TAMMY DOTRAUMA RESEARCH ASSOCIATES PROGRAM

8.24.2012

Necrosis

Necrosis

Premature death of cells/death of body tissueApoptosis vs. NecrosisCaused by:

Infections Toxins Trauma Ischemia

Causes

Ischemia Thrombosis/embolism

Infection/Disease Fungal/bacterial Diabetes

Chemicals Poisons/toxins venom

Trauma

Necrotic Wound from Spider Bite

Types of Necrosis

CoagulativeLiquefactiveCaseousFattyFibrinoidGangrenousAseptic

Coagulative Necrosis

Caused by ischemiaDenaturation of

structural proteinsEnzymatic digestion

of cellsArchitecture of tissue

preservedOccurs in organs like

heart, spleen, kidneyDoes not occur in

brain

Liquefactive Necrosis

Necrotic tissue digested by enzymes into liquid

Associated with abscess formation

Commonly seen in brain ischemia

Fungal or bacterial infection Not in brain

Caseous Necrosis

Necrotic tissue is crumbly and cheese-like

Typically caused by tuberculosis Syphilis fungal

Fat Necrosis

In response to traumaLipases break down

fatsReact with calcium:

saponificationChalky white depositsMost commonly seen

in pancreas and breasts Acute pancreatitis

Fibrinoid Necrosis

Caused by deposition of fibrin or fibrin-like materials

Vasculitis

Gangrenous Necrosis

Considerable mass of necrosis

Types of gangrene Dry Wet Gas

Dry Necrosis Form of coagulative Caused by ischemia Autoamputation Distal parts of limbs Dry, shrunken, black

Gangrenous Cont.

Wet Moist tissue and

organs Characterized by

bacterial infection Dark, swollen, foul

odor

Gas Bacterial infection that

produces gas within tissue

Deadly

Gangrenous Cont.

Aseptic Necrosis

Avascular necrosis or osteonecrosis

Necrosis of boneLack of blood supply

to boneMedications, trauma,

ischemia, hypercoagulable blood, alcoholism

Treatment

Depends on the extent of damageRestoration of blood flowMaggot TherapyDebridementAmputation

Sources

http://onlinemedicinefacts.com/pathology/caseous-necrosis-liquefactive-necrosis-and-fibrinoid-necrosis

http://www.symptomsbook.com/Facts-Therapy-Pictures-Diagnosed-Information-Diagnosis-Herceptin-Treated-necrosis-Diagnosed-Diagnosis.htm

http://www.medicinenet.com/aseptic_necrosis/article.htm

http://www.nlm.nih.gov/medlineplus/ency/article/002266.htm

http://www.mayoclinic.com/health/avascular-necrosis/DS00650

http://library.med.utah.edu/WebPath/CINJHTML/CINJ029.html