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Acute Respiratory Distress Acute Respiratory Distress Syndrome. Syndrome. Case presentation Case presentation Dr. Adel Hassan Sen. Consult. Anesthesiologist HOD Anesthesia & ICU. Kalba Hospital, MOH. 31 st March 2014

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Lungs might be affected by trauma, chemicals, infections. patients show in respiratory failure.

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Page 1: ARDS - trauma

Acute Respiratory Distress Syndrome.Acute Respiratory Distress Syndrome.Case presentationCase presentation

Dr. Adel HassanSen. Consult. Anesthesiologist

HOD Anesthesia & ICU. Kalba Hospital,

MOH.

31st March 2014

Page 2: ARDS - trauma
Page 3: ARDS - trauma

F. 35ys , 300 Kgs, Lt. TIBIA/FIBULA Fx (Impacted In place).8th D -in pat. w.- after admission, sudden severe hypoxia PH 7.22 PaCO2 =72 mmhg PaO2=43 mmhg HCO36 , Unconscious.

Anesthesia on duty was called to IPW. Supported ventilation shifted pt. to ICU. Management started as will be discussed later.

Page 4: ARDS - trauma

Acute Respiratory FailureAcute Respiratory Failure

• Failure in one or both gas exchange functions: oxygenation and carbon dioxide elimination

• In practice:

PaO2<60mmHg or PaCO2>46mmHg

• Derangements in ABGs and acid-base status

Page 5: ARDS - trauma

Acute Respiratory FailureAcute Respiratory Failure

• Hypercapnic v Hypoxemic respiratory failure

• ARDS and ALI

Page 6: ARDS - trauma

Hypercapnic Respiratory FailureHypercapnic Respiratory Failure

(PAO2 - PaO2)

Alveolar Hypoventilation

V/Q abnormality

PI max

increasednormal

Nl VCO2

PaCO2 >46mmHgNot compensation for metabolic alkalosis

CentralHypoventilation

NeuromuscularProblem

VCO2

V/Q Abnormality

HypermetabolismOverfeeding

Page 7: ARDS - trauma

Hypercapnic Respiratory FailureHypercapnic Respiratory Failure

(PAO2 - PaO2)

Alveolar Hypoventilation

V/Q abnormality

PI max

increasednormal

Nl VCO2

PaCO2 >46mmHgNot compensation for metabolic alkalosis

CentralHypoventilation

NeuromuscularProblem

VCO2

V/Q Abnormality

HypermetabolismOverfeeding

Page 8: ARDS - trauma

Hypercapnic Respiratory FailureHypercapnic Respiratory Failure

Alveolar Hypoventilation

Brainstem respiratory depression Drugs (opiates) Obesity-hypoventilation syndrome

PI max

CentralHypoventilation

NeuromuscularDisorder

nlPI max

Critical illness polyneuropathyCritical illness myopathy

HypophosphatemiaMagnesium depletion

Myasthenia gravisGuillain-Barre syndrome

Page 9: ARDS - trauma

Hypercapnic Respiratory FailureHypercapnic Respiratory Failure

(PAO2 - PaO2)

Alveolar Hypoventilation

V/Q abnormality

PI max

increasednormal

Nl VCO2

PaCO2 >46mmHgNot compensation for metabolic alkalosis

CentralHypoventilation

NeuromuscularDisorder

VCO2

V/Q Abnormality

HypermetabolismOverfeeding

Page 10: ARDS - trauma

Hypercapnic Respiratory FailureHypercapnic Respiratory Failure

V/Q abnormalityIncreased Aa gradient

Nl VCO2

VCO2

V/Q Abnormality

HypermetabolismOverfeeding

Page 11: ARDS - trauma

Hypercapnic Respiratory FailureHypercapnic Respiratory Failure

V/Q abnormalityIncreased Aa gradient

Nl VCO2

VCO2

V/Q Abnormality

HypermetabolismOverfeeding

• Increased dead space ventilation• advanced emphysema• PaCO2 when Vd/Vt >0.5

• Late feature of shunt-type• edema, infiltrates

Page 12: ARDS - trauma

Hypercapnic Respiratory FailureHypercapnic Respiratory Failure

V/Q abnormalityIncreased Aa gradient

Nl VCO2

VCO2

V/Q Abnormality

HypermetabolismOverfeeding

• VCO2 only an issue in pts with ltd ability to eliminate CO2

• Overfeeding with carbohydrates generates more CO2

Page 13: ARDS - trauma

Hypoxemic Respiratory FailureHypoxemic Respiratory Failure

Is PaCO2 increased?

Hypoventilation (PAO2 - PaO2)?

Hypoventilation alone

Respiratory driveNeuromuscular dz

Hypovent plus another

mechanism

Shunt

Inspired PO2

High altitudeFIO2

(PAO2 - PaO2) No

NoYes

Is low PO2 correctable

with O2?

V/Q mismatch

No Yes

Yes

Page 14: ARDS - trauma

The Case of Patient ESThe Case of Patient ES

77F s/p MVC. Injuries include multiple L rib fxs, L hemopneumothorax s/p chest tube placement, L iliac wing fx. PMH: atrial arrhythmia, on coumadin. INR>2

HD#1 RR 30s and shallow. Pain a/w breathing deeply.Placed on BiPAP overnight

PID#1BiPAP 80%: 7.45/48/66/32/+10

Page 15: ARDS - trauma

Hypoxemic Respiratory FailureHypoxemic Respiratory Failure

Is PaCO2 increased?

Hypoventilation (PAO2 - PaO2)?

Hypoventilation alone

Respiratory driveNeuromuscular dz

Hypovent plus another

mechanism

Shunt

Inspired PO2

High altitudeFIO2

(PAO2 - PaO2) No

NoYes

Is low PO2 correctable

with O2?

V/Q mismatch

No Yes

Yes

Page 16: ARDS - trauma

Hypoxemic Respiratory FailureHypoxemic Respiratory Failure

V/Q mismatch

V/Q mismatch DO2/VO2 Imbalance

PvO2>40mmHg PvO2<40mmHg

DO2: anemia, low COVO2: hypermetabolism

Page 17: ARDS - trauma

Hypoxemic Respiratory FailureHypoxemic Respiratory Failure

V/Q mismatch

SHUNTV/Q = 0

DEAD SPACEV/Q = ∞

AtelectasisIntraalveolar filling Pneumonia Pulmonary edema

Pulmonary embolusPulmonary vascular dzAirway dz (COPD, asthma)

Intracardiac shuntVascular shunt in lungs

ARDSInterstitial lung dzPulmonary contusion

Page 18: ARDS - trauma

Hypoxemic Respiratory FailureHypoxemic Respiratory Failure

V/Q mismatch

SHUNTV/Q = 0

DEAD SPACEV/Q = ∞

AtelectasisIntraalveolar filling Pneumonia Pulmonary edema

Pulmonary embolusPulmonary vascular dzAirway dz (COPD, asthma)

Intracardiac shuntVascular shunt in lungs

ARDSInterstitial lung dzPulmonary contusion

Page 19: ARDS - trauma

Hypoxemic Respiratory FailureHypoxemic Respiratory Failure

Acute Respiratory Distress Syndrome

• Severe ALI• B/L radiographic

infiltrates• PaO2/FiO2 <200mmHg

(ALI 201-300mmHg)• No e/o L Atrial P;

PCWP<18

Page 20: ARDS - trauma

Hypoxemic Respiratory FailureHypoxemic Respiratory Failure

Acute Respiratory Distress Syndrome

• Develops ~4-48h• Persists days-wks• Diagnosis:

– Distinguish from cardiogenic edema

– History and risk factors

Page 21: ARDS - trauma
Page 22: ARDS - trauma

Inflammatory Alveolar Injury

Page 23: ARDS - trauma

Inflammatory Alveolar Injury

Pro-inflmm cytokines (TNF, IL1,6,8)

Page 24: ARDS - trauma

Inflammatory Alveolar Injury

Pro-inflmm cytokines (TNF, IL1,6,8)

Neutrophils - ROIs and proteases damage capillary endothelium and alveolar epithelium

Page 25: ARDS - trauma

Inflammatory Alveolar Injury

Fluid in interstitium and alveoli

Pro-inflmm cytokines (TNF, IL1,6,8)

Neutrophils - ROIs and proteases damage capillary endothelium and alveolar epithelium

Page 26: ARDS - trauma

Inflammatory Alveolar Injury

Fluid in interstitium and alveoli

• Impaired gas exchange Compliance PAP

Pro-inflmm cytokines (TNF, IL1,6,8)

Neutrophils - ROIs and proteases damage capillary endothelium and alveolar epithelium

Page 27: ARDS - trauma

Hypoxemic Respiratory FailureHypoxemic Respiratory Failure

Acute Respiratory Distress Syndrome

Exudative phase Fibrotic phaseProliferative phase

Diffuse alveolar damage

Page 28: ARDS - trauma

Hypoxemic Respiratory FailureHypoxemic Respiratory Failure

Acute Respiratory Distress Syndrome

Direct Lung Injury• Infectious pneumonia• Aspiration, chemical pneumonitis• Pulmonary contusion, penetrating lung injury• Fat emboli• Near-drowning• Inhalation injury• Reperfusion pulmonary edema s/p lung transplant

Page 29: ARDS - trauma

Hypoxemic Respiratory FailureHypoxemic Respiratory Failure

Acute Respiratory Distress Syndrome

Indirect Lung Injury• Sepsis• Severe trauma with shock / hypoperfusion• Burns• Massive blood transfusion• Drug overdose: ASA, cocaine, opioids, phenothiazines, TCAs. • Cardiopulmonary bypass• Acute pancreatitis

Page 30: ARDS - trauma

Hypoxemic Respiratory FailureHypoxemic Respiratory Failure

Acute Respiratory Distress Syndrome

Complications• Barotrauma

• Nosocomial pneumonia

• Sedation and paralysis persistent MS depression and neuromuscular weakness

Page 31: ARDS - trauma

Hypoxemic Respiratory FailureHypoxemic Respiratory Failure

Acute Respiratory Distress Syndrome

• 861 patients, 10 centers• Randomized• Tidal Vol 12mL/kg PDW,

PlatP<50cmH2O• Tidal Vol 6mL/kg PDW,

PlatP<30cmH2O• NNT 12

• 31% mortality v 39.8%• 65.7% breathing without assistance by day 28 v 55%• Significantly more ventilator-free days• Significantly more days without failure of nonpulmonary

organs/systems