FULLY INTEGRATED RESEARCH AND MANUFACTURING PLATFORM FOR LIFE SCIENCES AND INDUSTRIES

HTS CompoundsBuilding BlocksFragment Libraries Targeted and Focused Libraries

Custom SynthesisComputational ChemistryEarly Drug DiscoveryPrimary Drug Trial Services

All New Chemistry — Yours to Explore

Fully Integrated Solutions for Drug Discovery

• Collection of HTS Compounds • Targeted Libraries• Fragment Libraries• Custom synthesis• Computational chemistry• Early drug discovery

Advanced building blocks

• Off-the-shelf building blocks• Tangible building blocks • Innovative design of building blocks• Custom synthesis of building blocks and intermediates

Fine Chemicals in Multigram Scale

• IR-Dyes• APIs• Fine reagents for organic synthsis• Scale-up synthesis (up to 100 kg)• Process optimization

Drug Safety

• General toxicity• Safety pharmacology (ICH S7A and S7B) Specific Pharmacological Activity

• Antihypertensive• Anti-inflammatory• Anti-ischaemic • Antiarrhythmiс

Drug Bioavailability Studies

In vitro and in vivo ADMET tests

FRAMEWORK OF PRODUCTS AND SERVICES

GLP PRIMARY DRUG TRIAL SERVICES -KEY PRECLINICALS

3lifechemicals.com

To keep pace with challenging professional trends Life Chemicals has efficiently advanced its business activity, production capacities and services. The Company has rapidly become a well-known and reputable producer and supplier of HTS compounds and provider of custom synthesis and computational chemistry services for pharmaceutical, biotech, agrochemical companies, universities and academic institutions across the globe.

Developing its business, Life Chemicals has associated and headquartered a family of R&D chemical companies, namely I.F. Lab, Spoluka, Spectrum Info (Kyiv, Ukraine), Life Chemicals USA (Woodbridge, CT) and Life Chemicals Europe (Munich, Germany), to operate as an integral whole where every single company is focused on its individual range of products and services and, at the same time, all are motivated by achieving their common goal. The Company has also got a network of regional sales representatives.

In terms of this association Life Chemicals performs sale, supply, customer support and coordination. Today Life Chemicals is a fully integrated platform for early drug discovery, providing the complete range of contract research and manufacturing services. Our broadly recognized experience in organic

chemistry and ever-growing synthetic and analytical capacities have allowed us to successfully carry out complex forefront tasks in custom synthesis of drug-like compounds and advanced building blocks in quantities, ranging from mg to multi-kg, as well as provide innovative design and synthesis of combinatorial libraries, route scouting and product scale-up.

Life Chemicals proficiency in computational chemistry and employment of versatile in cilico techniques, such as similarity and pharmacophore search, molecular descriptor analysis, molecular docking, virtual screening and protein modeling, has enabled pioneering design of in-house fragment collections, targeted and focused libraries and customized sets of compounds.

A comprehensive understanding of drug discovery process, with computer-assisted approaches today being its indispensable part, as well as our knowledge of medicinal chemistry and solid scientific background sustained by modern production facilities have created a profound basis and infrastructure to give efficient solutions for R&D programs of our customers, covering hit-to-lead and lead optimization, improvement of drug potency, selectivity and ADMET properties, development of QSAR models and medicinal chemistry design.

ABOUT LIFE CHEMICALS

Life Chemicals Inc. was founded in Burlington, Ontario, Canada, in 2004, as an overseas company to expand operations of I.F. Lab Ltd, the business, started by Dr. Volodymyr Fetyukhin, PhD, in Kyiv, Ukraine, in 1995, that entered the international drug discovery market as a vanguard laboratory producing and selling novel organic compounds for life sciences and industries.

4

Life Chemicals has recently renovated its production site where over 2,000 m² of space and all modern facilities are available for advanced chemistry practice. There are more than 50 synthetic chemists working in our laboratories and units that are engaged in creating the entire scope of our products, ranging from HTS compounds to custom synthesis and early drug discovery projects.

To perform most diverse and sophisticated synthetic procedures our chemists are provided with full sets of required equipment: Biotage® Microwave station, Paar® autoclaves, Photochemistry lab. In addition to the above, there are specialized facilities for handling highly toxic reagents. Our production capacities also include laboratories for complex multistep synthesis that can be carried out in milligram to kilogram scales.

FACILITIES

Quality assured standards of Life Chemicals products and services are guaranteed by the application of up-to-date experimental and analytical equipment for organic synthesis, combinatorial chemistry, quality control and storage. Well-established production processes and excellent logistic system enable safe and on-time delivery of compounds.

RenovatedBuilding

Synthetic Labs

NMR Lab The NMR Laboratory is equipped with three spectrometer consoles:• Varian® GEMINI 2000 400 MHZ with an Oxford Instruments

superconducting magnet• Varian® VXR-300 300 MHz• Varian® Gemini 200 MHz• Ready for ¹H, ¹³C, ¹⁹F, ²⁹Si, ³¹P measurements and advanced 2D

NMR techniques, such as, COSY, NOESY, HMQC, HSQC, INADEQUATE, etc

The Laboratory’s daily output amounts to 200+ ¹H NMR spectra.

5lifechemicals.com

Analytical Chromatography Lab

Preparative Chromatography Lab

Analytical Lab

This Laboratory carries on isolation of highly pure compounds in milligram and up to multi-hundred gram quantities by means of:

• Shimadzu® LC-8A HPLC machine• 2 Combi-Flash RF Teledyne® Isco units (direct/reverse phase columns)It also performs preparative thin layer chromatography.

The Laboratory is certified according to ISO/IEC 1025:2006, with the following tools being available:

• Agilent® 1200• Agilent® 1100• Over 10 types of columns• Agilent® 5975C GC/MSDVariation of measurement parameters as per client’s requirements can be provided (e.g., wave-length of detector, mobile phase type).The Laboratory’s daily output is over 200 samples.

The Laboratory is well-equipped for comprehensive physico-chemical analysis, including:

• Water determination by Karl Fischer Titration (Titroline KF SCHOTT Instruments)

• Qualitative and quantitative determination of functional groups in organic compounds

• Qualitative and quantitative determination of salt form of organic compounds

• Quality control of solvents and inorganic compounds• Measuring optical activity (POLAX-2L, ATAGO polarimeter)• Melting point verification (OptiMelt MPA100)

6

SCREENING COMPOUNDS

Scaffold Level Selection

Compound Level Selection

Scaffold uniqueness

Estimateddrug-likeness

Syntheticfeasibility

Original scaffold

Decoration of selected scaffolds

Combinatorial synthesis of selected compounds

Desirablefunctions

Compliance withLipinski’s “Rule of Five”

Tangible HTS compounds

Stock HTS compounds

The Life Chemicals Collection of small organic molecules for high-throughput screening currently contains more than 460,000 off-the-shelf compounds and is being permanently replenished withde-novo designed products having optimal physicochemical parameters for drug discovery.

Over 900,000 structures available through in-house developed and validated synthetic methods are represented in our Tangible Database, with the feasibility of syntheses exceeding 90 %. To design new compounds we use scaffold-based approach with subsequent filtering by relevant rigorous

criteria: Lipinski's “Rule of Five”, Fsp³ scoring and Medchem filters (PAINS, structures with reactive groups, toxicophores, etc. are removed).

Thus, all items in our Collection can be distinguished as original, most carefully chosen, diverse, well-characterized and pure, lead-like and drug-like new molecules that represent a wide chemical space.

The Life Chemicals HTS Compounds Collection is mainly built around 2,900 novel scaffolds. Decoration of scaffolds can also be made according to customers’ requirements.

460,000 compounds in stock

2,900 original scaffolds

Fsp³ enriched Library: 38,000 compounds

900,000 tangible compounds

Pre-plated Diversity Sets (non-overlapping): 5,000, 10,000, 15,000 and 20,000 compounds, with all these sets enabling to obtain a “blanket” collection of 50,000 unique compounds

Diversity

7lifechemicals.com

Life Chemicals has proven its leading position on the market, keeping high product and service standards with assured more than 90 % purity, as confirmed by LCMS and/or 400MHz NMR. Compounds are promptly delivered in any container as dry powder or DMSO solutions, with their bar-coding and labeling done according to specific customer’s requirements.

Quality and Handling Standards

Our on-line shopping option is a convenient way for many customers to buy desired products through The Life Chemicals Shop, simply clicking on shop.lifechemicals.com

O

O O

NN

N

N

NNN

NO

N

NN

SO

O

O

N

N

O

O

N N N

N

ON

N

CI

N N

F

OO

O

O O

N N

N

O

8

ADVANCED BUILDING BLOCKS

Aminoacids

N OOH

NH2

Active Aromatic Halides

N

Cl

N

N N

F

F

Alcohols

OH

Aldehydes

NH O

Alkynes

N

O

O

O

OH

IsocyanatesAryl Bromides and Iodides

Azides Bicyclic Compounds

Carboxylic Acids

Primary Aromatic Amines

Morpholines Naphthyridines Piperazines Primary Aliphatic Amines

Pyridines Secondary Amines

Spiro-Compounds Sulfochlorides

Life Chemicals building block structures are mostly based on rare chemotypes with favorable physico-chemical parameters, thus being excellent decorators in combinatorial synthesis of compound libraries and promising reagents for drug design.These novel compounds are stock available in multigram quantities. Their purity of more than 95 % is confirmed with 400MHz NMR and/or LCMS. We can provide re-synthesis and scale-up in weights up to 50 kg.

Life Chemicals offers its proprietary collection of advanced building blocks, low weight molecules bearing reactive functional groups that allow introducing certain structural motifs into the substrates, as well as its special catalogue of fine reagents.

The full database comprises about62,000 building blocks, including11,000 stock available items and nearly 50,000 tangible compounds that can be synthesized within 3-6 weeks timeframe, using our in-house validated synthetic procedures.

9lifechemicals.com

Receptor-based Libraries

TARGETED AND FOCUSED LIBRARIES

GPCR Targeted Library

Sharp-aimed Kinase Targeted

Libraries

Nuclear Receptors Targeted Library

Aquaporins Targeted Library

Epigenetic Targeted Libraries

PPI Targeted Libraries

(Receptor-based)

Deubiquitinase Targeted Libraries

Phosphodiesterase 10 (PDE10) Targeted Library

Targeted and Focused Libraries are specific pre-selections of in-stock drug-like compounds with certain predicted biological activity or binding affinity to a pharmacological target(-s). The Life Chemicals Targeted and Focused Libraries are designed on the basis of available knowledge on drug targets’ structure and functions and/or activity of their ligands as well as combination of various physico-chemical parameters and descriptors. They were created with application of most up-to-date scientific information and literature data combined with advanced computer-aided techniques, such as receptor and ligand-based virtual screening.

Our Targeted and Focused Libraries fall into four categories distinguished by their design approach or activity class:

Based on flexible docking to a target structure(-s) obtained with X-ray analysis or homology modeling:

10

Ligand-based Libraries

Based on known compounds’ activity, structure-activity relationships, pharmacophore features and structural 2D and 3D similarity:

Veterinary Library

Ion Channels Focused Libraries

• Kinase Screening Library• Protease LASSO Screening Libraries• Phosphatase Focused Library• Protease Focused Library

• ATPase Focused Libraries• Helicase Focused Library• Polymerase Focused Libraries• RNA Focused Library• Epigenetic Focused Library

• Cysteine Protease Focused Library• Peptidomimetics Library• Caspase Focused Library• CYP Inhibitors Library

PPI Focused Libraries

(Ligand-based)

Kinase Focused Similarity Search Library

Bioactive Compounds

Glutamate Receptors Focused Library

11lifechemicals.com

Natural Product-like Compounds Library

Agrochemical Libraries

Antibacterial Library

Covalent Inhibitors Library

Broad Focus Libraries

Designed with either ligand-, receptor- or cheminformatics-based approach, but focused towards general pharmacological activity rather than particular drug target or drug target family

Cheminformatics-based Libraries

Based on combination of physico-chemical parameters and descriptors, ADMET characteristics and presence of certain chemical groups and features.

• CNS Library• CUTE Targeted Libraries• PPI Foc used Library (“Rule of Four”)

• Cysteine Focused Covalent Inhibitors

• Serine Focused Covalent Inhibitors

• Anticancer Library• Antiviral Library• Antiprotozoal Library

• Anti-tuberculosis Library• Anti-HCV Library• Anti-inflammatory Library

12

Fragment-based drug discovery has proven to be a highly efficient and promising alternative to high-throughput screening. In response to this evident trend in drug discovery Life Chemicals has designed its proprietary Fragment Library containing nearly 68,000 original compounds characterized as diverse, lead-like, small MW (<300) and low ClogP (<3) molecules. It includes 38,000 in-stock compounds available for immediate delivery and 30,000 tangible compounds that can be synthesized upon request.

A selection of these remarkable subsets is given below:

FRAGMENT LIBRARIES

General Fragment Library (38,000 compounds)

The General Fragment Library comprises small

molecules with low ClogP (MW ≤ 300; ClogP ≤ 3).To perfectly fit the FBDD purposes an Advanced subset of 9,400 fragments was designed with the use of expanded “Rule of Three” criteria. Additionally, the compounds were passed through PAINS filter.

Ultimate Fragment Library (4,200 compounds)

This special Fragment Library was designed by applying ultimately selective criteria to the Life Chemicals stock screening compound collection: “Rule of Three”, TPSA<80Ų cut and solubility parameter logSw > -3. PAINS and compounds with toxicophores and undesired functionalities are removed.

Fragment Library with Experimental Solubility Data (12,800 compounds)

The Library contains low molecular weight fragments with experimentally measured solubility in DMSO and phosphate buffer solution at pH 7.5. Designed according to industry standards this library is distinguished by high quality hits for fragment screening programs.

Fsp³-enriched Fragment Library (11,500 compounds)

The Library was generated as a result of our deeper insight and modern understanding of importance of organic compounds molecular complexity that increases their potential to be suitable drug candidates. Application of Fsp³=0.47 cut-off to The Life Chemicals General Fragment Library resulted in our Fsp³-enriched Fragment Library of 8,600 compounds with inherent high selectivity towards pharmacological targets. Filtering the Library by strict "Rule of Three" criteria along with TPSA 90 Ų cut-off has led to an Advanced Fsp3-enriched Subset comprising 3,200 fragments. PAINS and toxicophore containing compounds were discarded.

Fluorine Fragment Library (3,300 compounds)

The Library was created to serve ¹⁹F NMR-based fragment screening that can be used as a very powerful tool for rapid and sensitive detection of fragment hits. “Fragment space” covered by Life Chemicals fluorinated fragments is quite comparable to this space coverage of all commercially available fluorinated fragments. The Fluorine Fragment Library selected from The General Fragment Stock Collection comprises about 3,300 fluorine-containing compounds, including an Advanced Subset of2,000 compounds picked out by more rigorous physico-chemical parameters.

13lifechemicals.com

Bromine Fragment Library (1,300 compounds)

The Library was designed for application of fragments in crystallographic fragment-based drug discovery. Bromine atom can be located uniquely due to its anomalous scattering that enables prompt recognizing the structure of fragment-target complex.

PPI Fragment Library (2,500 compounds)

The Library is a result of selecting fragments with application of descriptor-based ranking mechanism developed on the basis of careful analysis of literature data on PPI. Special set of important physico-chemical parameters was determined along with the values typical for the compounds targeting PPI: Fsp³, ClogP, TPSA, molecular weight, number of H-acceptors, number H-donors, number of Rotatable bonds and number of Hydrophobic cores.

Covalent Fragment Library (1,300 compounds)

The Library was created by identifying compounds with specific structural motifs (functional groups) that are known to form covalent bonds with amino acid residues in binding sites of target proteins: Lys, Cys, Ser, Asp, Glu, His and Tyr. Molecules with high reactive electrophilic and nucleophilic groups as well as compounds with nondrug-like cores are excluded.

3D Fragment Library (1,500 compounds)

Druggable 3D Fragment Library is designed with the use of the appropriate set of physicochemical properties and descriptors that allow to evaluate 3D-dimensionality and diversity of the molecules.

Low MW Fragment Library (3,000 compounds)

Recent tendencies in drug discovery shift towards aiming at leads with lower molecular weight and higher hydrophilicity. In particular, lowering upper molecular weight cut-off value (to 200–240 instead of 300) is positively considered by many companies practicing FBDD. To fulfill these criteria Life Chemicals has designed a Low MW Fragment Library taking advantage of a number of physico-chemical filters applied to its in-stock fragment collection. An Advanced Low MW set of 1,500 fragments was also generated using more rigorous physico-chemical and structural cut-offs.

Natural Product-like Fragment Library (3,200 compounds)

More than 17,000 level-two and level-three scaffolds were extracted from The Universal Natural Product Database (more than 220,000 structures) using scaffold tree analysis. After removal of unattractive and primitive chemotypes the scaffolds were used for substructure search in The Life Chemicals Fragment Collection that enabled to obtain more than 3,200 natural product-like fragments.

14

Synthesis of Individual Compounds

• Building blocks• Reference compounds and potential impurities• Metabolites• New chemical entities and analogs

for hit-to-lead development• Peptidomimetics• Drug-like compounds

CUSTOM SYNTHESIS

Life Chemicals has always persistently strived for creating excellent products and providing its customers with first-rank and flexible services. To meet most diverse outsourcing needs of life science research organizations and commercial enterprises worldwide we have successfully fulfilled custom synthesis projects for a number of pharmaceutical, biotech and agrochemical companies in terms of both fixed priced and FTE approaches.Taking best advantage of its professional expertise and years of good experience, Life Chemicals can offer the following custom synthesis services:

Synthesis of Compound Libraries

• Libraries based on scaffolds of Life Chemicals• Libraries based on scaffolds of the customer• Custom targeted libraries• Diversity libraries

Process Optimization

• Route-scouting and scale-up• Reaction and process optimization• Catalyst screening• Characterization of physical

and chemical properties

Early Drug Discovery

• Hit optimization• Hit-to-lead• Lead optimization

Our researchers work in various fields of modern organic chemistry, specializing, in particular, in heterocyclic and element organic chemistry. Up-to-date equipment and professional skills of our chemists ensure most advanced chemistry practice:

• Handling gaseous reagents, including selective catalytic hydrogenation

• Fluorination with CF₃CHN₂, SF₄/HF, SbF₃, DAST, Morph- DAST, Deoxo-Fluor, CF₃I, Halothane, Freon-113

• Microwave-assisted synthesis• Asymmetric synthesis,

involving chiral auxiliary groups, chiral homogeneous catalysts, separation of racemates

• Multigram scale photochemistry

• Handling flammable reducing agents: LAH, DIBAL, AlH₃, Vitride, L-Selectride,

Super-Hydride, BH₃, LiHMDS, n-BuLi, sec-BuLi, t-BuLi, MeLi, LDA, LTMP

• Use of toxic metalorganic reagents (Mg, Zn, Cd, Hg, Sn, Bi)

• Chemistry in liquid ammonia

15lifechemicals.com

Process Optimization

• Route-scouting and scale-up• Reaction and process optimization• Catalyst screening• Characterization of physical

and chemical properties

COMPUTATIONAL CHEMISTRY

Computational techniques to design focused chemical libraries and predict their useful properties have become indispensable instruments for modern chemical synthesis and drug discovery projects. Being in the mainstream of this approach, Life Chemicals has applied fast and accurate industry-leading software tools and calculation methods that have proven their

efficacy in multiple tests and investigations.

Offering its variety of computational services, Life Chemicals confidently relies on its fruitful experience and successfully completed projects. These services can be contracted under confidentiality terms as well as other specific conditions agreed with the customer.

List of Available Computational Services

• Computer-aided rational design of small organic molecules against any biological target

• Drug-likeness and lead-likeness prediction

• Diversity calculations, 2D/3D similarity and substructure search

• Compound filtering by any physico-chemical properties, molecular descriptors or chemical groups (toxic, reactive, custom specified groups, PAINS, etc.)

• Compound clustering• Scaffold hopping and

fragment linking• ADMET properties prediction;• Design of custom targeted

and focused libraries• Receptor-based virtual

screening (molecular docking)• Ligand-based virtual

screening (QSAR, shape similarity, pharmacophore search)

• Molecular dynamics simulation of macromolecules, including their complexes with natural or synthetic ligands

• Protein structure modeling, de novo or by homology

Software

The industry leading software we utilize to generate custom insights for each computational project includes the following:

Molecular modeling, docking, virtual screening:

• Schrödinger suiteCheminformatics:

• DataWarrior

• CanvasScaffold hopping:

• Core Hopping (Schrödinger)Homology modeling:

• Swiss-Model• Modeller• Prime (Schrödinger)• BLASTMolecular dynamics, geometry optimization:

• GROMACS

In Silico Screening and Molecular Modeling Services

16

EARLY DRUG DISCOVERY

Stock Collection

• Over 460,000 HTS compounds based on 2,900 innovative scaffolds

• 50,000 Diversity Library• Fragment Libraries• Targeted and Focused Libraries• 11,000 building blocks

MedChem Design

• Over 10 years’ experience in BigPharma MedChem projects

• In-house, customized or combined library design

• Most up-to-date MedChem concepts• Lead-oriented scaffold-based Libraries• Conformational restriction• Bioisosteric replacements• Scaffold hopping• Peptidomimetics• Scaffold-based libraries• Hit follow-up and SAR

Life Chemicals offers the entire scope of its products and services to open up widest horizons of our customers’ drug discovery endeavor, starting with most daring ideas and obtaining molecules to test and implement these ideas.

Entering the very first stage of your search for an appropriate product candidate by scrutinizing our stock HTS library, you can take best advantage of our tangible structures, chemoinformatics, MedChem design and all relevant services, presented below, to get compounds completely ready for screening:

Library Formatting

• Dry powders or DMSO solutions• Automated liquid handling lab in the USA• Standard 4mL Kimble/Kontes amber glass vials

with teflon-lined screw caps• Microtubes in microracks, single/loose• mg or µmol amounts• Barcoding and labeling as per customer’s

requirements

Chemoinformatic Services

• Substructure search• Similarity/dissimilarity search• Custom parameters filtering• Virtual docking screening• Protein modeling• Expertise of 3 PhDs Quality Control

• 10 analytical chemists (1 PhD, 7 MSc, 2 BSc)• Varian 400MHz and 300MHz NMR (¹H, ¹³C,

other nuclei, 2D NMR)• Agilent 1200/1100 HPLC-MS• Agilent 7890 GS-MS• Karl Fisher titration, elemental analysis

and other techniques

17lifechemicals.com

In vitro and in vivo ADMET tests

• Metabolic stability, stability in plasma and buffer• Animal pharmacokinetics• CYP induction/inhibition• Caco-2 permeability, uptake and influx transporters• Solubility, lipophilicity (logD/P), plasma protein binding, red blood cells binding, tissue binding, microsome/hepatocyte binding• Cytotoxicity, genotoxicity and cardiotoxicity screening

SCREEN–HIT–WIN!

18

LIBRARY SYNTHESIS

These scaffolds are distinguished by the following parameters:

• MW, ClogP, rotatable bonds, Fsp³• Maximum diversity

Synthesis of Compound Libraries

• based on scaffolds of Life Chemicals• based on scaffolds of the customer• design and synthesis of custom targeted libraries• hit follow-up, hit-to-lead and lead optimization

Linked Ring Systems Chiral Scaffolds

Up to 1,000 m² of lab space is available for library synthesis and 50 synthetic chemists can be involved (10 PhDs, 28 MSc, 12 BSc). To ensure desired quality of synthesized compounds within the library preparative TLC, NP LC (CombiFlash®) and RP HPLC (Shimadzu®) are used for isolation and purification. The standard purity is 90 % + backed with LCMS and/or NMR analysis data, additional purification can be performed upon customer’s requirements.

Proceeding from our latest investigation results, The Life Chemicals Exclusive Collection of Scaffolds for lead-oriented library synthesis has carefully been designed to include2,500 unique structures.

Having achieved its outstanding professional expertise in medicinal chemistry, compound library design and combinatorial synthesis due to over 20 years’ experience of its leading chemists, Life Chemicals provides high quality library synthesis services in order to support early stages of drug discovery projects of the customers:

• Novelty (better IP position)• Limited use of amide/sulfonamide couplings

lifechemicals.com

Fused Ring Systems Spiro- and Bicyclic Systems

Maintenance of Physicochemical Properties

Average values given below: MW = 184; ClogP = –0.14; Nrotb = 2.17; Fsp³ = 0.62provide enough room for lead-oriented library design, even if rigorous MW/ClogP limitations are applied.

MW

5

4

3

2

1

0

-1

-2

-3

100 200 300 400 500

Lipinski (Pfizer)Oprea et al (AstraZeneca)

Churcher et al (GSK)

ClogP

Life Chemicals Europe GmbH

Leonhardsweg 2Unterhaching, 82008GermanyAnna Bondarenko, MScCEOPhone: +49 (0) 89 724 936 28Fax: +49 (0) 89 724 936 29Anna.Bondarenko@lifechemicals-eu.com

Life Chemicals Worldwide

orders@lifechemicals.com

Life Chemicals USA

26B Selden StreetWoodbridge, CT 06477USA George Bondar, MBA, MScConsultant, Marketing and SalesPhone: +1 203 645 8468Fax: +1 203 795 9702Phone/Fax: +1 888 535 8880George.Bondar@lifechemicals.com

Life Chemicals Inc.

1a Dixie Avenue,Niagara-on-the-Lake, ON L0S 1J0Canada Irina Chabanny, MScDirector, Administration and FinancePhone: +1 905 634 5212Fax: +1 905 634 4719Phone/Fax: +1 800 591 9710Irina.Chabanny@lifechemicals.com

Vasily Pinchuk, PhDHead of Marketing and SalesPhone: +1 250 448 6545Cell: +1 250 469 0997Phone/Fax: +1 800 592 7430Vasily.Pinchuk@lifechemicals.com

Life Chemicals Ukraine

5 Murmanska St.Kyiv, 02094Ukraine Anton Chervyuk, MScCustomer ServicePhone: +38 044 391 6618Fax: +38 044 574 1417Anton.Chervyuk@lifechemicals.com

KEY CONTACTS: