clostridium tetani.pdf
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TetanusTRANSCRIPT
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Clostridium tetani dantetanus…..
Ernawati A. Giri-Rachman
Biofarma, 28 Februari 2007
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Clostridium tetanipenyebab tetanus….
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Pathogenesis of tetanus caused by C tetani.
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Tetanus : Penyakit fatal yang disebabkan oleh eksotoksin
Clostridium tetani akan masuk melalui luka, termasukkarena irisan atau tusukan.
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Tetanus : penyakit yang efeknya sangat fatal padamanusia
Angka kematian berkisar antara 40-78%.
Bukan disebabkan karena infeksi yang invasif, tapikarena disebabkan oleh neurotoxin
Pada sebuah studi tentang kematian setelah kelahiran diBangladesh, 112 dari 330 bayi meninggal disebabkan oleh
tetanus.
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PERUSAKAN INANG• TOKSIN BAKTERI
(EKSOTOKSIN)
• PRODUK/KOMPONEN BAKTERI YANG DIMEDIASI OLEH INANGANTIGENENDOTOKSIN (LPS)
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EKSOTOKSIN• SITOTOKSIN• SEL/ORGAN TERTENTU:
– NEUROTOKSIN– LEUKOTOKSIN– HEPATOTOKSIN– KARDIOTOKSIN
• PENGHASIL:– TOKSIN KOLERA, SHIGA,
DIFTERI, TETANUS• AKTIVITAS:
– ADENYLAT SIKLASE, LECITHINASE
• GEJALA: ENTEROTOKSIN
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MEKANISME KERJA
• TIPE 1: MENGIKAT PERMUKAAN SEL INANG (SUPERANTIGEN)
• TIPE II: MERUSAK MEMBRAN SEL EUKARIOT
• TIPE III: TOKSIN A-B
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TOKSIN TIPE III:TOKSIN A-B
• KOMPONEN B: MENGHANTARKAN TOKSIN KE SEL
• KOMPONEN A: AKTIVITAS →PERUSAKAN SEL
• TOKSIN KOLERA, TOKSIN TETANUS
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Toksin tetanus : satu diantara toksin yang paling beracun, seperti botulinumtoxin dan difteria toksin
BotoxTetanus toksin
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Tetanus ToxinAda 11 strain C. tetani, yang memiliki perbedaan‘flagellar antigen’ Strain ini memiliki perbedaandalam memproduksi toksin tetanus tetapi semua
strain memproduksi toksin yang sama sifatimmunologynya.
Toksin diproduksi saat sel berkembang dandilepaskan hanya saat sel lisis.
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Toksin tetanus dikode oleh plasmid
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Kerja toksin tetanus….
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• Animasi toksin tetanus
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Botulinum toksin….bandingannya….
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• Animasi botox
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LOKASI PATOGEN DALAM SEL INANG
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Vaksin efektif : tetanus toksoid•Kombinasi dengan diphteria toksoid dan
pertusis toksoid (DTP)•Kombinasi dengan diphteria toksoid (TD)
•Tetanus toxoid is a very effective immunogen that stimulates a protective
response in virtually all immunocompetentsubjects.
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• TERIMA KASIH…..