SHOAIBALAM,MD,M.Sc.

CurrentAppointment ProfessorofMedicine Division of Pulmonary & Critical Care Medicine, University of Arkansas for

MedicalSciences(UAMS),LittleRock,ArkansasDecember11,2015to-date[Visiting/part-timefacultysinceOctober04,2016]

OtherWork LocumWork/IncludingVisitingConsultantShaukatKhanumMemorialCancer

&ResearchHospital,Lahore Pulmonary&CriticalCareMedicine

Jan01,2015toDecember2015PreviousAppointments StaffClinician/Pulmonologist Cardiovascular&PulmonaryMedicineBranch

NationalHeartLungadBloodInstitute(NHLBI)NationalInstituteofHealth(NIH),Bethesda,MarylandJune02,2009toDecember30,2014.[SeeAnnex1fordetails]

AssistantProfessorofMedicine Divisionof Pulmonary,Allergy andCritical Care, Penn. StateUniversity-Hershey

MedicalCenter,Hershey,PennsylvaniaJuly01,2004toJune02,2009

BoardCertifications BoardCertifications

BoardCertifiedInternalMedicine:ABIM2001BoardCertifiedPulmonaryMedicine:ABIM2004BoardCertifiedCriticalCareMedicine:ABIM2005

BoardCertifiedSleepMedicine:ABSM2005 BoardRe-certificationInternalMedicine:ABIM2011 BoardRe-certificationPulmonaryMedicine:ABIM2014 BoardRe-certificationCriticalCareMedicine:ABIM2015

SpecializedTraining PulmonaryHypertensionandPulmonaryVascularDiseases ElectiverotationinPulmonaryHypertensionandPulmonaryvascularDiseasesat

UniversityofPennsylvaniawithDr.HaroldPalevskyApril30,2004toSeptember1,2004.

Education FormalMedicalEducation Penn.StateUniversity-HersheyMedicalCenter,Hershey,Pennsylvania Fellowship,PulmonaryandCriticalCareMedicine(andSleepMedicine)

July01,2001toJune30,2004.

47 Sologne Circle Little Rock, AR 82223

Phone: 501 686 5525 (Day) 717 608 0040 (Cell)

E-mail: shoaibalam@yahoo.com SAlam@uams.edu

HannemanUniversity-MonmouthMedCenter,LongBranch,NewJerseyResidency,InternalMedicine:July01,1998toJune30,2001.KingEdwardMedicalCollege,Lahore,PakistanM.B.B.S.,BachelorofMedicine,BachelorofSurgery.(1989–1995)Extra-MedicalEducationGovernmentCollege,Lahore,PakistanM.Sc.Physics,(1991-1993).B.Sc.Physics,MathematicsA&BCourses(1989-1991).

FellowshipTraining Clinical Fellow,Division of Pulmonary, Allergy andCritical Care, Penn. StateUniversity-

HersheyMedicalCenter,Hershey,PennsylvaniaJuly01,2001toJune30,2004. ResearchAffiliate-Research Fellow, Center for Nuclear Magnetic Resonance (NMR)Research,Penn.StateUniversity,Hershey,Pennsylvania.Mentors:QingX.YangPh.D.andMichaelB.Smith,Ph.D.FellowshipResearchProjectAssessmentofVarious Lung InfiltratesbyMagneticResonance ImagingUsingMultipleInhaledGasesEnhancement

ResearchGrant Tobacco Formula funding 2004-2005 (Grant: $250,000), for the project “MRI

StudyofLungInjuryinagingratsandIPFPatients”IwasCo-PrincipalInvestigatorofthestudy.

CurrentClinicalInterests 1.LungDiseasesinImmunocompromisedHost2.PulmonaryArterialHypertensionandPulmonaryVascularDiseasesStarted First Comprehensive Pulmonary Arterial Hypertension and PulmonaryVascularDiseasesPrograminCentralPennsylvaniathroughPenn.StateU.3. InterstitialLungDiseases.4. Scleroderma/ConnectiveTissueDisordersRelatedPulmonaryDiseases.5. AdvancedLungDiseases.

ResearchInterests/ProjectsCurrentResearchInterests1. SeeAnnex1fordetails.2. PulmonaryArterialHypertensionPathogenesisandNovelTherapies3. LungImaging4. Novelwaysofearlydetectionofdiseaseprogression.PastResearchProjectsMAINPROJECTS1. AssessmentofVariousLungInfiltratesbyMagneticResonanceImagingUsing

MultipleInhaledGasesEnhancement.2. MRIStudyofLungInjuryinagingratsandIPFPatients.OTHERCOLLABORATIVEWORK1. ClinicalStudyAssessingSSR126517E(3.0mgs.c.onceweekly)inPulmonary

Embolism Therapy Approach-Study Site Sub Investigator. An industrysponsored,multicenter,randomized,double-blindplacebo-controldrugtrial.

2. Outcome in Pulmonary Embolism Based on Clot Burden and Length ofTreatment. Faculty Advisor. A retrospective study by a pulmonary andcriticalcarefellowatPenn.State.

3. OutcomeandCharacteristicsofPatientswithElevatedPulmonaryVascularResistance as well as Elevated Pulmonary Capillary Pressure, withoutknown left ventricular systolic dysfunction or valvular heart diseasecompared to WHO-I Pulmonary Arterial Hypertension. Faculty Advisor. AretrospectivestudybyapulmonaryandcriticalcarefellowatPenn.State.

4. Restless Leg Syndrome: Neural Mechanisms Uncovered Using EyeblinkClassical Conditioning. Clinical Collaborator. A clinical study attempting toelucidateneuralmechanismsresponsibleofRLSusingastandardcerebellarlearning paradigm, called eyeblink classical conditioning and MRspectroscopy to analyze iron contents and various neurotransmitters invariouspartsofbrain.Thestudyinvolvescomparisonofvariousparametersbefore and one week after temporary interruption of RLS therapy in RLSpatientversuscontrols.Studyalsoassessesqualityoflifeinthesespatients.

5. Validation of Equation for Predicting Metabolic Rate in Critical CarePatients.Sub-investigator.Aprospectivestudyusingindirect-calorimetrytovalidate the equation (using body weight, height, body temperature) topredictthemetabolicrateincriticallyillpatients.

Publications

OriginalPapers,Reviews&BookChapters 1. E“Prostacyclin-AnalogTherapy InSickleCellPulmonaryHypertension.” Nargues

A. Weir, Rehan Saiyed, Shoaib Alam, Anna Conrey, Himanshu D. Desai, M.Patricia George, Jennifer H. Keeley, Elizabeth S. Klings, AlemMehari, James G.Taylor, Caterina P. Minniti, Gregory J. Kato. Haematologica January 2017haematol.2015.131227

2. levatedTranspulmonaryGradientandCardiacMagneticResonance-DerivedRightVentricularRemodelingPredictOutcomesinSickleCellDisease.NguyenKL,AlamS,TianX,MehariA,LeungSW,SeamonC,AllenD,MinnitiCP,SachdevV,AraiAE,KatoGJ.Haematologica.2016Feb;101(2):240-3

3. Oscillatory haematopoiesis in adults with sickle cell disease treated withhydroxycarbamide. BairdJH,MinnitiCP,LeeJM,TianX,WuC,JacksonM,AlamS,TaylorJG6th,KatoGJ.BritishJournalofHaematology.2015Mar;168(5):737-46

4. “Hemodynamic Predictors ofMortality inAdultswith Sickle CellDisease”.AlemMehari*, Shoaib Alam*, Xin Tian, Michael J. Cuttica, Christopher F. Barnett5,GeorgeMiles,DihuaXu, Catherine Seamon, PatriciaAdams-Graves,Oswaldo L.Castro, Caterina P. Minniti7, Vandana Sachdev, James G. Taylor VI, Gregory J.Kato,RobertoF.Machado.*Equallycontributingauthors.Am J Respir Crit Care Med2013,VOL187,No8(2013),pp.840-847.

5. Characterizing non-linear dependencies among pairs of clinical variablesandimagingdata.CabanJJ,BagciU,MehariA,AlamS,FontanaJR,KatoGJ,MolluraDJ.ConfProcIEEEEngMedBiolSoc.2012;2012:2700-3

6. Non-invasive Indicators of Pulmonary Hypertension from Pulmonary VeinsQuantification in Sickle Cell Disease”. Guido H. Jajamovich, Vivek Pamulapati,Shoaib Alam, AlemMehari, Gregory J. Kato, Bradford J.Wood,Marius GeorgeLinguraru. Manuscript accepted for International Symposium on BiomedicalImaging(ISBI)2012.(PaperID:1802).

7. Computer-AssistedDiagnostic Tool toQuantify thePulmonaryVeins in SickleCellAssociated Pulmonary Hypertension”. Guido H. Jajamovich, Vivek Pamulapati,Shoaib Alam, Alem Mehari, Gregory J. Kato, Bradford J. Wood1, Marius GeorgeLinguraru.Manuscriptaccepted for InternationalSociety forOpticsandPhotonics(SIPE), Biomedical Applications in Molecular, Structural, and Functional Imagingconference2012.(PaperNumber:8317-54).

8. “Sickle Cell Disease-Associated Pulmonary Hypertension: The Effect of Anemia

andHighCardiacOutput”.InvitedReview.ShoaibAlam,MD,andGregoryJKato,

MD.IntJClinRev2011;07:08doi:10.5275/ijcr.2011.07.089. Postmortem and imaging based analyses reveal CNS decreased myelination in

restless legs syndrome. James R. Connora,*, Padmavathi Ponnurua, Byeong-YeulLeeb,GeraldD.Podskalnyc,ShoaibAlamd,RichardP.Allene,ChristopherJ.Earleye,QingX.Yangf.SleepMedicine12(2011)614-619.

10. Predicting dead space ventilation in critically ill patients using clinically availabledata.Frankenfield,DavidC.MS,RD;Alam,ShoaibMD;Bekteshi,EdgarMD;Vender,RobertL.MD,FACPCriticalCareMedicine:January2010-Volume38-Issue1-pp288-291

11. “AnalysisofEstimationMethodsforRestingMetabolicRate inCritically IllAdults”FrankenfieldDC,ColemamA,AlamS, CooneyRN.JournalofParentralandEntralNutritionVol33;Number1:27-36,Jan/Feb2009.

12. “Standard therapies for pulmonary arterial hypertension”. Alam S,PalevskyHI.ClinChestMed.2007Mar;28(1):91-115.

13. “Respiratory Systems Abnormalities and Clinical Milestones for Patients withAmyotrophicLateralSclerosiswithEmphasisuponSurvival”VenderRL,MaugerD,WalshS,AlamS,SimmonsZ.AmyotrophLateralScler.2007Feb;8(1):36-41.

14. “ForeignBodyAspirationDuringEsophagogastroduodenoscopyWithBandLigation[Brief Reports]” Betancourt,ManuelMD, Bekteshi, EdgarMD, Toth, JenniferMD,Alam,ShoaibMD.JournalofBronchology&InterventionalPulmonology,Vol15(3)July2008pp204-205

15. A chapter on “Pulmonary Venoocclusive Disease” in web-based text book “E-medicine”HakimAzfarAli,ShoaibAlam.2009.

16. Achapteron“Dyspnea”in“AmbulatoryMedicine”,ShoaibAlam,MariusFigueredo,RehanHaque-2007.LippincottWilliams&Wilkins.ISBN-13:978-0-7817-6495-7.

17. A chapter on “Solitary Pulmonary Nodules” in “Ambulatory Medicine”, MariusFigueredo,ShoaibAlam-2007.LippincottWilliams&Wilkins. ISBN-13:978-0-7817-6495-7.

18. Achapteron“PulmonaryHypertensionandAcuteRightHeart Syndrome” inText Book “Respiratory Emergencies”. Shoaib Alam, Harold Palevsky. HodderArnoldPublications;1edition(November13,2006)ISBN-10:0340811951.

19. A chapter on “Secondary Lung Tumors” in web-based text book “E-medicine”RebeccaBascom,ShoaibAlam,etal.2006.

20. A chapter on “Pneumothorax” in web-based text book “E-medicine” RebeccaBascom,ShoaibAlam,etal.2006.

21. “Baum’s Text Book of Pulmonary Diseases-Book Review”, Shoaib Alam, RobertGillio.JAMA,Vol.291No.19,May19,2000.

Abstracts&CaseReports22. DiffusionlungcapacitychangesinHodgkinLymphomapatientsbeforeandafter

ABVDchemotherapy.AbdullahM,AlamS,ZafarW,MajidA,WahlaAS.Abstract.European Respiratory Society World Congress, Amsterdam 2015. EuropeanRespiratoryJournal,September01,2015:Vol46,issuesuppl59

23. “IncreasedTranspulmonaryGradientinPatientswithSickleCellAssociatedPulmonary Hypertension Predicts Poor Prognosis and is AssociatedwithRVDysfunctionbyMRI”.Kim-LienNguyen1,ShoaibAlam1,XinTian3,SteveW.Leung1,4,CatherineSeamon2,CaterinaP.Minniti2,JamesG.TaylorVI2,VandanaSachdev1,AndrewE.Arai1,GregoryJ.Kato2.Abstract.“5°WorldSymposiumonPulmonaryHypertension,Nice.2013

24. “RV dysfunction by MRI is associated with elevated transpulmonarygradient and poor prognosis in patients with sickle cell associatedpulmonary hypertension”. Kim-Lien L Nguyen*, Shoaib Alam, Xin Tian,SteveW Leung, Catherine Seamon, Caterina PMinniti, James G Taylor,Vandana Sachdev, Andrew E Arai, Gregory J Kato. Abstract. Journal ofCardiovascular Magnetic Resonance 2013, 15(Suppl 1):O43 (Poster andOralPresentation)

25. “SpectrumofPulmonaryFibrosisCTFindingsinSickleCellDiseaseUsinganEnhanced Visual Scoring System”. Les Roger Folio DO, MPH, JeniferWillmann Siegelman MD, MPH, Alem Mehari MD, Daniel JosephMollura MD, Jesus J Caban PhD, Joe Fontana MD, Alam Shoaib MD,Genevieve Jacobs, Gregory J. Kato MD. Abstract. Radiological Society ofNorthAmericaAnnualMeeting,2012.

26. “IncreasedTranspulmonaryGradientPredictsFunctionalClass,Mortality,and RV Dysfunction by MRI in Patients with Sickle Cell AssociatedPulmonary Hypertension”. Nguyen, Kim-Lien, Shoaib Alam, Xian Tian,Steve W. Leung, Catherine Seamon, Caterina Minniti, James G. Taylor,VandanaSachdev,AndrewE.Arai,andGregoryJ.Kato.Abstract.BLOOD.Vol. 120. No. 21. AMER SOC HEMATOLOGY, 2012. (Poster and OralPresentation)

27. “Study of Clinical Characteristics of Sickle Cell Disease Patients Developing Cor-Pulmonale during Acute Hospitalization”. Shoaib Alam,MD, AlemMehari,MD,Gregory J. Kato,MD, Nargues A.Weir,MD, Caterina P.Minniti,MD, James C.TaylorIII,MD,RobertoMachado,MD,MarkT.Gladwin,MD,Abstract.AmericanThoracic Society Annual Meeting, 2011. Am J Respir Crit Care Med183;2011:A5945.

28. “PulmonaryFunction inAdultWithSickleCellRelatedPulmonaryHypertension”Alem Mehari, Xin Tian, Shoaib Alam, Les Folio, Jenifer Siegelman, GenevieveJacobs, Daniel Mollura, Gregory J. Kato, Joseph Fontana. Abstract. AmericanThoracic Society Annual Meeting, 2011. Am J Respir Crit Care Med183;2011:A1932.

29. “Abnormal Methacholine Challenge Associated with Pulmonary ArterialHypertension inAdultswith Sickle Cell Disease”.AlemMehari, Xin Tian, ShoaibAlam, Roberto F.Machado,Mark T.Gladwin,Gregory J. Kato, Joseph Fontana.Abstract.AmericanThoracicSocietyAnnualMeeting,2011.AmJRespirCritCareMed183;2011:A2013.

30. “Serumtransferrin:An independentpredictorofmortality insicklecellanemia”.Zahra Pakbaz, Mariana Hildesheim, Shoaib Alam, Darlene Allen, Caterina R.Minniti, James G. Taylor VI, Gregory J. Kato. Abstract. American Society ofHematologyAnnualMeeting,2011

31. “DecreasedPlasmaHDL,ApoA-I, andPON1Activity butUnalteredTriglyceridesDuringSickleCellVaso-occlusiveCrisis”.LitaAFreeman,XundeWang,CatherineSeamon,Marlene Peters-Lawrence, LaurelMendelsohn, Shoaib Alam, James GTaylor VI, Caterina P Minniti, Gregory J Kato. Abstract. Arteriosclerosis,Thrombosis,andVascularBiologyAnnualMeeting,2011.

32. “A Lower TissueDoppler E/Ea Threshold Predicts Diastolic Dysfunction in SickleCellPatients”.HannoushH,KatoG,MachadoR,GladwinM,MehariA,AlamS,Minniti C, Taylor J, SachdevV.Abstract. American Societyof EchocardiographyAnnualMeeting,2011.

33. “Hemodynamic Parameters Predict Mortality In Sickle Cell Disease-RelatedPulmonary Hypertension”. AlemMehari, MD, Xin Tian, MD, Shoaib Alam,MD,Dihua Xu, MD, Catherine Seamon, RN, Mark T. Gladwin, MD, Roberto F.Machado, MD and Gregory J. Kato, MD Abstract. American Society ofHematologyAnnualMeeting,2010

34. “Hemodynamic Predictors of Mortality in Sickle Cell-Related PulmonaryHypertension”. Alem Mehari, Xin Tian, Dihua Xu, Catherine Seamon, ShoaibAlam., Mark T. Gladwin, Roberto F. Machado, and Gregory J. Kato. Abstract.SickleCellDiseaseAssociationofAmericaAnnualMeeting,2010.

35. “EvaluationofExerciseCapacity inChildrenwithSCDbySixMinuteWalkTest”.CaterinaP.Minniti,MD,ShoaibAlam,MD,GregoryJ.Kato,MD,MehdiNouraie,MD,PhD, Craig Sable,MD, Gregory Ensing,MD,AndrewCampbell,MD, SohailRana,MD,DeepikaDarbari,MD,1MarkT.Gladwin,MD,OswaldoL.Castro,MD,and Victor R. Gordeuk,MD. Abstract. American Society of Hematology AnnualMeeting,2010

36. “Prevalence and Impact of Elevated Pulmonary Capillary Wedge Pressures inPatientswithAdvancedLungDiseaseListedforTransplantation”.AlamS,WeirN,Nathan SD. Abstract. American Thoracic Society Annual Meeting, 2010. Am JRespirCritCareMed181;2010:A3394.

37. “ScreeningatNIH forPulmonaryHypertension inSickleCellDisease”. JamesG.Taylor VI, Darlene Allen, Catherine Seamon, Marlene Peters-Lawrence, MaryJackson, Mary K. Hall, Amy Chi, Brandi Dobbs, Anna Kokkalis Conrey, LaurelMendelsohn,JamesNichols,ShoaibAlam,CaterinaMinnitiandGregoryJ.Kato.Abstract.SickleCellDiseaseAssociationofAmericaAnnualMeeting,2010.

38. “Prospective Evaluation of the Effect of Anthropometrical, Hematological, andEchocardiographic variables on Six Minute Walk Distance in Children andAdolescents with Sickle Cell Disease”. CP Minniti1, S Alam, M Nouraie, A.Campbell,SRana,LLuchtman-Jones,OCastro,VGordeukandGJKato.Abstract.PittsburgAnnualLungMeeting,2009

39. “Diaphragmatic Paralysis Associated with a Parvovirus B-19 Infection”. MartinKarlicek,MD*,PablodelaCerda,MDandShoaibAlam,MD.CaseReport.Chest,October2009(ChestMeetingAbstracts2009136:12S-d.

40. “New Onset ofWegner’s Granulomatosis in a Patient with Idiopathic PulmonaryHypertensionTreatedwithEpoprostenol”.PablodelaCerda,MD*,MartinKarlicek,MD and Shoaib Alam, MD. Case Report. Chest, October 2009 (Chest MeetingAbstracts2009136:42S-c.

41. “DistributionofPulmonaryEmbolismRiskFactorsBasedonAgeatPresentation”N.Adampour, M.D., S. Alam, M.D., M.G. Benninghoff, M.S., D.O., L. Sweer, M.D.,Abstract. Proceedings of American Thoracic Society Annual Meeting, 2009[AcceptedforOralPresentation].

42. “Outcomes of Pulmonary Emboli Based on Clot Burden and Length ofAnticoagulation-A retrospective study” M. G. Benninghoff, T. S. King S. Alam, .

Abstract.ProceedingsofAmericanThoracicSocietyAnnualMeeting,2008.[A183-2008].

43. “Decreased R2 and Increased Concentrations of Multiple Cerebral Metabolites inthe Restless Leg Syndrome (RLS) Brain: Exploring Iron Deficiency Consequence inRLS”. B. Y. Lee, J. Vesek, E. Farace, S. Alam, J. R. Connor, Q.X. Yang. Abstract.Proceedings of International Society of Magnetic Resonance in Medicine AnnualMeeting,2008[A:4945]

44. “Voxel-based Morphometry Study in Restless Leg Symdrome (RLS): VolumetricIncrease inMultipleBrainRegions”.B.Y. Lee, J.Vesek,S.Alam, J.R.Connor,Q.X.Yang. Abstract. Proceedings of International Society of Magnetic Resonance inMedicineAnnualMeeting,2008[A:5828].

45. “Prediction of RestingMetabolic Rate in Critically Ill Patients”D. Frankenfield, A.Schubert, S. Alam. Abstract. American Society for Parentral and Entral NutritionAnnualMeeting,2008.

46. “Splenic Marginal Zone Lymphoma masquerading as ANA positive acutepneumonitis” H. Sheikh, S. Alam, H. Mobeen. Case Report. American College ofphysician–PennsylvaniaChapterAnnualMeeting,2007.

47. “Do Systemic Corticosteroids Alone Increase the Risk of Pneumocystis jiroveciPneumonia inPulmonaryPatients?”D.Direso,D.O.,S.Alam,M.D.,V. Imadojemu,M.D., K. Ingraham, D.O., M. Obrien, D.O., Abstract. Proceedings of AmericanThoracicSocietyAnnualMeeting,2007[A859-2007].

48. “Absolute Lymphocyte Counts in Non-HIV Patients with Pneumocystis jiroveciPneumonia”D.Direso,D.O.,S.Alam,M.D.,V.Imadojemu,M.D.,M.Obrien,D.O.,K.Ingraham, D.O., Abstract. Proceedings of American Thoracic Society AnnualMeeting,2007[A859-2007].

49. “Interstitial LungDiseaseAssociatedwithProximalMuscleWeakness and SkinRash,DevelopedafterPravostatinUse”,ShoaibAlam,MD*;RobertL.Vender,MD;Kathleen M. Chaisson, MD; Shazia Riaz, MBBS Case Report, Chest, October2003(Sup)124:243s-b-244s-b.

50. “Diffuse Alveolar Hemorrhage after Open Heart Surgery”, Shoaib Alam, MD*;Robert L. Vender, MD; Kathleen M. Chaisson, MD Case Report, Chest, October2003(Sup)124:294s-a-295s-a.

51. “Vasospasm and Fatal Cerebral Infarction Associated with Sumatriptan Use inMigraine”, ShoaibAlam,MD*;Yakub I.Khan,MD;ToddGruber,MD;ShaziaRiaz,CaseReport,MBBSChest,October2003(Sup)124:311s-312s.

52. “Narcolepsy Following an Insect Bite”, Shoaib Alam, MD*; Kevin Gleeson, MD;KathleenM. Chaisson, MD. Case Report, Chest, October 2003(Sup) 124: 306s-a-307s-a.

ManuscriptsundergoingPeerRevieworIn-Preparation1. “Abnormal Methacholine Challenge Associated with Pulmonary Arterial

Hypertension in Adults with Sickle Cell Disease”. Alem Mehari, MD1, 2,Shoaib Alam,MD1, Xin Tian PhD3, Joseph FontanaMD1,, and Gregory J.Kato,MD.2013

2. “Computer Aided Texture Analysis of PULmonary computed Tomograms(CATAPULT)PredictsRiskofPulmonaryHypertensionandDeath inAdultswith Sickle Cell Disease”. Les R Folio, DO,MPH, Jesus Caban, PhD, AlemMehari,MD,JeniferSiegelman,MD,MPH,GenevieveJacobs,BS,XinTian,PhD, Joseph R. Fontana, MD, Shoaib Alam, MD, Gregory J. Kato, MD,DanielJ.Mollura,MD.2013

3. “Validation of a Simple Novel One-Minute Stair Climbing Test forFunctionalAssessmentinAdvancedLungDiseasesPatients”.ShoaibAlam,NarguesWeir,MarySmith,ScottBarnett,StevenD.Nathan.2013

4. “Clinical Characteristics of Sickle Cell Disease Patients Developing Cor-PulmonaleduringAcuteHospitalization”.ShoaibAlam,MD,GeorgeMiles,MD, Nargues Weir, MD, Alem Mehari, MD, Vandana Sachdev, MD,CourtneyFitzhugh,MD, JamesG.TaylorVI,MD,CaterinaP.Minniti,MD,MarkT.Gladwin,MD,RobertoF.Machado,MD,GregoryJ.Kato,MD.2013

InvitedPresentations

Pulmonary and Critical Care Grand Rounds at Jefferson University Hospital, Philadelphia,Pennsylvania on “Secondary Pulmonary Hypertension; What is Expected? What is Out ofProportion?”December07,2011.

AdministrativeandOtherExperience

Administrative,ResearchandTeachingExperienceatPenn.StateUniversity DuringmyfiveyearsasAssistantProfessorofPulmonaryandCriticalCareMedicineatPenn.State University-Hershey Medical Center Started First Comprehensive Pulmonary ArterialHypertension and Pulmonary Vascular Diseases Program in Central Pennsylvania throughPenn.Stateandmentoredmanypulmonaryandcriticalcarefellows,residentsandmedicalstudents. Developing the curriculum for students and residents on Pulmonary Service.Conducted board review sessions for fellows. Actively participated in recruiting process offellows for the fellowship program. Collaborated with multiple researchers on campus.Participatedinqualityimprovementactivities.

Administrative,ResearchandTeachingExperienceatIntramuralNIH/NHLBI

SeeAnnex1fordetailsReorganizedthePulmonaryHypertensionProgramRe-organizedthePulmonaryHypertensionClinicalandResearchProgramatIntramuralNationalHeartLungandBloodInstitutetoimproveperformanceonPulmonaryArterialHypertensionSpecificDrugsprescriptionpracticesandexpandedthescopeofclinicalresearchrelatedtopulmonaryarterialhypertension.ScientificReviewofNewResearchProtocolsServedonCardiovascularandPulmonaryMedicineBranch/PulmonaryandVascularMedicineBranchScientificReviewBoard,responsibleforreviewingthescientificmeritoftheforthcomingresearchprotocolsQualityImprovementActivitiesParticipatedinQualityImprovement(QI)projectsandreviewofreportsforBronchoscopyServicesaswellasforgeneralQIprocessesforpulmonaryandvascularmedicinebranch

OtherScholasticUniversityofthePunjab,Lahore,PakistanAccomplishmentsProficiencyCertificateinFrenchLanguage&Communication,1990

AllianceFransaisDeLahore,Pakistan.PreliminaryLevelinFrenchLanguage&Communication,1991

IranianCulturalCenter,Lahore,Pakistan.DiplomainPersianLanguage&Literature,1992

InterestsTourismandSightseeingCountryBoatRowing,Hiking&Mountaineering,ChessLiteraturereading,prosewriting

PersonalBornandraisedinPakistan,fluentinEnglish,Urdu,Punjabi,Hindiandotherregionallanguages,proficiencyinFrenchandPersian.

MembershipsMemberAmericanThoracicSociety(ATS)2001to-date.

MemberAmericanCollegeofChestPhysicians(ACCP)2002to-date.MemberEuropeanRespiratorySociety(ERS)2001to2012.MemberPulmonaryHypertensionAssociation(PHA)2004to2012.MemberAmericanSocietyofEchocardiography(ASE)2008to2012.MemberPennsylvaniaThoracicSociety(PTS)2001-2004.MemberSocietyofCriticalCareMedicine(SCCM)2001-2004.MemberInternationalSocietyofMagneticResonanceinMedicine(ISMRM)2001-2005.

ReferencesAvailableuponrequest

ANNEX:1

NATIONALHEART,LUNGANDBLOOD/NATIONALINSTITUTESOFHEALTH,BETHESDA,MARYLAND

[June01,2009toDecember30,2014]EXPERIENCEATNIHCLINICALCENTER(www.cc.nih.gov)CLINICALEXPERIENCE:GeneralClinicalService:WorkedasStaffClinician/Pulmonologist,aprimarilyclinicaljobthatinvolvedprovidingcoverageforpulmonaryclinicalserviceforinpatient,outpatientandprocedureservice.Largeportionofclinicalworkloadinvolvedprovidingpulmonaryconsultationsforfloorandintensivecareunitpatients,performingbronchoscopiesforbronchoalveolarlavage,transbronchialbiopsiesandtransbronchialneedleaspirationbiopsies.Largeproportionsofpatientswereimmune-compromisedhostenrolledinNationalCancerCenter(NCI),NationalInstituteofAllergyandInfectiousDiseases(NIAID)andNationalHeart,LungandBloodInstitute(NHLBI)researchprotocolsundergoingresearchinvolvingnoveltherapiesorvariouskindsofStemCellTransplantation.TheclinicalservicealsoinvolvedprovidingconsultationsforPediatricPatientsandalsoperformingbronchoscopiesinPediatricPatients.PulmonaryArterialHypertensionService:ManagedPulmonaryArterialHypertensionprogramforNIHClinicalCenterinvolvingmanagingpatientswithpulmonaryhypertension,providingexpertconsultationsforNHLBIandotherinstitutesatNIH.PerformingRightHeartCatheterizationsforclinicalandresearchpurposes.SickleCellDiseaseService:ThisserviceincludedtakingcareofSickleCellDiseasePatients(primarilypatientswithpulmonaryhypertensionorpatientswhohaveundergonematchedrelateddonorallogeneicstemcelltransplantation).MENTORINGANDTEACHINGEXPERIENCE:

- MentoredPulmonaryArterialHypertensionFellow,AlemMehari,MD(currentlyAssistantProfessorofPulmonaryandCriticalCareatHowardUniversityandleadingPulmonaryHypertensionProgram)

- Co-MentoredAdvancedCardiovascularImagingFellow,fromUCLAKim-LienNguyen,MDonherprojectexamininghemodynamicandMRIpredictorsofearlymortalityinpatientswithSickleCellDiseaserelatedpulmonaryhypertension

- TeachingofPulmonaryandCriticalCareFellowsfromWalterReedNationalMilitaryMedicalCenter,Bethesda,MarylandonNIHClinicalCenterPulmonaryService.

- TeachingofNCIandNHLBIHematology-OncologyFellowsonNIHClinicalCenterSickleCellService

RESEARCHEXPERIENCEScientificReviewofResearchProtocols:ServedonscientificcommitteeforbranchscientificreviewofnewresearchprotocolsatPulmonaryandVascularMedicineBranch(PVMB)andCardiovascularandPulmonaryMedicineBranch(CPB)atNIHClinicalCenter.DataMonitoringandSafetyBoard(DSMB):ParticipatedinDSMBactivitiesasinvestigator.ClinicalSupportforResearch:ProvidedclinicalsupportfordiverseongoingAdultandPediatricResearchProtocolsundervariousinstitutesatNIHClinicalCenter.FollowingisthelistofResearchProtocolswheremyinvolvementwasmoredirect:RESEARCHPROJECTS/PROTOCOLSROLE:LEADINVESTIGATORAPilotStudyofTreatmentofAdultswithSickleCellDiseaseAssociatedPulmonaryHypertensionBasedonHemodynamicStratification:SafetyandTolerabilityStudyofImatinibandCarvedilol.NIH-CCProtocol:12-H-0093www.clinicaltrials.gov:NCT01568645ROLE:ASSOCIATEINVESTIGATORAPhase1,Placebo-Controlled,Randomized,Double-BlindStudytoEvaluatetheSafety,Tolerability,Pharmacokinetics,andPharmacodynamicsofEscalating,SingleorMultipleOralDosesofAes-103inSubjectswithStableSickleCellDisease.NIH-CCProtocol:12-H-0127www.clinicaltrials.gov:NCT01597401MicrovascularandCardiacDysfunctioninSickleCellDiseaseNIH-CCprotocol:12-H-0124www.clinicaltrials.gov:NCT01602809End-alveolarCarbonMonoxideasaMeasureofErythrocyteSurvivalandHemolyticSeverityinSickleCellDiseaseNIH-CCProtocol:12-H-0069www.clinicaltrials.gov:NCT01547793APilotStudyoftheEffectofSpironolactoneTherapyonExerciseCapacityandEndothelialDysfunctioninPulmonaryArterialHypertension.NIH-CCProtocol:12-CC-0211www.clinicaltrials.gov:NCT01712620THEIMPROVETRIAL:ImprovingPainManagementandOutcomeswithVariousStrategiesofPatient-ControlledAnalgesia(PCA)NIH-CCProtocol:10-H-0031www.clinicaltrials.gov:NCT00999245ARandomized,Placebo-Controlled,Double-BlindPilotStudyofPioglitazoneHydrochlorideinSevere,RefractoryAsthmaNIH-CCProtocol:09-H-0244www.clinicaltrials.gov:NCT00994175

PulmonaryHypertensionandtheHypoxicResponseinSCDNIH-CCProtocol:07-H-0181www.clinicaltrials.gov:NCT00495638TreatmentofPulmonaryHypertensionandSickleCellDiseasewithSildenafilTherapyNIH-CCProtocol:07-H-0177www.clinicaltrials.gov:NCT00492531CardiopulmonaryFunctionAssessmentandNOBasedTherapiesforPatientswithHemolysis-AssociatedPulmonaryHypertensionNIH-CCProtocol:06-H-0202www.clinicaltrials.gov:NCT00352430AProspective,Multicenter,Double-Blind,Randomized,Placebo-ControlledStudyofNitricOxideforInhalationintheAcuteTreatmentofSickleCellPainCrisisNIH-CCProtocol:05-H-0019www.clinicaltrials.gov:NCT00094887StudiesoftheNaturalHistoryofSickleCellDiseaseandOtherHemolyticDisordersNIH-CCProtocol:04-H-0161www.clinicaltrials.gov:NCT00081523InhaledNitricOxideandTransfusionTherapyforPatientswithSickleCellAnemiaandSecondaryPulmonaryHypertensionNIH-CCProtocol:01-H-0223www.clinicaltrials.gov:NCT00023296DeterminingthePrevalenceandPrognosisofSecondaryPulmonaryHypertensioninAdultPatientswithSickleCellAnemiaNIH-CCProtocol:01-H-0088www.clinicaltrials.gov:NCT00011648EvaluationandTreatmentofPulmonaryPatientsnotParticipatinginResearch(TrainingProtocol)NIH-CCProtocol:97-H-0061www.clinicaltrials.gov:NCT00001621HydroxyureainPrimaryArterialHypertensionNIH-CCProtocol:T-H-0271CollectionofBloodfromVolunteersandPatientsforStudiesofEndothelialFunctionandSystemicInflammationNIH-CCProtocol:03-H-0015