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Best Practice Sharing for Fighting COVID-19

March 2020

1

Confidential Information 2

Key Actions Taken and 0 Infection Among 5500+ Staff

1 A cross-functional operations team was established to coordinate the response across operational units and sites. This

team is led by Chris Chen, CEO, and Daily Operation Update Meeting.

2 An online tool has been developed from the onset to engage with each employee to self-report their location and health

status. Contacts have been established for all employees for efficient self-reporting and self-tracking.

3 Work closely with employees and local governments to ensure full compliance with local quarantine requirements, including

securing temporary accommodations.

4 Full salary coverage during employee quarantine time to discourage under-reporting and ensure a safe workplace for all

employees.

5 Secured masks and other PPE (Personal Protective Equipment) with daily distribution to employee to meet requirement to

wear a mask at all times.

6 Well trained EHS team with robust emergency response plan and publishing of employee handbook

7 Frequent disinfection of common spaces including HVAC, strict employee cross-building access and staggered work

schedule to decrease exposure risks.

9 Cafeteria reconfiguration executed to minimize transmission during meal time (maintaining 6-ft distance)

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Contractor/Visitor/Supplier Control: cancel all non-essential visits and tighten the management of all contractors with health

commitment letter required prior to visit.

8 Twice daily body temperature reporting and tracking, measuring temperature before entering the campus and café

Confidential Information 3

Cross-Functional Operations Team

MFG – Key Person

Quality – Key Person

Dev – Key Person

BID – Key Person

OU – Key Person

EHS

Sanitize Company areas

Staff Temperature

monitoring

Access control

Guidance for preventiveAdministration

Office Cleaning

Cafeteria & Lunch box

Shuttle Bus

Staff Dormitory

HR

Special HR Policy

Staff Q&A hotline

Employee caring

Government Affairs

Daily Policy Update

Official information

Work close with Gov.

IT

Online work support

VPN

App for reporting location

and temperature

Operation Team

Unit/Site Contacts

DEPARTMENT

Obey and

implement

Company

policy and

regulation

Collect

employee

information

Department

area sanitize

Quick Response

CEO

Confidential Information 4

Guidance for Preventive Actions - Commuting & Work Area C

om

mu

tin

g

Must know for staffs Preventive actions

• Prepare mask on the first day of work

• Try not to use public transportation

• Measure temperature before work; do not go to work and report to supervisor if

abnormalities are observed.

• Wear masks in vehicles, avoid touching objects using bare hands.

•

• Sanitize company shuttles with 75% bleach every day.

• Sanitation Log for Company Shuttle will be attached to the shuttle and maintained

by the driver.

Wo

rkA

rea • Take temperature before entering the company, wash hands after entering.

• During work hours, staffs should report to their supervisor if they need to leave

the work zone. After return, the staff will be asked to take his/her temperature

and wash hands again.

• Shuttle bus is recommended when traveling between different work zones

• Temperature will be taken before entering the company. Staffs with body

temperature above 37.2 ℃ are not allowed to enter the company and will be

advised to see the doctor.

• Sanitize public areas every day, such as foyers, hallways, meeting rooms,

elevators, stairways, bathroom and etc., using bleach or 75% ethanol (spray is

preferred)

Confidential Information 5

Guidance for Preventive Actions - Work AreaW

ork

Are

a

Must know for staffs Preventive actionsIn the elevator (high risk):

Wear mask; avoid touching elevator buttons with bare hands; wash hands

after coming out of the elevator

Dining Halls (high risk):

Do not take off your mask until eating; avoid taking a meal seating across

the table with each other; avoid talking while eating ; Wash hands after

dining.

Office (high risk):

• Wear mask; keep distance when talking; keep ventilation; EHS will provide

ethanol for staffs to clean the work area.

• Keep the work area tidy; ventilation is recommended 3 times a day.

• Keep one meter distance from your coworkers; avoid face to face

communication.

• Avoid touching door knobs or elevator buttons with a bare hand; wash

hands immediately if touched; drink adequate amount of water.

Meeting Room:

• Use online meeting if possible

• If face-to-face meeting is necessary, wear masks during the entire course

of meeting, wash hands before entering the meeting room

• Attendees need to sit one meters away from each other. Ventilate every

hour, if the meeting exceeds an hour.

• Sanitize the meeting room, furniture, office supplies after the meeting; tea

sets also need to be sanitized.

Sharing documents:

Wash your hands after delivery of documents; wear masks when reading

shared paper documents.

Physical exercise during break:

Moderate exercise is recommended.

Logistics:

• Sanitize public areas every day, such as foyers, hallways, meeting rooms, elevators, stairways,

bathroom and etc., using bleach or 75% ethanol.

• Provide liquid and solid hand soap in the bathroom

• Logistic staffs including security and janitors are required to wear masks during work and keep

adequate distance from others.

• Janitors will wear single-use rubber gloved and wash hands after work.

Sanitize public areas, labs, door knobs of bathrooms, printer surface, elevator buttons and other hot

spots using bleach or 75% ethanol, four times a day. Buttons on the water dispensers will be cleaned

once a day.

• Floor of public areas and bench tops will be mopped or wiped with sanitizer twice a day.

• Trash cans in the office area will be emptied timely every day and sanitized with sanitizer.

• Other trash cans will be cleaned daily. Trash disposal areas will be sanitized twice a day.

• Towel and mops will be sanitized with sanitizer after use in order to be reused.

Sanitation of ventilation systems:

A. HVAC

• The return air vent in the cleanroom will be sanitized with 75% ethanol every day.

• The engineering department will clean the air outlet of the CNC air conditioner with 75% ethanol

every day.

B. VRV air conditioner and other non-cleanroom air conditioner:

1) The engineering department will clean the ventilation system of VRV with 1:100-fold diluted bleach

every day.

2) For offices that are not in use, the engineering department will clean ventilation system of VRV

with 1:100-fold diluted bleach once. Those offices will be labels as “Not in use”. If those offices are

needed, the label will be removed, and the engineering department will be notified for daily

sanitization operation.

3) Bleach will be sprayed when opening VRV and other ventilation systems for sanitization.

Confidential Information 6

Guidance for Preventive Actions - Dining & LeaveD

inin

g

Must know for staffs Preventive actions

• Recommend staffs to come to dining halls at different time

intervals to avoid gathering.

• At the dining hall, do not take off your mask until eating. Avoid

taking a meal face to face across a table. Avoid talking while

eating and avoid gathering. Wash hands before and after eating.

Overall strategy:

• Recommend staffs to come to dining halls at different time intervals to avoid gathering.

• Sanitize the dining area at least once a day every day; sanitize the furniture and utensils.

• Sanitize the dining area at least once a day every day; sanitize the furniture and utensils.

• Keep the kitchen dry and tidy; put cooked and uncooked materials separately and especially

avoid mixture of raw meat.

• Tightly control the resource of food ingredients; use the appropriate purchasing channel.

• Recommend balanced menu

Leavin

g f

rom

Wo

rk • Before leave, wash hands and wear mask.

• On public transportation or company shuttle, wear a mask all the

time and avoid touching objects on the vehicle with bare hands as

much as possible.

• After taking off the mask upon arriving home, wash hands first

and then sanitize your cellphone and keys with 75% ethanol or

antiseptic wipes.

• Ventilate and keep tidy at home and; avoid gathering.

• Sanitize company shuttles with 75% bleach every day.

• Sanitation Log for Company Shuttle will be attached to the shuttle and maintained by the

driver.

Confidential Information 7

Wuhan Staff

Overall, less than 6% of our

staff have traveled to

Wuhan, transited through Wuhan,

or had contact with people coming

from Wuhan

Infected

No employee from WuXi Biologics has

been diagnosed with COVID-19 infection

Return to work

All three sites (Shanghai, Wuxi and Suzhou) resumed

operation on Feb 12th after the extended Chinese

New Year break

Rate of Return to Work

Approximately 97% of staff are already back to the cities in which they work. We have already resume normal operations

Employee Health Monitoring and Safe Workspace

Confidential Information

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01ACTION

02ACTION

03ACTION

Before Manufacturing

Before entering the GMP facility, each and every GMP staff is checked according to WuXi Bio’s policy on COVID related health and exposure history. Only authorized staff are allowed to enter GMP areas.

During Manufacturing

Each and every staff strictly perform temperature monitoring twice a day.

After Manufacturing

QA for all CB/DS/DP product release will verify whether there is any suspected and/ or confirmed cases (COVID-19) of personnel involved in GMP manufacturing and conduct impact assessment for product quality if required.

04ACTION

Quality Statement Issued

WuXi Bio will provide quality statement for each batch to certify that all of the personnel involved in the manufacturing and shipping are healthy as there is no suspected or confirmed cases of personnel involved in manufacturing and shipping contracting COVID-19 virus reported up to the date of shipment.

Cautious Quality Measures to Safeguard GMP Productions

Confidential Information 9

Human Resource Supply & Employee Morale

Established employee WeChat

groups to stay in touch with

employees to keep them updated

about government and company

policies and their situation

Adopted work-from-home + work-on-site

approach: ensure manageable population

on site, and gradually increase to its

normal state.

The Sr. Leaders meet daily

to assess needs and

reallocate resources to

ensure the continuity of

GMP manufacturing

We applied a dynamic 5-tiered

mechanism to identify low risk

employees to return to work

• 1st tier: employees who have been

working during the Chinese New Year

holiday break and can continue to work

• 2nd tier: didn’t leave work city and can

called back to work

• 3rd tier: cross-facility personnel support.

4th tier: employees who have returned

and completed 14 day quarantine

• 5th tier: employees in key positions

take expanded responsibilities

Confidential Information 10

Material Supply & General Requirements

Supply Chain

Work closely with Procurement, Quality and Manufacturing facilities

to put in place material supply emergency plans

Establish back-up supplier resources in case of supply interruption

work with government to obtain all kinds of permits to ensure smooth

domestic transportation of key materials

Maintain healthy inventory of key production materials and disease

protection materials

Production Facilities

Obtain materials from Supply

Chain department ahead of

time

Adjust the usage of masks to

reduce mask consumption

Employees

Required to take their temperatures

before they leave for work. If not

feeling well, recommend to stay at

home/work from home.

Avoid going to populated places

after work and during weekends

While on Site

While on site, wear masks all

the time, and not to touch

elevator buttons and door

knobs with bear hands.

Wash hands often and

thorough

Reduce movements and

contacts with colleagues.

Ensure the traceability of

one’s movements

Confidential Information 11

Customer Engagement

• The business Continuity Plan is well implemented during the outbreak with SOPs and risk mitigation strategies in place for potential disaster events

• Provided update to our global clients and investors on both Jan 29 2020 and Feb 11 2020

• “WuXi Biologics Provides Operation Update Related to the Coronavirus Outbreak” (https://www.wuxibiologics.com/wuxi-biologics-provides-operation-update-related-coronavirus-outbreak/)

• “WuXi Biologics Provides Back-to-work Operation Update Related to the Coronavirus Outbreak” (https://www.wuxibiologics.com/wuxi-biologics-provides-back-work-operation-update-related-coronavirus-outbreak/)

• Both PM and CMC leads for each individual project have done thorough project impact assessments and have been in active communications with clients throughout the outbreak for alignment on upcoming project execution plans. Our clients have expressed caring words and unanimous support for us to overcome these short term challenges

• Until the outbreak is under full control, we encourage clients to consider alternative approaches for information exchange instead of on-site visits

• We replaced Skype with Zoom to improve TC quality and are developing software supporting remote PIP and virtual site tour

Confidential Information 12

Join the Fight Against COVID-19

WuXi Biologics and its employees have made donations and carried out rescue work in

response to the coronavirus outbreak. In total, one million RMB was donated, and

much needed medical supplies were received by Wuhan hospitals

WuXi Biologics has already mobilized a large team of more than 240 scientists and is

working closely with global organizations to develop and manufacture multiple

neutralizing antibodies to potentially treat the viral infection

Link

A 3-hour global virtual forum entitled “Let Science Lead: A Special Online Forum on

COVID-19” was co-hosted with 5800+ participated on-line. Video recording can be found

from HERE.