Look Up>Drugs>Clomiphene

Clomiphene

Pronunciation

U.S. Brand Names

Generic Available

Synonyms

Pharmacological Index

Use

Pregnancy Risk Factor

Contraindications

Warnings/Precautions

Adverse Reactions

Drug Interactions

Stability

Mechanism of Action

Pharmacodynamics/Kinetics

Usual Dosage

Reference Range

Test Interactions

Mental Health: Effects on Mental Status

Mental Health: Effects on Psychiatric Treatment

Dental Health: Local Anesthetic/Vasoconstrictor Precautions

Dental Health: Effects on Dental Treatment

Patient Information

Nursing Implications

Dosage Forms

References

Pronunciation

(KLOE mi feen)

U.S. Brand Names

Clomid; Milophene; Serophene

Generic Available

No

Synonyms

Clomiphene Citrate

Pharmacological Index

Ovulation Stimulator

Use

Treatment of ovulatory failure in patients desiring pregnancy

Pregnancy Risk Factor

X

Contraindications

Hypersensitivity or allergy to clomiphene citrate or any of its components; liver disease, abnormal uterine bleeding, suspected pregnancy, enlargement or development of ovarian cyst, uncontrolled thyroid or adrenal dysfunction in the presence of an organic intracranial lesion such as pituitary tumor

Warnings/Precautions

Patients unusually sensitive to pituitary gonadotropins (eg, polycystic ovary disease); multiple pregnancies, blurring or other visual symptoms can occur, ovarian hyperstimulation syndrome, and abdominal pain

Adverse Reactions

>10%: Endocrine & metabolic: Hot flashes, ovarian enlargement 1% to 10%: Cardiovascular: Thromboembolism Central nervous system: Mental depression, headache Endocrine & metabolic: Breast enlargement (males), breast discomfort (females), abnormal menstrual flow Gastrointestinal: Distention, bloating, nausea, vomiting, hepatotoxicity Ocular: Blurring of vision, diplopia, floaters, after-images, phosphenes, photophobia 95% to albumin and -glycoprotein Metabolism: Extensive first pass metabolism Bioavailability: ~2% Half-life: 27.7-32.5 hours Elimination: Primarily in the feces and 0.2% renal

Usual Dosage

Adults: Female: Oral: 60 mg/day which may be administered any time of the day without regard to meals

Monitoring Parameters

Radiologic evaluation of bone mineral density (BMD) is the best measure of the treatment of osteoporosis; to monitor for the potential toxicities of raloxifene, complete blood counts should be evaluated periodically.

Mental Health: Effects on Mental Status

May cause insomnia or depression

Mental Health: Effects on Psychiatric Treatment

None reported

Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions

Dental Health: Effects on Dental Treatment

No effects or complications reported

Patient Information

May be taken at any time of day without regard to meals. This medication is given to reduce incidence of osteoporosis; it will not reduce hot flashes or flushing. You may experience flu-like symptoms at beginning of therapy (these may resolve with use). Mild analgesics may reduce joint pain. Rest and cool environment may reduce hot flashes. Report fever; acute migraine; insomnia or emotional depression; unusual weight gain; unresolved gastric distress; urinary infection or vaginal burning or itching; chest pain; or swelling, warmth, or pain in calves. Pregnancy/breast-feeding precautions: Inform prescriber if you are pregnant. Do not breast-feed.

Dosage Forms

Tablet, as hydrochloride: 60 mg

Danazol

Pronunciation

U.S. Brand Names

Generic Available

Canadian Brand Names

Pharmacological Index

Use

Pregnancy Risk Factor

Contraindications

Warnings/Precautions

Adverse Reactions

Drug Interactions

Mechanism of Action

Pharmacodynamics/Kinetics

Usual Dosage

Mental Health: Effects on Mental Status

Mental Health: Effects on Psychiatric Treatment

Dental Health: Local Anesthetic/Vasoconstrictor Precautions

Dental Health: Effects on Dental Treatment

Patient Information

Nursing Implications

Dosage Forms

References

Pronunciation

(DA na zole)

U.S. Brand Names

Danocrine

Generic Available

No

Canadian Brand Names

Cyclomen

Pharmacological Index

Androgen

Use

Treatment of endometriosis, fibrocystic breast disease, and hereditary angioedema

Pregnancy Risk Factor

X

Contraindications

Undiagnosed genital bleeding, hypersensitivity to danazol or any component; pregnancy

Warnings/Precautions

Use with caution in patients with seizure disorders, migraine, or conditions influenced by edema; impaired hepatic, renal, or cardiac disease, pregnancy, lactation

Adverse Reactions

>10%: Cardiovascular: Edema Dermatologic: Oily skin, acne, hirsutism Endocrine & metabolic: Fluid retention, breakthrough bleeding, irregular menstrual periods, decreased breast size Gastrointestinal: Weight gain Hepatic: Hepatic impairment Miscellaneous: Voice deepening 1% to 10%: Endocrine & metabolic: Virilization, androgenic effects, amenorrhea, hypoestrogenism Neuromuscular & skeletal: Weakness