The Value and Future of

Prostate Brachytherapyin a Changing Healthcare Environment

December 7-8, 2013MD Anderson Cancer CenterDan L. Duncan Building (CPB)Floor 8 Conference Center1155 Pressler StreetHouston, Texas

The Value and Future of Prostate Brachytherapyin a Changing Healthcare EnvironmentDecember 7-8, 2013MD Anderson Cancer Center, Dan L. Duncan Building (CPB) Floor 8 Conference Center, 1155 Pressler Street, Houston, Texas

GoalThe conference intends to convince clinicians to change to a standardized process of quality assurance for prostate brachytherapy using MRI-based treatment planning and MRI-based post-implant evaluation. We aim to remove the subjective nature of brachytherapy treatment with definable objective parameters. We further intend to define the value of prostate brachytherapy in the emerging healthcare system based on patient reported outcomes measures and standardized costing methodologies.

Educational ObjectivesAfter attending this conference, participants should be able to•Incorporatethemodelforvalueforprostatebrachytherapyinthenewhealthcare

environment (knowledge, competence, performance);•Applyaprocessofqualityassuranceinprostatebrachytherapyinclinical

practice (knowledge, competence, performance, patient outcomes);•InterpretthediseaseoutcomesfollowingHighDoseRateandLowDoseRate

prostate brachytherapy in practice to improve patient outcomes (knowledge, competence, performance, patient outcomes);

•Applyqualityoflifeoutcomesinprostatebrachytherapyandincorporatetheminto daily practice to provide optimal patient care (knowledge, competence, performance, patient outcomes);

•Demonstrateknowledgeofthemanagementofpatientswithrecurrentprostatecancer (knowledge, competence); and

•IdentifytheroleofMRIinprostatebrachytherapy(knowledge, competence).

Planning Committee Steven J. Frank, MD, ChairMDAndersonCancerCenterHouston,Texas

Thomas J. Pugh, MDMDAndersonCancerCenterHouston,Texas

Peter Grimm, DOProstateCancerCenterofSeattleSeattle,Washington

Bradley R. Prestidge, MD, MSBonSecoursHealthSystemNorfork,Virginia

Rajat Kudchadker, PhDMDAndersonCancerCenterHouston,Texas

David A. Swanson, MDMDAndersonCancerCenterHouston,Texas

Nicole Jones, MBAMDAndersonCancerCenterHouston,Texas

Corliss Broussard, BSMDAndersonCancerCenterHouston,Texas

Felisha Estelle, BBAMDAndersonCancerCenterHouston,Texas

Target AudienceThis conference should be of interest to Radiation Oncologists, Urologists, Physicists, Dosimetrists,Therapists,Nurses,andResidents.

Educational Methods•Lectures•Question-and-AnswerSessions•CaseStudies•PanelDiscussions•AudienceResponseSystem

EvaluationA course evaluation form will provide participants with the opportunity to comment on the value of the program content to their practice decisions, performance improvement activities, or possible impact on patient health status. Participants will also have the opportunity to comment on any perceived commercial bias in the presentations as well as to identify future educational topics.

Accreditation/Credit Designation•PHySiCiANS TheUniversityofTexasMDAndersonCancerCenterisaccreditedbythe AccreditationCouncilforContinuingMedicalEducationtoprovidecontinuing medical education for physicians.

TheUniversityofTexasMDAndersonCancerCenterdesignatesthisliveactivityforamaximumof13.25AMA PRA Category 1 CreditsTM. Physicians should claim only credit commensuratewiththeextentoftheirparticipationintheactivity.

•MEDiCAL DOSiMETRiSTS PendingapprovalbytheMedicalDosimetristCertificationBoard(MDCB)forcontinuing

education credit.

•PHySiCiSTS CourseispendingapprovalbytheCommissiononAccreditationofMedicalPhysicistsEducationPrograms(CAMPEP)ofCategoryAcontinuingeducationcredits.

CME Certificates and Attendance Verification CertificatesCertificatesawardingAMA PRA Category 1 CreditTM or certificates documenting attendance will be distributed to participants when an individual departs the conference. ToobtainaCMEcertificate,physiciansmustsubmitacompletedevaluationquestionnaire and a CME Verification Form.

Uponrequest,arecordofattendance(certificate)willbeprovidedon-sitetootherhealthcare professionals for requesting credits in accordance with state nursing boards, specialty societies, or other professional associations.

Saturday December 7, 2013 7:00 am Continental Breakfast and Registration 8:00 Welcome Thomas A. Buchholz, MD 8:05 Opening Remarks Steven J. Frank, MD

MORNING SESSION I (8:15 am–9:30 am) The Current State of Prostate Brachytherapy

8:15 The State of Prostate Brachytherapy in 2013 – US Usama Mahmood, MD 8:25 The State of Prostate Brachytherapy in 2013 – Canada Mira Keyes, MD, FRCPC 8:35 The State of Prostate Brachytherapy in 2013 – Europe Robert Laing, MD 8:45 The State of Prostate Brachytherapy in 2013 – Asia Jaeho Cho, MD 8:55 The State of Prostate Brachytherapy in 2013 – Australia Jeremy Millar, MBChB, FRANZCR, FAChPM 9:05 The Affordable Health Care Act and Prostate

Brachytherapy Mark R. Buyyounouski, MD, MS 9:15 Panel on Current State of Prostate Brachytherapy 9:30 Break

Program

MORNING SESSION II (10:00 am–12:00 pm) Defining Value in Prostate Brachytherapy 10:00 Defining Value in the New Healthcare System Robert S. Kaplan, PhD 10:45 Defining Value in Prostate Brachytherapy Steven J. Frank, MD 11:00 International Consortium for Health Outcomes

Measurement Neil E. Martin, MD, MPH 11:15 Time Driven Activity Based Costing Louis Potters, MD, FACR, FASTRO 11:30 Panel on Value in Prostate Brachytherapy 12:00 pm Lunch (provided) - From Simulator to Treatment -

Coordinating Quality for Clinical Practice Michael L. Krachon, MBA Coalition for the Advancement of Brachytherapy (CAB)

AFTERNOON SESSION I (12:45 pm-3:30 pm) Advances in HDR and LDR Prostate Brachytherapy 12:45 MRI Prostate - Optimizing Protocol Sequences Tharakeswara K. Bathala, MD 1:00 MRI Prostate Anatomy and Brachytherapy P. William McLaughlin, MD 1:15 Patient Selection Brian J. Moran, MD 1:30 Ultrasound Anatomy and Simulation John Sylvester, MD 1:45 MRI Simulation Peter Grimm, DO 2:00 Ultrasound-based Treatment Planning by Isotope -

I-125, Pd-103, Cs-131 Rajat Kudchadker, PhD 2:15 HDR Treatment Planning Michel Ghilezan, MD, PhD 2:30 U/S and CT-based HDR Implant Techniques Bradley R. Prestidge, MD, MS 2:45 MRI HDR Implant Techniques Marco Van Vulpen, MD, PhD 3:00 RTOG QA for HDR Brachytherapy I-Chow “Joe” Hsu, MD, FACR 3:15 Panel on HDR and LDR Brachytherapy 3:30 Break

AFTERNOON SESSION II (3:45 pm-5:45 pm) The Process of Quality Assurance in Prostate Brachytherapy

3:45 CT (fusion) Post-implant Dosimetry Juanita Crook, MD, FRCPC

4:00 MRI-based Post-implant Dosimetry Thomas J. Pugh, MD

4:15 PSA Follow-up and Management Brian J. Davis, MD, PhD

4:30 Disease Outcomes in Brachytherapy Peter Grimm, DO

4:45 Novel MRI Approaches to Brachytherapy Cynthia Menard, MD

5:00 MRI-based Salvage Brachytherapy Mack Roach III, MD, FACR

5:15 Medical Event Reporting in Brachytherapy Zoubir Ouhib, MS, DABR

5:30 Panel on Process of QA

5:45-6:30 Adjourn and Reception

Sunday, December 8, 2013 7:00 am Continental Breakfast and Registration

Breakfast - Faculty Working Session Robert S. Kaplan, PhD

MORNING SESSION I (8:00 am-10:00 am) Defining Value of Prostate Brachytherapy

8:00 Gaps of Knowledge in Value in Healthcare Robert S. Kaplan, PhD

8:15 Comparative Effectiveness in Prostate Cancer Treatment Michael J. Zelefsky, MD

8:45 Cost Effectiveness - LDR Brachytherapy Brett Cox, MD

9:00 Cost Effectiveness - HDR Brachytherapy Peter Rossi, MD

9:15 Bundled Payments and Fee for Service – Brachytherapy Bradley R. Prestidge, MD, MS

9:30 Panel on Defining the Value of Brachytherapy

10:00 Break MORNING SESSION II (10:15 am-12:30 pm) Brachytherapy Clinical Trials and Disease Management

10:15 Quality of Life in Brachytherapy - SPIRIT Trial Juanita Crook, MD, FRCPC

10:30 Intermediate Risk Prostate Cancer - RTOG 0232 Update Bradley R. Prestidge, MD, MS

10:45 MD Anderson Phase II Trial of Prostate Brachytherapy Steven J. Frank, MD

11:00 Quality of Life and Patient Satisfaction in Phase II Brachytherapy Trial - MD Anderson

Thomas J. Pugh, MD

11:15 The Impact of BED and Trimodality Therapy Richard Stock, MD

11:30 Management of Urinary Complications William Graber, MD

11:45 Management of Erectile Function Run Wang, MD

12:00 pm Panel on Trials and Management

12:30 Adjourn

MD Anderson Faculty

Tharakeswara K. Bathala, MDAssistant ProfessorDiagnosticRadiology

Thomas A. Buchholz, MDDivisionHeadRadiation Oncology

Steven J. Frank, MDAssociate ProfessorRadiation Oncology

William Graber, MDAssociate ProfessorUrology

Rajat Kudchadker, PhDAssociate ProfessorRadiationPhysics-PtCare

Usama Mahmood, MDAssistant ProfessorRadiation Oncology

Thomas J. Pugh, MDAssistant ProfessorRadiation Oncology

Run Wang, MDProfessorUrology

Guest Speakers

Mark K. Buyyounouski, MD, MSAssociate ProfessorStanfordCancerCenterStanford,California

Jaeho Cho, MDRadiation OncologistYonseiCancerCenterSeoul,Korea

Brett Cox, MDRadiation OncologistNorthShore-LIJHealth SystemFoundationGreatNeck,NewYork

Juanita Crook, MD, FRCPCProfessor, Radiation Oncology and DevelopmentalRadiotherapeuticsBritishColumbiaCancerAgencyKelowna,BC,Canada

Brian J. Davis, MD, PhDProfessorMayoClinicRochester, Minnesota

Michel Ghilezan, MD, PhDRadiation OncologistMichiganHealthcareProfessionals/21st CenturyOncologyNationalDirectorof Brachytherapy ResearchFarmingtonHills,Michigan

Peter Grimm, DORadiation OncologistProstateCancerCenterofSeattleSeattle,Washington

i-Chow “Joe” Hsu, MD, FACRProfessor,ViceChairand ChiefofClinicalServicesDepartmentofRadiationOncologyUCSFHelenDillerFamilyComprehensiveCancerCenterSanFrancisco,California

Robert S. Kaplan, PhDMarvin Bower Professor of LeadershipDevelopment,EmeritusHarvardBusinessSchoolBoston, Massachusetts

Mira Keyes, MD, FRCPCRadiation Oncologist,HeadBCCAProvincial Brachytherapy ProgramClinicalAssociateProfessor,DepartmentofSurgeryUBCVancouverCancerCentreVancouver,BC,Canada

Michael L. Krachon, MBAChairman,CoalitionfortheAdvancement of BrachytherapyAssociateDirector, GlobalUrologicalHealth, C.R.BardCovington,Georgia

Robert Laing, MDClinicalOncologistTheRoyalSurreyCountyHospitalGuildford,Surrey,UnitedKingdom

Neil E. Martin, MD, MPHAssistant ProfessorDepartmentofRadiationOncologyDana-Faber/BrighamandWomen’sHospitalCancerCenterBoston, Massachusetts

Cynthia Menard, MD Radiation OncologistPrincessMargaretCancerCentreToronto,Ontario,Canada

P. William McLaughlin, MDProfessor, University of Michigan HealthSystemAnn Arbor, Michigan

Jeremy Millar, MD MBChB, FRANZCR, FAChPMDirectorRadiationOncologyWilliamBucklandRadiotherapyCentreAlfredHospitalMelbourne,Victoria,Australia

Brian J. Moran, MDMedicalDirector ChicagoProstateCenterWestmont, Illinois

Zoubir Ouhib, MS, DABRChiefMedicalPhysicistBocaRatonRegionalHospitalBocaRaton,Florida

Louis Potters, MD, FACR, FASTRO Investigator,TheFeinsteinInstitute for Medical Research ChairmanDepartmentofRadiationMedicine,NorthShore- LIJHealthSystemProfessor&Chairman,RadiationMedicine,HofstraNorthShore- LIJSchoolofMedicineNorthShore-LIJHealth SystemFoundationGreatNeck,NewYork

Bradley Prestidge, MD, MSDirector,RadiationOncologyBonSecoursHealthSystemNorfork,Virginia

Mack Roach iii, MD, FACRProfessor,DepartmentsofRadiation Oncology & UrologyChairman,DepartmentofRadiation OncologyHelenDillerFamily ComprehensiveCancerCenterSanFrancisco,California

Peter Rossi, MDAssistant ProfessorRadiation OncologyWinshipCancerInstituteEmoryUniversityAtlanta, Georgia

Richard Stock, MDProfessor, Radiation OncologyMountSinaiMedicalCenterNewYork,NewYork

John Sylvester, MDMedicalDirectorLakewoodRanch Radiation Oncology21stCenturyOncologyBradenton/Sarasota,Florida

Marco Van Vulpen, MD, PhDProfessor, Radiation Oncology and Image Guided Oncologic InterventionsUniversityMedicalCentreUtrechtThe Netherlands

Michael J. Zelefsky, MDProfessor of Radiation OncologyVice-ChairClinicalResearchChief,BrachytherapyServiceMemorialSloan-Kettering CancerCenterProfessor of Radiation OncologyWeill-CornellMedicalSchoolNewYork,NewYork

Registration InformationOn-siteregistrationopensat7:00amonSaturday,December7,2013atMDAndersonCancerCenter,DanL.DuncanBuilding(CPB),Floor8ConferenceCenter.Theopeningsessionoftheconferencewillbeginat8:00amonSaturday,December7thandtheconferencewilladjournat12:30pmonSunday,December8th.

Advance registration is encouraged as space and materials are limited. Please see the registration form for applicable fees.

The deadline for advance registration is Monday, November 18, 2013.

There are three ways to register:•ByMail:MailtoDepartmentofCME/ConferenceManagement,Unit1381,TheUniversityofTexasMDAndersonCancerCenter,P.O.Box301439,Houston,TX77230-1439

•ByFax:Faxto713-794-1724•On-line:Registeron-lineatwww.mdanderson.org/conferences Telephone registrations are not accepted.

We accept the following forms of payment:•Check(payablethroughU.S.banksonly)•Moneyorder•Creditcards(MasterCard,VISA,andAmericanExpress)•Cash(on-siteregistrationonly)

Registration Fee Schedule-Seeregistrationformforfeeschedule.

When registering online a receipt/confirmation letter will be automatically emailed to the emailaddressyoulistontheregistrationform.Ifyouregisterbyfaxormailareceipt/confirmationletterwillbesenttoyouwithintenworkingdaysofreceiptofyourfee.

Theconferenceregistrationfeeincludesthetuition,CMEfinalprogrampages,breakfasts,lunch,breaks,andreception.

Refund/Cancellation Policy Theregistrationfee,minusa$50administrativehandlingfee,isrefundableifawrittenrequest is received on or before Friday, November 22, 2013. No refunds will be granted afterNovember22nd.Therequestforaregistrationrefundmustincludethetaxidentificationnumber of the company or institution if registration was paid by a company or institution check.Foradditionalinformation,contactCME/ConferenceManagementat713-792-2223 ortollfreeat866-849-5866.

TheDepartmentofCME/ConferenceManagementreservestherighttocancelactivities priortothescheduleddate,iflowenrollmentorothercircumstancesmakeitnecessary. Eachregistrantwillbenotifiedbymail,e-mail,oratthephoneorfaxnumbersgivenontheregistration form.

Incaseofactivitycancellation,theliabilityoftheDepartmentofCME/ConferenceManagementislimitedtotheregistrationfee.CME/ConferenceManagementwillrefund the full registration fee.

TheDepartmentofCME/ConferenceManagementreservestherighttolimitthenumber ofparticipantsinaprogramandisnotresponsibleforanyexpensesincurredbyanindividualwhose registration is not confirmed and for whom space is not available.

Special Assistance ContacttheDepartmentofCME/ConferenceManagementat713-792-2223ortollfreeat866-849-5866ifyouhaveanyspecialdietaryorADAaccommodationneeds.

Accommodations•AblockofroomshasbeenreservedforconferenceattendeesattheJesse H. Jones

Rotary House international, 1600HolcombeBoulevard,Houston,Texas.•Earlyhotelreservationissuggested.•TheJesseH.JonesRotaryHousephonenumbersare713-790-1600and1-800-847-5783.

•Whenyoumakereservations,besuretomentiontheBrachytherapy Conference, Client Code: CONMAN to be assured of receiving the special meeting rate of $115.00Kingoccupancy,$125Kingoccupancywithkitchenette,$121.00DoubleQueenoccupancyand$134.00DoubleQueenoccupancywithkitchenette.Pleaseadd17%(Texas)stateandlocaltaxes.

•ReservationsanddepositsreceivedafterSaturday, November 23, 2013 will be confirmed if space is available and at current hotel published guest room rates.

Ground Transportation(pricesaresubjecttochange)•Houstonisservedbytwoairports,GeorgeBushIntercontinental(IAH)andWilliamP.Hobby(HOU).

•Taxicabsareavailableatanestimatedcostof$40-60,toorfromWilliamP.HobbyAirport or George Bush Intercontinental Airport.

•SuperShuttleoperatesashuttlebusbetweenGeorgeBushIntercontinentalAirportandJesseH.JonesRotaryHouseInternationalfor$27one-wayand$52round-trip.Formoreinformation,call713-523-8888ortoll-freeat800-258-3826oronlineatwww.supershuttle.com.

•SuperShuttleoperatesashuttlebusbetweenWilliamP.HobbyAirportand JesseH.JonesRotaryHouseInternationalfor$19one-wayand$42round-trip. Formoreinformation,call713-523-8888ortoll-freeat800-258-3826oronlineatwww.supershuttle.com.

Pleaseletusknowwhatspecifictopics,issues,orquestionsyouwishtoseeaddressedoremphasizedin thisactivity.Faxore-mailCME/ConferenceManagement.All responseswillbeforwardedtotheProgramChairforconsideration.

TheUniversityofTexasMDAndersonCancerCenterhasimplementedaprocesswherebyeveryonewhois in a position to control the content of an educational activity must disclose all relevant financial relationships with any commercial interest that could potentially affect the information presented. MDAndersonalsorequiresthatallfacultydiscloseanyunlabeleduseorinvestigationaluse(notyetapprovedforanypurpose)ofpharmaceuticalandmedicaldeviceproducts.Specificdisclosurewillbemade to the participants prior to the educational activity.

Agendas are subject to change because we are always striving to improve the quality of your educa-tionalexperience.MDAndersonmaysubstitutefacultywithcomparableexpertiseonrareoccasionsnecessitated by illness, scheduling conflicts, and so forth.

Photographing, audio taping, and videotaping are prohibited.

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