d_r&d_6 liquid xenon detector technology workshop fjppl’07, 9-12 may 2007, kek, japan 3 ...
TRANSCRIPT
D_R&D_6 Liquid xenon detector technology
Workshop FJPPL’07, 9-12 May 2007, KEK, Japan
3 Medical Imaging with liquid xenon and 44Sc
Eric Morteau, Patrick Le Ray, Cyril GrignonNoel Servagent, Jean-Pierre CussonneauDominique Thers(Nantes)
Tom Haruyama (KEK)
Wednesday, 09 May 2007
1. 3 Medical Imaging : concept and motivation
2. 44Sc production at ARRONAX
3. Simulation and expected results with liquid xenon telescope
4. Liquid xenon technology
5. Expected schedule and Milestones
Positron Emission Tomography with + emitters
+ disintegration
L
Main incertitude on the emitter position : LOR length
1 mm5 mmLOR2D
~ 6 cm~ 30 cmL
Rat bodyHuman bodyTOF-PET (260 ps)
L ~ 9 cm T. Doke et al.
NIMA 569 (2006)
Sub-centimetre precision along the LOR achievable ?
Single detection with a Compton telescope
Measured Event quantities:
E1 = Energy lost by the scattered electron at the first hitx1,y1,z1 = First Interaction Location x2,y2,z2 = Second Interaction Location
E0
E1,x1,y1,z1
Known Event quantities:
E0 = Incident energy
Derived Event quantities:
E0 and E1 => scatter angle from Compton kinematics
x1, y1, z1 and x2, y2,,z2=> cone axis
)E(EE
Emc=θ 2
100
1 1cos
E2,x2,y2,z2
spatial resolution => axis of the cone
ray
Reconstructed direction: energy resolution => opening angle
LXeGRIT: E. Aprile et al. NIMA 480 (2002)
emitter
… 3 imaging
With a Compton telescope and a emitter …
Compton Telescope
LReconstructed cone:axis , opening angle
E0
1
2
- positron range- LOR2D - Compton Telescope
L related to
Which emitter ?Which Compton telescope ?
For which performances ?
E ~ 1 MeV
Only one
No background
Good for the Compton telescope
Ultra fast emission
Very precise time coincidence
Mean + energy: 632 keVMaximum + energy: 1474 keV
+ 94.3 %
A Compton telescope in association with a new radio-medicament
Other nuclides could be used, but 44Sc is the most promising …
44Sc, 44mSc and 47Sc productions at ARRONAXAccelerator for Research in Radiochemistry and Oncology in Nantes Atlantique
< 3570 - Fixed Alpha
5015 - 35Deuteron
< 5035 - fixed
< 35030 - 70Proton
Intensity
µA
Energy
MeV
Projectile
• 1 hall for high intensity• 1 experimental hall
F. Haddad et al.,To be published, ND2007 conf.
September 2008: first beam2009 : 44Sc et 44mSc production
2010 : 47Sc production
+ (Line Of Response) measured in a classical micro-PET
Liquid xenon Compton telescope 88 individual cells (3030120 mm3)
240 mm
240 mm120 mm
Micro-PET (LSO crystals): Transverse FOV: = 260 mmAxial FOV = 76 mm
Rat phantom (water): = 60 mmLength = 150 mm
148 mm
Simulation for the proof of concept with small animalPresent: Geant 4, Future: GATE (Subatech joined the collaboration in 2006)
Scpoint sourcepositron range, + acolinearity
isotropic emission for 3rd
3rd -ray measured in the Compton Telescope
Rat phantom
44Sc emitter
Compton Telescope
Micro-PET (LSO crystals)
XY slice
voxel: 222 mm3
Image
Rat phantom
+ LOR
cone
L ~ 2 mm
Absolute sensibility on 3th > 5%Angular resolution < 2° Maximum Flux per inch2 ~ 104 s-1
Activity in the field of view ~ 1 MBq
Keys characteristics for the Compton telescope :
Liquid xenon is the good technology
Liquid xenon technology : main physical properties
Liquid xenon :
Z = 54, ~ 3 kg/l 95 % Compton Interaction @ 1 MeV
Energy deposited in liquid xenon : Both light and charge conversion
Intrinsic scintillation due to dimer : 175 nm
For @ 2 kV/cm:Scintillation yield ~ 17000 UV/MeV Ionization yield ~ 55000 e-/MeV
Cryocooler
External cryostat
Internal cryostat
Prototype for the proof of concept and for the R&D
PMT
Micromeshes and Anode
Liquid xenon
Cathode Teflon
Entrance window
Cryogenic and xenon distribution will be presented by Tom
Liquid Xenon Compton Telescope Principle
3 x 3 cm2
Micromegas(micromesh +
anode)
12 cm
Cathode
LXe
PMT
44Sc -ray
1122
collection of e/i=> t1, E, x, y
TPC :z = (t0-t1) x vdrift
E UV
Z
XY
1 individual cell
e-
R&D for the TPC read-out …
detection of scintillation light => trigger time t0
R&D on UV detector
Amos Breskin et al., NIM A530(2004)258
Gas-Avalanche Charge induction
→ Choice before end of 2008
Collaboration founded by French Ministry for Foreign Affairs
R5900-06AL12S-ASSY
27mm
1 inch PMT :
HPD :
Developed by T.Doke et al.
for liquid xenon TOF-PET
Under discussion with PHOTONIS-DEP
G(Gaseous)PM :
In test inside the prototype from June 2007
R&D on ionization detector
cathode Conversion
anode
Ampli
12 cm
50 m
t0
t0
t1 t2
E1
E2
Micromesh
Spacer
511 keV
t0 t1 t2
E1 E2
(AU
)
Expected Induced current on anode without amplification
Induced current shape mostly independent of altitude
MICROMEGAS Y. Giomataris et al. NIMA376 (1996)
→ First tests in liquid xenon from June with unsegmented anode to check the liquid xenon purity
Associated electronic and anode segmentation :
→ Compton tracking in 2008
Adaptation of the IDEFIX chip, a low noise charge preamplifier for CdTe device
200 e- noise on (¼ inch)2 pixel ?
Schedule and Milestones
Proof of concept Expected Achievement
1/ Conception and design 2/ Liquefaction commissioning (next Tom’s talk)3/ First Signal and safety investigation4/ Liquid xenon light and charge yield measurement5/ Compton Tracking6/ R&D for the TPC read-out
July 2007Oct. 2007Feb. 2008End 2008
2006April 2007
Decision ~ 2010
3 Imaging dedicated to the Whole-Body and the Public Health, research or industrialization ?
Future
3 Imaging on Small Animal at the Ecole Nationale Vétérinaire de Nantes
First Image2009/2010
7/ Conception and design for the Small Animal8/ Whole Body simulation with GATE9/ Small Animal camera characterization
June 2008End 2008
2009
Small Animal Imaging Submission to FJPPL in 2008 ?