implongmbh...leading biomaterial innovations focused expertise: worldwide leading innovations in...
TRANSCRIPT
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Company and Dental Products Presentation
bioimplonGmbHBiotech Innovation Pioneers
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We develop, manufacture and market
patented, unique, natural bovine biomaterials
for regenerative medicine.
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Agenda
The Company
Unique Features
Products
Product Safety and Certifications
Agenda
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The Company
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Leading Biomaterial Innovations
Focused expertise: worldwide leading innovations in bovine biomaterials fornatural bone & soft tissue regeneration (GBR & GTR)
Unique patented technologies: unique processing of bovine material maintaining the natural structure and properties of collagen and all its advantages
Future-oriented innovations: own scientific department – constantly developing new up-to-date products for enhancing therapeutical results and a better quality of life
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Global market launch Bioimplon GmbH foundedin Germany; took over thebusiness activities ofCardiophil Ltd. (active in biomaterials since1998)
1992 2011 TodayToday we sell our productsin more than 60 countries worldwide
History
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We strive to improve the quality of life.
We…
…invest continuously in the development of state-of-the-art biomaterial products.
…want everybody to enjoy safe and high quality treatment.
…are planning to expand our business into new markets.
Our Goals
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Membranes for GBR / GTR
Hypro-Sorb® MHypro-Sorb® F
Alveolar Ridge Preservation
Hypro-Sorb® XHypro-Sorb® Z
The Biggest Portfolio Worldwide
in bioregenerative materials Bovine Bone Substitute Material
Hypro-Oss®
Wound Healing
Hypro-Flex®
Haemostatics
Hypro-Sorb® R, NT, O
Our Atelo-Collagen Type I products
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tissue engineering
bone and tissue regeneration
wound healing
dental surgery
spinal/ neuro surgery
orthopedic surgery
plastic surgery
Fields of Application
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Unique Features
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Unique Features
All our products are atelopeptidized and lyophilized
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Atelopeptidation
Patented, Enzymatic Manufacturing Procedure
Physicochemical deletion of the antigenic terminal peptide sequence in a Collagene molecule
Result: modified collagen called Atelo-Collagen Type I – a safe, bio-compatible, non-immunogenic collagen
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Atelo-Collagen Type I
Biocompatible
Non-immunogenic
Telopeptide free
Natural structure
Most effective haemostatic
Bacteriostatic effect
No swelling or haematoma complications
Safe and sterile
Easy Handling
Atelopeptidation
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Lyophilization
Process of Freeze-Drying
Freeze-drying removes water from the material bysublimation
Sublimation is directly converting ice to water vapor, without passing through the intermediary stage of liquid
Freeze-dried materials become highly absorbent and canbe stored at room temperature
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Advantages of lyophilized bovine material
Chemical and physical similarity to human bone
Strong hydrophilicity
Long shelf-life
Availability
Cost-effectiveness
Suitable for the treatment of Muslims
Comparison of the chemical composition between human and bovine bone
Lyophilization
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Our Dental Products
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Hypro-Oss®
Bovine bone substitute
A revolutionary, patented, natural, atelopeptidizedand lyophilized bovine bone graft composite for implantology, periodontology and maxillofacial surgery
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The result of six years intensive research and development
A solution for preserving biocompatible Atelo-Collagen Type I within natural bovine bone granules
Enhanced bone formation and integration
Stimulates cell proliferation, differentiation and osteogenesis
Bovine bone substitute
Hypro-Oss®
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Native, not heated, bovine bone composite30% Atelo-Collagen Type I, 70% hydroxyapatite
Natural crystalline structure of hydroxyapatite;no physical / chemical changes of the native bone material
Lyophilized, strong hydrophilic properties;atelopeptidized, free of antigenic telopeptide
Contains native active bioelements (growth factors)
Bovine bone substitute
Hypro-Oss®
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0,5 – 1 mm 1 – 2 mm
Effective haemostatic properties;anti-haematoma effect, no need for steroids
Highest quality of new bone formation with no volume loss
Osteopromotive and osteoconductive properties; osteoinductive bioelements (TGF - beta, IGF, PDGF)
Excellent handling due to sticky Atelo-Collagen Type I
Bovine bone substitute
Hypro-Oss®
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Bovine bone substitute
• Sinus Lifting
• Vertical and horizontal augmentation
• Intraosseos defects
• Preimplant defects
• Extraction sockets
• Furcation defects
• Filling of cysts
• Preiodontal defects
Hypro-Oss used together with Hypro-Sorb F. Images courtesy of Dr. Amir Gazmawe DMD Prosthodontist
Hypro-Oss®
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Hypro-Sorb® M & Hypro-Sorb® F
Guided tissue and bone regeneration
rigid medium-rigid and soft
The natural Atelo-Collagen Type I membranes for guided tissue and bone regeneration
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Hypro-Sorb® M & Hypro-Sorb® F
Guided tissue and bone regeneration
Bilayer, biphasic, native, resorbable
99.9% pure, crystalline Atelo-Collagen Type I, non-crosslinked
Material origin: bovine achilles tendon
Atelopeptidized: free of the immunogenic telopeptide, non-antigenic,non-immunogenic, highest biocompatibility
Lyophilized: strong hydrophilic and haemostatic properties
Contains growth factors for accelerated soft-tissue regeneration
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• Sinus Lifting
• Segmental growing of the alveolar tissue
• Preimplantitis
• Furcation Treatment
Hypro-Sorb® M & Hypro-Sorb® F
Guided tissue and bone regeneration
• Vertical and segmental augmentation
• Cystectomy
• Maxillofacial and Periodontal surgery
• Cleft lip and palate
Application of Hypro-Sorb® M and Hypro-Oss® – Images courtesy of Dr. Labazanov Ashab, Maxillofacial Surgeon, Moscow, Russia
Periodontists tend to prefer Hypro-Sorb M, Hypro-Sorb F is often favoured by maxillofacial surgeons.
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Guided tissue and bone regeneration
Hypro-Sorb® M & Hypro-Sorb® F
Rough side of Hypro-Sorb® M
Smooth side of Hypro-Sorb® M
Better stability and barrier functionality
Rough layer: favours bone tissue integration
Compact smooth layer: prevents proliferation of soft tissue; excellent for soft tissue adhesion and wound healing
Rough side of Hypro-Sorb® F
Smooth side of Hypro-Sorb® F
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Guided tissue and bone regeneration
Application of Hypro-Sorb® F and Hypro-Oss® - Images courtesy of Fahim Atamni, DDS, specialist for oral surgery
Hypro-Sorb® M & Hypro-Sorb® F
Bilayer membrane, excellent cutting up and fixation; can be attached with pins and suturing material
Tear-proof fibrous tissue structure
Does not stick to surgical instruments, membrane memory
Adheres very well to the operation site
Complete resorption, no reopening necessary
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Hypro-Sorb® M Matrix
Guided tissue regeneration
Our multilayer Atelo-Collagen Type I matrix for guided tissue regeneration in periodontology and maxillofacial surgery
Made of biocompatible pure, crystalline Atelo-Collagen Type I –free of antigenic telopeptides
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20 x 25 x 2 mm 25 x 25 x 2 mm 25 x 50 x 2 mm
Guided tissue regeneration
Hypro-Sorb® M Matrix
Multilayer, native, resorbable
No need for autograft harvesting – high patient acceptance
Reliable clinical results and cost effectiveness
Rapid neovascularization and integration
Complete remodelling into patient’s own tissue
Excellent barrier function – resorption time of approximately six months
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Hypro-Sorb® R
Haemostatic sponges
Our natural Atelo-Collagen Type I sponge for effective haemostatic and wound regeneration
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Haemostatic sponges
Hypro-Sorb® R 20 x 25 x 4 mm
Hypro-Sorb® R 10 x 10 x 10 mm
Hypro-Sorb® R 50 x 50 x 4 mm
Hypro-Sorb® R
99.9% pure crystalline Atelo-Collagen Type I; the most efficient haemostatic known
Control of capillary and parenchymatous bleeding (surgery, dentistry and traumatology)
Burns management
Complicated wound treatment
Diabetic ulcers
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Haemostatic sponges
Hypro-Sorb® R
Atelo-Collagen Type I haemostatics are the fastest in helping to achieve haemostasis, reduce blood loss substantially and are better than other haemostatic materials in stopping parenchymatous bleeding from surgically cut liver
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Hypro-Sorb® X and Z
Alveolar ridge preservation and haemostasis
Our natural Atelo-Collagen Type I cones for the preservation of the alveolar ridge and an effective haemostasis
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Alveolar ridge preservation and haemostasis
Hypro-Sorb® X; 10x20x6mm Hypro-Sorb® Z; 6x15x3mm
Hypro-Sorb® X and Z
99.9% pure crystalline Atelo-Collagen Type I enables quick and reliable haemostasis. In the shape of tooth roots the conus form facilitates easy handling.
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Sterilization & BSE Safety
Strict control of animal feeding (EN 12442-2)
Historical documentation and decent traceability of cattle
Cattle younger than three years, appropriate for human nutrition
Cattle under veterinary control, BSE tested
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Sterilization & BSE Safety
Controlling the risk of contamination (bacteria, viruses, yeasts) by treating raw materials with:
- bactericidal solutions (sodium chloride, peracetic acid)
- saturated solution of calcium hydroxide (alkaline PH 12.5)
Gamma Irradiation of the final products
These procedures induce structural changes resulting in irreversible, non-toxic conformation of the prion protein.
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Certifications
All our products are CE and ISO certified.
Quality management ISO 13485:2012, ISO 9001:2009
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Contact US
Address: Friedrich-List-Str. 27D-35398 Giessen
Tel: +49 (0) 641- 6868 1123Fax: +49 (0) 641- 6868 1124
E-Mail: [email protected]: www.bioimplon.de