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Serviço de Química e Toxicologia Forenses
87% of psychodrugs included in top 100 of substances with the highest number of sales in
2012 in Portugal are included in post mortem toxicological screening.
Psychodrugs in 2012 accounted for 55% of drug sales with action on Central Nervous
System
Psychodrugs drugs in 2012 accounted for 14% of total drug sales
DH
D
Evolution of Psychodrugs (DHD) by pharmacotherapeutic subgroup between 2000 and 2012
http://www.infarmed.pt/portal/page/portal/INFARMED/MONITORIZACAO_DO_MERCADO/OBSERVATORIO/ESTATISTICA_DO_MEDICAMENTO/EstMed-2011.pdf
25 % of all packages sold in
2011
56%
Serviço de Química e Toxicologia Forenses
24,5 % of all packages sold in
2012
55%
http://www.infarmed.pt/portal/page/portal/INFARMED/MONITORIZACAO_DO_MERCADO/OBSERVATORIO/ESTATISTICA_DO_MEDICAMENTO/EstMed-2012.pdf
Serviço de Química e Toxicologia Forenses
Serviço de Química e Toxicologia Forenses
65% of the telephone calls received in CIAV are associated to intoxication with drugs
Serviço de Química e Toxicologia Forenses
Total = 6636
anxiolytics
antidepressants
antipsychotics
66%
Serviço de Química e Toxicologia Forenses
Distribution of positive results by pharmacotherapeutic subgroup in post-mortem cases
80,7%
6,2% 7,3%
2,6% 1,3% 0,9% 0,3% 0,2% 0,4%
Psicofármacos Analgesicos estupefacientes
Anticonvulsivantes Anestésicos Locais
Anticoagulantes Beta bloqueantes
Vasodilatadores Antiaritmicos
Outros
Ano 2013
Antiarrhythmics
Beta Blockers
Analgesics narcotics
Local anaesthetics
Psychodrugs
Anticonvulsivants
Anticoagulants
Vasodilators
Others
Antidepressants
Amitriptyline
Citalopram
Clomipramine
Diltiazem
Dosulepine
Fluoxetine
Fluvoxamine
Maprotiline
Mianserine
Mirtazapine
nor-clomipramine
Nor-sertraline
Nortriptiline
Paroxetine
Quetiapine
Sertraline
Trazodone
Trimipramine
Venlafaxine
Serviço de Química e Toxicologia Forenses
Distribution of psychodrugs by pharmacotherapeutic subgroup in post-mortem cases
Anxiolytics (Benzodiazepines)
Antipsychotics
Antidepressants 79,6%
14,8% 5,6%
Antipsychotics
Amisulpride
Ciamemazine
Chlorpromazine
Clozapine
Dothiepine
Haloperidol
Levomepromazine
Melperone
Olanzapine
Risperidone
Tiapride
Ano 2013
Anxiolytics
(benzodiazepines )
2-hidroxi-etilflurazepam
7-amino-clonazepam
a-Hidroxi-alprazolam
a-hidroxi-midazolam
Alprazolam
Bromazepam
Chlordiazepóxide
Clobazam
Clonazepam
Demoxepam
Desalquilflurazepam
Diazepam
Estazolam
Flurazepam
Lorazepam
Midazolam
Nordiazepam
Oxazepam
Temazepam
Zolpidem
Serviço de Química e Toxicologia Forenses
Serviço de Química e Toxicologia Forenses
South Centre North Total
Positives (Bzp) 436 260 493 1189
Positive (Bzp+EtOH) 60 65 67 192
(%) 13,8 25 13,6 16,15
Range (g/L) 0,1 - 4,23 0,1 - 4,17 0,1 - 5 0,1 - 5
Média (g/L) 1,09 1,38 1,53 1,34
Median 0,82 1,13 1,12 1,025
Benzodiazepines / Ethanol
%
Anfet./Met 4 0,34
Cocaíne 11 0,93
Cannabis 16 1,35
Methadone 35 2,94
Opiates 44 3,70
Antipsychotics 139 11,69
Antidepressants 334 28,09
Pesticides 11 0,93
Tramadol 52 4,37
Outhers 180 15,14
Benzodiazepines / Other Substances
n= 1189
Serviço de Química e Toxicologia Forenses
Serviço de Química e Toxicologia Forenses
0,0
10,0
20,0
30,0
40,0
50,0
60,0
70,0
80,0
<18 years 19-24 years 25-34 years 35-49 years >=50 years
Male
Women
%