Methods in Enzymology

Volume 137

Immobilized Enzymesand Cells

Part D

Klaus Mosbach

CONTRIBUTORS TO VOLUME 137 Xi

PREFACE XVII

VOLUMES IN SERIES XX I

Section I . Analytical Applications with Emphasis on Biosensor s

1. Introduction

B . DANIELSSON ANDK . MOSBACH

3

A . Bioselective Electrodes

2. Enzyme Electrode Probes

GEORGE G . GUILBAULT

1 4

3 . Coupled Enzyme Reactions in Enzyme Electrodes FRIEDER W . SCHELLER ,Using Sequence, Amplification, Competition, REINHARD RENNEBERG, AN Dand Antiinterference Principles

FLORIAN SCHUBERT

2 9

4 . Industrial Applications of Enzyme Electrodes In- J . L . ROMETTE AN Deluding Instrumentation

D . THOMAS

44

5. Multienzyme Membrane Electrodes

KENTARO YoDA

6 1

6 . Long-Term Implantation of Voltammetric Oxi- LELAND C . CLARK, JR . ,dase/Peroxide Glucose Sensors in the Rat Peri- LINDA K . NoYES ,toncum

ROBERT B . SPOKANE ,RANJAN SUDAN, AN DMARIAN L . MILLER

6 8

7 . Amperometric Biosensors Based on Mediator- ANTHONY P. F . TURNER

9 0Modified Electrodes

8 . Immobilized Flavin Coenzyme Electrodes for An- LEMUEL B . WINGARD, JR.alytical Applications

AND KRISHNA NARASIMHAN 10 3

9. Bioaffinity Sensors

YOSHIHITO IKARIYAMA AN DMASUO AIZAWA

11 1

B. Hybrid, Cell, and Tissue Electrode s

10 . Microbial Sensors for Estimation of Biochemical MoTOHIKO HIKUMA AN DOxygen Demand and Determination of Gluta- TAKEO YASUDA

124mate

11 . Hybrid Biosensors for Clinical Analysis and Fer- ISAo KARUBE

13 1mentation Contro l

12 . Bioselective Membrane Electrodes Using Tissue GARRY A . RECHNITZ

13 8Materials as Biocatalysts

13 . Organelle Electrodes

FLORIAN SCHUBERT AN DFRIEDER W . SCHELLER

15 2

C . Bioluminescence-Immobilized System s

14 . Continuous-Flow Assays with Nylon Tube-Immo- ALDO RODA ,bilized Bioluminescent Enzymes

STEFANO GIROTTI ,SEVERINo GHINI, AN DGIACOMO CARREA

16 1

15 . Flow-Injection Analysis with Immobilized KALEvi KURKIJARVI ,Chemiluminescent

and

Bioluminescent PEKKA TURUNEN ,Columns

TIINA HEINONEN ,OUTI KOLHINEN ,RAIMO RAUNIO ,ARNE LUNDIN, ANDTIMO LÖVGREN

17 1

D . Thermistor Probe s

16 . Enzyme Thermistors

BENGT DANIELSSON AN DKLAUS MOSBACH

18 1

17 . Flow-Injection Analysis for Automated Determi- GEORG DECRISTOFORO

197nation of ß-Lactams Using Immobilized En-zyme Reactors with Thermistor or Ultraviole tSpectrophoto metric Detection

18 . Biomedical Applications of the Enzyme Thermis- IKUO SATOH

21 7for in Lipid Determinations

19 . Flow Enthalpimetric Determination of Glucose

NOBUTOSIn KIBA AN DN40TOHISA FURUSAWA

225

E. Enzyme Transistor s

20 . Use of Hydrogen- and Ammonia-Sensitive Semi- FREDRIK WINQUIST ,conductor Structures in Analytical Biochemis- BENGT DANIELSSON ,try : Enzyme Transistors

INGEMAR LUNDSTRÖM, ANDKLAUS MOSBACH

23 2

21 . Enzymatically Sensitive Field Effect Transistors STEVE CARAS AN DJIM JANATA

247

22 . Microenzyme Sensors

ISAo KARUBE ANDTOYOSAKA MORIIZUMI

255

F . Enzyme Reactors

23 . Use of Immobilized Enzyme Column Reactors in TAKASHI MuRACHI AN D

Clinical Analysis

MASAYOSHI TABATA

26 0

24 . Use of Immobilized Enzyme Reactors in Flow- MAT H . Ho

27 1

Injection Analysi s

25 . Routine Analysis with Immobilized Enzyme Ny- P . V . SUNDARAM

288

lon Tube Reactors

G. Continuous Monitorin g

26 . Enzyme Sensors for Fermentation Monitoring : SVEN-OLOF ENFORS ANDSample Handling

NEIL CLELAND

29 8

27 . Enzyme Thermistors for Process Monitoring and CARL FREDRIK MANDENIUSControl

AND BENGT DANIELSSON

30 7

28. Portable Continuous Blood Glucose Analyzer

HAKAN HAKANSON

31 9

29 . Needle-Type Glucose Sensor

MoTOAKI SHICHIRI ,RYuzo KAWAMORI, AN DYOSHIMITSU YAMASAKI

326

30 . Automated TELISA Procedure for Process Moni- STAFFAN BIRNBAUM ,

toring

LEIF BÜLow ,BENGT DANIELSSON, AN DKLAUS MOSBACH

33 4

H. Optical Methods

31. Solid-Phase Optoelectronic Biosensors

CHRISTOPHER R . LowE ANDMICHAEL J . GOLDFINCH

33 8

32. Optical Fiber Affinity Sensors

JEROME S . SCHULTZ AN DSOHRAB MANSOURI

349

33 . Surface-Oriented Optical Methods for Biomedical HANS ARWIN AN DAnalysis

INGEMAR LUNDSTRÖM

36 6

34. Surface Immobilization Techniques in Combina- ULF JÖNSSON ,tion with Ellipsometry

MAGNUS MALMQVIST ,GÖRAN OLOFSSON, AN DINGER RÖNNBERG

38 1

35 . Coupling of Biomolecuics to Silicon Surfaces for CARL FREDRIK MANDENIUS ,

Use in Ellipsometry and Other Related Tech- STEFAN WELIN ,

niques

INGEMAR LUNDS'I RÖM, AN DKLAUS MOSBACH

388

I . Miscellaneous New Technique s

36 . Construction of Dry Reagent Chemistries : Use of BERT WALTER

39 4Reagent Immobilization and Compartmentaliza-tion Technique s

37 . Mass Spectrometry Combined with Immobilized JAMES C . WEAVER

42 1Cells and Enzyme s

38 . Bioelectrocatalysis : Conductive and Semiconduc- S . D . VARFOLOMEEV

43 0tive Matrices for Immobilized Enzyme s

Section II . Medical Applications

39. Overview

KLAUS MOSBACH

443

40 . Medical Applications of Immobilized Proteins, T . M . S . CHANG

444Enzymes, and Cell s

41 . Extracorporeal Systems for Adsorption of Anti- CHRISTIAN FREIBURGHAUS ,

bodies in Hemophilia A and B

STEN OHLSON, AN D

INGA MARIE NILSSON

458

42 . Low Density Lipoprotein-Pheresis : Selective Im- T . S . PARKER AND

munoadsorption of Plasma Lipoproteins from J . F . STUDEBAKER

466Patients with Premature Atherosclerosi s

43 . Enzyme Reactors for the Removal of Amino GOTTFRIED SCHMER AN D

Acids from Plasma

WAYNE L . CHANDLER

479

44 . Dialysis Membranes Containing Asparaginase En- PETER EDMAN, ULF NYLfN ,

trapped in Microparticles

AND INGVAR SJ6HOLM

49 1

45 . Preparation of Protein A Immobilized on Collo- DAVID S . TERMAN

496dion-Coated Charcoal and Plasma Perfusio nSystem for Treatment of Cancer

46 . Immobilized Heparin Lyase System for Blood De- HOWARD BERNSTEIN ,

heparinization

VICTOR C . YANG ,

CHARLES L . COONEY, AN D

ROBERT LANGER

51 5

47. Clinical Applications of Urokinase-Treated Mate- TAKESHI OHSHIRO ,

rial

MOU CHUNG Liu ,JUNIcm KAMBAYASHI, AN D

TAKESADA MORI

52 9

48 . Application of Immobilized Enzymes for Biomate- SATOSIIi WATANABE ,

rials Used in Surgery

YASUHIKO SHIMIZU ,

TAKASHI TERAMATSU ,

TAKASHI MURACHI, AN D

TSUNETOSHI HINO

54 5

49 . Immobilized Enzymes for Thrombolytic Therapy V . P . TORCHI.IN ,

A . V . MAKSIMENKO, AND

A. V . MAZAEV

552

50 . Soluble Enzyme-Albumin Conjugates : New Pos- MARK J . POZNANSKY

56 6sibilities for Enzyme Replacement Therapy

51 . Microencapsulation of Pancreatic Islet Cells : A ANTHONY M . SUN

57 5Bioartificial Endocrine Pancrea s

Section III . Novel Techniques for and Aspects ofImmobilized Enzymes and Cell s

52. Overview

K . MOSBACH

58 3

53. Enzyme Stabilization by Immobilization

PIERRE MONSAN AN DDIDIER COMBES

58 4

54 . Stabilization of Pyranose 2-Oxidase and Catalase ZE ' EV SHAKED AN Dby Chemical Modification

SIDNEY WOLFE

599

55 . Stabilization of Enzymes by Intramolecular KAREL MARTINEK AN DCross-Linking Using Bifunctional Reagents

V . P . TORCHILIN

61 5

56 . Long-Term Stability of Nongrowing Immobilized LENA HÄGGSTRÖM AN D

Cells of Clostridium acetobutylicum Controlled CECILIA FÖRBERG

626by the Intermittent Nutrient Dosing Technique

57 . Production of Proinsulin by Entrapped Bacteria L . BüLow ,with Control of Cell Division by Inhibitors of S . BIRNBAUM, AN DDNA Synthesis

K . MOSBACH

63 2

58. Permeabilized and Immobilized Cells

HANSRUEDI FELIX

63 7

59. Cells Coimmobilized with Enzymes

BÄRBEL HAHN-HÄGERDAL

64 1

60. Affinity Immobilization

Bo MATTIASSON

647

61 . Bioconversions in Aqueous Two-Phase Systems : Bo MATTIASSON

65 7An Alternative to Conventional Immobilizatio n

62 . Biochemical Energy Conversion by Immobilized IsAO KARUBE AN DPhotosynthetic Bacteria

SHUICHI SuzuKI

668

63 . Immobilization of a Cytochrome P-450 Enzyme DAVID J . KING ,from Saccharomyces cerevisiae

MAHMOOD R . AZARI, AN DALAN WISEMAN

675

64 . Enzyme Production by Immobilized Cells

Yu-YEN LINKO, G .-X . LI ,LI-CHAN ZHONG ,SUSAN LINKO, AN DP . LINKO

686

65 . Application of Immobilized Captured Microorgan- J . D . BRYERS AND G . HAMER 697

isms in Water Purification : An Overview

AUTHOR INDEX 71 3

SUBJECT INDEX 731