curriculum vitae hossein p. nazarloo, m.d., ph.d.curriculum vitae hossein p. nazarloo, m.d., ph.d....
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C.V. Page 1 Hossein P. Nazarloo, M.D., Ph.D.
CURRICULUM VITAE
Hossein P. Nazarloo, M.D., Ph.D.
BIOGRAPHICAL
Work address: Indiana University
The Kinsey Institute
Bloomington, IN 47405
Phone; (773) 886-3560
E-mail: [email protected]
Curent Position: Senior Scientist
EDUCATION AND TRAINING
1990 - 1996; Medical School University of Medicine “Carol Davila”
Bucharest - Romania
Sep. 1996; Received M.D. degree University of Medicine “Carol Davila”
Bucharest - Romania
1996 - 1999; Residency in Cardiology Emergency Hospital of Bucharest
Section of Cardiovascular Diseases
Bucharest - Romania
1999 - 2003; Graduate Student Kochi Medical School,
Department of Internal Medicine
Kochi - Japan.
2001 - 2002; Lecturer Assistant Kochi Medical School,
Department of Internal Medicine
Kochi - Japan.
2002 - 2003; Research Assistant Kochi Medical School,
Department of Internal Medicine
Kochi - Japan.
March 2003; Received Ph.D. degree Kochi Medical School,
Kochi - Japan.
C.V. Page 2 Hossein P. Nazarloo, M.D., Ph.D.
2003- 2003; Postdoc. Research Associate Ottawa Health Research Institute,
Laboratory of Aging Diseases, Ottawa-Canada
2003 - 2004; Postdoctoral Fellow Louisiana State University,
Department of Pharmacology
2004 - 2006; Postdoc. Research Associate University of Illinois at Chicago,
Department of Psychiatry
2006 - 2012; Research Assistant Professor University of Illinois at Chicago,
Department of Psychiatry
2012 - 2013; Senior Res. Neuroscientist 3 Research Triangle Institute,
Drugs Develop. & Discovery
2013 - 2015; Research Associate Professor University of North Carolina,
Department of Psychiatry
2015 - Present; Senior Scientist Indiana University,
The Kinsey Institute
AWARDS/HONORS/SCHOLARSHIPS
1994; Students & Investigators travel award Conference of Medical Sciences in Belgium
1994-1996; Romanian Government Scholarship for 4th – 6th years of Medical School
1996; Honors in the College, “Carol Davila” University of Medicine & Pharmacology
1996-1998; Romanian Government Scholarship for Residency in Cardiology
1999-2003; Japanese Government Scholarship for 4 years of Ph.D. program
2001; Young Investigators travel award for 26th International Conference of Medicine
2002; Recognition Award for original article & oral presentation in endocrine in Tokyo
2003; Recognition Award in Ph.D. program of Kochi Medical School, Japan
2007; Travel award for 3rd International Conference of Heart Disease in Toronto, Canada
C.V. Page 3 Hossein P. Nazarloo, M.D., Ph.D.
ORGANIZATION AND MEMBERSHIPS
Editorial Board of International Journal of Cardiovascular Practice
Editorial Board of Open Biochemistry Journal
Editorial Board of ISRN Neuroendocrinology
Japanese Endocrine Society
Society for Neuroscience
METHODOLOGICAL LBORATORY SKILS
Cell Culture (primary culture and passage of such kinds of cells)
Test the proliferation and growth
Extract and purify DNA/RNA from tissue or cultured cells
Design the primer for PCR
Reverse transcription reaction and PCR amplification
Real Time PCR
Radioimmunoassay
Enzyme immunoassay (ELISA)
RNase Protection Assay (RPA)
Immunocytochemistry
Western blot
Validation of Hormone Assays
Handling and Breeding rats, mice and prairie voles
Genotype determination (using PCR) of Knockout mice
SNP genotyping, Fragment length analysis, direct gene re-sequencing
Surgical techniques such as; Streotaxic, iv & icv canulation, adrenalectomy, vagotomy,
laparotomy, dissection of central/peripheral tissues in rodents
C.V. Page 4 Hossein P. Nazarloo, M.D., Ph.D.
CLINICAL EXPERIENCES
Clinical experience in diagnose & treatment of cardiac patients
Clinical experience in performing diagnostic Echocardiography & Angiography
Clinical experience in performing diagnostic and therapeutic PCI
Clinical research experiences in evaluation of HIV patients
Clinical research experiences in drug development programs
ADDITIONAL EXPERIENCES
Evaluate/analyze scientific information
Teaching & Supervision of Medical staffs and Medical students
Teaching & Supervision of Graduate students and Researchers
Management of Medical and Research Laboratories
Peer-Reviewed Book Chapters:
Hossein Pournajafi Nazarloo and Adrian J. Dunn. “Cytokines and HPA axis during stress”.
In: New Research Communications on Messenger RNA (Ed. Frank Columbus) Nova Science
Publishers, Hauppauge, NY, 2007.
Hossein Pournajafi Nazarloo and Sue C. Carter. “HPA axis and cardiovascular system during
stress”. In: New Research Communications on Messenger RNA (Ed. Frank Columbus) Nova
Science Publishers, Hauppauge, NY, 2007.
Carter CS, Pournajafi Nazarloo H, Kramer KM, Ziegler TE, White-Traut R, Bello D, Schwertz
D: “Oxytocin; Behavioral Associations and Potential as a Salivary Biomarker”. (Daniel Malamud
& R. Sam Niedbala) Blackwell Publishing, 2007. ISBN: 9781573316613.
Pournajafi Nazarloo H, and Carter SC. “Oxytocin and stress” pp.241-253. In: Handbook of
Oxytocin Research: Synthesis, Storage and Release, Actions and Drug Forms (Frank Columbus)
Nova Science Publishers, Hauppauge, NY, 2009.
C.V. Page 5 Hossein P. Nazarloo, M.D., Ph.D.
PUBLICATIONS
Rubin LH, Connelly JJ, Reilly JL, Carter CS, Drogos LL, Pournajafi-Nazarloo H, Ruocco AC,
Keedy SK, Matthew I, Tandon N, Pearlson GD, Clementz BA, Tammiga CA, Gershon ES,
Keshavan MS, Bishop JR, Sweeney JA: “Sex and diagnosis specific associations between DNA
methylation of the oxytocin receptor gene, emotion processing, and temporal and limbic-prefrontal
structures in psychotic disorders”. Biological Psychiatry 2016; 1:141-151.
Lancaster K, Carter CS, Pournajafi-Nazarloo H, Karaoli T, Lillard TS, Jack A, Davis JM, Morris
JP, Connelly JJ: “Plasma oxytocin explains individual differences in neural substrates of social
perception”. Front Hum Neurosci 2015; 9:132.
Rubin LH, Carter CS, Bishop JR, Pournajafi-Nazarloo H, Drogos LL, Hill SK, Ruocco,AC,
Keedy SK, Reilly JL, Sweeney JA: “Effects of sex, menstrual cycle phase, and endogenous
hormones on cognition in schizophrenia”. Schizophr Res. 2015;166 (1-3):269-75.
Rubin LH, Carter CS, Bishop JR, Pournajafi-Nazarloo H, Drogos LL, Hill SK, Ruocco AC,
Keedy SK, Reilly JL, Keshavan MS, Pearlson GD, Tamminga CA, Gershon ES, Sweeney JA:
“Reduced Levels of Vasopressin and Reduced Behavioral Modulation of Oxytocin in Psychotic
Disorders.”. Schizophr Bull. 2014;40 (6):1374-84.
Prevost M, Zelkowitz P, Tulandi T, Hayton B, Feeley N, Carter CS, Pournajafi-Nazarloo H,
Yong Ping E, Abenhaim H, Gold I: “Oxytocin in pregnancy and the postpartum: relations to labor
and its management”. Front Public Health. 2014 Jan 27;2:1.
Munro ML, Brown SL, Pournajafi-Nazarloo H, Carter CS, Lopez WD, Seng JS: “In search of
an adult attachment stress provocation to measure effect on the oxytocin system: A Pilot Validation
Study”. Journal of The American Psychiatric Nurses Association 2013;19:180-91.
Kenkel WM, Paredes J, Lewis G, Yee JR, Pournajafi-Nazarloo H, Grippo AJ, Porges S, Carter,
CS: “Autonomic Changes Associated with Alloparenting in Male Prairie Voles”. PLos ONE 2013;8
C.V. Page 6 Hossein P. Nazarloo, M.D., Ph.D.
(8):e69965.
Pournajafi-Nazarloo H, Kenkel B, Sanzenbacher L, Yee J, Hashimoto K, Carter CS: "Exposure
to chronic isolation modulates receptors mRNAs for oxytocin and vasopressin in the hypothalamus
and heart". Peptides 2013;43:20-26.
Rubin LH, Carter CS, Bishop JR, Pournajafi-Nazarloo H, Harris MSH: “Peripheral vasopressin
but not oxytocin relates to severity of acute psychosis in women with acutely-ill untreated first-
episode psychosis”. Schizophrenia Research 2013;146:138-43.
Gouin JP, Carter CS, Pournajafi-Nazarloo H, Malarkey WB, Loving TJ, Stowell J, Kiecolt-
Glaser JK:: “Plasma vasopressin and interpersonal functioning”. Biological Psychology.
2012;91(2):270-4.
Carson DS, Bosanquet DP, Carter CS, Pournajafi-Nazarloo H, Blaszczynski A, McGregor IS:
“Preliminary evidence for lowered basal cortisol in a naturalistic sample of methamphetamine
polydrug users”. Experimental & Clinical Psychopharmacology. 2012;20(6):497-503.
Dai L, Carter CS, Ying J, Bellugi U, Pournajafi-Nazarloo H, Korenberg JR: “Oxytocin and
Vasopressin are Dysregulated in Williams Syndrome, A Genetic Disorder Affecting Social
Behavior”. PLoS ONE 2012; 7(6): e38513.
Kenkel WM, Paredes J, Yee JR, Pournajafi-Nazarloo H, Bales KL and Carter, CS:
“Neuroendocrine and behavioural responses to exposure to an infant in male prairie voles”.
Journal of Neuroendocrinology 2012; 24(6): 874-86.
Grippo AJ, Pournajafi-Nazarloo H, Sanzenbacher L, Trahanas DM, McNeal N, Clarke DA,
Porges SW, Carter CS: “Peripheral oxytocin administration buffers autonomic but not behavioral
responses to environmental stressors in isolated prairie voles”. Stress 2012; 15(2):149-61.
Rubin LH, Carter CS, Drogos L, Jamadar R, Pournajafi-Nazarloo H, Sweeney JA, Maki PM:
C.V. Page 7 Hossein P. Nazarloo, M.D., Ph.D.
“Sex-specific associations between peripheral oxytocin and emotion perception in schizophrenia”.
Schizophrenia Research 2011; 130: 266-270.
Pournajafi-Nazarloo H, Partoo L, Yee J, Stevenson J, Sanzenbacher L, Kenkel W, Mohsenpour
SR, Hashimoto K and Carter CS: “Effects of social isolation on mRNA expression for
corticotrophin-releasing factor receptors in prairie voles”. Psychoneuroendocrinology 2011; 36:
780-789.
Rubin LH, Carter CS, Drogos L, Pournajafi-Nazarloo H, Sweeney JA, Maki PM: “Peripheral
oxytocin is associated with reduced symptom severity in schizophrenia”. Schizophrenia Research
2010; 124: 13-21.
Gouin JP, Carter CS, Pournajafi-Nazarloo H, Glaser R, Malarkey WB, Loving TJ, Stowell J,
Kiecolt-Glaser JK: “Marital behavior, oxytocin, vasopressin, and wound healing”.
Psychoneuroendocrinology 2010; 35: 1082-1090.
Carter CS, Boone EM, Pournajafi-Nazarloo H, Bales KL: “The Consequences of Early
Experiences and Exposure to Oxytocin and Vasopressin are Sexually-Dimorphic”. Developmental
Neuroscience 2009; 31(4):332-41.
Pournajafi-Nazarloo H, Partoo L, Sanzenbacher L, Esmaelzadeh M, Paredes J, Hashimoto K,
Azizi F, Carter CS: “Social isolation modulates corticotropin-releasing factor type 2 receptor,
urocortin 1 and urocortin 2 mRNAs expression in the cardiovascular system of prairie voles”.
Peptides 2009; 30:940-946.
White-Traut R, Watanabe K, Pournajafi-Nazarloo H, Schwertz D, Bell A, Carter CS: "Detection
of salivary oxytocin levels in lactating women". Developmental Psychobiology 2009; 51(4):367-
373.
Pournajafi-Nazarloo H, Partoo L, Sanzenbacher L, Parades J, Hashimoto K, Azizi F, Carter CS:
“Stress differentially modulates mRNA expression for corticotrophin-releasing factor receptors in
C.V. Page 8 Hossein P. Nazarloo, M.D., Ph.D.
hypothalamus, hippocampus and pituitary of prairie voles”. Neuropeptides 2009; 43(2):113-23.
Nishiyama M, Makino S, Iwasaki Y, Tanaka Y, Nazarloo HP, Kaneda T, Asaba K, Hashimoto K:
"CRH mRNA expression in the hypothalamic paraventricular nucleus is inhibited despite the
activation of the hypothalamo-pituitary-adrenal axis during starvation". Brain Research 2008;
1228:107-112.
Carter CS, Grippo AJ, Pournajafi-Nazarloo H, Ruscio MG, Porges SW: “Oxytocin, vasopressin
and sociality”. Progress in Brain Research 2008; 170:331-336.
Bello D, White-Traut R, Schwertz D, Pournajafi-Nazarloo H, Carter CS: “Neurohormonal
Responses of Healthy Men to Massage”. Journal of Alternative and Complementary Medicine
2008; 14:387-94.
Pournajafi Nazarloo H, Partoo L, Papademeteriou E, Saadat H, Cushing BS: “Modulation of
cardiac oxytocin receptor and estrogen receptor alpha mRNAs expression following neonatal
oxytocin treatment”. Endocrine 2007; 31(2): 140-46.
Pournajafi-Nazarloo H, Partoo L, Sanzenbacher L, Azizi F, Carter CS: “Modulation of
corticotropin-releasing hormone type 2 receptor, urocortin 1 and urocortin 2 mRNAs expression
in the cardiovascular system of prairie voles following acute or chronic stress”.
Neuroendocrinology 2007; 86(1): 17-25.
Pournajafi Nazarloo H, Perry A, Partoo L, Papademeteriou E, Azizi F, Carter CS, Cushing BS:
“Neonatal oxytocin treatment modulates oxytocin receptor, atrial natriuretic peptide, nitric oxide
synthase and estrogen receptor mRNAs expression in rat heart”. Peptides 2007; 28(6): 1170-77.
Carter CS, Pournajafi Nazarloo H, Kramer KM, Ziegler TE, White-Traut R, Bello D, Schwertz
D: “Oxytocin; Behavioral Associations and Potential as a Salivary Biomarker”. Ann. N.Y. Acad.
Sci. 2007; 1098: 312–322.
C.V. Page 9 Hossein P. Nazarloo, M.D., Ph.D.
Pournajafi Nazarloo H, Carr MS, Papademeteriou E, Schmidt JV, Cushing BS: “Oxytocin
selectively increases ER mRNA expression in the hypothalamus and hippocampus of neonatal
female prairie voles”. Neuropeptides 2007; 41: 39-44.
Pournajafi Nazarloo H, Buttrick PM, Saadat H and Dunn AJ: “The roles of corticotropin-
releasing factor-related peptides and their receptors in cardiovascular system”. Review in; Current
Protein and Peptide Science 2006; 7 (3):229-239.
Wieczorek M, Swiergiel A.H, Pournajafi Nazarloo H and Dunn A.J. “'Physiological and
Behavioral Responses to Interleukin-1beta and LPS in Vagotomized Mice”. Physiology &
Behavior 2005; 85: 500-511.
Makino S, Tanaka Y, Nazarloo HP, Noguchi T, Nishimura K, Hashimoto K: “Expression of type
1 corticotropin-releasing hormone (CRH) receptor mRNA in the hypothalamic paraventricular
nucleus following restraint stress in CRH-deficient mice”. Brain Research 2005; 1048: 131-137.
Hashimoto K, Nishiyama M, Tanaka Y, Noguchi T, Asaba K, Pournajafi Nazarloo H, Nishioka
T and Makino S: “Urocortins and corticotropin releasing factor type 2 receptors in the
hypothalamus and the cardiovascular system”. Peptides 2004;25:102-8.
Hashimoto K, Nishiyama M, Pournajafi Nazarloo H, Asaba K, Nishioka T and Makino S:
[“Urocortin II, Urocortin III and CRH receptors”]. Acth Related Peptides 2004; 13: 19-26.
Pournajafi Nazarloo H, Takao T and Hashimoto K: “Modulation of IL-1 receptors and IL-1
mRNA in corticotropin-releasing factor (CRF)-deficient mouse by endotoxin treatment”. Journal
of Neuroimmunology 2003; 140: 102-108.
Takao T, Nanamiya W, Nazarloo HP, Matsumoto R, Asaba K, De Souza EB and Hashimoto K:
“Exposure to the enviromental estrogen bisphenol A differentially modulated estrogen receptor-
and – immunoreactivity and mRNA in male mouse testis”. Life Sciences 2003, 72 (10); 1159-
1169.
C.V. Page 10 Hossein P. Nazarloo, M.D., Ph.D.
Pournajafi Nazarloo H, Tanaka Y, Dorobantu M and Hashimoto K: “Modulation of
corticotropin-releasing hormone receptor type 2 mRNA expression by CRH deficiency or stress in
the mouse heart”. Regulatory Peptides 2003; 115 (2): 131-138.
Pournajafi Nazarloo H, Nishiyama M, Tanaka Y, Makino S, Takao T and Hashimoto K: [“Effect
of corticosterone on ghrelin messenger ribonucleic acid expression in rat stomach”]. Clinical
Endocrinology 2003; 51: 96-101.
Pournajafi Nazarloo H, Nishiyama M, Tanaka Y and Hashimoto K. “Down-regulation of
corticotropin- -
in the rat cardiovascular system following food deprivation”. Regulatory Peptides 2002; 105(2):
121-129.
Pournajafi Nazarloo H, Takao T, Nanamiya W, Asaba K, De Souza EB and Hashimoto K: “Effect
of non-peptide corticotropin-releasing factor receptor type 1 antagonist on adrenocorticotropic
hormone release and interleukin-1 receptors followed by stress”. Brain Research 2001; 902: 119-
126.
Takao T, Nanamiya W, Nazarloo HP, Asaba K and Hashimoto K: “Possible reproductive toxicity
of styrene in peripubertal male mice”. Endocrine Journal 2000; 47 (3):343-347.
Selected Published Abstracts:
Dai L, Carter CS, Pournajafi-Nazarloo H, Bellugi U, Korenberg JR: “Social Neuropeptides
Oxytocin and Vasopressin are Dysregulated in Williams Syndrome”. The 9th World Congress on
Neurohypophysial Hormones, Boston, 2011.
Yee J, Frijlin J, Saber M, Dodhia S, Pournajafi-Nazarloo H, Tovar S, Kenkel W, Lewis G, Onishi
K, Porges SW, Carter CS. “The effects of oxytocin pre-treatment on social and anxiety-related
behaviors, functional neural connectivity, hormone release, and autonomic regulation”. Society
C.V. Page 11 Hossein P. Nazarloo, M.D., Ph.D.
For Neuroscience, Washington, 2011.
Weihs KL, Frank D, Roe D, Pournajafi-Nazarloo H, Carter CS: Oxytocin administration, but not
social housing condition, reduces growth rate of human breast cancer xenografts (MCF7) in SCID
mice”. 31st Annual San Antonio Breast Cancer Symposium, San Antonio, 2008.
Jacob S, Carter CS, Suppatkul P, Brune CW, Pournajafi-Nazarloo H, Cook EH: "Plasma
Oxytocin Variation in Families with Children with Autism Spectrum Disorders". International
Society for Autism Research, Chicago, 2009.
Baggott MJ, Galloway G, Jang M, Didier R, Pournajafi-Nazarloo H, Carter CS, Mendelson J:
"3,4-Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) and Prazosin Interactions in
Humans". Annual Meeting of the Society for Neuroscience, San Diego, 2008.
Frank DH, Roe DJ, Nagle RB, McDaniel K, Pournajafi-Nazarloo H, Carter CS, Weihs K: "Role
of Oxytocin in Mammary Tumor Development in a Mouse Model". 2008.
Pournajafi Nazarloo H, Paredes J, Carter SC. Effects of social isolation on plasma oxytocin and
vasopressin in socially monogamous prairie voles. Annual Meeting of the Society for
Neuroscience, San Diego, 2007.
Paredes J, Bale K, Pournajafi Nazarloo H, Carter SC: Exposure to an infant facilitates pair
bonding in socially monogamous prairie voles. Annual Meeting of the Society for Neuroscience,
San Diego, 2007.
Drogos L, Rubin LH, Mordecai KL, Carter SC, Pournajafi-Nazarloo H, Maki PM: Nonapeptides
and Cognition. International Neuropsychological Society, Portland-Oregon, U.S.A., February 7-
10, 2007.
Drogos L, Rubin LH, Mordecai KL, Carter SC, Pournajafi-Nazarloo H, Maki PM. Effects of
C.V. Page 12 Hossein P. Nazarloo, M.D., Ph.D.
oxytocin on mood in premenopausal women: Investigations of menstrual cycle effects and oral
contraceptive use. 38th Annual Psychoneuroendocrinology Conference. Madison, WI, 2007.
Elisabeth Dykens, Elizabeth Roof, Elizabeth Pantino, Rebecca Kossler, Ray Johnson, Mayim
Bialik, Hossein Nazarloo, Sue Carter:
40th Annual Gatlinburg Conference On Research and Theory in Intellectual & Developmental
Disabilities. The Loews Annapolis • Annapolis • Maryland, March 2007.
Wieczorek M, Pournajafi Nazarloo H, Swiergiel AH, Dunn AJ: The role of the vagus nerve in
the behavioral, neurochemical and neuroendocrine responses to interleukin-1 and endotoxin in
mice. Annual Meeting of the Society for Neuroscience, San Diego, October 23-28, 2004.
Tanaka Y, Nishiyama M, Pournajafi Nazarloo H, Kaneda T, Asaba K, Hashimoto K, Makino S :
Elevated circulating corticosterone decreased corticotropin-releasing hormone mRNA in the
hypothalamic paraventricular nucleus during starvation. The Endocrine Society 2001. Denver,
USA.
Kaneda T, Makino S, Nishiyama M, Asaba K, Pournajafi Nazarloo H, Mimoto T, Hashimoto K :
Differential neuropeptide responses to starvation in young versus aged rats. The Endocrine Society
2001. Denver, USA.
Nishiyama M, Makino S, Asaba K, Kaneda T, Pournajafi Nazarloo H, Takao T, Hashimoto K :
Leptin administration does not reduce food intake and the expression of hypothalamic functional
receptor mRNA in diet induced obese rat. 6th International Congress of Neuroendocrinology,
2000.
Takao T, Pournajafi Nazarloo H, Asaba K, Nanamiya W, De Souza EB, Hashimoto K: Effect of
non-peptide corticotropin-releasing factor receptor type 1 antagonist on hypothalamic-pituitary
axis and interleukin-1 receptors followed by endotoxin treatment and ether-laparatomy stress. 11th
International Congress of Endocrinology. 2000,10,30.