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Endocrine Pathology

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Pituitary Gland Anterior Pituitary Anterior Pituitary HORMONS ?? Posterior Pituitary Posterior Pituitary HORMONS ??Diseases Non-neoplastic Too much hormone Too little hormone SOL Benign Malignant

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Clinical Manifestation Hyperpituitarism Adenoma, Hyperplasia & Carcinoma Hypopituitarism Ischemia, Surgery, inflammation & nonfunctional pituitary adenoma Local Mass Effect Visual field abnormalities, elevated ICP

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Pituitary Adenoma Functional Nonfunctional Microadenoma Macroadeoma

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Posterior Pituitary Syndromes Diabetes Insipedius SIADH

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Thyroid Gland Pathology Congenital Anomalies thyroglossal cyst Ectopic thyroid tissue Hyperthyroidism Hypothyroidism Mass lesions

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Hyperthyroidism Most common causes Diffuse hyperplasia of thyroid MNG Adenoma of thyroid Clinical features

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Hypothyroidism Most common causes Congenital Hashimoto thyroiditis Iodine deficiency Drugs Surgery Clinical features

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Hashimoto's thyroiditis

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Subacute granulomatous thyroiditis

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Colloid Cysts

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Grave's disease

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follicular adenoma

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papillary carcinoma

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Papillary thyroid carcinoma

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papillary carcinoma

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follicular CA

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Medullary carcinoma

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Remember about papillary CA Most common type 60-80 % Papillary projections, tumor cells with Orphan Annie nuclei & psammoma bodies Best prognosis Lymph nodes metastasis

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Remember about follicular CA 17 % of all CA Consist of cell forms follicles More male incidence Bloodstream metastasis ( BONE )

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Remember about Medullary CA 6% only Originate from C cell Sheets of tumor cells in an amyloid containing stoma Associated with MEN syndrome

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Parathyroid Glands Hyperparathyroidism Primary Secondary Tertiary Hypoparathyroidism

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Parathyroid hyperplasia

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Parathyroid adenoma

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Adrenal Glands Cushing syndrome Conn syndrome Addisons disease Pheochromocytoma

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Adrenal glands

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Adrenals with meningococcemia

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Tuberculosis in the adrenal gland

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Metastatic carcinoma

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Neuroblastoma

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Adrenal adenoma

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Adrenal cortical carcinoma

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Pheochromocytoma

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Pheochromocytoma

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Pheochromocytoma

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Endocrine Pancreas

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Insulitis of an islet of Langerhans

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Islet cell adenoma