1 William I. Wood

RESUME

William I. Wood March 20, 2012 15060 Montebello Road Born: 1947 Cupertino, CA 95014 Bloomington, Indiana Home Phone: 408-872-1540 Fax: 415-680-2327 Email: w@wood47.com Research Interests

Bioinformatics and the application of computer systems to compile, analyze, and identify novel proteins of potential therapeutic interest. Large scale collection of information about genes and gene expression, construction of relational databases to compile genome wide information, and database mining tools to analyze genomic information. Biochemical characterization, cloning, and expression of proteins of therapeutic interest--particularly proteins that control the growth of cells and organisms. Development of technological methods for molecular biology including the cloning of new genes by expression cloning.

Academic Qualifications PhD 1977 Harvard University, Department of Biochemistry and Molecular Biology

(Interrupted two years to fulfill selective service obligation as a USPHS officer at NIH) MA 1971

Thesis: Mycobacterium smegmatis Fatty Acid Synthetase: Kinetic Properties and Subunit Structure

Advisor: Konrad Bloch BA 1970 Cornell University, Chemistry Major

Magna cum Laude, Outstanding Chemistry Senior, Phi Beta Kappa, Dean's List, Honorary University Scholarship

Research and Professional Experience March 2008 Retired from Genentech after 26 Years 2006-2008 Senior Director, Research Operations Director, Department of Bioinformatics (below) Genentech, Inc., South San Francisco Responsible for managing the $200M budget for 800 people at

Genentech Research including hiring, promotions, and compensation.

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2000-2005 Director and Staff Scientist, Department of Bioinformatics, Genentech, Inc., South San Francisco. Founder of the Bioinformatics Department with 35 bioinformatics scientists and programmers. Lead and direct efforts 1) to find large numbers of secreted and membrane-bound human proteins from EST and genomic databases, 2) to provide full bioinformatics support for in house cDNA expression arrays including finding the genes to spot, imaging the arrays, image analysis to determine the hybridization intensities, storing the results in a relational database, and analyzing the expression results, and 3) to provide to 700 scientists in Genentech Research access to the Unix hardware (Compaq GS-160 and ES-40 servers), bioinformatics software, and sequence databases for DNA and protein sequence analysis.

1997-1999 Head of Research Bioinformatics, Genentech, Inc., South San Francisco.

Lead a group of 5-15 bioinformatics scientists and programmers (C, C++, Java, HTML, SQL) to organize and analyze internal and public DNA sequence data including EST sequences purchased from Incyte. Set up information systems to identify a large number of novel EST sequences for full-length cloning and biological assay of the expressed proteins. Set Research wide priorities for bioinformatics support. Wrote and maintained GSeqEdit, a powerful, native MAC application written in C for the editing and display of DNA and protein sequences stored on a central Unix server.

1990-1999 Staff Scientist, Department of Molecular Biology, Genentech, Inc.,

South San Francisco. Head of a laboratory of 5-6 people. A lead scientist in a functional genomics project to clone, express, and assay thousands of novel and known secreted proteins. Investigate the signal transduction of the growth hormone receptor and other proteins involved in the growth process. Clone and express VRP, a novel ligand for the flt4 tyrosine kinase. Expression clone cardiotrophin-1, a novel cytokine in the IL-6 family that induces cardiac myocyte hypertrophy. Expression clone the receptor for interleukin-8 that is present on the surface of neutrophils. Clone and express heregulin, the ligand for the neu oncogene. Develop and utilize new methods for the cloning (including expression cloning) and expression of new genes of therapeutic interest. Second level oversight of the Genentech DNA sequencing lab.

1985-1989 Senior Scientist, Department of Developmental Biology, Genentech,

Inc., South San Francisco. Head of a laboratory of 4-11 people, including Ph.D.'s in protein biochemistry and molecular biology. Purification, cloning, and expression in tissue culture cells of the growth hormone receptor. Cloning and expression of parathyroid hormone related protein, a factor involved in hypercalcemia of malignancy. Cloning and expression of an IGF binding protein and ovine placental lactogen.

3 William I. Wood

1982-1984 Scientist, Department of Molecular Biology, Genentech, Inc., South San Francisco. Cloning and expression in tissue culture cells of active, human Factor VIII for the treatment of hemophilia. Factor VIII purified from this expression system was approved by the FDA for clinical use in 1993. Testing of Factor VIII variants generated by in vitro mutagenesis. Characterization of the Factor VIII gene and elucidation of the molecular basis of hemophilia.

1978-1981 Staff Fellow, Laboratory of Molecular Biology, NIAMDD, NIH, Bethesda.

Chromatin structure and the control of chicken globin gene expression. Cloning, characterization, and transcription of the genomic β-globin gene region. Physical chemistry of the interaction of nucleosomes with HMG proteins. Determination of the globin gene chromatin structure by digestion with DNAase I and other nucleases.

1973-1977 Graduate Student, Laboratory of Dr. Konrad Bloch, Department of

Biochemistry and Molecular Biology, Harvard University, Cambridge. Purification and subunit structure of M. smegmatis fatty acid synthetase complex. The rate-limiting step of M. smegmatis fatty acid synthetase and its stimulation by mycobacterial polysaccharides. Time course of the onset of fatty acid elongation in newborn mouse brain.

1973-1974 Teaching Fellow, Harvard University, Cambridge. Assisted in the

teaching of undergraduate biochemistry and graduate biochemistry laboratory courses.

1971-1973 U. S. Public Health Service Officer, NIDR, NIH, Bethesda. In charge of a

medium-sized computer system for the real-time data acquisition and control of a variety of instruments and experiments throughout the National Institute for Dental Research. Systems and applications software and hardware interfacing for a neurophysiology laboratory.

1969-1970 Senior Research Thesis, Laboratory of Dr. Efraim Racker, Department of

Biochemistry, Cornell University, Ithaca. Purification of cytochrome c1 and its role in a reconstituted electron transport system.

Professional Societies AAAS American Society for Biochemistry and Molecular Biology Distinguished Inventor Award, 1999

4 William I. Wood

Original Research Publications 1. Yan Zhang, Shiuh-Ming Luoh, Lawrence S. Hon, Robert Baertsch, Wil l iam I. Wood, and

Zemin Zhang. (2007) GeneHub-GEPIS: Digital Expression Profiling for Normal and Cancer Tissues Based on an Integrated Gene Database, Nucleic Acids Research, 35: W152-W158.

2. Yan Zhang, David A. Eberhard, Gretchen D. Frantz, Patrick Dowd, Thomas D. Wu, Yan

Zhou, Colin Watanabe, Shiuh-Ming Luoh, Paul Polakis, Kenneth J. Hillan, Wil l iam I. Wood, and Zemin Zhang. (2004) GEPIS—Quantitative Gene Expression Profiling in Normal and Cancer Tissues, Bioinformatics, 20: 2390-2398.

3. Yan Zhou, Shiuh-Ming Luoh, Yan Zhang, Colin Watanabe, Thomas D. Wu, Michael Ostland,

Wil l iam I. Wood, and Zemin Zhang. (2003) Genome-wide Identification of Chromosomal Regions of Increased Tumor Expression by Transcriptome Analysis, Cancer Research, 63: 5781-5784.

4. Hilary F. Clark, Austin L. Gurney, … Zemin Zhang, Audrey Goddard, Wil l iam I. Wood,

and Paul Godowski. (2003) The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmemberane Proteins, Genome Research, 13: 2265-2270.

5. Zemin Zhang and Wil l iam I. Wood. (2003) A Profile Hidden Markov Model for Signal

Peptides Generated by HMMER, Bioinformatics, 19: 307-308. 6. James Lee, Wei-Hsien Ho, Miko Maruoka, Racquel T. Corpuz, Daryl T. Baldwin, Jessica S.

Foster, Audrey D. Goddard, Daniel G. Yansura, Richard L. Vandlen, Wil l iam I. Wood, and Austin L. Gurney. (2001) IL-17E, A Novel Proinflammatory Ligand for the IL-17 Receptor Homolog IL-17Rh1, Journal of Biological Chemistry, 276: 1660-1664.

7. Ming-Hong Xie, Sudeepta Aggarwal, Wei-Hsien Ho, Jessica Foster, Zemin Zhang, Jeremy

Stinson, Wil l iam I. Wood, Audrey D. Goddard, and Austin L. Gurney. (2000) Interleukin (IL)-22, A Novel Human Cytokine That Signals Through the Interferon Receptor-related Proteins CRF2-4 and IL-22R, Journal of Biological Chemistry, 275: 31335-31339.

8. Hanzhong Li, Jian Chen, Arthur Huang, Jeremy Stinson, Sherry Heldens, Jessica Foster,

Patrick Dowd, Austin L. Gurney, and Wil l iam I. Wood. (2000) Cloning and Characterization of IL-17B and IL-17C, Two New Members of the IL-17 Cytokine Family, Proc. Nalt. Acad. Sci. USA, 97: 773-778.

9. A. L. Gurney, S. A. Marters, A. Huang, R. M. Pitti, M. Mark, D. T. Baldwin, A. M. Gray, P.

Dowd, J. Brush, S. Heldens, P. Schow, A. D. Goddard, W. I. Wood, K. P. Baker, P. J. Godowski, and A. Ashkenazi. (1999) Identification of a New Member of the Tumor Necrosis Factor Family and its Receptor, a Human Ortholog of Mouse GITR, Current Biology, 9: 215-218.

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10. Robert M. Pitti, Scot A. Marsters, David A. Lawrence, Margaret Roy, Frank C. Kischkel, Patrick Dowd, Arthur Huang, Christopher J. Donahue, Steven W. Sherwood, Daryl T. Baldwin, Paul J. Godowski, Wil l iam I. Wood, Austin L. Gurney, Kenneth J. Hillan, Robert L. Cohen, Audrey D. Goddard, David Botstein, and Avi Ashkenazi. (1998) Genomic Amplification of a Decoy Receptor for Fas Ligand in Lung and Colon Cancer. Nature, 396: 699-703, with News and Views by Douglas R. Green.

11. Ruey-Bing Yang, Melanie R. Mark, Alane Gray, Arthur Huang, Ming Hong Xie, Min Zhang,

Audrey Goddard, Wil l iam I. Wood, Austin L. Gurney, and Paul J. Godowski. (1998) Tool-Like Receptor-2 Mediates Lipopolysaccharide-Induced Cellular Signaling. Nature, 395: 286-288, with News and Views by Craig Gerard.

12. Jane Gitschier, Barbara Moffat, Dorothea Reilly, Wil l iam I. Wood, and Wayne J.

Fairbrother. (1998) Solution Structure of the Fourth Metal-Binding Domain from the Menkes Copper-Transporting ATPase. Nature Structural Biology, 5: 47-54.

13. Hongkui Jin, Renhui Yang, Annie Ko, Diane Pennica, Wil l iam I. Wood, and Nicholas F.

Paoni. (1998) Effects of Cardiotrophin-1 on Haemodynamics and Cardiac Function in Conscious Rats. Cytokine, 10: 19-25.

14. James P. Sheridan, Scot A. Marsters, Robert M. Pitti, Austin Gurney, Maya Skubatch,

Daryl Baldwin, Lakshmi Ramakrishnan, Christa L. Gray, Kevin Baker, Wil l iam I. Wood, Audrey D. Goddard, Paul Godowski, and Avi Ashkenazi. (1997) Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors. Science, 277: 818-821.

15. Rebecca H. Hackett, Yi-Ding Wang, Sharon Sweitzer, Gerald Feldman, Wil l iam I. Wood,

and Andrew C. Larner. (1997) Mapping of a Cytoplasmic Domain of the Human Growth Hormone Receptor that Regulates Rates of Inactivation of Jak2 and Stat Proteins. J. Biol. Chem., 272: 11128-11132.

16. Hongkui Jin, Renhui Yang, Gilbert A. Keller, Anne Ryan, Annie Ko, David Finkle, Todd A.

Swanson, Wei Li, Diane Pennica, Wil l iam I. Wood, and Nicholas F. Paoni. (1996) In Vivo Effects of Cardiotrophin-1. Cytokine, 8: 920-926.

17. James Lee, Alane Gray, Jean Yuan, Shiuh-Ming Luoh, Hava Avraham, and Wil l iam I.

Wood. (1996) Vascular Endothelial Growth Factor-Related Protein: A Ligand and Specific Activator of the Tyrosine Kinase Receptor Flt4. Proc. Natl. Acad. Sci. USA, 93: 1988-1992.

18. Mark W. Moore, Grace Cacalano, Wil l iam I. Wood, and Ed Bailish. (1995) Neutrophilia

in Mice that Lack the Murine IL-8 Receptor Homolog (Technical Comment). Science, 269: 1590-1591.

19. Kai C. Wollert, Tetsuya Taga, Mikiyoshi Saito, Masashi Narazaki, Tadamitsu Kishimoto,

Christopher C. Glembotshi, Ann B. Vernallis, John K. Heath, Diane Pennica, Wil l iam I. Wood, and Kenneth R. Chien. (1996) Cardiotrophin-1 Activates a Distinct Form of Cardiac Muscle Cell Hypertrophy. J. Biol. Chem., 271: 9535-9545.

20. Yulong Han, Douglas W. Leaman, Diane Watling, Neil C. Rogers, Bernd Groner, Ian M.

Kerr, Wil l iam I. Wood, and George R. Stark. (1996) Participation of JAK and STAT Proteins in Growth Hormone-Induced Signaling. J. Biol. Chem., 271: 5947-5952.

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21. Zelin Sheng, Diane Pennica, Wil l iam I. Wood, Kenneth R. Chien. (1996) Cardiotrophin-

1 Displays Early Expression in the Murine Heart Tube and Promotes Cardiac Myocyte Survival. Development, 122: 419-428.

22. Diane Pennica, Todd A. Swanson, Kenneth J. Shaw, Wun-Jing Kuang, Christa Gray, and

Wil l iam I. Wood. (1996) Human Cardiotrophin-1: Protein and Gene Structure, Biological and Binding Activities, and Chromosomal Localization. Cytokine, 8: 183-189.

23. Diane Pennica, Kenneth J. Shaw, Todd A. Swanson, Mark W. Moore, David L. Shelton,

Kimberly A. Zioncheck, Arnon Rosenthal, Tetsuya Taga, Nicholas F. Paoni, and Wil l iam I. Wood. (1995) Cardiotrophin-1: Biological Activities and Binding to the Leukemia Inhibitory Factor Receptor/gp130 Signaling Complex. J. Biol. Chem., 270: 10915-10922.

24. James Lee, Grace Cacalano, Tom Camerato, Karen Toy, Mark W. Moore, and Wil l iam I.

Wood. (1995) Chemokine Binding and Bological Activities Mediated by the Mouse IL-8 Receptor. J. Immunology, 155: 2158-2164.

25. Yi-Ding Wang, Ka Wong, and Wil l iam I. Wood. (1995) Intracellular Tyrosine Residues

of the Human Growth Hormone Receptor are Not Required for the Signaling of Proliferation of Jak-STAT Activation. J. Biol. Chem., 270: 7021-7024.

26. Diane Pennica, Kathleen L. King, Kenneth J. Shaw, Elizabeth Luis, Janette Rullamas,

Shiuh-Ming Luoh, Walter C. Darbonne, Deborah S. Knutzon, Randy Yen, Kenneth R. Chien, Joffre Baker, and Wil l iam I. Wood. (1995) Cardiotrophin-1, a Novel Cytokine that Induces Cardiac Myocyte Hypertrophy. Proc. Natl. Acad. Sci. USA, 92: 1142-1146.

27. Diane Pennica, Kenneth J. Shaw, Shiuh-Ming Luoh, and Wil l iam I. Wood. (1995)

Isolation of cDNA Clones Encoding the Mouse Protein V-1. Gene, 158: 305-306. 28. Yi-Ding Wang and Wil l iam I. Wood. (1995) Amino acids of the Human Growth

Hormone Receptor that are Required for Proliferation and Jak-STAT Signaling. Mol. Endo., 9: 303-311.

29. J. W. Park, K. Hong, P. Carter, H. Asgari, L. Y. Guo, G. A. Keller, C. Wirth, R. Shalaby, C.

Kotts, W. I. Wood, D Papahadjopoulos, and C. C. Benz. (1995) Development of Anti-p185Her2 Immunoliposomes for Cancer Therapy. Proc. Natl. Acad. Sci. USA, 92: 1327-1331.

30. Grace Cacalano, James Lee, Kristine Kikly, Ann M. Ryan, Sharon Pitts-Meek, Bruce

Hultgren, Wil l iam I. Wood, and Mark W. Moore. (1994) Neutrophil and B Cell Expansion in Mice that Lack the Murine IL-8 Receptor Homolog. Science, 265: 682-684.

31. A. Chuntharapai, J. Lee, J. Burnier, W. I. Wood, C. Hebert, and K. Jin Kim. (1994)

Neutralizing Monoclonal Antibodies to Human IL8 Receptor A Map to the NH2-Terminal Region of the Receptor. J. Immunology, 152: 1783-1789.

32. James Lee, Zhengyu Wang, Shiuh-Ming Luoh, Wil l iam I. Wood, and David T. Scadden.

(1994) Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene. Gene, 138: 247-251.

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33. Peter Colosi, Ka Wong, Steven Leong, and Wil l iam I. Wood. (1993) Mutational

Analysis of the Intracellular Domain of the Human Growth Hormone Receptor. J. Biol. Chem., 268: 12617-12623.

34. James Lee and Wil l iam I. Wood. (1993) Assignment of Heregulin (HGL) to Human

Chromosome 8p22-11 by PCR Analysis of Somatic Cell Hybrid DNA. Genomics, 16: 790-791.

35. Germaine Fuh, Peter Colosi, Wil l iam I. Wood, and James A. Wells. (1993) Mechanism-

based Design of Prolactin Receptor Antagonists. J. Biol. Chem., 268: 5376-5381. 36. Etsuko Ishizaka-Ikeda, Rikiro Fukunaga, Wil l iam I. Wood, David V. Goeddel, and

Shigekazu Nagata. (1993) Signal Transduction Mediated by the Growth Hormone Receptor and its Chimeric Molecules with the G-CSF Receptor. Proc. Nalt. Acad. Sci. USA, 90: 123-127.

37. Gary K. Scott, Robert Robles, John W. Park, Pamela A. Montgomery, Janice Daniel,

William E. Holmes, James Lee, Gilbert A. Keller, Wen-Lu Li, Brian M. Fendly, Wil l iam I. Wood, H. Michael Shepard, and Christopher E. Benz. (1993) A Truncated Intracellular Her2/neu Receptor Produced by Aternative RNA Processing Affects Growth of Human Carcinoma Cells. Mol. Cell. Biol., 13: 2247-2257.

38. James Lee, Richard Horuk, Glenn C. Rice, Gregory L. Bennett, Tom Camerato, and

Wil l iam I. Wood. (1992) Characterization of Two High-Affinity Human Interleukin-8 Receptors. J. Biol. Chem., 267: 16283-16287.

39. William E. Holmes, Mark X. Sliwkowski, Robert W. Akita, William J. Henzel, James Lee,

John W. Park, Daniel Yansura, Nasrin Abadi, Helga Raab, Gail D. Lewis, H. Michael Shepard, Wun-Jing Kuang, Wil l iam I. Wood, David V. Goeddel, and Richard L. Vandlen. (1992) Identification of Heregulin, a Specific Activator of p185erbB2. Science, 256: 1205-1210.

40. Jane Gitschier and Wil l iam I. Wood. (1992) Sequence of the Exon-Containing Regions

of the Human Factor VIII Gene. Human Molecular Genetics, 1: 199-200. 41. Steven R. Leong, Robert C. Baxter, Tom Camerato, Jin Dai, and Wil l iam I. Wood.

(1992) Structure and Functional Expression of the Acid-Labile Subunit of the Insulin-Like Growth Factor-Binding Protein Complex. Mol. Endocrinol., 6: 870-876.

42. James Lee, Wun-Jing Kuang, Glenn C. Rice, and Wil l iam I. Wood. (1992)

Characterization of cDNA Clones Encoding the Rabbit Interleukin-8 Receptor. J. Immunol., 148: 1261-1264.

43. William E. Holmes, James Lee, Wun-Jing Kuang, Glenn C. Rice, and Wil l iam I. Wood.

(1991) Structure and Functional Expression of a Human Interleukin-8 Receptor. Science, 253: 1278-1280.

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44. R. Glenn Hammonds, Jr., Ralph Schwall, Andrew Dudley, Lucy Berkemeier, Cora Lai, James Lee, Noreen Cunningham, A. H. Reddi, Wil l iam I. Wood, and Anthony J. Mason. (1991) Bone Inducing Activity of Mature BMP-2b Produced from a Hybrid BMP-2a/2b Precursor. Mol. Endocrinol., 5: 149-155.

45. D.T. Schermer, S.D.H. Chan, R. Bruce, R.A. Nissenson, W.I. Wood, and G.J. Strewler.

(1991) Chichen Parathyroid Hormone-Related Protein and Its Expression During Embryologic Development. J. Bone and Mineral Res., 6: 149-155.

46. M. Barri, S.K. Abbas, D.W. Pickard, R.G. Hammonds, W.I. Wood, I.W. Caple, T.J. Martin,

and A.D. Care. (1990) Fetal Magnesium Homeostasis in the Sheep. Exp. Physiol., 75, 681-688.

47. Michael J. Waters, Steven A. Spencer, Gary Hamlin, William J. Henzel, and Wil l iam I.

Wood. (1990) Purification and Partial Sequence of the Rabbit Mammary Gland Prolactin Receptor. Int. J. Biochem., 22: 1089-1095.

48. Steven J. Shire, Patrick McKay, David W. Leung, George J. Cachianes, Eugene Jackson,

Wil l iam I. Wood, Krishnamurthy Raghavendra, Lamia Khairallah, and Todd M. Schuster. (1990) Preparation and Properties of Recombinant DNA Derived Tobacco Mosaic Virus Coat Protein. Biochemistry, 29: 5119-5126.

49. Paul J. Godowski, David W. Leung, Lillian R. Meacham, John P. Galgani, Renate Hellmiss,

Ruth Keret, Peter S. Rotwein, John S. Parks, Zvi Laron, and Wil l iam I. Wood. (1989) Characterization of the Human Growth Hormone Receptor Gene and the Demonstration of a Partial Gene Deletion in Two Patients with Laron-Type Dwarfism. Proc. Nalt. Acad. Sci. USA , 86: 8083-8087.

50. R. Glenn Hammonds, Jr., Patrick McKay, Genine A. Winslow, Hannelore Diefenbach-

Jagger, Vivian Grill, Jane Glatz, Christine P. Rodda, Jane M. Moseley, Wil l iam I. Wood, and T. John Martin. (1989) Purification and Characterization of Recombinant Human Parathyroid Hormone-related Protein. J. Biol. Chem., 264: 14806-14811.

51. Peter Colosi, Gudmundur Thordarson, Renate Hellmiss, Isabel A. Forsyth, Peter

Gluckman, and Wil l iam I. Wood. (1989) Cloning and Expression of cDNA Clones Encoding Ovine Placental Lactogen. Molec. Endocrinol., 3: 1462-1469.

52. S.K. Abbas, D.W. Pickard, C.P. Rodda, J.A. Heath, R.G. Hammonds, W.I. Wood, I.W.

Caple, T.J. Martin, and A.D. Care. (1989) Stimulation of Ovine Placental Calcium Transport by Purified Natural and Recombinant Parathyroid Hormone-Related Protein (PTHrP) Preparations. Q. J. Exp. Physiol., 74: 549-552.

53. D.E. Barton, B.E. Foellmer, W.I. Wood, and U. Francke. (1989) Chromosomal Mapping

of the Growth Hormone Receptor Gene in Man and Mouse. Cytogenetics and Cell Genetics, 50: 137-141.

54. Frank P. Luyten, Noreen S. Cunningham, S. Ma, N. Muthukumaran, R. Glenn Hammonds,

W. Byron Nevins, Wil l iam I. Wood, and A.H. Reddi. (1989) Purification and Amino Acid Sequence of Osteogenin, A Protein Initiating Bone Differentiation. J. Biol. Chem., 264: 13377-13380.

9 William I. Wood

55. L.J. Suva, K.A. Mather, M.T. Gillespie, G.C. Webb, K.W. Ng, G.A. Winslow, W.I. Wood, T.J. Martin, and P.J. Hudson. (1989) Structure of the 5' Flanking Region of the Gene Encoding Human Parathyroid Hormone-related Protein (PTHrP). Gene, 77: 95-105.

56. Venkat R. Mukku, Robert G. Courter, Cori Gorman, Monica Parker, Brent Larsen, and

Wil l iam I. Wood. (1989) Expression, Purification, and Characterization of Recombinant BP53, the GH-Dependent IGF Binding Protein. Insulin-Like Growth Factor Binding Proteins, eds. Drop and Hintz, Elsevier Science Publishers, 65-70.

57. Will iam I. Wood, George Cachianes, William J. Henzel, Genie A. Winslow, Steven A.

Spencer, Renate Hellmiss, Janet L. Martin, and Robert C. Baxter. (1988) Cloning and Expression of the Growth Hormone-Dependent Insulin-Like Growth Factor-Binding Protein. Molec. Endocrinol., 2: 1176-1185.

58. S.C. Kukreja, D.H. Shevrin, S.A. Wimbiscus, P.R. Ebeling, J.A. Danks, C.P. Rodda, W.I.

Wood, and T.J. Martin. (1988) Antibodies to Parathyroid Hormone-related Protein Lower Serum Calcium in Athymic Mouse Models of Malignancy-Associated Hypercalcemia Due to Human Tumors. J. Clin. Invest., 82: 1798-1802.

59. Steven A. Spencer, R. Glenn Hammonds, William J. Henzel, Henry Rodriquez, Michael J.

Waters, and Wil l iam I. Wood. (1988) Rabbit Liver Growth Hormone Receptor and Serum Binding Protein: Purification, Characterization and Sequence. J. Biol. Chem., 263: 7862-7867.

60. David W. Leung, Steven A. Spencer, George Cachianes, R. Glenn Hammonds, Carol

Collins, William J. Henzel, Ross Barnard, Michael J. Waters, and Wil l iam I. Wood. (1987) Growth Hormone Receptor and Serum Binding Protein: Purification, Cloning, and Expression. Nature, 330: 537-543.

61. L.J. Suva, G.A. Winslow, R.E.H. Wettenhall, R.G. Hammonds, J.M. Moseley, H. Diefenbach-

Jagger, C.P. Rodda, B.E. Kemp, H. Rodriquez, E.Y. Chen, P.J. Hudson, T.J. Martin, and W.I. Wood. (1987) A Parathyroid Hormone-Related Protein Implicated in Malignant Hypercalcemia: Cloning and Expression. Science, 237: 893-896. Winner of the Chemofux Research Prize in Bone and Mineral Metabolism as the best paper in calcium and phosphate metabolism of 1987. Listed as a 'Hot Paper' by The Scientist, May 1988.

62. Jane Gitschier, Wil l iam I. Wood, Marc A. Shuman, and Richard M. Lawn. (1986)

Identification of a Missense Mutation in the Factor VIII Gene of a Mild Hemophiliac. Science, 232, 1415-1416.

63. Dan L. Eaton, Wil l iam I. Wood, Debbie Eaton, Philip E. Haas, Philip Hollingshead, Karen

Wion, Jeannie Mather, Richard M. Lawn, Gordon A. Vehar, and Cornelia Gorman. (1986) Construction and Characterization of an Active Factor VIII Variant Lacking the Central One-Third of the Molecule. Biochemistry, 25: 8343-8347.

64. R.M. Lawn, W.I. Wood, J. Gitschier, K.L. Wion, D. Eaton, G.A. Vehar, E.G.D. Tuddenham.

(1986) Cloned Factor VIII and the Molecular Genetics of Hemophilia. Cold Spring Harbor Sym. Quan. Biol., 51: 365-369.

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65. Jane Gitschier, Wil l iam I. Wood, Edward G. D. Tuddenham, Marc A. Shuman, Therese M. Goralka, Ellson Y. Chen, and Richard M. Lawn. (1985) Detection and Sequence of Mutations in the Factor VIII Gene of Hemophiliacs. Nature, 315: 427-430.

66. Will iam I. Wood, Jane Gitschier, Lawrence A. Lasky, and Richard M. Lawn. (1985) Base

Composition Independent Hybridization in Tetramethylammonium Chloride: A Method for Oligonucleotide Screening of High Complexity Gene Libraries. Proc. Natl. Acad. Sci. USA, 82: 1585-1588.

67. Jane Gitschier, Wil l iam I. Wood, Therese M. Goralka, Karen L. Wion, Ellson Y. Chen,

Dennis H. Eaton, Gordon A. Vehar, Daniel J. Capon, and Richard M. Lawn. (1984) Characterization of the Human Factor VIII Gene. Nature, 312: 326-330.

68. Will iam I. Wood, Daniel J. Capon, Christian C. Simonsen, Dan L. Eaton, Jane Gitschier,

Bruce Keyt, Peter H. Seeburg, Douglas H. Smith, Philip Hollingshead, Karen L. Wion, Eric Delwart, Edward G. D. Tuddenham, Gordon A. Vehar, Richard M. Lawn. (1984) Expression of Active Human Factor VIII from Recombinant DNA Clones. Nature, 312: 330-337.

69. Gordon A. Vehar, Bruce Keyt, Dan Eaton, Henry Rodriquez, Donogh P. O'Brien, Frances

Rotblat, Herman Oppermann, Rodney Keck, Wil l iam I. Wood, Richard N. Harkins, Edward G. D. Tuddenham, Richard M. Lawn, and Daniel J. Capon. (1984) Structure of Human Factor VIII. Nature, 312: 337-342.

70. Alex Ullrich, Alane Gray, Wil l iam I. Wood, Joel Hayflick, and Peter Seeburg. (1984)

Isolation of cDNA Clone Coding for the γ-Subunit of Mouse Nerve Growth Factor Using a High-Stringency Selection Procedure. DNA, 3: 387-392.

71. Will iam I. Wood and Gary Felsenfeld. (1982) Chromatin Structure of the Chicken β-

Globin Gene Region. Sensitivity to DNAase I, Micrococcal Nuclease, and DNAase II. J. Biol. Chem., 257: 7730-7736.

72. James D. McGhee, Wil l iam I. Wood, Maureen Dolan, James Douglas Engel, and Gary

Felsenfeld. (1981) A 200 Base Pair Region at the 5' End of the Chicken Adult β-Globin Gene is Accessible to Nuclease Digestion. Cell, 27: 45-55.

73. Will iam I. Wood, Joanne Nickol, and Gary Felsenfeld. (1981) Repeated Sequence

Organization and RNA Transcription Map of the Chicken Adult β-Globin Gene Region. J. Biol. Chem., 256: 1502-1505.

74. Georgianna Sandeen, Wil l iam I. Wood, and Gary Felsenfeld. (1980) The Interaction of

High Mobility Proteins HMG14 and 17 with Nucleosomes. Nucleic Acids Research, 8: 3757-3778.

75. Gordon D. Ginder, Wil l iam I. Wood, and Gary Felsenfeld. Isolation and Characterization

of Recombinant Clones Containing the Chicken Adult β-Globin Gene. (1979) J. Biol. Chem., 254: 8099-8102.

76. Will iam I. Wood, David O. Peterson, and Konrad Bloch. (1978) Subunit Structure of

Mycobacterium smegmatis Fatty Acid Synthetase. Evidence for Identical Multifunctional Polypeptide Chains. J. Biol. Chem., 253: 2650-2656.

11 William I. Wood

77. Will iam I. Wood, David O. Peterson, and Konrad Bloch. (1977) Mycobacterium

smegmatis Fatty Acid Synthetase. A Mechanism Based on Steady State Rates and Production Distributions. J. Biol. Chem., 252: 5745-5749.

78. Will iam I. Wood. Tables for the Preparation of Ammonium Sulfate Solutions. (1976)

Anal. Biochem., 73: 250-257. 79. R. Dubner, R. Sumino, and Wil l iam I. Wood. (1975) A Peripheral "Cold" Fiber

Population Responsive to Innocuous and Noxious Thermal Stimuli Applied to Monkey's Face. J. Neurophysiol., 38: 1373-1389.

80. Charles C. Sweeley, Bruce D. Ray, Wil l iam I. Wood, John F. Holland, and Micah I.

Krichevsky. (1970) On-Line Digital Computer Systems for High-Speed Single Focusing Mass Spectrometry. Anal. Chem., 42: 1505-1516.

81. J.M. Tanzer, Wil l iam I. Wood, and M.I. Krichevsky. (1969) Linear Growth Kinetics of

Plaque-Forming Streptococci in the Presence of Sucrose. J. Gen. Microbiol., 58: 125-133.

12 William I. Wood

Abstracts, Book Chapters, and Other Publications 1. Diane Pennica and Wil l iam I. Wood (1998) Cardiotrophin-1. Human Cytokines:

Handbook for Basic and Clinical Research, Volume III, ed. Bart Aggarwal, Blackwell Science, Inc.

2. Diane. Pennica, Wil l iam. I. Wood, and Kenneth. R. Chien (1996) Cardiotrophin-1: A

Multifunctional Cytokine that Signals via LIF Receptor-gp130 Dependent Pathways. Cytokine & Growth Factor Reviews, 7: 81-91.

3. J.W. Park, G. Colbern, J. Baselga, K. Hong, Y. Shau, D. Kirpoten, A. Nuijens, W. Wood,

D. Papahadjopoulos, and C. Benz. (1996) Antitumor Efficacy of the Anti-p185HER2 Immunoliposomes: Enhanced Therapeutic Index Due to Targeted Delivery. American Society of Clinical Oncology, abstract.

4. Yulong Han, Douglas W. Leaman, Ian M. Kerr, Wil l iam I. Wood, and Geroge R. Stark.

(1995) Requirements for JAK2 in Growth Hormone Signaling. International Society for Interferon and Cytokine Research, abstract.

5. J.W. Park, K. Hong, H. Asgari, Y. Shao, D. Kirpotin,, W.F. Zheng, S. Baughman, G. Keller,

W.I. Wood, C. Benz, and D. Papahadjopoulos. (1995) Pharmacodynamic and Pharmacokinetic Advantages of Anti-p185HER2 Immunoliposomes. American Society of Clinical Oncology, abstract.

6. Hongkui Jin, Renhui Yang, Wei Li, Jadine Lai, Greg Bennett, Andrew Nuijens, Annie Ko,

Gilbert Keller, Anne Ryan, Diane Pennica, Wil l iam I. Wood, and Nicholas F. Paoni. (1995) Analysis of the Role of Cardiotrophin-1 on Cardiac Hypertrophy in Vivo. American Heart Association, abstract.

7. Renhui Yang, Hongkui Jin, Diane Pennica, Wil l iam I. Wood, and Nicholas F. Paoni.

(1995) Hemodynamic Effects of Cardiotrophin-1, a New Cytokine, in Conscious Rats. American Heart Association, abstract.

8. Zelin Sheng, Diane Pennica, Wil l iam I. Wood, and Kenneth R. Chien. (1995)

Cardiotrophin 1 (CT-1): A gp130 Dependent Cytokine Promotes Cardiac Myocyte Survival and Displays Restricted Expression to the Myocardium in the Early Murine Embryonic Heart. American Heart Association, abstract.

9. Kai C. Wollert, Diane Pennica, Nick Paoni, Christopher C. Glembotski, Wil l iam I. Wood,

Tetsuya Taga, Tadamitsu Kishimoto, Kenneth R. Chien. (1995) Divergent Signaling Pathways Mediate the Induction of the Atrial Natriuretic Factor Gene During Cardiotrophin-1 versus Phenylephrine Mediated Cardiomyocyte Hypertrophy. American Heart Association, abstract.

10. Y. Han, D. Leaman, D. Watling, N.C. Rogers, W.I. Wood, and G.R. Stark. (1994) Growth

Hormone-Induced Tyrosine Phosphorylation of Jak Kinases. International Cytokine Society Meeting, Banff Springs, abstract.

13 William I. Wood

11. Wil l iam I. Wood. (1993) Structure and Functional Analysis of the Human Growth Hormone Receptor. Lawson Wilkins Pediatric Endocrine Society Symposium, invited lecture and abstract.

12. Wil l iam I. Wood. (1992) Structure of the Growth Hormone Receptor. Endocrine

Society Symposium, invited lecture and abstract. 13. P. Colosi, E. Ishizaka-Ikeda, R. Fukunaga, S. Nagata, and W.I. Wood. (1992) Growth

Hormone Receptor Function in the Myeloid Cell Line FDC-P1. Endocrine Society, abstract 683.

14. Wil l iam I. Wood. (1992) G-protein Coupled Receptors for Interleukin-8. FASEB

Symposium, invited lecture. 15. R.G. Clark, B. Cunningham, J.A. Moore, M.G. Mulkerrin, L.M.S. Carlsson, S.A. Spencer,

W.I. Wood, and M.J. Cronin. (1991) Growth Hormone Binding Protein Enhances the Growth Promoting Activity of GH in the Rat. Endocrine Society, abstract 1611.

16. Z. Laron, P.S. Rotwein, L.R. Meacham, J.S. Parks, P.J. Godowski, and W.I. Wood. (1990)

Laron-Type Dwarfism and Growth Hormone Gene Deletion. New Perspectives on Genetic Markers and Diseases Among the Jewish People, eds. Bonne-Tamir, Oxford University Press, 248-258.

17. M.J. Waters, R.T. Barnard, P.E. Lobie, L. Lim, G. Hamlin, S.A. Spencer, R.G. Hammonds,

D.W. Leung, and W.I. Wood. (1990) Growth Hormone Receptors--Their Structure, Location and Role. Acta Pediatr. Scand. (Suppl.), 366: 60-72.

18. D.T. Schermer, S.D.H. Chan, R. Bruce, R.A. Nissenson, W.I. Wood, and G.I. Strewler.

(1990) The Chicken Parathyroid Hormone-Related Protein: Its Sequence and Expression During Embryologic Development. Endocrine Society, abstract 1070.

19. R. Selvanayagam, K. Graves, W.I. Wood, C. Cooper, and S. Rajaraman. (1990) Tissue

Distribution of the Parathyroid Hormone-Related Peptide in the Adult Rat. The FASEB Journal, 4: A702.

20. Steven A. Spencer, David W. Leung, Paul J. Godowski, R. Glenn Hammonds, Michael J.

Waters, and Wil l iam I. Wood (1990) Growth Hormone Receptor and Binding Protein. Recent Progress in Hormone Research, 46: 165-183.

21. Wil l iam I. Wood, David W. Leung, Steven A. Spencer, R. Glenn Hammonds, and Michael

J. Waters. (1989) Purification, Cloning, and Expression of the Rabbit and Human Growth Hormone Receptors. Third Joint Meeting of the European Society for Pediatric Endocrinology and Lawson Wilkins Pediatric Endocrinology Society, invited symposium lecture and abstract.

22. M.J. Waters, S.A. Spencer, D. Leung, R.G. Hammonds, G. Cachianes, W.J. Henzel, W.I.

Wood, R. Barnard, P. Quirk, and G. Hamlin. (1989) Growth Hormone Receptors and Binding Proteins. Biotechnology in Growth Regulation, ed. Heap, Butterworths Scientific, 15-25.

14 William I. Wood

23. Z. Laron, P.J. Godowski, R. Keret, A. Silbergeld, L.R. Meacham, J.S. Parks, W.I.Wood (1989) Demonstration of a Partial Gene Deletion of the GH Receptor in Laron Type Dwarfism (LTD). Israel Endocrine Society Meeting.

24. L.J. Suva, M.T. Gillespie, W.I. Wood, T.J. Martin and P.J. Hudson. (1989) Multiple

Tissue-Specific Promoters and Alternative Splicing of the Human Parathyroid Hormone-Related Protein Gene. J Bone Min. Res. 4: suppl. 1, 67.

25. A.D. Care, S.K. Abbas, D.W. Pickard, W.I. Wood, R.G. Hammonds, C.P. Rodda, I.W.

Caple, and T.J. Martin. (1989) The Role of Parathyroid Hormone-Related Protein (PTHrP) in Placental Calcium Transfer. J Bone Min. Res. 4: suppl. 1, 615.

26. V. Grill, H. Diefenbach-Jagger, P.R. Ebeling, J.A. Glatz, J.M. Moseley, G.R. Hammonds,

W.I. Wood, and T.J. Martin. (1989) Characterization of Parathyroid Hormone-Related Protein with Region Specific Antisera. J Bone Min. Res. 4: suppl. 1, 779.

27. S.C. Kukreja, T.J. Rosol, S.A. Wimbiscus, D.H. Shevrin, R.G. Hammonds, T.J. Martin, and

W.I. Wood. (1989) Comparison of the Effects of Parathyroid Hormone-Related Protein (PTHrP) (1-34) and PTHrP (1-141) on Quantitative Bone Histomorphometry in Mice. J Bone Min. Res. 4: suppl. 1, 806.

28. Steven A. Spencer, David Leung, R. Glenn Hammonds, Michael Waters, and Wil l iam I.

Wood. (1989) Molecular Biology of the Growth Hormone Receptor. Second International Pituitary Congress, Palm Springs.

29. Wil l iam I. Wood, Steven A. Spencer, David W. Leung, R. Glenn Hammonds, and Michael

J. Waters. (1989) Similarity of the Growth Hormone Receptor and the Growth Hormone Binding Protein. Endocrine Society Symposium, invited lecture and abstract, 2.

30. P. Colosi, G. Thordarson, I.A. Forsyth, and W.I. Wood. (1989) Isolation of cDNA Clones

Encoding Ovine Placental Lactogen. Endocrine Society, abstract 339. 31. A. Bowcock, L.L. Cavalli-Sforza, W. Wood, T. Jenkens, B. Hewlett, and T. Merimee.

(1989) The Growth Hormone Receptor Gene in the African Pygmy. Clin. Res. 37: 599A. 32. A.D. Care, S.K. Abbas, D.W. Pickard, W.I. Wood, C.Rodda, I.W. Caple, and T.J. Martin.

(1989) The Role of Parathyroid Hormone Related Protein (PTHrP) in Fetal Calcium Homeostasis. XXXI International Congress of Physiological Sciences, Helsinki .

33. T.J. Martin, E.H. Allan, I.W. Caple, A.D. Care, J.A. Danks, H. Diefenbach-Jagger, P.R.

Ebeling, M.T. Gillespie, G. Hammonds, J.A. Heath, P.J. Hudson, B.E. Kemp, S.C. Kukreja, J.M. Moseley, K.W. Ng, L.G. Raisz, C.P. Rodda, H.A. Simmons, L.J. Suva, R.E.H. Wettenhall, and W.I. Wood. (1989) Parathyroid Hormone-Related Protein: Isolation, Molecular Cloning and Mechanism of Action. Recent Progress in Hormone Research, 45: 467-506.

34. Gordon A. Vehar, Richard M. Lawn, Edward G.D. Tuddenham, and Wil l iam I. Wood.

(1989) Factor VIII and Factor V: Biochemistry and Pathophysiology. The Metabolic Basis of Inherited Disease, Sixth Edition, eds. Scriver, Beaudet, Sly, and Valle, McGraw Hill, 2155-2170.

15 William I. Wood

35. K. Raghavendra, G. MacDonald, T.M. Schuster, S.J. Shire, D.W. Leung, G.J. Cachianes, E. Jackson, W.I. Wood, and P. McKay. (1989) Comparative Self-Assembly Properties of Recombinant and Native Coat Proteins of Tobacco Mosaic Virus: Effects of N-Terminal Acetylation. 33rd Annual Biophysical Society Meeting.

36. Michael J. Waters, Ross Barnard, Gary Hamlin, Steven A. Spencer, R. Glenn Hammonds,

David W. Leung, William J. Henzel, George Cachianes, and Wil l iam I. Wood. (1988) Growth Hormone and Prolactin Receptors: A New Class of Transmembrane Signalling Molecules. Progress in Endocrinology, eds. H. Imura et al., Elsevier Science Publishers.

37. Wil l iam I. Wood. (1988) Purification, Cloning, and Expression of the Growth Hormone

Receptor. Hormonal Regulation of Growth, Serono Symposia Publication, eds. Herwig Frisch and Michael O. Thorner, 58: 171-174.

38. Wil l iam I. Wood, Larry J. Suva, R. Glenn Hammonds, Genine Winslow, Jane M. Moseley

and T. John Martin. (1988) Parathyroid Hormone-Related Protein and Humoral Hypercalcemia of Malignancy. Endocrine Society Symposium, invited lecture and abstract, 6.

39. R. Glenn Hammonds, Genine Winslow, Jane M. Moseley, T. John Martin, and Wil l iam I.

Wood. (1988) Activity of Full-Length PTH-Related Protein Expressed in E. coli. J. Bone Mineral Res., 3: suppl. 1, 2.

40. L.J. Suva, K.A. Mather, K.W. Ng, M.R. Gillespie, W.I. Wood, T.J. Martin, and P.J. Hudson.

(1988) Genomic Structure of the Promoter and 5' Untranslated Region of the Gene Encoding Human Parathyroid Hormone-Related Protein. J. Bone Mineral Res., 3: suppl. 1, 580.

41. S.C. Kukreja, D.H. Shevrin, P.R. Ebeling, P.A. York, S. Wimbiscus, K.I. Gorny, W.I. Wood,

and T. J. Martin. (1988) Antibodies to PTH-Related Protein Lower Serum Calcium in Malignancy-Associated Hypercalcemia. J. Bone Mineral Res., 3: suppl. 1, 619.

42. Steven A. Spencer, R. Glenn Hammonds Jr., Michael J. Waters, and Wil l iam I. Wood.

(1987) Purification and Characterization of a Growth Hormone Receptor from Rabbit Liver and a Related Binding Protein from Rabbit Serum. International Symposium on Growth Hormone, Tampa, Florida.

43. T.J. Martin, B.F. Kemp, J.M. Moseley, L.G. Raisz, L.J. Suva, and W.I. Wood. (1987) PTH-

related Protein of Cancer - A Novel Gene Product with Some Actions Like PTH. First International Conference on New Actions of Parathyroid Hormone, Kobe, Japan.

44. W.I. Wood. (1987) Gene Cloning Based on Long Oligonucleotide Probes. Meth.

Enzymol., 152: 443-447. 45. Wil l iam I. Wood. (1986) Expression of Cloned Human Factor VIII and the Molecular

Basis of Gene Defects that Cause Hemophilia. Prog. Clin. Biol. Res., 211: 297-302. 46. D. Eaton, W. Wood, D. Capon, J. Gitschier, R. Lawn, and G. Vehar. (1986) The

Recombinant Factor VIII Protein. XXI Congress of the International Society of Hematology, Sydney, Australia.

16 William I. Wood

47. Wil l iam I. Wood. (1986) Genetic Engineering. McGraw-Hill Yearbook of Science and Technology 1987, McGraw-Hill, New York, 216-218.

48. Gary Felsenfeld, James McGhee, WiI l iam I. Wood, Georgianna Sandeen, and Henryk

Eisenberg. (1981) Nucleosome Interactions and Chromatin Function. Biomolecular Stereodynamics, 2: 99-107.

49. Wil l iam I. Wood and David O. Peterson. (1981) Fatty Acid Synthase from

Mycobacterium smegmatis. Meth. Enzymol., 71: 110-116. 50. Wil l iam I. Wood. (1976) The Acquisition and Graphical Display of Neurophysiology

Data with an Online Multiprogramming Computer System. Computer Technology in Neuroscience, ed. Paul D. Brown, Hemisphere, Washington, 211-220.

51. Wil l iam I. Wood, John J. Wilson, and Fredrick Brown. (1975) A Dual Processor

Approach to Expanding a Laboratory Automation System. Computing in the Mid-70's: An Assessment, ed. Marvin V. Zelkowita. Fourteenth Annual Technical Symposium of the Association for Computing Machinery, Washington, 7-10.

17 William I. Wood

US Patents Issued 1. 8,106,156 PRO1120 polypeptides 2. 8,097,700 TAT294 polypeptides 3. 8,088,386 Treatment of complement-associated disorders 4. 8,084,200 Compositions and methods for the diagnosis and treatment of tumor 5. 8,075,888 Methods of treatment using antibodies to IL-17 homologous polypeptides 6. 8,063,186 Antibodies to PRO7436 polypeptides 7. 8,034,342 Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-

17E 8. 8,007,798 Treatment of complement-associated disorders 9. 7,960,531 EG-VEGF nucleic acids and polypeptides and methods of use 10. 7,939,650 Stra6 polypeptides 11. 7,855,278 Antibodies to Stra6 polypeptides 12. RE41,888 Polynucleotide overexpressed in tumors 13. 7,807,385 Method of detecting PRO9917 14. 7,795,412 Nucleic acids encoding PRO6308 polypeptides and related vectors and host cells 15. 7,786,272 Antibodies to PRO352 16. 7,777,007 PRO9907 antibodies 17. 7,771,719 Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to

IL-17E 18. 7,749,500 Antibodies to IL-17 polypeptides and therapeutic uses thereof 19. 7,741,439 Isolated stra6 polypeptides 20. 7,741,056 Use of A33 antigens and JAM-IT 21. 7,736,645 EG-VEGF nucleic acids and polypeptides and methods of use 22. 7,728,108 PRO1550 polypeptides 23. 7,727,536 EG-VEGF nucleic acids and polypeptides and methods of use 24. 7,723,488 Monoclonal antibodies to secreted and transmembrane polypeptides 25. 7,718,770 PRO1305-polypeptides 26. 7,718,397 Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof 27. 7,718,173 Anti-pro6094 antibodies 28. 7,709,603 PRO1190 polypeptides 29. 7,709,602 PRO1078 polypeptides 30. 7,704,496 Antibodies against PRO1341 polypeptide 31. 7,700,736 PRO350 antibodies 32. 7,696,319 PRO1772 antibodies 33. 7,691,978 Antibodies that bind TAT294 34. 7,642,242 PRO34128 polypeptides 35. 7,635,478 Secreted and transmembrane polypeptides and nucleic acids encoding the same 36. 7,629,145 VEGF-related protein 37. 7,619,062 PRO214 polypeptides 38. 7,601,514 Nucleic acid encoding PRO10268 polypeptides 39. 7,589,172 PRO256 polypeptides 40. 7,582,293 Anti-PRO6308 antibodies 41. 7,579,161 Assay methods for suppressor of fused modulation of hedgehog signaling 42. 7,576,185 PRO34128 antibodies 43. 7,576,182 Compositions and methods for the treatment of immune related diseases 44. 7,566,774 PRO4977 polypeptides 45. 7,563,867 PRO4356 polypeptides 46. 7,557,192 Anti-PRO335 antibodies

18 William I. Wood

47. 7,550,573 Secreted and transmembrane polypeptides and nucleic acids encoding the same 48. 7,547,507 Methods for the diagnosis of tumors 49. 7,544,482 Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof 50. 7,538,086 PRO1303 polypeptides 51. 7,534,856 PRO19624 antibodies 52. 7,524,497 Antibodies to PRO 1120 polypeptide 53. 7,521,539 Anti-PRO4989 antibodies 54. 7,514,538 Compositions and methods for the diagnosis and treatment of tumor 55. 7,507,557 Nucleic acids encoding PRO1375 polypeptides 56. 7,507,404 Secreted and transmembrane polypeptides and nucleic acids encoding the same 57. 7,504,484 Antibodies to the PRO1561 polypeptide 58. 7,504,480 PRO10275 polypeptides 59. 7,495,083 PRO940 antibodies 60. 7,495,082 Antibodies to PRO4349 polypeptides 61. 7,491,797 PRO6308 polypeptide 62. 7,491,529 Secreted and transmembrane polypeptides and nucleic acids encoding the same 63. 7,491,512 Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof 64. 7,488,796 PRO1269 polypeptides 65. 7,488,795 PRO846 polypeptides 66. 7,488,586 PRO4409 polypeptides 67. 7,479,545 PRO6001 antibodies 68. 7,476,723 Immunoconjugates and antibodies to PRO9917 69. 7,473,763 Receptor for IL-17 homologous polypeptides and uses thereof 70. 7,470,774 Anti-pro1477 antibodies 71. 7,470,771 Secreted and transmembrane polypeptides and nucleic acids encoding the same 72. 7,468,427 Antibodies to PRO1275 polypeptide 73. 7,468,424 Secreted and transmembrane polypeptides and nucleic acids encoding the same 74. 7,465,786 PRO1801 polypeptides 75. 7,465,785 Polypeptide encoded by a nucleic acid over-expressed in melanoma 76. 7,462,692 PRO1477 polypeptides 77. 7,456,261 PRO9830 antibodies 78. 7,452,975 Anti-PRO7168 antibodies 79. 7,449,554 Antibodies against the PRO4977 polypeptides 80. 7,449,551 PRO211 polypeptides 81. 7,449,549 PRO9822 polypeptides 82. 7,446,168 EG-VEGF nucleic acids and polypeptides and methods of use 83. 7,445,905 Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the

treatment of pancreatic disorders 84. 7,442,772 Antibodies to PRO361 polypeptide 85. 7,442,765 Secreted transmembrane polypeptides and nucleic acids encoding the same 86. 7,439,325 PRO6001 polypeptides 87. 7,435,798 Antibodies to a polypeptide encoded by a nucleic acid overexpressed in normal

stomach, normal skin and kidney tumor 88. 7,435,793 Peptides that induce chondrocyte redifferentiation 89. 7,432,345 PRO1475 polypeptide 90. 7,429,641 PRO9830 polypeptides 91. 7,429,640 PRO6181 polypeptides 92. 7,427,667 PRO9835 antibodies 93. 7,427,664 Antibodies to polypeptides that stimulate TNF-.alpha. release 94. 7,425,621 Antibodies against the PRO4401 polypeptide 95. 7,425,613 PRO1375 polypeptides

19 William I. Wood

96. 7,425,609 PRO4330 polypeptides 97. 7,425,605 PRO1486 polypeptides 98. 7,423,130 PRO1158 polypeptides 99. 7,423,127 Antibodies to a polypeptide encoded by a nucleic acid overexpressed in melanoma 100. 7,423,120 PRO19814 polypeptides 101. 7,423,119 Secreted and transmembrane polypeptides and nucleic acids encoding the same 102. 7,419,663 Treatment of complement-associated disorders 103. 7,417,126 PRO246 antibodies 104. 7,417,125 Antibodies that bind a PRO1158 polypeptide 105. 7,417,123 PRO4399 Antibodies 106. 7,417,116 PRO7155 polypeptides 107. 7,417,115 PRO6027 polypeptides 108. 7,414,112 Antibodies to PRO1550 polypeptides 109. 7,411,047 PRO6097 antibodies 110. 7,411,040 PRO6182 polypeptides 111. 7,411,037 Polypeptides encoded by a nucleic acid underexpressed in melanoma 112. 7,408,042 Anti-PRO6181 antibodies 113. 7,408,035 PRO9864 polypeptides 114. 7,408,034 PRO20025 polypeptides 115. 7,408,033 PRO5995 polypeptides 116. 7,408,032 PRO1188 polypeptides 117. 7,405,269 Secreted and transmembrane polypeptides and nucleic acids encoding the same 118. 7,405,268 Secreted and transmembrane polypeptides and nucleic acids encoding the same 119. 7,402,661 Secreted and transmembrane polypeptides and nucleic acids encoding the same 120. 7,402,656 PRO10013 polypeptides 121. 7,399,834 Anti-PRO1558 antibodies 122. 7,399,828 Secreted and transmembrane polypeptides and nucleic acids encoding the same 123. 7,399,824 PRO19680 antibodies 124. 7,396,916 Antibody to a polypeptide overexpressed in tumors 125. 7,396,907 Antibodies that bind PRO6182 polypeptides 126. 7,396,906 Pro4399 Polypeptides 127. 7,393,931 Secreted and transmembrane polypeptides and nucleic acids encoding the same 128. 7,393,917 PRO1482 polypeptides 129. 7,390,887 Antibodies against PRO4330 130. 7,390,886 PRO9822 antibodies 131. 7,390,883 PRO4428 antibodies 132. 7,390,879 Secreted and transmembrane polypeptides and nucleic acids encoding the same 133. 7,390,878 PRO6090 polypeptides 134. 7,390,877 PRO4381 polypeptides 135. 7,390,876 Secreted and transmembrane polypeptides and nucleic acids encoding the same 136. 7,390,486 PRO4381 antibodies 137. 7,388,073 PRO9835 polypeptides 138. 7,385,033 PRO12970 polypeptides 139. 7,385,031 PRO6097 polypeptides 140. 7,385,030 Secreted and transmembrane polypeptides and nucleic acids encoding the same 141. 7,381,809 Compositions and methods for the treatment of immune related diseases 142. 7,381,791 PRO9739 polypeptides 143. 7,378,507 PRO217 polypeptides 144. 7,378,502 PRO4389 antibodies 145. 7,378,501 Secreted and transmembrane polypeptides and nucleic acids encoding the same 146. 7,378,491 Secreted and transmembrane polypeptides and nucleic acids encoding the same

20 William I. Wood

147. 7,378,487 PRO19675 polypeptides 148. 7,378,486 PRO1482 antibodies 149. 7,375,196 PRO19814 antibodies 150. 7,375,195 Anti-PRO7171 polypeptides 151. 7,375,184 PRO1382 polypeptides 152. 7,375,179 PRO19680 polypeptides 153. 7,371,836 PRO526 nucleic acids 154. 7,371,827 Antibodies against the PRO1126 polypeptide 155. 7,371,824 PRO6093 polypeptides 156. 7,371,817 PRO9783 polypeptides 157. 7,371,816 PRO10284 polypeptides 158. 7,371,815 PRO19644 polypeptides 159. 7,371,814 Secreted and transmembrane polypeptides and nucleic acids encoding the same 160. 7,368,558 PRO357 nucleic acids 161. 7,368,250 Compositions and methods for the diagnosis and treatment of tumor 162. 7,365,157 PRO9912 polypeptides 163. 7,365,156 PRO1316 polypeptides 164. 7,361,732 PRO4400 polypeptides 165. 7,361,337 Antibodies against the PRO1754 polypeptides 166. 7,358,340 PRO19563 antibodies 167. 7,358,339 Secreted and transmembrane polypeptides and nucleic acids encoding the same 168. 7,357,926 Antibodies against PRO1879 and the use thereof 169. 7,355,013 PRO6017 antibodies 170. 7,355,007 Antibodies that bind PRO5005 Polypeptides 171. 7,355,006 Antibodies against the PRO1271 polypeptides 172. 7,355,002 Secreted and transmembrane polypeptides and nucleic acids encoding the same 173. 7,355,000 PRO1380 polypeptides 174. 7,354,999 PRO1481 polypeptides 175. 7,354,998 PRO7171 polypeptides 176. 7,354,997 Polypeptide encoded by a nucleic acid underexpressed in stomach tumor 177. 7,351,804 Antibodies against PRO4421 178. 7,351,802 PRO19672 antibodies 179. 7,351,796 PRO9904 polypeptides 180. 7,351,795 PRO19563 polypeptides 181. 7,351,794 PRO1754 polypeptides 182. 7,351,793 PRO1286 polypeptide 183. 7,351,789 PRO19624 polypeptides 184. 7,351,543 Antibodies to a polypeptide encoded by a nucleic acid underexpressed in melanoma 185. 7,348,415 PRO1316 antibodies 186. 7,348,414 Antibodies against the PRO1154 polypeptide 187. 7,348,405 PRO10274 polypeptides 188. 7,345,147 PRO16089 polypeptides 189. 7,345,146 PRO1271 Polypeptides 190. 7,345,145 Secreted and transmembrane polypeptides and nucleic acids encoding the same 191. 7,344,880 Nucleic acid encoding PRO9912 polypeptides 192. 7,343,721 PRO4406 polypeptide 193. 7,342,104 Antibodies against the PRO4320 polypeptide 194. 7,342,098 PRO1154 polypeptide 195. 7,342,097 PRO1309 polypeptides 196. 7,342,096 PRO1879 polypeptide 197. 7,339,034 PRO1305 antibodies

21 William I. Wood

198. 7,339,033 PRO1481 199. 7,339,025 PRO6246 polypeptides 200. 7,339,024 PRO1772 polypeptides 201. 7,335,746 Anti-pro4976 antibodies 202. 7,335,745 Antibodies against the PRO4403 polypeptides 203. 7,335,740 Antibodies against the PRO7434 polypeptides 204. 7,335,732 PRO9799 polypeptides 205. 7,335,731 PRO4332 polypeptides 206. 7,335,730 PRO7436 polypeptides 207. 7,335,729 PRO4320 polypeptide 208. 7,335,728 PRO1310 polypeptides 209. 7,332,583 PRO19628 Antibodies 210. 7,332,578 Anti-pro4407 antibodies 211. 7,332,573 PRO1571 polypeptides 212. 7,329,730 PRO4348 polypeptides 213. 7,329,404 Antibodies against PRO1310 214. 7,326,773 PRO6493 antibodies 215. 7,326,413 Antibodies against the PRO1434 polypeptide 216. 7,323,550 Anti-PRO4318 antibodies 217. 7,323,545 PRO1885 polypeptides 218. 7,323,544 PRO1434 polypeptides 219. 7,319,137 PRO1339 polypeptides 220. 7,319,136 PRO7434 polypeptides 221. 7,319,135 PRO1341 polypeptides 222. 7,319,008 Nucleic acid underexpressed in melanoma 223. 7,318,922 Anti-PRO5337 antibodies 224. 7,317,093 PRO1339 antibodies 225. 7,317,092 Secreted and transmembrane polypeptides and nucleic acids encoding the same 226. 7,317,088 PRO5993 polypeptides 227. 7,317,084 PRO9907 polypeptides 228. 7,317,083 PRO4501 polypeptides 229. 7,317,082 PRO1018 polypeptides 230. 7,317,081 PRO4371 polypeptides 231. 7,317,080 PRO4303 polypeptides 232. 7,317,079 PRO812 polypeptides 233. 7,317,076 PRO21340 polypeptides 234. 7,317,075 PRO21384 polypeptides 235. 7,317,074 Pro4976 polypeptides 236. 7,314,920 Antibodies against the PRO4340 polypeptide 237. 7,314,918 PRO6246 antibodies 238. 7,314,913 PRO1891 polypeptides 239. 7,312,316 PRO16090 antibodies 240. 7,312,315 PRO9742 antibodies 241. 7,312,314 Antibody that binds a pro1693 polypeptide 242. 7,312,313 Anti-PRO1309 antibodies 243. 7,312,312 PRO6242 polypeptides 244. 7,312,310 PRO6015 polypeptides 245. 7,312,309 PRO6017 polypeptides 246. 7,312,308 Secreted and transmembrane polypeptides and nucleic acids encoding the same 247. 7,312,307 PRO1056 polypeptides 248. 7,312,303 Anti-PRO4980 antibodies

22 William I. Wood

249. 7,311,909 PRO4348 antibodies 250. 7,309,778 Secreted and transmembrane polypeptides and nucleic acids encoding the same 251. 7,309,777 Antibodies against the PRO1556 polypeptide 252. 7,309,776 PRO12970 antibodies 253. 7,309,775 Secreted and transmembrane polypeptides and nucleic acids encoding the same 254. 7,309,771 PRO19646 polypeptides 255. 7,309,770 PRO1757 polypeptides 256. 7,309,769 PRO1487 polypeptides 257. 7,309,768 PRO4347 polypeptides 258. 7,309,767 Secreted and transmembrane polypeptides and nucleic acids encoding the same 259. 7,309,766 PRO5774 polypeptides 260. 7,309,765 PRO4349 polypeptides 261. 7,309,764 PRO4401 polypeptide 262. 7,309,763 PRO1126 polypeptide 263. 7,309,762 PRO1360 polypeptides 264. 7,309,761 Secreted and transmembrane polypeptides and nucleic acids encoding the same 265. 7,307,153 Antibodies that bind PRO9912 266. 7,307,152 Secreted and transmembrane polypeptides and nucleic acids encoding the same 267. 7,307,151 Secreted and transmembrane polypeptides and nucleic acids encoding the same 268. 7,307,144 PRO 6493 polypeptides 269. 7,306,795 PRO5774 antibodies 270. 7,304,145 PRO19646 antibodies 271. 7,304,143 PRO1571 antibodies 272. 7,304,140 PRO4503 polypeptides 273. 7,304,136 PRO4407 polypeptides 274. 7,304,135 PRO9859 polypeptides 275. 7,304,134 PRO9742 polypeptides 276. 7,304,133 PRO4389 polypeptides 277. 7,304,132 PRO1693 polypeptides 278. 7,304,131 PRO1483 polypeptides 279. 7,304,126 Secreted and transmembrane polypeptides and nucleic acids encoding the same 280. 7,303,896 Nucleic acid encoding novel type-1 cytokine receptor GLM-R 281. 7,301,008 PRO7174 polypeptides 282. 7,301,007 PRO4340 polypeptides 283. 7,300,758 Nucleic acid underexpressed in esophageal tumor 284. 7,297,776 PRO1374 antibodies 285. 7,297,770 PRO6496 polypeptides 286. 7,297,769 PRO698 polypeptides 287. 7,297,768 PRO3574 polypeptide 288. 7,297,767 PRO1374 polypeptides 289. 7,297,766 PRO5337 polypeptides 290. 7,297,765 Secreted and transmembrane polypeptides and nucleic acids encoding the same 291. 7,297,764 PRO4318 polypeptides 292. 7,297,333 Anti-PRO10268 antibodies 293. 7,294,705 Anti-PRO3580 antibodies 294. 7,294,703 PRO6093 Antibodies 295. 7,294,702 Secreted and transmembrane polypeptides and nucleic acids encoding the same 296. 7,294,700 Anti-PRO846 antibodies 297. 7,294,696 PRO7168 polypeptides 298. 7,294,695 PRO10268 polypeptides 299. 7,294,694 PRO19628 polypeptides

23 William I. Wood

300. 7,294,693 Pro4428 Polypeptides 301. 7,294,692 Pro6014 polypeptides 302. 7,294,690 Polypeptides encoded by a nucleic acid differentially expressed in lung tumor 303. 7,294,495 PR03580 polypeptides 304. 7,294,335 PRO19645 antibodies 305. 7,291,719 PRO4332 antibodies 306. 7,291,718 PRO1758 antibodies 307. 7,291,717 PRO3446 antibodies 308. 7,291,716 PRO4400 antibodies 309. 7,291,715 Antibodies to the PRO4329 polypeptide 310. 7,291,712 Interleukin-8 homologous polypeptides and therapeutic uses thereof 311. 7,291,708 PRO1785 polypeptides 312. 7,291,707 PRO1337 polypeptides 313. 7,291,706 PRO4352 polypeptides 314. 7,291,705 PRO19645 polypeptides 315. 7,291,704 PRO1758 polypeptides 316. 7,291,703 PRO1508 polypeptides 317. 7,291,702 PRO4326 polypeptides 318. 7,291,701 PRO1777 polypeptides 319. 7,291,700 PRO4985 polypeptide 320. 7,291,329 Antibodies against PRO4406 321. 7,288,629 Pro9925 polypeptides 322. 7,288,628 PRO20088 polypeptides 323. 7,288,627 PRO4322 polypeptides 324. 7,288,626 PRO4403 polypeptides 325. 7,288,625 PRO4395 polypeptides 326. 7,288,384 Antibodies to polypeptides encoded by a nucleic acid underexpressed in esophageal

tumor 327. 7,285,645 PRO4356 antibodies 328. 7,285,644 Secreted and transmembrane polypeptides and nucleic acids encoding the e 329. 7,285,636 PRO6095 polypeptides 330. 7,285,629 Pro5005 polypeptides 331. 7,285,628 PRO1867 polypeptides 332. 7,285,627 PRO4989 polypeptides 333. 7,285,626 PRO1076 polypeptides 334. 7,285,625 PRO536 polypeptides 335. 7,285,624 Secreted and transmembrane polypeptides and nucleic acids encoding the e 336. 7,285,623 PRO337 polypeptides 337. 7,282,570 Compositions and methods for the treatment of immune related diseases 338. 7,282,569 PRO1508 antibodies 339. 7,282,566 PRO1779 polypeptide 340. 7,282,565 PRO362 polypeptides 341. 7,282,562 Compositions and methods for the treatment of immune related diseases 342. 7,282,561 PRO16090 polypeptides 343. 7,282,560 PRO 4326 polypeptides 344. 7,282,559 Secreted and transmembrane polypeptides and nucleic acids encoding the e 345. 7,282,558 PRO4329 polypeptide 346. 7,279,553 PRO1083 polypeptides 347. 7,279,552 Pro1782 polypeptides 348. 7,279,551 Pro1556 Polypeptide

24 William I. Wood

349. 7,276,586 Antibodies to a polypeptide encoded by a nucleic acid under-expressed in ach and lung tumor

350. 7,276,578 PRO4334 polypeptides 351. 7,276,577 PRO1866 polypeptides 352. 7,273,926 Antibody to PRO1779 polypeptides 353. 7,273,726 Compounds, compositions and methods for the treatment of diseases acterized by A-

33 related antigens 354. 7,271,250 PRO1757 antibodies 355. 7,271,247 Antibodies to a polypeptide encoded by a nucleic acid differentially essed in melanoma 356. 7,268,217 PRO4421 polypeptides 357. 7,265,210 Anti-PRO9821 antibodies 358. 7,264,801 EG-VEGF nucleic acids and polypeptides and method of use 359. 7,259,238 Polypeptide encoded by a nucleic acid under-expressed in stomach and lung or 360. 7,258,983 Cardiotrophin-1 compositions and methods for the treatment of tumor 361. 7,256,264 Receptor for IL-17 homologous polypeptides and uses thereof 362. 7,256,262 Secreted and transmembrane polypeptides and nucleic acids encoding the e 363. 7,256,261 Polypeptides encoded by a nucleic acid over expressed in normal stomach mal skin and

kidney tumor 364. 7,256,039 PRO4405 nucleic acids 365. 7,253,256 Polypeptides encoded by a nucleic acid are expressed in esophageal and ey tumor 366. 7,253,255 Polypeptide encoded by a nucleic acid underexpressed in esophageal tumor and

melanoma7,250,495 PRO20044 polypeptides 367. 7,250,490 PRO1480 polypeptides 368. 7,247,710 PRO4395 antibodies 369. 7,247,446 PRO34128 nucleic acids 370. 7,244,817 Pro1357 polypeptide 371. 7,244,816 Secreted and transmembrane polypeptides and nucleic acids encoding the same 372. 7,244,428 PRO1357 antibodies 373. 7,241,872 Secreted and transmembrane polypeptides and nucleic acids encoding the same 374. 7,241,865 Secreted and transmembrane polypeptides and nucleic acids encoding the same 375. 7,241,862 Polypeptides that induce cell proliferation or induce fetal hemoglobin 376. 7,238,790 PRO1313 polypeptides 377. 7,238,787 Antibodies to a polypeptide encoded by a nucleic acid underexpressed in melanoma 378. 7,235,642 Anti-PRO 1313 antibodies 379. 7,235,633 Cytokine receptors and nucleic acids encoding the same 380. 7,235,630 PRO994 polypeptides 381. 7,232,892 Antibodies to a polypeptide encoded by a nucleic acid differentailly expressed in

stomach, lung and melanoma tumor 382. 7,232,889 PRO300 antibodies 383. 7,232,882 Polypeptide uder-expressed in melanoma 384. 7,230,082 Secreted and transmembrane polypeptides and nucleic acids encoding the same 385. 7,230,077 Polypeptide encoded by a nucleic acid underexpressed in melanoma 386. 7,230,076 Secreted and transmembrane polypeptides and nucleic acids encoding the same 387. 7,227,000 Secreted and transmembrane polypeptides and nucleic acids encoding the same 388. 7,226,591 Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the

treatment of pancreatic disorders 389. 7,223,841 PR0994 antibodies 390. 7,223,838 Secreted and transmembrane polypeptides and nucleic acids encoding the same 391. 7,223,586 Secreted and transmembrane polypeptides and nucleic acids encoding the same 392. 7,220,850 Secreted and transmembrane polypeptides and nucleic acids encoding the same

25 William I. Wood

393. 7,220,841 Antibody to PRO1557 polypeptide encoded by a nucleic acid highly expressed in esophageal and kidney tumors

394. 7,220,835 Secreted and transmembrane polypeptides and nucleic acids encoding the same 395. 7,220,831 PRO235 polypeptides 396. 7,220,830 Polypeptide underexpressed in stomach tumors 397. 7,220,568 Nucleic acids encoding the PRO1561 polypeptide 398. 7,217,787 Polypeptide encoded by a nucleic acid underexpressed in rectal tumor 399. 7,217,412 IL-17C related mammalian cytokine polypeptides 400. 7,214,777 Secreted and transmembrane polypeptides and nucleic acids encoding the same 401. 7,214,656 PRO792 polypeptides 402. 7,211,645 PRO268 polypeptides 403. 7,211,400 Compounds, compositions and methods for the treatment of diseases characterized

by A-33 related antigens 404. 7,208,575 PRO531 polypeptides 405. 7,208,321 Secreted and transmembrane polypeptides and nucleic acids encoding the same 406. 7,208,316 Polynucleotide overexpressed in tumors 407. 7,208,312 Secreted and transmembrane polypeptides and nucleic acids encoding the same 408. 7,208,308 Secreted and transmembrane polypeptides and nucleic acids encoding the same 409. 7,205,391 Antibodies to a polypeptide suppressed in stomach tumors 410. 7,205,389 Secreted and transmembrane polypeptides and nucleic acids encoding the same 411. 7,202,345 PRO 1384 antibodies 412. 7,202,338 PRO731 polypeptides 413. 7,202,337 Polypeptide encoded by a nucleic acid overexpressed in esophageal tumor, normal

stomach and melanoma 414. 7,202,336 Polypeptide encoded by a nucleic acid overexpressed in kidney tumor and

underexpressed in lung tumor 415. 7,202,335 PRO300 polypeptides 416. 7,198,917 Compounds, compositions and methods for the treatment of diseases characterized

by A-33 related antigens 417. 7,196,176 Secreted and transmembrane polypeptides and nucleic acids encoding the same 418. 7,196,174 PRO1557 polypeptide encoded by a nucleic acid highly expressed in esophageal and

kidney tumors 419. 7,196,173 PRO1315 polypeptide encoded by a nuclear acid highly expressed in esophageal

tumors 420. 7,196,167 Polypeptide underexpressed in lung tumor 421. 7,196,166 Secreted polypeptide overexpressed in rectal tumor 422. 7,196,165 PRO363 polypeptides 423. 7,195,760 Anti-pro363 antibodies 424. 7,193,074 Secreted and transmembrane polypeptides and nucleic acids encoding the same 425. 7,193,063 Antibodies to a polypeptide encoded by a nucleic acid overexpressed in esophageal

tumor, normal stomach and melanoma 426. 7,193,062 Antibodies to a polypeptide encoded by a nucleic acid over expressed in esoprageal

and lung tumor, and under expressed ey tumor andnoma 427. 7,193,061 Antibodies to a polypeptide encoded by a nucleic acid underexpressed in esophageal

tumor and melanoma 428. 7,193,060 Antibodies to a polypeptides encoded by a nucleic acid overexpressed in kidney tumor

and underexpressed in lung tumor 429. 7,193,059 Antibodies that recognize a polypeptide overexpressed in rectal tumors 430. 7,193,057 Antibodies to a polypeptide encoded by a nucleic acid underexpressed in rectal tumor 431. 7,193,050 Secreted and transmembrane polypeptides and nucleic acids encoding the same 432. 7,193,049 PRO862 polypeptides

26 William I. Wood

433. 7,193,048 Secreted and transmembrane polypeptides and nucleic acids encoding the same 434. 7,193,047 Polypeptide encoded by a nucleic acid underexpressed in esophageal tumor 435. 7,193,046 Polypeptide encoded by a nucleic acid overexpressed in esophageal and lung tumor,

and underexpressesd in kidney tumor lanoma 436. 7,193,045 Polypeptides that induce cell proliferation 437. 7,192,589 Treatment of inflammatory disorders with STIgMA immunoadhesins 438. 7,192,587 Secreted and transmembrane polypeptides and nucleic acids encoding the same 439. 7,189,838 PRO9834 nucleic acids 440. 7,189,822 Antibodies to a polypeptide encoded by a nucleic acid underexpressed in stomach and

lung tumor 441. 7,189,821 Antibodies to a polypeptide encoded by a nucleic acid underexpressed in lung tumor 442. 7,189,817 Secreted and transmembrane polypeptides and nucleic acids encoding the same 443. 7,189,815 Secreted and transmembrane polypeptides and nucleic acids encoding the same 444. 7,189,814 Secreted and transmembrane polypeptides and nucleic acids encoding the same 445. 7,189,813 PRO1338 polypeptides 446. 7,189,807 PRO4994 polypeptides 447. 7,189,806 Pro 1384 polypeptides 448. 7,189,805 Secreted and transmembrane polypeptides and nucleic acids encoding the same 449. 7,189,804 PRO1335 polypeptides 450. 7,189,803 Secreted and transmembrane polypeptides and nucleic acids encoding the same 451. 7,189,566 PRO347 nucleic acids 452. 7,189,564 PRO1335 nucleic acids 453. 7,189,563 Secreted and transmembrane polypeptides and nucleic acids encoding the same 454. 7,189,534 PRO4320 polynucleotide 455. 7,189,533 Secreted and transmembrane polypeptides and nucleic acids encoding the same 456. 7,189,532 Nucleic acid underexpressed in stomach tumor and lung tumor 457. 7,189,530 Secreted and transmembrane polypeptides and nucleic acids encoding the same 458. 7,189,529 PRO792 nucleic acids 459. 7,186,801 Polypeptide encoded by a nucleic acid underexpressed in stomach tumor and lung

tumor 460. 7,173,115 Stra6 polypeptides 461. 7,169,912 PRO1017 nucleic acids 462. 7,169,906 PRO211 polypeptides 463. 7,166,703 PRO1561 polypeptides 464. 7,166,700 PRO703 Polypeptides 465. 7,166,282 Secreted and transmembrane polypeptides and nucleic acids encoding the same 466. 7,164,009 Pro9821 polypeptides 467. 7,164,007 Anti-PR020044 antibodies 468. 7,164,001 Compositions and methods for the treatment of immune related diseases 469. 7,160,993 Nucleic acids encoding PRO4400 polypeptides 470. 7,160,985 Pro180 polypeptide 471. 7,157,558 Polypeptide encoded by a polynucleotide overexpresses in tumors 472. 7,157,267 Secreted and transmembrane polypeptides and nucleic acids encoding the same 473. 7,157,247 Secreted and transmembrane polypeptides and nucleic acids encoding the same 474. 7,153,941 Antibodies that bind PRO4994 polypeptides 475. 7,153,939 PRO354 antibodies 476. 7,151,160 Secreted and transmembrane polypeptides and nucleic acids encoding the same 477. 7,147,853 Anti-pro211 polypeptide antibodies 478. 7,144,996 Nucleic acid encoding human suppressor of fused 479. 7,144,990 Antibody to a polypeptide overexpressed in tumors 480. 7,141,652 Antibodies to PRO1561 polypeptide

27 William I. Wood

481. 7,135,334 PRO20044 nucleic acids 482. 7,132,283 PRO273 polypeptides 483. 7,129,325 Pro9836 polypeptides 484. 7,129,324 Secreted and transmembrane polypeptides and nucleic acids encoding the same 485. 7,125,962 Anti-Pro268 antibodies 486. 7,125,959 PRO4405 polypeptides 487. 7,122,631 Secreted and transmembrane polypeptides and nucleic acids encoding the same 488. 7,122,375 PRO274 nucleic acids 489. 7,119,177 Secreted and transmembrane polypeptides and nucleic acids encoding the same 490. 7,119,173 Secreted and transmembrane polypeptides and nucleic acids encoding the same 491. 7,118,887 Nucleic acid overexpressed in esophageal tumor, normal stomach and melanoma 492. 7,115,713 Compounds, compositions and methods for the treatment of diseases

characterized by A-33 related antigens 493. 7,115,415 PRO9821 nucleic acids 494. 7,115,398 IL-17 homologous polypeptides and therapeutic uses thereof 495. 7,112,657 PRO697 polypeptides 496. 7,112,656 PRO1312 polypeptides 497. 7,109,318 Nucleic acids encoding PRO830 498. 7,109,305 Secreted and transmembrane polypeptides and nucleic acids encoding the same 499. 7,109,292 Secreted and transmembrane polypeptides and nucleic acids encoding the same 500. 7,105,640 Anti-pro792 antibodies 501. 7,105,639 Anti-PRO 4405 antibodies 502. 7,105,335 Secreted and transmembrane polypeptides and nucleic acids encoding the same 503. 7,101,984 Secreted and transmembrane polypeptides and nucleic acids encoding the same 504. 7,101,970 PRO1570 polypeptides 505. 7,101,687 Nucleic acids encoding PRO943 506. 7,098,312 Secreted and transmembrane polypeptides and nucleic acids encoding the same 507. 7,098,003 PRO 1384 nucleic acids 508. 7,094,567 Secreted and transmembrane polypeptides and nucleic acids encoding the same 509. 7,087,738 Secreted and transmembrane polypeptides and nucleic acids encoding the same 510. 7,087,737 Pro1278 nucleic acids 511. 7,087,428 Secreted and transmembrane polypeptides and nucleic acids encoding the same 512. 7,087,421 Pro1278 polypeptides 513. 7,087,404 PRO1306 nucleic acids 514. 7,084,258 Antibodies against the PRO862 polypeptides 515. 7,084,255 PRO1278 polypeptides 516. 7,083,978 Nucleic acid encoding PRO1111 polypeptides 517. 7,083,946 PRO1343 nucleic acids 518. 7,081,521 Anti-PRO788 antibodies 519. 7,081,520 Anti-pro 1570 antibodies 520. 7,081,514 PRO1347 polypeptides 521. 7,074,912 Secreted and transmembrane polypeptides and nucleic acids encoding the same 522. 7,074,910 PRO4340 nucleic acids 523. 7,074,897 Pro943 polypeptides 524. 7,074,593 PRO 703 nucleic acids 525. 7,074,592 Secreted and transmembrane polypeptides nucleic acid encoding 526. 7,071,304 Secreted and transmembrane polypeptides and nucleic acids encoding the same 527. 7,070,979 Secreted and transmembrane polypeptides and nucleic acids encoding the same 528. 7,070,955 Secreted and transmembrane polypeptides and nucleic acids encoding the same 529. 7,067,636 Anti-pro 1017 antibodies 530. 7,067,628 PRO788 polypeptides

28 William I. Wood

531. 7,060,812 PRO1312 nucleic acids 532. 7,057,018 Pro 1474 polypeptides 533. 7,056,736 Secreted and transmembrane polypeptides and nucleic acids encoding the same 534. 7,045,603 Secreted and transmembrane polypeptides and nucleic acids encoding the same 535. 7,041,805 Secreted and transmembrane polypeptides and nucleic acids encoding the same 536. 7,041,804 Antibodies to PRO1387 polypeptides 537. 7,038,019 Antibodies to PRO1410 538. 7,037,710 Secreted and transmembrane polypeptides and nucleic acids encoding the same 539. 7,037,679 Nucleic acids encoding PRO1184 polypeptides 540. 7,034,136 Nucleic acids encoding PRO1159 polypeptides 541. 7,034,123 Anti-PRO1347 antibodies 542. 7,034,122 Antibodies to PRO1159 polypeptides 543. 7,034,106 Pro1159 polypeptides 544. 7,033,825 Secreted and transmembrane polypeptides and nucleic acids encoding the same 545. 7,033,786 Pro1340 nucleic acids 546. 7,033,785 PRO1347 nucleic acids 547. 7,029,875 PRO1343 nucleic acids 548. 7,029,874 Secreted and transmembrane polypeptides and nucleic acids encoding the same 549. 7,029,873 Nucleic acids to PRO1387 polypeptides 550. 7,026,455 Anti-pro 1343 antibodies 551. 7,026,449 Secreted and transmembrane polypeptides and nucleic acids encoding the same 552. 7,026,448 Secreted and transmembrane polypeptides and nucleic acids encoding the same 553. 7,022,817 PRO1325 polypeptides 554. 7,022,498 Pro 1325 nucleic acids 555. 7,019,124 PRO788 nucleic acids 556. 7,019,116 PRO 1387 polypeptides 557. 7,019,115 Pro1017 polypeptides 558. 7,018,837 Nucleic acids encoding secreted polypeptides that stimulate release of proteoglycans

from cartilage 559. 7,018,811 Nucleic acids encoding PRO189 polypeptides 560. 7,012,131 Pro1410 polypeptides 561. 6,984,519 Nucleic acids encoding peptides that induce chondrocyte redifferentiation 562. 6,974,696 PRO853 nucleic acids 563. 6,974,689 Nucleic acid encoding PRO211 polypeptides 564. 6,972,325 PRO273 polypeptides 565. 6,972,186 Nucleic acid encoding pro 1410 polypeptides 566. 6,972,185 Nucleic acids encoding PRO844 polypeptides 567. 6,969,758 Secreted and transmembrane polypeptides and nucleic acids encoding the same 568. 6,965,015 Secreted and transmembrane polypeptides and nucleic acids encoding the same 569. 6,965,011 Secreted and transmembrane polypeptides and nucleic acids encoding the same 570. 6,962,797 Nucleic acids encoding PRO615 571. 6,956,108 PRO1184 antibodies 572. 6,953,841 Secreted and transmembrane polypeptides and nucleic acids encoding the same 573. 6,953,836 PRO844 polypeptides 574. 6,951,921 Secreted and transmembrane polypeptides and nucleic acids encoding the same 575. 6,951,920 PRO1340 polypeptides 576. 6,951,737 Secreted and transmembrane polypeptides and nucleic acids encoding the same 577. 6,946,263 Secreted and transmembrane polypeptides and nucleic acids encoding the same 578. 6,946,262 Secreted and transmembrane polypeptides and nucleic acids encoding the same 579. 6,936,697 Secreted and transmembrane polypeptides and nucleic acids encoding the same 580. 6,936,436 Secreted and transmembrane polypeptides and nucleic acids encoding the same

29 William I. Wood

581. 6,936,254 Method of inducing fetal hemoglobin synthesis 582. 6,930,172 Secreted and transmembrane polypeptides and nucleic acids encoding the same 583. 6,930,170 PRO1184 polypeptides 584. 6,929,947 Secreted and transmembrane polypeptides and nucleic acids encoding the same 585. 6,924,355 PRO1343 polypeptides 586. 6,916,648 Secreted and transmembrane polypeptides and nucleic acids encoding the same 587. 6,914,130 Compositions and methods for the diagnosis and treatment of tumor 588. 6,913,919 Secreted and transmembrane polypeptides and nucleic acids encoding the same 589. 6,908,993 Secreted and transmembrane polypeptides and nucleic acids encoding the same 590. 6,894,148 Secreted and transmembrane polypeptides and nucleic acids encoding the same 591. 6,878,807 Secreted and transmembrane polypeptides and nucleic acids encoding the same 592. 6,852,848 Secreted and transmembrane polypeptides and nucleic acids encoding the same 593. 6,838,554 Nucleic acids encoding proteins that stimulate the proliferation of t-lymphocytes 594. 6,828,146 Nucleic acid encoding PRO229 polypeptides 595. 6,818,746 Secreted and transmembrane polypeptides and nucleic acids encoding the same 596. 6,818,449 Secreted and transmembrane polypeptides and nucleic acids encoding the same 597. 6,806,352 Secreted and transmembrane polypeptides and nucleic acids encoding the same 598. 6,800,604 Polypeptides that inhibit human serum-induced cleavage of hepatocyte growth factor 599. 6,767,995 Secreted and transmembrane polypeptides and nucleic acids encoding the same 600. 6,764,679 Antibodies to DcR3 Polypeptide, a TNFR Homolog 601. 6,740,520 Cytokine receptor and nucleic acids encoding the same 602. 6,734,288 Antibodies against a secreted polypeptide that stimulates release of

proteoglycans from cartilage 603. 6,723,535 Secreted and transmembrane polypeptides and nucleic acids encoding

the same 604. 6,686,451 Secreted and transmembrane polypeptides and nucleic acids encoding

the same 605. 6,673,343 SAL-S1 receptor protein tyrosine kinase agonist antibodies 606. 6,664,376 Secreted and transmembrane polypeptides and nucleic acids encoding

the same 607. 6,642,360 Secreted polypeptides that stimulate release of proteoglycans from

cartilage 608. 6,635,468 Secreted and transmembrane polypeptides and nucleic acids encoding

the same 609. 6,579,520 IL-17 related mammalian cytokine polypeptides (IL-17E) 610. 6,576,608 Methods of using VEGF-related protein 611. 6,569,645 IL-17 homologous polypeptides and therapeutic uses thereof 612. 6,569,420 Human interferon-.epsilon.: a type I interferon 613. 6,551,799 Interleukin-22 polypeptides, nucleic acids encoding the same and

methods for the treatment of pancreatic disorders 614. 6,472,585 Cardiotrophin-1 defective mouse 615. 6,451,764 VEGF-related protein 616. 6,410,708 Nucleic acids encoding A-33 related antigen polypeptides 617. 6,387,657 WISP polypeptides and nucleic acids encoding same 618. 6,331,302 Protein tyrosine kinase agonist antibodies 619. 6,300,475 Interferon PRO655 620. 6,299,877 Type I interferons 621. 6,299,869 Human interferon-epsilon: a type I interferon 622. 6,200,780 Human interferon-.epsilon.(IFN-.epsilon.), a type I interferon 623. 6,087,475 PF4A receptor 624. 5,922,541 Method for detection of PF4A receptor nucleic acid

30 William I. Wood

625. 5,919,896 PF4A receptor 626. 5,892,017 Nucleic acid encoding PF4A receptor 627. 5,856,457 Nucleic acids encoding a human IL-8 receptor 628. 5,783,415 Method of producing an IL-8 receptor polypeptide 629. 5,776,457 Antibodies to human PF4A receptor and compositions thereof 630. 5,767,063 Human IL-8 receptor and antibodies thereto 631. 5,763,195 Method and compositions for making ACSF and ACSF antagonists 632. 5,723,585 Method of purifying cardiac hypertrophy factor 633. 5,688,763 Compositions and methods for the synthesis of growth hormone

receptor and growth hormone binding protein 634. 5,683,905 Vectors and cell lines capable of correctly splicing exon regions 635. 5,679,545 Gene encoding cardiac hypertrophy factor 636. 5,668,108 Preparation of functional human factor VIII and pharmaceutical

treatment therewith 637. 5,668,106 Method and compositions for making ACSF and ACSF antagonists 638. 5,656,455 Method and compositions for making ACSF and ACSF antagonists. 639. 5,654,147 Method of hybridization using oligonucleotide probes 640. 5,633,150 Preparation of functional human factor VIII 641. 5,633,141 Human IL-8 receptor binding assay 642. 5,627,073 Hybridomas producing antibodies to cardiac hypertrophy factor 643. 5,624,806 Antibodies to cardiac hypertrophy factor and uses thereof 644. 5,618,789 Functional human factor VIII 645. 5,618,788 Preparation of functional human factor VIII and pharmaceutical

treatment therewith 646. 5,571,893 Cardiac hypertrophy factor 647. 5,571,702 Amplification method for detection of human PF4A receptors 648. 5,571,675 Detection and amplification of candiotrophin-1(cardiac hypertrophy

factor) 649. 5,552,284 Detection of interleukin-8 receptors by nudeic acid hybridization 650. 5,534,615 Cardiac hypertrophy factor and uses therefor 651. 5,328,891 Insulin-like growth factor binding protein and pharmaceutical

compositions 652. 5,312,810 Method and compositions for making ACSF and ACSF antagonists 653. 5,258,287 DNA encoding and methods of production of insulin-like growth factor

binding protein BP53 654. 5,057,417 Compositions and methods for the synthesis of growth hormone

receptor and growth hormone binding protein 655. 4,965,199 Preparation of functional human factor VIII in mammalian cells using

methotrexate based selection 656. 4,857,637 Methods and compositions for immunologically modulating growth

hormone receptor activity