ards management
TRANSCRIPT
ARDS MANAGEMENT
SAMIR EL ANSARYICU PROFESSOR
AIN SHAMSCAIRO
Global Critical Carehttps://www.facebook.com/groups/1451610115129555/#!/groups/1451
610115129555/ Wellcome in our new group ..... Dr.SAMIR EL ANSARY
Pulmonary capillary leak
Inactivation of surfactant
Interstitial & alveolar edema
Severe & refractory hypoxemiaSHUNTING - Stiff lungs
Alveolar atalectasis
Damage to alveolar capillary membrane
DIFFUSE lung injury
CAUSES
Early pathologic features of ARDS • Diffuse alveolar damage (DAD)
• There is minimal alveolar septal thickening, hyperplasia of pneumocytes
• Eosinophilic hyaline membranes present
Links Between VILI and MSOF
Biotrauma and Mediator Injuries
What does surfactant do?
Alveoliwithout
surfactant
Alveoliwith
surfactant
Cyanosis
Pao2 / Fio2 < 200REFRACTORY HYPOXEMIA
Gas Extravasation Barotrauma
1
A Portal for Gas & Bacteria?
Microvascular Fracture in ARDS
Excessive PEEP, particularly in combination with hypovolemia, can decrease cardiac output and
oxygen delivery, and increase the risk of barotrauma
Subcutaneous emphysema
CT scan showed Severe surgical emphysema and pneumomediasteum
Diseased Lungs Do Not Fully Collapse,Despite Tension Pneumothorax
…and
They cannot always be fully “opened”
Dimensions of a fully Collapsed Normal Lung
Tension Cysts
Spectrum of Regional Opening Pressures (Supine Position)
Superimposed Pressure Inflated 0
Alveolar Collapse(Reabsorption) 20-60 cmH2O
Small AirwayCollapse
10-20 cmH2O
Consolidation Lung Units at Risk for Tidal Opening & Closure
=
OpeningPressure
How Much Collapse Depends on the Plateau
R = 100%
20
60
100
Pressure [cmH2O]20 40 60
Tota
l Lun
g C
apac
ity [%
]
R = 22%
R = 81%R = 93%
00R = 0%
R = 59%
Some potentially recruitable units open only at high pressure
More Extensive Collapse But Lower PPLAT
Less Extensive Collapse But Greater PPLAT
Mechanical Ventilator
PRESSURE VOLUME CURVE
Recruitment Maneuvers (RMs)
Proposed for improvingArterial oxygenation
Enhancing alveolar recruitment
All consisting of short-lasting increases in intrathoracic pressures
Recruitment Maneuvers (RMs)
–Vital capacity maneuver (inflation of the lungs up to 40 cm H2O,
maintained for 15 - 26 seconds)
–Intermittent sighs–Extended sighs
Recruitment Maneuvers (RMs)
–Intermittent increase of PEEP–Continuous positive airway pressure
(CPAP)–Increasing the ventilatory pressures to a
plateau pressure of 50 cm H2O for 1-2 minutes
Other manoeuvres
• Prone positioning ventilation• Prolonged inspiration
• Inverse ratio ventilation
Limit of open lung strategy
• To minimise VILI
to the less damaged alveoli
Max insp pressure
(plateau pressure 30-32cm H20)
Limit of open lung strategyMax pressure remains unchanged
TV will decreaseAlveolar ventilation will decrease
Alv V: dead space vent ratiowill decrease
Increasing PaCO2
• Management options
Increase resp rateMinute volume
Delivered TV TV ml/kg Resp rate
6.4 L 640 ml 8 10
6.4 L 480 ml 6 14
6.4 L 320 ml 4 20
6.4 L 160 ml 2 40
Anatomical dead space 150ml
Increasing PaCO2
• Permissive hypercapnia
• Tracheal gas insuflation
•Reduce•dead space
Increasing PaCO2As alveolar ventilation decreases
will require increasing FIO2
Otherwise will result
in alveloar hypoxia and arterial hypoxaemia
Liquid Ventilation
More clinical trials are req. to demonst. efficacy.
• Inert• No odor• No color• Low surface tension• Carry large amount of O2 & CO2
Perfluorocarbon (PFC)
Medication: Morphine sulfate
(0.1mg/kg/dose), pavulon (0.1 mg/kg/dose)
Rimar (30 ml/kg)Ventilation settings:
Ti 5 sec, hold 10 sec, Te 5 sec (3-6 cycles/min)
CO2 eleminated by increase tidal volume
O2 managed by change O2 content and FRC
ON START OF GAS VENTILATION
ONE HOUR AFTER PLV
48 HOUR AFTER PLV 3 WEEKS AFTER PLV
Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome
High-frequency Oscillatory Ventilation
• Active expiration Pressurised circuit
High-frequency Ventilation
35cm H20 90 cm
3-9 hz0.1-3ml/kg
43
Pressure transmission HFOV
P
T
proximal
trachea
alveoli
Due to the attenuation of the pressure wave
by the time it reaches the alveolar region
it is reduced down to .1 - 5 cmH2O
BRONCHOTRONVENTILATOR
CONVENTIONAL ( = LOW FREQUENCY )
VENTILATION UNIT
PULSATION ( = HIGH FREQUENCY )
VENTILATION UNIT
However …Risks of barotrauma and hemodynamic compromise with high frequency ventilation can approximate those of conventional ventilation
KINETIC THERAPY
MEDISCUS AIR CUSHION BED PULMONAIR
MEDISCUS TRAUMA BED ROTOREST
APPLICATION OF SURFACTANT
CUROSURF - SURVANTA
ALVEOLFACT50 – 200 mg/kgBW
BY ENDOTRACHEAL OR ENDOBRONCHIAL ROUTE
APPLICATION OF SURFACTANT
• PREVENT END-EXPIRATORY COLLAPSE OF ALVEOLI
• RECRUITMENT OF ATELECTATIC LUNG AREAS
• IMPROVED COMPLIANCE• IMPROVED OXYGENATION• IMPROVED VENTILATION /PERFUSION
RATIO
SECRETION ELEMINATIONVIA IPPB
• BETTER DISTRIBUTION OF MEDICATED AEROSOLS
• BRONCHOSPASMOLYTIC• IMPROVED OXYGENATION• SECRETOLYSIS
JET THERAPY
• SECRETOLYSIS ( SECRETION MOBILISATION )• DISSOLUTION OF RESORPTIVE ATELECTASES• IMPROVED OXYGENATION• INTRACRANIAL PRESSURE REDUCTION
CLINI – JET HIGH FREQUENCY JET VENTILATION
HFJV
HANDY INSTRUMENTPRODUCES SHORT
GAS PULSES
FOR SECRETOLYSIS
DISSOLVE SECRETIONS ( KETCHUP EFFECT )
INCENTIVE SPIROMETRYSUSTAINED MAXIMAL INSPIRATION
• ALVEOLAR RECRUITMENT• PREVENTION OF ATELECTASES• MUSCLE TRAINING• COUGH PROVOCATION• IMPROVED OXYGENATION AND VENTILATION
Dilates pulmonary blood vessels and
helps reduce shunting
REDUCTION IN INTRAPULMONARY R-L SHUNT
Nitric Oxide
GOOD LUCK
SAMIR EL ANSARYICU PROFESSOR
AIN SHAMSCAIRO
Global Critical Carehttps://www.facebook.com/groups/1451610115129555/#!/groups/145161011512955
5/ Wellcome in our new group ..... Dr.SAMIR EL ANSARY