tms poster

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  1. 1. ProtocolfortheRandomPlacementParadigm S#muliwereplacedrandomlywithina6cmby6cmgrid,supercialtothehandareaofthe motorcortex Gridwasmaintainedviareal#meframelessstereotaxy,anddisplayedonBrainSight2.0 Agureofeightbatwingcoil(Mags#mRapid2.0)elicited80s#muliwithinters#mulus intervalsof1.5s(0.67Hz) Mapparameterswereexaminedinresponsetothreecondi8ons: 110%,120%and130%oftheres#ngmotorthreshold(RMT) DataAnalysis S#mulifromeachsessionwererecordedforoineanalysis;threecor#calexcitabilitymaps weregeneratedfromeachintensityelicited,resul#nginninemapsperpar#cipant EffectofStimulationIntensityusingaNovelProtocolforTranscranial MagneticStimulation Katelyn Simair Neuroscience Lab, University of Birmingham Background| TheuseofTranscranialMagne#cS#mula#on(TMS)toinves#gatecor#cospinalexcitabilityandmotor controlhaspopularizedsubstan#allysinceitsadventin1985.However,itsemploymentforclinical purposesremainsselflimi7ng,bythelengthyprotocolinherentintheconven7onalmethodology Purpose| Theaimofthepresentstudywastodeterminetheeectofs7mula7onintensityonmapsderivedfrom thenovelTMSprotocolthatwillgenerateexcitabilitymapswithsignicantlyimproved#meeconomy (2minsvs15mins). Hypothesis|Therela#onshipbetweenmappingparametersands#mula#onintensitywasexpectedto reectthoseresul#ngfromconven#onalmethods[1].Itwasalsopredictedthatthesechangeswouldnot inuencemapshape,butthatvariabilitywoulddisplayaninverserela#onshipwithintensity. Wehavedemonstratedthevalidityofthenovelprotocolbyreproducingestablished trendsinthethreeparametersmeasured(area,volumeandCoG). Theresultsalsoindicatereliabilityofmapshape.Thesendingspromoteemployment of the novel, 7meecient protocol in clinical seDngs (ex. to monitor plas#city in rehabilita#onsengs). Conclusion Methods References Acknowledgements MichaelJ.GreyandMarkvandeRuit Introduc8on EMGandTMSRecordings Subjects(n=12)satcomfortablywiththeirrighthandsupinatedonasupport Electrodesontherstdorsalinterosseous(FDI),andabductordigi#minimus(ADM) measuredtheinvoluntarymotorevokedpoten#als(MEPs) Fig.1Theimagecontrasts thetwoparadigmsfor s#muliplacement RandomizedConven8onal vs [1]Miles,T.,Ridding,M.&Uy,J.(2002).StabilityofMapsofHumanMotorCortexMadewithTranscranialMagne#cS#mula#on. BrainTopography,14(4),293297. Results Fig3.SampledatafromFDIofSubjectno.5depic#ngthegradedresponseofvolumeand areatointensity,aswellastheconsistencyofCoGandshape. 120%RMT110%RMT 130%RMT Resultswereaspredicted: VolumeandAreashowedastrong,posi#verela#onshipwithintensity Mapshapewasnotinuencedbychangesinitsarea Variabilityshowedanega#vecorrela#onwithintensity,especiallyintheperiphery CoGwasnotsignicantlyinuenced