17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 1/31

Get connected to me on

HomeResearchArticlesPodcastsForumFind A DoctorAbout Dr LynchContact Dr LynchResources

MTHFR.Net Your Expert Resource on MTHFR Gene Mutations

Read This First!Question? AskSpeaking Inquiries

Home MTHFR Mutations LMethylfolate, Methylfolate, 5MTHF, L5MTHF. What is theDifference!?

by Dr Lynch on April 5, 2012 in MTHFR Mutations

Those with MTHFR mutations scan labels, read websites or listen to their doctors rattle of conflicting termsfor a nutrient they really need.

Understanding which form of methylfolate is best must be clear.

Why all the confusion?

Because there are so many different terms used for methylfolate.

By the end, you will understand everything you need to know about methylfolate.

More significantly – you will understand how to pick the right form of methylfolate.

Terms often used for methylfolate are:

Methylfolate

L-MTHF

L-Methylfolate

L-Methylfolate Calcium

DBL NETWORKSélectionner une langue

L-Methylfolate, Methylfolate, 5-MTHF, L-5-MTHF. What is the Difference!?

10 653 2

MTHFR is a Serious and Complex Problem. Gain Clarity and Take Action. Access the Highly Reviewed Conference by Dr Lynch. CLICK HERE

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 2/31

D-Methylfolate

D-5-Methylfolate

Levomefolic Acid

Metafolin

5-MTHF

5-Methylfolate

5-Methyltetrahydrofolate

L-5-MTHF

L-5-Methyltetrahydrofolate

6(S)-5-MTHF

6(S)-5-Methyltetrahydrofolate

6(R)-5-MTHF

6(R)-5-methyltetrahydrofolate

Quatrefolic

Are these forms of methylfolate all the same?No.

Are any of these forms of methylfolate the same?Yes. The same forms are grouped together here. These forms are synonymous with each other:

1. L-5-MTHF = L-5-Methyltetrahydrofolate = 6(S)-L-MTHF = 6(S)-L-Methyltetrahydrofolate

Good forms which are well absorbed

2. L-Methylfolate Calcium = Metafolin = Levomefolic Acid

Good forms which are all well absorbed

3. D-5-MTHF = D-5-Methyltetrahydrofolate = 6(R)-L-MTHF = 6(R)-L-Methyltetrahydrofolate

Avoid these (learn why soon…)

Then what are the other forms of methylfolate?

The other forms of methylfolate may or may not be 99% pure biologically active methylfolate.

5-MTHF

5-Methylfolate

5-Methyltetrahydrofolate

How come these may or may not be 99% pure biologically active methylfolate?These forms do not specify the L form (or 6(S) form) of methylfolate; therefore, you do not know what youare ingesting.

The forms of methylfolate not specifying L or 6(S) likely contain more than 1% of the D form of methylfolate.

What is the difference between D and L forms of Methylfolate?In organic chemistry, one learns compounds may have the exact same molecular formula and sequence ofbonded atoms but differ three dimensionally. These compounds are known as steroisomers.[1]

There are two common forms of sterioisomers:

1. Enantiomers:

mirror images of each other, such as our hands.

same physical properties

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 3/31

may have different biological effects

2. Diastereoisomers:

not mirror images of each other

rarely have same physical properties

have different biological effects

Methylfolate has stereoisomers in the form of diastereoisomers.

The forms of methylfolate that are biologically active are:

L forms

6(S) forms

L-5 forms

Metafolin

L-Methylfolate Calcium

Levomefolic Acid

Quatrefolic

The forms of methylfolate that are NOT biologically active are:

D forms

6(R) forms

The forms of methylfolate that may or may not be biologically active are the:

forms which do not specify L, 6(S) or trademarked name of Metafolin

5-MTHF

5-methylfolate

5-methyltetrahydrofolate

From the package insert of Metanx, a prescription drug using biologically active Metafolin[2]:“L-methylfolate or 6(S)-5-methyltetrahydrofolate [6(S)-5-MTHF], is the primary biologically activediastereoisomer of folate and the primary form of folate in circulation. It is also the form which istransported across membranes into peripheral tissues, particularly across the blood brain barrier. In the cell,6(S)-5-MTHF is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THFis the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA)and methionine. About 70% of food folate and cellular folate is comprised of 6(S)-5-MTHF. Folic acid, thesynthetic form of folate, must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR)to become biologically active. Genetic mutations of MTHFR result in a cell’s inability to convert folic acid to6(S)-5-MTHF.

Metafolin® (L-methylfolate calcium) is a substantially diastereoisomerically pure source of L-methylfolatecontaining not more than 1% D-methylfolate which results in not more than 0.03 milligrams of D-

methylfolate in Metanx®

D-methylfolate or 6(R)-5-methyltetrahydrofolate [6(R)-5-MTHF] is the other diastereoisomer of folate. Studiesadministering doses of 2.5 mg per day or higher resulted in plasma protein binding of D-methylfolate higherthan L-methylfolate causing a significantly higher renal clearance of L-methylfolate when compared to D-methylfolate. Further, D-methylfolate is found to be stored in tissues in the body, mainly in the liver. D-methylfolate is not metabolized by the body and has been hypothesized to inhibit regulatory enzymes relatedto folate and homocysteine metabolism and reduces the bioavailability of L-methylfolate.”

Example of why all this is important to knowA supplement company has a supplement called, “5-MTHF”

Let’s say this supplement states it contains 10 mg of 5-MTHF.

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 4/31

One assumes this contains 10 mg of biologically active L-methylfolate.

Don’t assume.

The likelihood of it containing 99% of the biologically active form of L-methylfolate is slim tonone.

Why?

Prescription drugs such as Deplin contain 99% active L-methylfolate as Metafolin. Deplin provides twopotencies of L-methylfolate: 7.5 mg and a 15 mg

This much L-methylfolate is VERY potent and must be prescribed by a physician.

Merck does not allow any supplement company to provide more than 1 mg of their L-methylfolate in astand-alone supplement. If L-methylfolate, as Metafolin, is included in a formula along with othernutrients, then a maximum of 800 mcg is allowed.

What amount of this 10 gram 5-MTHF supplement actually contains the biologically active L-methylfolate?It is not known without requesting a lab report.

The likelihood of it containing a significant amount of the inactive D form of methylfolate is high.

Remember, the D form of methylfolate is undesirable and actually may reduce the bioavailability of L-methylfolate.

What to do?Two things:

1. Request a prescription from their physician to obtain drugs containing Metafolin.

2. Look for supplements specifying the amount of active L-methylfolate.

Drugs containing Metafolin are:

Metanx

Deplin

Cerefolin

CerefolinNAC

Neevo

NeevoDHA

Supplements with MethylfolateOne must carefully evaluate supplements specifying the use of Metafolin, Quatrefolic or the L form.

If the supplement does not specify on the label that it uses Metafolin, Quartrefolic or the L formof methylfolate, then it is not recommended to use without first inquiring directly to themanufacturer. A manufacturer may have named their product as 5-MTHF and use the pure Lform of methylfolate; however, one must inquire to be certain.

Quatrefolic: What is this?This is a new form of methylfolate that uses glucosamine instead of calcium to bind the L-methylfolate.Quatrefolic is also a quality form of L-methylfolate.

Key Points about Methylfolate:

1. Not all methylfolate is the same

2. The D form of methylfolate actually is undesired and should be avoided

3. The L form of methylfolate is the desired form

READ PREVIOUS POST:

Ten Day Transformation Between Mother and Child

There are two people close to me that cannot have agood time in each other's presence. One is an...

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 5/31

4. There are many names for the same thing. Understand them.

___________________

Supplements using the pure form of L-Methylfolate

Seeking Health uses purely the L-methylfolate as Metafolin.

You may find over-the-counter L-methylfolate as Metafolin here in these select Seeking Healthsupplements.

5mthf, l5mthf, Lmethylfolate, methylfolate

← Ten Day Transformation Between Mother and ChildRecurrent Miscarriage Causes: Look Beyond the Woman →

View Comments (97)Submit A Comment

1. Laura April 26, 2012 at 6:40 pm # Reply

Thank you for the work you’re doing to help those of us with MTHFR and repeatedmiscarriages! I’ve been taking Garden of Life’s Raw One for Women multivitamin. It lists“Folate” 800 mcg. Would that be an acceptable form? We have a call out to Garden of Life,

10 653 2

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 6/31

but haven’t heard back yet. I just found out that I’m pregnant, and trying to wade through theinformation to figure out what to do as far as a prenatal and B vitamins. I am hetro for C677t.I’ve had four miscarriages. Three secondtrimester, and one at nine weeks. I have 6 healthychildren, but my last three pregnancies were miscarried, and this is the only possible causethat was found. I also have hashimotos. I have upped my synthroid dose and am now onheparin. I’m planning on ordering the sublingual B12 w/ Methylfolate.

Laura April 29, 2012 at 6:03 pm # Reply

Dear Dr. Lynch,

I am hetero for MTHFR, C677T allele. I have a 13 yr old son who is diagnosed withADHD, Autism/Aspergers ( very high functioning), severe asthma, allergies,autoantibodies to folate ( Dr. Edward Quadros test), hypothyroid, immune dysfunction,mitochondrial dysfunction complexes 1 & 3, and has been identified recently by hisneurologist as having significant problems with methylation.

He is currently on 25mg of Leucovorin daily. Within 3 months his binocular visiondefects resolved. This year in school ( after nearly a year on leucovorin, his readingcomprehension has improved greatly to grade level ( truely amazing). He takes manysupplements – too many to list here – all prescribed by his DAN! Doctor and hisneurologist. I put him on an oral IgG supplement due to chronic illnesses enabled byLow IgG and low neutrophils ( not low enough to qualify for IVIG). He has alsodemonstrated low IgM. Since starting the oral IgG last sumer, his health has beenmuch better. He also gets B12 (methylcolbalamin shots every 3 days.

I am considering having him tested for MTHFR mutations. Is the Leucovorin the bestform of folate for him?

My own health issues are endometriosis, hypothyoid, premature ovarian failure,chronic hives, keratoconus and other collagen related problems.

Thanks in advance!Laura

Melissa June 11, 2012 at 6:09 pm # Reply

Laura,Don’t know if this is appropriate posting etiquette or how we could get in touchand still maintain everyone’s privacy, but please, if it’s possible, could you tellme who your DAN doc/Neurologist is? They sound amazing, and goodNeurologists, especially, seem notoriously difficult to come by–especially onesthat may understand the whole cerebral folate metabolism issues, methylationpolymorhisms, etc. I have a son who has, for the most part, recovered fromautism, but continue to do research for him and my myriad, lifelong, vaguehealth issues. In doing so I have recently put some GIANT puzzle piecestogether regarding my extended family’s health history and really want to workwith someone knowledgable. I will continue to dig in to this (amazing–aGodsend) website, hopefully contact Dr. Ben, but your post struck a chord and Ithought I’d reach out, momtomom. Also, dying to find out how to get Dr.quadros’ test…can’t seem to find it? Who did you find to do it? Please help!Thanks in advance…Melissa

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 7/31

Dr Ben June 11, 2012 at 7:01 pm # Reply

Melissa –

I will be making Dr Quadro’s test available soon on my website. It is animportant test to evaluate.

Asking for doctor referrals from each other is perfectly fine – andencouraged – please post directly in the comments

Des October 7, 2012 at 4:21 pm #

Just an IMPORTANT FYI: many of the Brands you listed such asNEEVO, contain Soy Lecithin (MSG) and Titanium Dioxide…Toxic when ingested on a daily basis…

Laura June 11, 2012 at 9:32 pm # Reply

Dr. Richard Frye is my son’s Neurologist. He is at Arkansas ChildrensHospital. Just moved and not seeing patients yet. Well worth the time forany parent of an autistic child.

Dr. Bryan Jepson was my son’ s DAN Dr. Unfortunately, he is no longerseeing patients. He has an excellent book called ” Changing The Course ofAutism”, though.Feel free to email me @ lauc174@aol.com

Sherrie LineCoil November 14, 2012 at 11:56 pm #

my Neurologist in Davis, California is Eric Hassid, M.D. of Instituteof Restorative Health a functional Neurology, AntiAging andRegenerative Medicine clinic.He tested me and I am compound heterozygous for the mutations.Am now taking 5MTHF and having IV treatments.

It is a releif to have some answers and a road less traveled to takemy journeySherrie

2. Jennifer July 27, 2012 at 6:02 pm # Reply

Hi Dr. Ben,

First of all, I’d like to say thank you for all of your responses to my questions and everyoneelse’s – you are providing us with so much good information!

I have a question regarding the Prenatal Pro multivitamin made by Designs for Health. I sawit mentioned on another post as a potentially good option. In looking at their ingredient list, Isee its folate is a blend called NatureFolate (a trademark blend). Then I saw on another postthat you said naturefolate is not an adequate type of folate for MTHFR. Are these two termsreferring to the same entity? If they are the same, do you feel the Prenatal Pro is not a good

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 8/31

option?

Thanks so much,Jennifer

3. prasad August 6, 2012 at 12:19 pm # Reply

what is profalactic use of l5,methyltetrahydrofolate?

4. Jennifer August 13, 2012 at 9:48 pm # Reply

Hi Dr. Ben,

In my quest to find a good prenatal vitamin, I made an inquiry to Designs for Health, afterseeing it listed on one of your posts. I asked specifically what type of methylfolate they used(they call their folate blend “NatureFolate”, which I thought I had read somewhere on herethat it was not a good type). This is the response I received from them:

“I asked our product development manager to help answer your question.

His replied with the following information: “NatureFolate is a blend of the natural Sform ofboth 5Methyl and 5Formyl tetrahydofolate. The amounts of each is proprietary information.”

Would you consider this to be an acceptable form of methylfolate for a heterozygous C677Tperson like myself?

Thank you for your advice,Jennifer

Pat December 31, 2013 at 7:22 pm # Reply

Jennifer, did you every get a response to this question? I am interested to know thisalso.

5. Latoria September 1, 2012 at 2:02 pm # Reply

I was online researching 5MTHF and came across this page. I have a 5 year old son whowas diagnosed with autism at age 2. For the past 3 months, we have been slowly introducingsupplements recommended by his DAN specialist. Following testing we found that my sonwould benefit from: Calcium citrate, DPP IV digestive enzyme, Super Nu Thera liquidmultivitamin, VSL #3 morning and ProBio Gold at dinner, Speak (which contains vitamin E,omega 3, GLA, and vitamin K), LGlutamine, AlphaKetoglutaric acid, Ester C; antifungalsgoldenseal and grapefruit seed extract (which we rotate every four weeks), Uva Ursi for 2week periods and switch to Oregon grape extract for six weeks, and rotate the Biofilmstrippers Interfase and Nattokinase every four weeks. We have yet to introduce, Acetyl LCarnitine, LMethylFolate, 5HTP, Lipoceutical Glutathione, NacetylLcysteine, andTransfer Factor Sensitive/MultiImmune…which brings me to my research today. Of thesenew supplements, I will be introducing one today and would appreciate any input youviewers can offer. This site has helped me understand the differences in Folate supplements,but I question if my son has a good brand. My son takes a brand containing 1,000 mcg Folate(as Metafolin L5methyltetrahydrofolate). I would appreciate any advice/info you could

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 9/31

provide Dr. Ben.

6. Ann September 21, 2012 at 4:01 pm # Reply

I have a 5MTHF product that is 10mg derived from 5methyltetrahydrofolate 20mg. I justasked the manufacturer about the 6S vs 6R composition, and here is their reply:

“10 mg (6S)5MTHF and 10 mg (6R)5MTHF. As stated on the label, we use 20 mg totalracemic (50/50) 5MTHF to yield 10 mg (6S)5MTHF. ”

Thanks Dr Lynch for your post. This product is going in the trash.

Marie December 21, 2012 at 7:23 pm # Reply

Ann, is the product you mention by Metabolic Maintenance? I have several bottleswith the same ingredients.

Dr. Ben, is it okay to give this folic acid to someone who does not have the MTHFRgene mutation, or is it better not to use it at all?

Also, I have a product by Jigsaw called Activated B w/SRT. It’s an activated Bcomplex with Quatrefolic 5MTHF in 200 mcg. Do you know anything about thissupplement? I’m wondering if it’s safe to take.

7. Meg January 6, 2013 at 2:36 am # Reply

Hi,

Thanks so much for writing this.

I am 30 yrs old and have MTHFR and Leiden Factor 5. Is it acceptable to take the NewChapter Prenatal (it has folate) plus one of the seeking health’s Lmethylfolates?

Also does a thyroid issue have anything to do with MTHFR?

Thanks so much

8. Sharon March 11, 2013 at 1:09 am # Reply

Dr.Ben,I have a homozygous MTHR 667t defect – my naturopath has me on Thorne Laboratories 5MTHF – the active ingredient is not listed as an L or a D methyltetrahydrofolate. Do youknow if this brand has the most bio available forms that you suggest in your writings?Thank you

9. Bec April 11, 2013 at 11:35 pm # Reply

Folate (as Quatrefolic® [6S]5methyltetrahydrofolic acid equivalent to 1.6 mg of [6S]5methyltetrahydrofolic acid

Not sure if i can post specific brands but i found this one with the above stated ingredients

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 10/31

and am wondering if ‘folinic acid’ is okay to take for MTHFR homozygous.

Fruitbat December 13, 2013 at 8:12 am # Reply

How much Quatrefolic is equivalent to 1.6 mg of [6S]5 methyltetrahydrofolic acid?

Megan December 1, 2014 at 1:18 am # Reply

I also have a supplement with these exact ingredients. Did you find an answer to thisquestion?

Michael_Dowdy December 29, 2014 at 8:48 pm # Reply

Hello Megan. I’ve looked for the answer. To me the much more serious questionis; “Can the body produce 5D MTHF when it sees the wrong molecule?”5MTHF has both but exactly what happens to the wrong one which is in 5MTHFstill seems to be not fully known or understood. 5D MTHF is going to havedifferent properties than 5LMTHF and toxicity is something I think is likely.Thalidomide is an example of what can go wrong when there’s a chiral problem.http://www.chirality.org/homepage.htm

10. jslim180 April 19, 2013 at 8:38 pm # Reply

I’m taking 4,500 mg of Cysteine HCL per day. The protocol also calls for 400 mcg of Folateper day. I would like to use L5MTHF instead. How do I figure out how much I need take?

11. Karen July 20, 2013 at 2:46 pm # Reply

Hi Dr. Lynch,

Is folate in a multivitamin as broccoli the same as folate in a bcomplex as Metafolin, L5MTHF? There is a multivitamin with 4,000mcg of folate as broccoli and a bcomplex with400mcg of folate as Metafolin, L5MTHF. Though the dosage for the multivitamin is muchhigher, is it a safer bet to start with since the source of folate is natural foods? Please advise,thank you.

Karen

Dr Ben July 21, 2013 at 12:19 am # Reply

Hi Karen –

I’d call the supplement manufacturer and ask.

My bet is it is most likely a form of THF or folinic acid and not methylfolate.

I like to know exactly which forms of folate one is getting. Food forms may be greatbut I prefer knowing what I and my clients are supplementing with exactly.

Then eating folate rich foods on your own is great.

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 11/31

12. Zach August 1, 2013 at 2:08 am # Reply

Hi Dr. Ben.

First off, thank you for all the work that you do. Clearly it’s highly valuable to all thosestruggling with these issues.

Just a couple of quick questions. I’ve taken 5MTHF as a way to augment my current SNRI(Pristiq) and to be honest I felt quite good. I was taking 1mg per day in the morning. ON the3rd day I had some mild insomnia and muscle aches in the shoulders/upper back. 4th day, Iactually pulled something in my upper back, which seemed to be due to muscle weakness.I’ve read about taking niacin to combat the side effects of the 5mthf, but should I continuewith the 5mthf regimen and just include niacin daily? Should the niacin be taken at a certaintime or just as needed?

13. Ryan August 22, 2013 at 1:14 am # Reply

Is (6S)5methyltetrahydrofolate good? My supplement includes 800 mcg a day. I’m adouble heterozygote.

Dr Lynch August 22, 2013 at 8:25 am # Reply

Hello Ryan – yes absolutely. It is a great form of methylfolate which I also use.

Ryan August 22, 2013 at 9:21 am # Reply

Is 800 mcg enough? I haven’t yet been able to see a doctor, but until then, whatcan I do? I’m taking the Country Life Coenzyme BComplex, but I don’t knowhow to tell if it’s working.

14. Jaime Michaels August 28, 2013 at 5:07 pm # Reply

Hi Dr. Lynch, I am really confused about the B Complex Seeking Health sells. It lists forfolate: 5methyltetrahydrofolate which is a questionable form you don’t recommend. Why doyou support this product? And why don’t they use the metafolin form? Also I read thatQuatrefolic is much better absorbed than Metafolin – what do you think? Thanks for all yourincredible information!

Dr Lynch August 29, 2013 at 12:44 am # Reply

Hi Jaime –

The B Complex provided by Seeking Health offers the 5methyltetrahydrofolate asMetafolin which is L5MTHF.

Quatrefolic is a bit better absorbed from what I am finding as well. We have switchedout from Metafolin to Quatrefolic in our:– Prenatal– Active B12 with L5MTHF– HomocysteX Plus

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 12/31

We will continue to move from Metafolin to Quatrefolic.

The differences are minimal overall. I have other reasons from switching fromMetafolin to Quatrefolic and it does not relate to absorption or quality. Just a personalpreference.

Rachel February 25, 2014 at 4:45 pm # Reply

Hi Dr. Lynch,

Could you please elaborate further on why you are switching from Metafolin toQuatrefolic, even if it is just personal preference.

I have switched back and forth between the two forms myself. I don’t know if itis placebo effect that Metafolin seems to work slightly better for me.

Also, I have spent hours researching which of the two forms is better, and it isfrustrating not to find a clear answer other than that Quatrefolic is the newer,next generation.

Thank you for your response!

Dr Lynch February 25, 2014 at 8:09 pm # Reply

Rachel –

The switch was for a few reasons:– better absorption (slightly)– prefer the noncalcium bound methylfolate

Both are very good forms of methylfolate – I think the differences are veryslight.

The difference you feel may be that Quatrefolic is actually stronger thanMetafolin – try taking less Quatrefolic compared to Metafolin – don’t takethe equal amount. See if that helps. You may be taking too muchmethylfolate when taking Quatrefolic compared to Metafolin – due toimproved absorption.

15. Cariker C September 25, 2013 at 3:15 pm # Reply

Thank you so much for this detailed and clear information

16. Fruitbat December 13, 2013 at 8:39 am # Reply

Can you give any advice on the relative available folate in the different acceptablesupplement forms?

I ask because of wondering about the situation of switching from L5MTHF (Metafolin) toQuatrefolic. I have read contradictory advice elsewhere about adjusting the dosage ofQuatrefolic both up and down relative to the Metafolin. Would be great to know yourthoughts on this.

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 13/31

Many thanks

17. Gary December 29, 2013 at 3:03 pm # Reply

Dr. Lynch,

Do you know if there is a connection between folacin and histamine? I started using theSolgar Metafolin which seems to restore libido when everything else has failed. All myhormone labs look normal, and I’m wondering if I could be histapenic…

18. Carie February 18, 2014 at 9:19 pm # Reply

Hi, Dr. Lynch!Thanks for all your info from your research.My multi for women over 40 is listed as Folate(500 mcg as Calcium Folinate and 500 mcg asLMethyltetrahydrofolate from L5Methyltetrahydrofolinic Acid, Glucosamine salt) 1 mg.I heard your webinar with Dr Christianson that hypothyroid patients are very likely to havethe MTHFR mutation. I have been avoiding synthetic folic acid as a result.Would this Calcium Folinate be “safe”. Thanks.

Dr Lynch February 18, 2014 at 9:49 pm # Reply

Hello Carie –

Yes – calcium folinate can be very useful as it supports DNA base production.Methylfolate supports SAMe production and homocysteine recycling.

Since the Methionine synthase enzyme is so picky, it is best, in my opinion, to supportpeople with folinic acid a bit as well.

If you are feeling good and your doctor agrees, then should be good to go.

Josh August 1, 2014 at 5:55 pm # Reply

Dr. Lynch,

I first want to commend and thank you for providing resources about MTHFRand the hard work and effort you are putting into the effort to spread awareness.

I do have one followup question based on this post.

The supplement (a Thorne product) that I am taking to help my own healthissues has L5Methyltetrahydrofolate from L5Methyltetrahydrofolic Acid,Glucosamine Salt. Is this the same thing as the Quatrefolic you discussed in yourpost?

If not, is this form of folate still effective (bioavailable) for helping withMTHFR issues?

Thank you so much!

Best regards,

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 14/31

Josh

19. Alex February 22, 2014 at 5:16 am # Reply

Hi Dr. Lynch. Thank you for all you do. The information on your website has helped meidentify that I have a MTHFR mutation and I’ve been working with my primary carephysician and taking a quality methylfolate supplement.

In this article, you mention “steroisomers” and how we need a certain type of methylfolate tomake sure we get the right form. I’m wondering if there are other vitamins/mineralsupplements that could also have nonactive, undesirable forms.

I take a variety of supplements, and am curious if there are inactive forms of other nutrients –B12/methylcobalamin, B6/P5P, etc.

Thank you!

20. Simon March 16, 2014 at 4:22 pm # Reply

Dear Dr. Ben,

I was wondering about the potency bioavailability of Lmethylfolate as Metafolin , or whatsused in Deplin vs Quatrefolic . If Quatrefolic is just as potent (or more) as you suggest, mg.vs mg. why is Quatrefolic alot less expensive?

Thanks!

Simon

21. Chris April 26, 2014 at 10:03 pm # Reply

Dr. Lynch,

I’m heterozygous A1298C. The person who diagnosed me and ordered the lab testing is avery well read nurse practitioner and she has a compound diagnosis herself. She wants me togo on Deplin and B12 (methylcobalamin form). I found an affordable and good formulationof methylcobalamin that I like. Unfortunately as you know, Deplin is VERY expensive, I stillcan’t figure why it is so expensive other than Merk took out a patent on it and there is onlyone “authorized” generic that is cheaper but still expensive. I asked her about several otherproducts that appear to be legitimate to me and are much more affordable. She went to aconference of sorts for medical professionals and afterwards said, “There are no products thatcan be taken in place of Deplin or the generic LMethyfolate Calcium made byBreckenridge… Now I have a hard time swallowing that and I have my doubts about thatstatement.

I have looked at your guidelines above as well as in your introductory video at the home pageof mthfr.net. I have tirelessly looked for other products with methylfolate and they are alsoexpensive (like Deplin), illegitimate forms of methylfolate, or aren’t the dose my NP wantsme on.

I have found several products (see links below) called MethylPro. The methylfolate seems tomeet your guidelines and criteria for the good form. They get their methylfolate from GnosisS.p.A. They have both Quatrefolic and ExtrafolateS (both registered trademarks). I’m

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 15/31

looking at the 10 mg dose. It looks like it’s based in Sisters, Oregon.

http://www.methylpro.com

My questions to you are:1. Are these legitimate forms of methylfolate?2. Knowing I already take B12, which MethylPro product, assuming these are legitimate,would you recommend (ExtrafolateS, Quatrefolic, Quatrefolic+cofactors)?

If you would like there is helpful narrative about their products and a section on how itcompares to Deplin: http://www.methylpro.com/more_info

On another note, I guess Gnosis in the past had a labeling problem with the ExtrafolateS(see http://www.gnosisbio.com/pdf/Corrective%20advertising%20letter%20for%20Extrafolate%20&%20ExtrafolateS.pdf)however, it appears they have corrected this under court order.

I really appreciate any guidance you can offer on this matter to me. I also appreciate thewealth of information you have here and that it is free to all so that they may better theirhealth.

22. Chris May 3, 2014 at 8:46 pm # Reply

I forgot to mention I’m currently on Gabapentin, Doxepin, and methylcobalamin.

Kim Hildreth June 27, 2015 at 3:02 am # Reply

Chris…I found your post searching Gabapentin and Doxepin…I am trying to help myniece with her MTHFR and she is on that same drug combo. I was wondering if youhave found a winning supplement combo. You can email me at kim@drugtestyourteen.com.Thanks!

23. Val May 15, 2014 at 7:21 pm # Reply

Hello Dr. Lynch,My understanding is that 6S L5 MTHF is processed from folic acid. It is a syntheticform of folate and that Formaldehyde is used in the distillation process to obtain this form offolate. Could you please clarify all of this!!! Of course my concern is in the possibility ofingesting any formaldehyde residue.

Many Thanks,Valerie

24. Sucramdw May 20, 2014 at 2:24 am # Reply

So what does it mean for this whole foods Woman’s multi to have real Folate as 100%Organic?? http://www.herbalprovider.com/WholefoodWomensMultiOrganic

Thank You!!

25. Michelle May 21, 2014 at 2:03 am # Reply

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 16/31

Seeking Health Kids Optimal Multivitamin lists Folate as 5methyltetrahydrofolate. Itdoesn’t specify D or L and doesn’t mention Metafolin. You put that type on yourquestionable list.

26. Dale June 12, 2014 at 9:56 pm # Reply

What do you think about the use of Rheumate?

27. rex August 1, 2014 at 7:40 pm # Reply

I was hoping that you would have references to your statements about the biological activityand effectiveness of the various forms of folic acid so that I can share this info my wife’sphysician. So I went onto PubMed.com and typed “folic acid and l5methyltetrahydrofolate” in the search section. There are many studies showing that L5MTHF supplements areeffective. Some say that it is better or at least the same as a general form of folic acidsupplementation. Obviously, L5MTHF would be far superior for those who have issues withfolic acid. here are 3 articles that I found regarding L5MTHF effectiveness:

1: Pietrzik K, Bailey L, Shane B. Folic acid and L5methyltetrahydrofolate:comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet.2010 Aug;49(8):53548. doi: 10.2165/1153299000000000000000. Review. PubMedPMID: 20608755.

2: Akoglu B, Schrott M, Bolouri H, Jaffari A, Kutschera E, Caspary WF, Faust D.The folic acid metabolite L5methyltetrahydrofolate effectively reduces totalserum homocysteine level in orthotopic liver transplant recipients: adoubleblind placebocontrolled study. Eur J Clin Nutr. 2008 Jun;62(6):796801.Epub 2007 May 23. PubMed PMID: 17522618.

3: Venn BJ, Green TJ, Moser R, Mann JI. Comparison of the effect of lowdosesupplementation with L5methyltetrahydrofolate or folic acid on plasmahomocysteine: a randomized placebocontrolled study. Am J Clin Nutr. 2003Mar;77(3):65862. PubMed PMID: 12600857.

28. Catherine August 11, 2014 at 1:16 pm # Reply

Hi, Dr. Lynch. Thank you so much for explaining about the different forms of folate. If thegeneric equivalent of Deplin 15 mg (LMethylfolate Calcium manufactured by Virtus) statesit has less than 1% of Dmethylfolate, is this safe to take for someone who is compoundheterozygous MTHFR? I had planned to take 1/4 of the tablet daily along with methyl b12.Having just learned about the harmful effects of Dmethylfolate on your website, I am notsure what to do. This stuff cost a lot of money, but should I throw it in the trash? Can youplease advise? Thank you so much!!

29. Adrian August 20, 2014 at 2:11 pm # Reply

My question is does anyone notice a recurring theme here with the companies manufacturingthese supplements? Very few that I have found have actually been worth much.

I suffer from mild depression and have had very bad experiences with anti depressants. Theyactually make the depression worse. I have a great doctor though who tested my genes and

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 17/31

found several traits that predispose me to depression and not responding to serotoninreuptake inhibitors. He said that I was lacking certain chemicals that helped me to absorbfolic acid. He told me that it was necessary to have the proper amount of folic acid in orderfor my body to create serotonin, dopamine and other chemicals that helped ones moods anddepression. He put me right on LMethylfolate Calcium and said that he wanted to give it atry. Within a few weeks, I was feeling a bit better. Within a few months I was happier ingeneral than I have ever been. Great! I was able to get excited about fun things that werecoming up and remain stable even in bad times.

My girlfriend suffers from similar symptoms of light depression. Her doctor puts her on Antidepressants and she gets worse just like I did. She can see what the Deplin has done for me.She goes to her doctor to ask about LMethylfolate and he tells her that she is crazy. He upsher dosage of antidepressant and she gets even worse. I discuss this with my doctor whounfortunately does not accept my girlfriends insurance. He cant believe that her doctor wontjust try the Deplin. The more I have read up on this though, the more I have found that thereare LOTS of doctors out there who refuse to try LMethylfolate. Why is this? People arebeing forced to find alternatives on the internet and other places that are nowhere near aseffective as the prescription. These companies are getting rich and doing no good for theirpatients.

Why are doctors so afraid to leave the confines of conventional Antidepressants and trysomething that is mostly natural? We aren’t hippies trying to be All Natural just for the heckof it. This vitamin really does some good. Especially when you can get the purest formpossible. I just don’t know why so many are so against helping us obtain that.

My doctor is retiring soon and I have been left to find a new doctor. A lot of these newdoctors would put me on just about any chemical that I want, but the second that I mentionthe Deplin they have all told me “No, Just take B12″ or ” you can buy supplements onlinethat has folate in it” HUH!?!?!?!

I am asking you for a simple thing here. LMethylfolate Calcium. How about someOXYCODONE Doc? “Sure thing Adrian, but I’m not writing a prescription for LMethylfolate” Whats wrong with this picture?

30. Natasha August 20, 2014 at 2:47 pm # Reply

Hi Dr, so here goes…long story short…I have suffered from sensorial neuropathy andanxiety since my plastic surgery procedure 5 months ago. I have been tested for everythingimaginable and nothing to explain the neuropathy so my Neuro had me take Metanx. When Istarted researching the drug medication after experiencing itching, dizziness, and irritability Istarted reading about MTHFR. I had my PCP test me for it and found out I’m homozygousC677t. I tried to quit the Metanx and experiment with Country Life Coenzyme B Complex(anxiety, itchiness), Garden of Life Kind Organic Women’s Once a Day (instant Niacinlikereaction of red and itchy flush), Real Food Organics Prenatal Daily (anxiet, itchiness),Seeking Health Optimal Multivitamin Chewable (dizziness, depression, anxiety). Eventaking supplements for my neuropathy such as acetyl l carnitine backfired by giving medizziness and anxiety for 23 days. I have been juicing for about 2 months and noticed thatadding the spinach makes me itchy! Therefore I am now down to just taking my Vitamin Dand Omega 3 supplements and juicing. None of my doctors are knowledgable enough aboutmy MTHFR to help me. Someone suggested that an added ingredient in the Metanx iscausing the itching and being off of it so long with my MTHFR issue is not addressing theneuropathy. I have noticed feeling more neuropathy lately. Could you recommend a doctorfor me to see in the Miami Rea that can help me get on track?

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 18/31

31. Deb August 23, 2014 at 1:39 am # Reply

I am looking for foods that have the active form of folate, my husband has one of theMTHFR defects and my daughter has both.mLooking for natural food source to supplementtheir diets. I live on a farm and if I can plant berries that have this will grow my own… Butneed to know if ALL berries have the active form… I have been told blackberries andraspberries do, just not sure about strawberries and blueberries. or any other types of berries.Any help would be appreciated.

Dr Lynch August 26, 2014 at 6:45 am # Reply

Folate comes from the root ‘folar’ I believe which means leaves. Eat anything greenand that will provide you a lot of folates – especially if they are uncooked.

Mara September 7, 2014 at 6:37 pm # Reply

Would organic folate be tolerated as well as the good forms of folate forsomeone with MTHFR and COMT? Or could it still cause overmethylation. I’vebeen taking an organic whole food multivitamin (Kind Organics), which saytheir folate (800mcg) is from organic lemon, but I’ve been feeling a bit off.

Deb September 10, 2014 at 2:57 pm # Reply

Dr Lynch, can you explain something to me?Husband has : c677t mutation is heterozygous a1298c was negativeDaughter has: c677t mutation is heterozygous a1298c is heterozygousI was told I have no mutations…I would have expected to have at least 1298c…

Dr Lynch September 11, 2014 at 6:49 am # Reply

Deb –

Which lab company did the MTHFR testing? Considerhttp://www.23andMe.com for all three of you – I do recommend it. Read this:http://mthfr.net/mthfrtestoptionsoralswabbloodtestorsaliva/2013/06/26/

32. Samantha McRorie September 8, 2014 at 2:40 am # Reply

I use a Thorne Multi – B product – easiest for me to get in Canada as I can get it from mynaturopath and I don’t have to pay shipping.

I have 2 of their multiB’s right now. On one label it says: Folate (L5Methyltetrahydrofolicacid) – which I do not see on your list. Yes it has the L and the 5 but why would it say folicacid at the end?

The other product says Folic Acid (5Methyltetrahydrofolate). So this one doesn’t have theL. I am very confused by all of this and want to be sure I am using the correct folate since Iam heterozygous for C677T.

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 19/31

Do you have any advice on this?

Dr Lynch September 9, 2014 at 6:10 pm # Reply

You need to have the L form or the 6S form. If they are not stating this, it may beracemic meaning that there are two forms in there of methylfolate. One of those formsis absorbed and used by your body and the other one is not.

Deb September 11, 2014 at 3:36 pm # Reply

Husband and daughter had blood drawn, sent of to Clinical Pathology Labs, Inc.whom the Dr office uses. Mine was done by cheek swab. It was done by acompany, DNASTAT Pharmacogenomic Testing Services.

Would you expect mother to have one or these defects if child has both andfather only has one?

33. Mara September 11, 2014 at 4:52 pm # Reply

Would organic folate be tolerated as well as the good forms of folate for someone withMTHFR and COMT? Or could it still cause overmethylation. I’ve been taking an organicwhole food multivitamin (Kind Organics), which say their folate (800mcg) is from organiclemon, but I’ve been feeling a bit off.

34. ing November 13, 2014 at 6:47 pm # Reply

I just wanted to add my experience with different brandsI tried three. Only one worked for me.Jarrow Quatrefolic had no effect at all.Solgar metafolin worked for some aspects of my health but caused irritability.Thorne 5Mthf ExtrafolateS (uses Gnosis S.p.A.’s L5Methyltetrahydrofolate) worksbeautifully with added benefits on mood and sleep.

Can you tell me why you say all active forms work the same when clearly all these differentactive forms work differently for me?

Can you comment on ExtrafolateS, Im concerned over some things Ive read about it.

thanks much

Dr Lynch November 14, 2014 at 7:31 am # Reply

Good points.

They should work the same but clearly they do not with you.

It also depends on the quality of the manufacturer – how do they handle the rawmaterial, how do the encapsulate it, store it, how fresh, how seal it, delivery system?

My company, http://www.SeekingHealth.com is switching to all Gnosis Quatrefolic and mostof our products currently use that.

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 20/31

I am not sure about ExtrafolateS but my first thought is that they use calcium salt vsglucosamine salt – like Metafolin. Also it may be racemic – I am not sure of thepercentage of each isomer.

ing November 15, 2014 at 9:19 pm # Reply

Thank you Dr Lynch for your response.

I have done more research and seems Gnosis extrafolates is not recemic – fromtheir website:“extrafolateS® is the calcium salt of (6S)5methyltetrahydrofolate, and issuitable as a food ingredient.they also make “extrafolate – the calcium salt of (6R,S)5methyltetrahydrofolicacid.”

I have found that the quatrefolic form of methylfolate gives me many of thenegative symptoms listed as “side effects” on your website. For me personally irritiblity, anxiety, racing heart, aching muscles, weak muscles, back pain)whereas extrafolates gives me only excellent results with added benefits onsleep and mood.

I have found many people online commenting that this has been their experienceas well with quatrefolic and would ask you to consider selling a supplement thatcontains extrafolates as an alternative to those who can not tolerate quatrefolic.

Had I tried quatrefolic first I would not have believed that methylfolate therapywas for me and based on the negative reactions would not have continuedsupplementation nor would I have tried a different form of methylfolate becausemost websites claim all active form of methylfolate work the same.

Thankfully my first try with a methylfolate supplement was with a brand thatuses extrapolates and I had no side effects and could tell right away that it wasindeed working for my symptoms.

I fear many people who may be intolerant like I was may try quatrefolic firstsince it is what you and many other websites are endorsing based on the fact thatit is the latest/fourth generation form of methylfolate and may give up based onnegative symptoms, and not consider another form/brand of methylfolate.

I feel like methylfolate in the form of extrafolates has given me back my lifeand I would hate for someone like myself to miss out only to not have found theright form of methylfolate that works for their personal chemisty.

I would love to know what you think about my personal experience and wouldlove for an article to be writen for those like me.

Thank you very much for your response and consideration!

ing November 18, 2014 at 8:30 pm # Reply

edit..metafolin (solgar brand) was causing negative symptoms not quatrefolic.However quatrefolic (Jarrow) has no beneficial effect for me unlike like

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 21/31

extrapolates.Sorry for the mix up.

Jeff November 20, 2014 at 7:31 pm #

Hi “ing”,Since you’ve tried various forms of active methylfolate I’mwondering if you have ever taken multiple forms of activemethylfolate simultaneously on a daily basis?

Do you know if the effectiveness of the folate is adversely affectedor are there any safety concerns you’d have with taking multipleforms of methylfolate ?

I’m planning on taking these two supplements when they arrive:L5MTHF 1000 from the “Seeking Health” company.and BComplex #12 from “Thorne Research”.

There is 200 mcg. of L5Methyltetrahydrofolic Acid, GlucosamineSalt and200 mcg. of Calcium Folinate in each of the BComplex capsules byThorne Research.AND1,000 mcg. of Quatrefolic(6S)5methyltetrahydrofolate,glucosamine salt contained in the Seeking Health L5 MTHFcapsules.Thank you very much!

Jeff November 20, 2014 at 3:39 am # Reply

Hello,I’m so glad to have found this excellent site. My physician suspected that I mayhave MTHFR mutations and ordered the blood lab test. I just received my testresults back which show that I have both the C677T & A1298C mutations.

I’m sure there’s a lot of factors that affect this question, but I’m wondering whatis a good general starting dose of 5MTHF for someone like me with bothmutations?

I ordered L5MTHF 1000 from your “Seeking Health” company.I also ordered BComplex #12 from “Thorne Research”.I need to know if these three different forms of folate are safe to take together?

There is 200 mcg. of L5Methyltetrahydrofolic Acid, Glucosamine Salt and 200mcg. of Calcium Folinate in each of my BComplex capsules by ThorneResearch.I then plan on taking your L5MTHF 1000 from “Seeking Health” whichcontains 1,000 mcg. of Folate from Quatrefolic(6S)5methyltetrahydrofolate,glucosamine salt in the Seeking Health L5 MTHF capsules.

My doctor wants to prescribe me a large 15mg starting dose of folate, but afterreading a little of the wealth of information on this site it sounds like this may beway too much with a high probability of causing adverse side effects.

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 22/31

I’d sure appreciate your input on the recommended starting dose and to theeffectiveness and safety of taking the multiple forms of folate I listed.

Thanks in advance for your input, I appreciate it very much!

35. Bridget November 14, 2014 at 9:30 pm # Reply

Dr. Lynch, can you explain the difference between just plain folate and methylfolate? (Iunderstand the difference between folate and folic acid.) I am taking an organic, raw veganvitamin formula that lists “folate” as one of the ingredients. But I am also taking asupplement that says “(6S5)5Methyltetrahydrolic Acid.” A fiend says I shouldn’t take thevitamin with the folate because it could interfere with metabolizing the methylfolate. Thankyou for your reply.

36. Pamela November 27, 2014 at 2:18 am # Reply

Dr. Lynch,Thank u for your remarkable information. My MD actually recommended it since I wasdiagnosed with heterozygous A1298c/A1298c. We discussed the methylation Plus that sherecommends. But when I asked for a prescription instead, she said there wasny one availablein a dose small enough. She mentioned 300 or 400mcg. I guess I’m wondering if you mayknow of one that she might not. She also mention the methylation plus will take care of my B2, 6, &9 deficiencies all at once instead of having to take separate pills . I have very goodprescription insurance. & would rathe go that route if possible due to finances. Will this be alifelong requirement or would/could it resolve with the candida irradication ?Thank you

37. Judit B. January 1, 2015 at 10:31 pm # Reply

Dear Dr. Lynch!

I am MTHFR C677T homozygotes.I have polyneuropathia with a very late stage of chroniclyme disease ( + other lots of symptoms). I have been very ill for many years.I have done aNutrahacker health info from my 23andme test. I am Hungarian and really can’ t imaginewho could help me. I am 27 years old.I would like to ask you what kind of folate should I take if Nutrahacker “reports”me to avoidfolinic acid and methyl donors! (methyl B12 too). I also have three kind of COMT gene andrs6922269, rs1801133, rs1805087, rs1802059, rs1801394 , rs7946, rs7925545, rs234706.A huge problem is nerve pain.I have tried taking Turmeric (300mg600mg), but the painincreased insupportably so I have finished taking it.

I just want you to help me a little bit.

Thank you very much in advance: Judit B.

38. Sherry Goeke January 8, 2015 at 3:11 pm # Reply

Dr Lynch,What about “folate” in whole food based vitamins, and more specifically Garden of Life rawvitamins?I have been unable to tolerate medium chain triglycerides in “Seeking Health” products.

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 23/31

Thank you for your response.

Dr Lynch January 9, 2015 at 9:06 am # Reply

Sherry – if they don’t specify which form of folate it is, then I wouldn’t trust it.Medium chain triglycerides are derived from coconut oil – and the amount is very verysmall. Are you sure that’s the problem?

39. suzan January 14, 2015 at 7:01 am # Reply

Hi! Thank you for this article it is very helpful! I have been diagnosed with mthfrhomozygous c677.. I am finding it hard to find methylfolate, can I supplement with folate (pill not just naturally) and if yes what is the dosage? For folate or methylfolate. Would reallyappreciate some insight! Where i am from it seems lime they dont really consider mthfr as aproblem! I have experienced already 2 miscarriages so i want to get it right this time. Thanksin advance.

40. sowmya January 20, 2015 at 8:04 pm # Reply

Dear Dr.Ben LynchCould you explain to me when does one use L5 MTHF or its various forms mentioned,versus Leucovorin? I understand that lack of 5mtf causes Cerebal Folate deficiency , but theysupplement it with Leucovorin, I am trying to understand, what matters where? Thank you

Dr Lynch January 21, 2015 at 10:49 pm # Reply

I’m not sure why they use folinic acid vs MTHF in those studies.

Cost?

As far as I know, folinic acid is needed to produce DNA bases and MTHF is neededfor methylation – the general overview anyhow – they do other things as well – butthose are the two major ones.

Neurotransmitters need methylation to be formed and eliminated – the major ones –

I need to research further if folinic acid plays a role specifically – as folinic acid – inneurotransmission. At this point, I am not aware of that but I could be just ignorant onthe matter.

Sowmya January 22, 2015 at 8:31 am # Reply

Dear Dr.LynchI got the answer from some of the moms who are working towards healingchildren with autism like me, from what I understood, Leucovorin would beconverted to L5MTHF however if you have mutations etc, then the conversionwould be affected or slowed down..here is what someone answered, I am sharingit incase someone else would be interested to know..Leucovorin does not containmethyl groups and thus, this form does not participate directly in the methylcycle. However, it is a valuable player in generating pyramidines and it can betransformed into 5MTHF. Of course, this is best accomplished if a child does

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 24/31

not have an MTHFr polymorphism in which that enzyme is less efficient. TheMTHF reductase will still transform Leucovorin into 5MTHF, albeit somewhatslower. This can be especially hindered by homozygous polymorphism in thatparticular gene.

Folinic acid (INN) or leucovorin (USAN), generally administered as calcium orsodium folinate (or leucovorin calcium/sodium),……..Folinic acid is a 5formylderivative of tetrahydrofolic acid. It is readily converted to other reduced folicacid derivatives (e.g., tetrahydrofolate), and, thus, has vitamin activity that isequivalent to that of folic acid. However, since it does not require the action ofdihydrofolate reductase for its conversion, its function as a vitamin is unaffectedby inhibition of this enzyme by drugs such as methotrexate.Folinic acid, therefore, allows for some purine/pyrimidine synthesis to occur inthe presence of dihydrofolate reductase inhibition, so that some normal DNAreplication and RNA transcription processes can proceed.

Deplin is a trade name for 5MTHF. Folapro is also the same thing, but in a lowOTC dose, i.e., 800 mcg/tab. Deplin is the prescription version of this and myunderstanding of this is that it is much higher …in milligrams rather thanmicrograms. This is does have methyl groups attached. It is the only form thatpartakes directly in the Met cycle. This one can overcome the MTHF reductaseblockade if it is present.thank you for all the inputs, it really brings in so much knowledge and so muchhope that if there are solutions to problems and we can some way help ourchildren to lead a normal life!Best WishesSowmya Fesenbeck

41. Zach March 15, 2015 at 5:08 pm # Reply

Dr. Lynch,After countless hours of educating myself about L5Methyfolate and B12 (Methyl,Hydroxy), I want to personally thank you for your dedication to helping others. It gives hopeto those of us who have suffered with chronic depression & anxiety over the years withoutany success to typical SSRI treatments. I wish more doctors and mental health professionalswere aware of this as an alternative treatment when antidepressants simply do not work insome people, such as myself. There is hope in feeling “normal” again.

Zach

Dr Lynch March 21, 2015 at 5:01 am # Reply

Hi Zach –

My pleasure! I am pleased to here that this information is helping you.

Do listen/watch this as well – may provide some more useful info –http://www.seekinghealth.org/gift

Keep getting better!

42. Zori April 11, 2015 at 11:09 am # Reply

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 25/31

Hello, Dr Ben. I thank you so much for your work?Can you tell me whether folate – as (6S)5methyltetrahydrofolic acid, is the same as folate –as Quatrefolic (6S)5methyltetrahydrofolate?

43. Amanda April 14, 2015 at 9:22 pm # Reply

Thank you so much for this website and all the information! I was diagnosed withhypothyroidism and PCOS in 2009 just before we had our first daughter who was stillborn.Then we got pregnant with our second daughter with the help of Clomid which is also whatwe used for our first pregnancy. In 2010 i was diagnosed with MTHFR after the stillbirth ofour first daughter and I was told to take 4 mg of folic acid. Now we are trying to conceiveagain and the Clomid isn’t working at all – I’m not ovulating. The only thing I have donedifferent is taking the folic acid and I can’t help but think this is our issue! Could the folicacid be the culprit for my anovulation and causing the clomid to not work this time when itworked with both of our other pregnancies? What should I be taking in place of the folicacid? Thank you so much!

Aron April 24, 2015 at 9:49 pm # Reply

Hi Amanda,

Dr. Ben is a HUGE proponent of getting rid or all forms of folic acid (manmade form)in supplementation and fortified foods. He recently created a brief overview of thedifferences between folic acid and folate (found in nature) (https://www.youtube.com/watch?v=oZzR1NMg0hM). In short, there is really no reason to be taking folic acid.

There is also a post on prenatal supplementation that you might find interesting:http://mthfr.net/prenatalsupplementationoptimizingyourfuturechild/2012/01/20/

Hope this helps!

44. Terri Maxwell May 5, 2015 at 4:32 pm # Reply

My dr prescribed Methylfolate 3 MG everyday, I went to the herb store and the gave meMethylation Complete by Neuro Biologix. Is this the same . 3.2 mg

45. Debbie May 5, 2015 at 10:34 pm # Reply

Sorry about the typos. My daughter recently was diagnosed with the MTHFR gene problemand has been taking Folate as L5Methyltetrahydrofolate and many of her lupuslikesymptoms have abated. Thank GOD.I recently was told, as her mom, to also begin taking it and I wonder if this product is whatthey say it is. Swanson Health Products has a Folate product that is labeled as: Folate (asQuatrefolic [6S]5methyltetrahydrofolic acid equivalent to 1.6 mg of [6S]5methyltetrahydrofolic acid, glucosamine salt).My question isThis is listed as folic acid instead of folate. Is that a problem? Is there anydifference between the 2?

Aron May 8, 2015 at 7:33 pm # Reply

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 26/31

Hi Debbie – I’m glad to hear that your daughter’s symptoms have abated. The namingconventions can be very confusing! There are many forms of folates, which is ageneral term. In this case, this particular Swanson product is using folate asQuatrefolic, which is the same form of highly bioavailable folate that Dr. Ben has usedin his own formulations. Folic acid is the synthetic form that is not as bioavailable andpotentially harmful in those with MTHFR gene mutations. See Dr. Ben’s post on thisvery topic: http://mthfr.net/folicacidawarenessweek2014wantawarenesshereyougo/2014/01/08/.

All the best!

46. Esther May 22, 2015 at 3:43 am # Reply

Is this ok?Folate (as (6S)N5methyltetrahydrofolic acid calcium salt (molar equivalent to 600 mcg offolic acid) and folic acid, USP 400 mcg)

It is part of a prescription for iron due to pregnancy anemia. In prescription drug Feriva

Dr Lynch May 26, 2015 at 10:58 pm # Reply

I dont believe anyone should take folic acid.

I dont see why we cannot use more active forms of folate – folinic acid andmethylfolate are the active forms.

Folic acid is far from active.

Please talk with your doctor about using more active forms of folate –

Look at the folate on the label here in this prenatal vitamin:http://www.seekinghealth.com/optimalprenatal240vegetariancapsulesseekinghealth.html

It shows the active forms of folate.

You can use that as an example.

Also learning more about folate is important – please review http://www.seekinghealth.org/gift

Thank you

47. Sara June 14, 2015 at 6:55 pm # Reply

Hi Dr. lynch. I am nearly 30 w 2 copies of the 1298c mutation. I have had severalmiscarriages and turned up positive for this after transferring a genetically normal embryovia IVF and suffering a blighted ovum. My doc prescribed fool guard but I take Thorne’sbasic prenatal (1000 mcg folate) and 400 mcg of methyl folate.ive been doing so sinceOct/Novish. I am now pregnant again and will be 6 weeks tomorrow. I’m not sure if this onewill make it, but due to a suspected sub chorionic hematoma (confirmed), I had an early scanat 5weeks3days and saw a sac and yolk sac, so already better than last time. After doingresearch today, I saw that my version of the mutation may only absorb 10% of the folate Itake. I’m wondering whether I really need 4000 mcg? And whether I should up my vitaminsor folate through food. That is a lot of green smoothies. Thank you.

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 27/31

Dr. Aron June 15, 2015 at 10:11 pm # Reply

Hi Sara – Upping your intake of vitamins and methylfolate through food is usually theideal way to get these essential nutrients…plus many other essential vitamins,minerals, and antioxidants. Leafy greens are great because they contain methylfolateplus 100+ other forms of folate! I’ll assume 4000mcg was a typo and you arewondering about 400mcg. 400mcg is not a lot of methylfolate. I like to tell patientsthat they should average 57 cups of vegetables per day making sure to eat a rainbowof colors. Colors represent different nutrients and eating a rainbow will make sure youget as much as you can from food. Supplementation makes up the difference.

You might find Dr. Ben’s prenatal supplementation article helpful: http://mthfr.net/prenatalsupplementationoptimizingyourfuturechild/2012/01/20/

Please keep us updated on your progress!

All the best,Dr. Aron

48. Dominique June 22, 2015 at 11:51 pm # Reply

Hello,I was just wondering, if a supplement just says folate, is that acceptable? Thank you.

Dr. Aron June 23, 2015 at 6:22 am # Reply

Dominique – there are over 150+ forms of folate. The most common form in mostsupplements is synthetic folic acid. It’s important to know specifically which form.

1. MTHFR November 5, 2012

[…] I found this site to be an expert resource on MTHFR Gene Mutations: mthfr.net […]

2. The supplements August 13, 2013

[…] “folate is generally safe and helpful and most people benefit from 3 mg per day”. I usethe active form from Solgar because some people don’t convert well from folic acid. As onFDC member put it […]

3. My Meth • MTHFR Living August 21, 2013

[…] even seen in person the more insidious substance that drives that program. I’m talkingabout methylated B vitamins here, which are crucial to conquering MTHFR. I’m notplanning on telling you how to dose in this […]

4. Tinnitus: Treatments, Causes, Genetics, Metabolism, and LOUD NOISES | Metabolic Giant September 4, 2013

[…] According to Dr. Ben Lynch, people interested in active folate should purchase LMethylfolate (see a detailed explanation of which type of folate to buy here). You also want

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 28/31

to be careful with copper as too much can also be a problem, especially if you have […]

5. Have MTHFR? How To Avoid Folic Acid In Food • MTHFR Living September 29, 2013

[…] form of B12) and B6. If you have MTHFR you want the active forms of these vitamins,which means specific types of methylfolate instead of Folic Acid (see the linked articlebefore purchasing active B9 supplements), […]

6. (FAQ) Frequently Asked Questions • MTHFR Living June 13, 2014

[…] foods like bread, flour, processed foods, conventional pastas, etc. Dr. Lynch talks aboutthe different forms of folate here. It is important to remember that you want to have anadequate intake of B12 as well in a form you […]

7. The Epigenetic Epidemic | Michael Chad (StayatHome Dad) October 26, 2014

[…] chlorine. Supplement with SAM. Consult with an MTHFRknowledgeable doctor andfigure out which methylfolate is right for […]

8. Why Your Prenatal Folic Acid Might Not Be Enough… January 5, 2015

[…] Lmethyltetrahydrofolate. There is a nice writeup about the different supplementalforms of folate here. Be aware, however, that some people can experience side effects frommethylated folate because […]

9. Peeling back layers of the onion | journeyforourbaby May 12, 2015

[…] Fairhaven Health OvaBoost (contains CoQ10, 2000 mg MyoInositol, melatonin, 100 IUVitamin E, Alpha Lipoic Acid, Grapeseed Extract, and 400 mcg Folate (there is a differencebetween Folic Acid and Folate!! Additionally, there is a difference between various types ofFolate.) […]

Name (Required)

Email (Required)

Website

Sum of 2 + 3 ? (Required)

Comment

Submit Comment

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 29/31

Notify me of followup comments via email. You can also subscribe without commenting.

PopularLatestCommentsTags

Methylfolate Side Effects March 1,2012MTHFR A1298C Mutation: SomeInformation on A1298C MTHFRMutations November 30, 2011MTHFR C677T Mutation: Basic ProtocolFebruary 24, 2012

Bedwetting and MTHFR? June 15, 2015Histamine Intolerance, MTHFR andMethylation June 11, 2015Is MTHFR Related to X Condition? XDisease? X Symptom? X Syndrome?June 10, 2015

Kay: I have been dealing with my momwho most likely ha...Michael_Dowdy: Hello Margaret M. Ican only say what has worked a...Kna: Hi Dr Ben..I have asked thisquestion somewhere el...

A1298C antacids awareness babybipolar C677T cancer consultationdeplin detox doctor fetus folate folbee

folguard folic acid genetics helphomocysteine homocystex infantinterview L-methylfolate metanxMethylation methylfolatemiscarriage MTHFR MTHFR

doctor MTHFR Test MTHFR testingnatural medications natural medicinesNatural Medicines Comprehensive

Database Podcast pre-eclampsia

pregnancy Presentationpulmonary embolisms Q and Arecurrent pregnancy loss stroketesting toxic what is mthfr

Search...

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 30/31

About Dr Ben

My story is long and can get pretty involved so I am going to skip many details and get straight to significant life events. I feel once you understand who I am as an individual

based on my experiences, you and I will resonate on a deeper level. After all, DrBenLynch.com is not about me - it is about how I can help you.

Life experiences change a person. Or do life experiences create a person?

Bottom line: I am not your typical guy nor am I your typical doctor....

read more »

Twitter Feeds

Follow @DrBenLynch on Twitter

17/7/2015 LMethylfolate, Methylfolate, 5MTHF, L5MTHF. Why many variations?

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/ 31/31

© 2014. All rights reserved.The information provided on Dr Ben Lynch Network Sites are designed tosupport, not replace, the relationship that exists between a patient/site visitorand his/her physician. Sitemap | Timeline