learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

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247 patients from 2004 to 2012 Prostate cancer Brachytherapy low-dose Nucletron 125I seeds Spot Pro SPC, SeedSelectron delivery system SPSS statistical analysis

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Learning curve impact from 8 years of experience in low-dose brachytherapy for prostate cancer

Learning curve impact from 8 years of experience in low-dose brachytherapy for prostate cancer

Servicio de Radiofsica y PRInstituto Oncolgico

Juan-Senabre XJ, Prez M, Snchez AL, Lpez-Tarjuelo J, Santos-Serra A, Conde AJ, Beltran J, Ferrer C.Purpose

WTF ?Purpose

Dr. Mateo Prez, urologistI believe is feasible to analyzechart data patients to find outlearning curve results Go aheadWhats the learning curve?

Tm = T1 m(log2 L) T1: time 1st PPBTm: time mth PPBL = learning rateGo aheadIs it applicable for this study?PPB time execution#PPB?D90, V100#PPB?Patients & methods

Kruskall-Wallis test144 Gy PD(100, 108) Gy PDTest de Kuskall-Wallis es una prueba no paramtrica de comparacin de tres o ms grupos independientes, que debe cumplir las siguientes caractersticas: -es libre de curva, no necesita una distribucin especfica. nivel ordinal de la variable dependiente. Se usa para comparar al menos 3 grupos de rangos y determinar que la diferencia no se debe al azar, y por tanto que la diferencia sea estadsticamente significativa.6Patients & methodsToshiba, Hitachi TRUS acquisitionTrack-stepper software controlSPOT Pro TPS (Nucletron/Elekta)125-I Nucletron seeds (Isotron)SeedSelectron automatic delivery system#Med. Phys.: 4#Rad. Oncol.: 3#Urol.: 2Interobserver dispersion?Results. Time procedure

Results. Time procedure

n = 220, 11% rejectedL = 85.7% learning rateResults. Nomogram

Results. DVH

?!CN: nmero conformacional. Es la relacin entre el volumen de la prstata y le valor del volumen englobado por la isodosis de la mnima dosis perifrica.DHI = (V100-V150)/V100 . Dose homogeneity index.11ConclusionsSignificant statistical results:Time procedureD90, V100RV100Consistent results:Nomogram#seeds, #needlesCN, DHI