learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

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Learning curve impact from 8 years of experience in low-dose brachytherapy for prostate cancer Servicio de Radiofísica y PR Instituto Oncológico Juan-Senabre XJ, Pérez M, Sánchez AL, López-Tarjuelo J, Santos-Serra A, Conde AJ, Beltran J, Ferrer C.

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247 patients from 2004 to 2012 Prostate cancer Brachytherapy low-dose Nucletron 125I seeds Spot Pro SPC, SeedSelectron delivery system SPSS statistical analysis

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Page 1: Learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

Learning curve impact from 8 years of experience in low-dose

brachytherapy for prostate cancer

Servicio de Radiofísica y PRInstituto Oncológico

Juan-Senabre XJ, Pérez M, Sánchez AL, López-Tarjuelo J, Santos-Serra A, Conde AJ, Beltran J, Ferrer C.

Page 2: Learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

Purpose

Page 3: Learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

Purpose

Dr. Mateo Pérez, urologist

I believe is feasible to analyzechart data patients to find out

learning curve results

Page 4: Learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

Go ahead

What’s the learning curve?

Tm = T1 m(log2 L)

T1: time 1st PPBTm: time mth PPBL = learning rate

Page 5: Learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

Go ahead

Is it applicable for this study?

PP

B t

ime

exec

uti

on

#PPB

D90

, V10

0

#PPB

Page 6: Learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

Patients & methodsKruskall-Wallis test

144 Gy PD

(100, 108) Gy PD

Page 7: Learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

Patients & methods

• Toshiba, Hitachi TRUS acquisition• Track-stepper software control• SPOT Pro TPS (Nucletron/Elekta)• 125-I Nucletron seeds (Isotron)• SeedSelectron automatic delivery system• #Med. Phys.: 4• #Rad. Oncol.: 3• #Urol.: 2

Interobserver dispersion?

Page 8: Learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

Results. Time procedure

Page 9: Learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

Results. Time procedure

n = 220, 11% rejectedL = 85.7% learning rate

Page 10: Learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

Results. Nomogram

Page 11: Learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

Results. DVH

Page 12: Learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

Conclusions

Significant statistical results:• Time procedure• D90, V100• RV100

Consistent results:• Nomogram• #seeds, #needles• CN, DHI

Page 13: Learning curve along 8 years of exprience prostate brachytherapy low-dose seeds

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