neurological disease ontology alexander diehl university at buffalo october 5, 2011
TRANSCRIPT
Neurological Disease Ontology
Alexander DiehlUniversity at Buffalo
October 5, 2011
Ontologies for Neuroscience and Neurology
• The Neurological Disease Ontology (ND)– Based on the Ontology for General Medical
Sciences– Incorporates parts of NIF-Dysfunction and the
Disease Ontology– Three initial areas of focus• Dementia, in particular Alzheimers• Multiple Sclerosis• Stroke, Cerebralvascular events
Ontology Development
• Based on published existing ontologies as well as the scientific literature, including original articles, reviews, and text books
• Ontology terms (classes) are given both textual and logical definitions. Logical definitions relate the term to terms in other ontologies.
Ontology Development
• Top-Down and Bottom-Up Approaches Utilized.
• Top-Down starts with high level categories and fills in more specialized classes.
• Bottom-Up looks at specific literature and sees what classes are needed to represent a domain.
The Ontology for General Medical Sciences (OGMS)provides top level classes for the Neurology Disease Ontology.
The Ontology for General Medical Sciences (OGMS)provides top level classes for the Neurology Disease Ontology.
Bottom-Up (Annotation-Driven) Ontology Development
Lancet (1998) 352:1498
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Bottom-Up (Annotation-Driven) Ontology Development
Lancet (1998) 352:1498
Bottom-Up (Annotation-Driven) Ontology Development
Journal of Neuroimmunology (2007) 188:167
Bottom-Up (Annotation-Driven) Ontology Development
Journal of Neuroimmunology (2007) 188:167
Bottom-Up (Annotation-Driven) Ontology Development
Nature Genetics (2010) 42(6):495
Bottom-Up (Annotation-Driven) Ontology Development
Nature Genetics (2010) 42(6):495
A Proto-MS Ontology
Alexander [email protected]
Neurological Disease Ontology(MS, Dementia, Stroke)
Mark Jensen, Alexander Cox, Bianca Weinstock-Guttman, Kinga Szigiti, Alan Ruttenberg, Barry Smith