emtriva and Viread. Do not take with Atripla, Combivir, Emtriva, Epivir, Epivir-HBV, Epzicom, rilpivirine/Truvada Trizivir, or Viread, since all or part of these medications are already in Truvada or have equivalent medications.

    A guide to HIV drug interactionsby swarup Mehta, PharmD anD eniD Vzquez

  • positivelyaware.coM March+april 201 1 | 53

    2011 HIV Drug guide

    Drug interactions

    Videx & Videx EC(didanosine, or ddI)

    Alcohol, allopurinol, cimetidine, dapsone, ganciclovir, HIV protease inhibitors, hydroxyurea, itraconazole, ketoconazole, methadone, pentamidine, Rescriptor, Retrovir (zidovudine), ribavirin, valganciclovir, Viread, and Zerit.

    Viread(tenofovir)

    Do not take with Atripla, rilpivirine/Truvadam or Truvada since Viread is in these medications. Hepsera, Kaletra, Norvir, Reyataz, Videx and Videx-EC.

    Zerit(stavudine, or d4T)

    Amphotericin B, dapsone, foscarnet, ganciclovir, pentamidine, Valcyte, Videx and Videx-EC, and Retrovir (zidovudine).

    Ziagen(abacavir sulfate)

    Do not take with Epzicom or Trizivir, since Ziagen is already in these medications. Alcohol and methadone.

    NoN-NucleosIDe reVerse traNscrIptase INHIbItorsalso called non-nucleosides, NNRTIs, or non-nukes

    Potential drug class interactions Anti-convulsants; HIV protease inhibitors; methadone.

    Intelence(etravirine, or ETR)

    Aptivus/Norvir, Atripla, Biaxin, Cialis, Coumadin (warfarin), diazepam, Dilantin (phenytoin), fluconazole, Kaletra, Lexiva/Norvir, Mycobutin, Levitra, Norvir, phenobarbital, Plavix, Rescriptor, Reyataz/Norvir, rifampin, rilpivirine, Selzentry, St. Johns wort, Sustiva, Tegretol (carbamazepine), Viagra, Viramune, voriconazole, and unboosted (without Norvir) PIs.

    Rescriptor(delavirdine, or DLV)

    Agenerase, amlodipine, certain amphetamines and antiarrhythmic drugs, Atripla, Biaxin, birth control pills, Cialis, cisapride, Coumadin (warfarin), Crixivan, dapsone, Dilantin (phenytoin), ergot alkaloids (Cafergot, D.H.E. 45, Methergine, Wigraine), felodipine, fluticasone (Advair, Flonase, Flovent), immunosuppressants, Intelence, Invirase, Kaletra, Levitra, Lexiva, methadone, lovastatin, midazolam, Mycobutin, nifedipine, Norvir, phenobarbital, pimozide, Propulsid, quinidine, Reyataz, rifampin, rilpivirine, simvastatin, St. Johns wort, Sustiva, Tegretol (carbamazepine), trazodone, triazolam, Viagra, Viracept, Viramune, Vytorin, and Xanax (alprazolam).

    rilpivirine(TMC-278)

    Methadone. Atripla, Intelence, Rescriptor, Sustiva, and Viramune. Available data is limited due to its experimental drug status at press time.

    Sustiva(efavirenz, or EFV)

    Do not take with Atripla, since Sustiva is already in Atripla. Bepridil, Biaxin, birth control pills, buprenorphine, bupropion, Coumadin (warfarin), Crixivan, Dilantin (phenytoin), diltiazem, ergot alkaloids (Cafergot, D.H.E. 45, Methergine, Wigraine), Gingko biloba, immunosuppressants, Intelence, Invirase, itraconazole, Kaletra, Lexiva, Lipitor, Malarone, methadone, midazolam, Mycobutin, Norvir, Noxafil (posaconazole), pimozide, pravastatin, Rescriptor, Reyataz, rifampin, rilpivirine, phenobarbital, pravastatin, sertraline, simvastatin, St. Johns wort, Tegretol (carbamazepine), triazolam, Vfend, Viramune, and Zoloft .

    Viramune(nevirapine)

    Atripla, Biaxin, birth control pills, calcium channel blockers (Adalat, Norvasc, Procardia, and others), cisapride, clonazepam, Cordarone, Coumadin (warfarin), Crixivan, Dilantin (phenytoin), disopyramide, ergot alkaloids (Cafergot, D.H.E. 45, Methergine, Wigraine), ethosuxomide, flucanozole, immunosuppressants, Intelence, Invirase, Kaletra, ketoconazole, Lexiva, lidocaine, methadone, midazolam, Mycobutin, Norvir, phenobarbital, prednisone, Rescriptor, Reyataz, rifampin, rilpivirine, St. Johns wort, Sustiva, Tegretol (carbamazepine), and triazolam.

    FIxeD Dose regImeNs

    Atripla(Sustiva/Truvada)

    See Sustiva and Truvada (Emtriva/Viread). Do not take Combivir, Emtriva, Epivir, Epivir-HBV,Epzicom, rilpivirine/Truvada , Sustiva, Trizivir, Truvada, or Viread while taking Atripla, since all or part of these medications are already in Atripla or have equivalent medications.

  • 54 | March+april 201 1 positivelyaware.coM

    2011 HIV Drug guide

    Drug interactions

    FIxeD Dose regImeNs

    rilpivirine/Truvada See rilpivirine and Truvada. Do not take Atrilpa, Combivir, Emtriva, Epivir, Epivir-HBV, Epzicom, rilpivirine, Sustiva, Trizivir, Truvada, or Viread while taking rilpivirine/Truvada, since all or part of these medications are already in ril pivirine/Truvada or have equivalent medications. Available data is limited due to its experimental drug status at press time.

    protease INHIbItors (PIs)

    Potential drug class interactions Cardiac medications, cholesterol medications, dexamethasone, erectile dysfunction drugs, ergot derivatives (vasoconstrictors), migraine medications, sedatives, tuberculosis drugs.

    Aptivus(tipranavir, or TPV) (must be taken with Norvir)

    There are many interactionssee the package insert for the most complete list and tell your health care professional about all the medications you are taking. Advicor, alfuzosin, Altoprev, antacids, birth control pills, bosentan, buprenorphine, bupropion, calcium channel blockers (Adalat, Norvasc, Procardia, and others), Cialis, colchicine, Coumadin (warfarin), Crestor, ergot alkaloids (Cafergot, D.H.E. 45, Methergine, Wigraine), disulfirum (Antabuse), Flagyl, fluconazole, fluticasone (Advair, Flonase, Flovent), Fuzeon, other HIV protease inhibitors, immunosuppressants, itraconazole, ketoconazole, Lescol, Levitra, Lipitor, Livalo, lovastatin, methadone, midazolam (oral), Mycobutin, Paxil, phenobarbital, phenytoin (Dilantin and others), pimozide, pravastatin, Prilosec (omeprazole), quinidine, Revatio, rifabutin, rifampin, Rythmol, salmeterol, simvastatin, St. Johns wort, Suboxone, Tambocor, Tegretol (carbamazepine), trazodone, triazolam, valproic acid, Viagra, vitamin E, Videx, Vytorin, Ziagen, Retrovir (zidovudine), and Zoloft.

    Crixivan(indinavir sulfate, or IDV)

    Advicor, alfuzosin, Altoprev, birth control pills, bosentan, calcium channel blockers (Adalat, Norvasc, Procardia, and others), Cialis, coffee or alcohol (and other diuretics), colchicine, Cordarone, Coumadin (warfarin), Dilantin (phenytoin), ergot alkaloids (Cafergot, D.H.E. 45, Livalo, Methergine, Wigraine), fluticasone (Advair, Flonase, Flovent), garlic supplements, grapefruit juice, itraconazole, immunosuppressants, ketoconazole, Lescol, Levitra, Lipitor, lovastatin, methadone, midazolam, Mycobutin, phenobarbitol, pimozide, pravastatin, Rescriptor, Revatio, Reyataz, rifampin, Rythmol, salmeterol, simvastatin, St. Johns wort, Sustiva, Tambocor, Teg