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    Anatomy and Physiology Chapter

    #3

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    3.1 Introduction Cells vary considerable in size, shape,

    and function.

    The shape of cells in the body varybased on their function.

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    3.2 Composite Cell Because cells vary so greatly in size,

    shape, content, and function, describing

    a typical cell is impossible.All of the structures described in the

    composite cell can NOTbe found inevery cell regardless of function.

    The organelles are found in thecytoplasm of the cell.

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    Cell Organelles1. Cell Membrane

    2. Cytoplasm

    3. Endoplasmicreticulum (ER)

    4. Ribosomes

    5. Golgi Apparatus

    6. Mitochondria7. Lysosomes

    8. Peroxisomes

    9. Microfilaments andMircotubules

    10.

    Centrosomes11. Cilia and flagella

    12. Vesicles

    13. Nucleus

    14. Nuclear envelope15. Nucleolus

    16. Chromatin

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    Cell Membrane Extremely thin and semipermeable. The cell membrane contains many kinds of proteins,

    each with a special function.

    Function: The membrane allows some substances toenter and leave the cell but not others, participates insignal transduction, and helps cells adhere to othercells. The membrane forms a boundary around thecellular contents,, and the basic structure of the cell

    membrane is a lipid-protein bilayer. Structure: The basic framework of the cell membrane

    consists of a (bilayer) double layer of phospholipid,with fatty acid tails turned in.

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    Cell Memebrane The Phosphate Head is HYDROPHILIC

    meaning "WATER

    LOVING". Because of its hydrophilicnature, the head of a Phospholipid willorient itself so that it is as close aspossible to water molecules.

    The Lipid Tails are HYDROPHOBICmeaning "WATER-FEARING", theHydrophobic tails will tend to orientthemselves away from water.

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    Cytoplasm The cytoplasm consists of a clear liquid

    called cytosol, a supportive

    cytoskeleton, and networks ofmembranes and organelles.

    Cell activities occur mainly in the

    cytoplasm, where nutrients arereceived, processed, and used.

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    Endoplasmic Reticulum ER is made up of membrane-bounded flatten

    sacs and elongated canals. ER provides atubular transport system inside the cell.

    Rough ER: Has ribosomes on its outer layerWhat does it function in the synthesis andtransport of? PROTEIN

    Smooth ER: No ribosomes. What does it

    function in the transport of? LIPIDS Vesicles that have a role in secretion are

    formed by the ER.

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    Ribosomes They are found in the cytoplasm and ER

    They composed of Protein and RNAmolecules.

    Function is protein synthesis.

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    Popeye is active because he eats spinach.

    However, for Popeye's cellsto be active, hisribosomes help create proteins.

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    Golgi Apparatus They are composed of about 6 flattened,

    membranous sacs.

    Function is to refine, package, and deliverproteins synthesized on ribosomes, and itpackages the cells products.

    Vesicles that have a role in secretion are

    formed by the golgi apparatus (and ER). Plays a central role in the transport of new

    molecules from inside to outside the cell.

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    Mitochondria

    Is the POWERHOUSEof the cell andcontain enzymes that catalyze reactions

    that release energy from nutrientsneeded for aerobic respiration.

    Enzyme is a protein that catalyzes a

    specific biochemical reaction.Adenosine Triphosphate(ATP) energy.

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    Lysosomes

    The "garbage disposals of the cell

    They contain powerful enzymes to

    break up old cell components andbacteria. Example white blood cells canengulf bacteria to fight bacterial

    infections.

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    Peroxisomes

    Membranous sacs are abundant in liverand kidney cells.

    They contain enzymes that function inthe synthesis of bile acids, breakdownof lipids, degradation of rare

    biochemicals, and detoxification ofalcohol.

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    Microfilaments andmicrotubules

    Thin, threadlike processes within thecytoplasm that function in various kinds of

    cell movement and that serve as thecytoskeleton of the cell.

    Microfilaments, made of the protein actin,cause various cellular movements.

    Mictotubules, made of the globular proteintubulin. Form 9+2 pattern.

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    Centrosome

    is a structure made up of two hollowcylinders called centrioles.

    Function in cell reproduction.

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    Cilia and flagella

    They are motile extensions from thecell.

    Cilia is short and move to-and-fro. Cilia function is to move fluids.

    Flagella are longer and move in an

    undulating wavelike motion. What is the only flagellated cell in the

    body? SPERM

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    Vesicles

    Or vacuolesare formed by part of thecell membrane.

    They contain some liquid or solidmaterial formerly outside the cell.

    Golgi and ER also form vesicles.

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    Nucleus, nuclear envelope

    Is bounded by a double-layered nuclearmembrane (nuclear envelope)

    containing relatively large nuclear poresthat allow the passage of certainsubstances.

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    Nucleolus

    Is a small, dense body composedmainly of RNA.

    Has no surrounding membrane.

    Ribosomesform in the nucleolus.

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    Chromatin

    Consist of loosely coiled fibers of DNAand protein called chromosomes.

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    3.3 Movements through cellmembranes

    Passivemechanisms do not

    require energy.1. Diffusion

    2. Facilitated diffusion

    3.

    Osmosis4. Filtration

    Active mechanismsrequire cell energy.

    1. Active transport

    2. Endocytosis

    3. Exocytosis

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    Passive

    Diffusion is the process by whichmolecules or ions scatter or spread

    spontaneously from high concentrationto low concentration.

    Oxygen and carbon dioxide can diffuse

    readily through the cell membrane. Equilibrium is reached.

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    Passive

    Substances that are not able to passthrough the lipid bilayer need the help

    of membrane proteins to get across,this is called facilitated diffusion.

    Carrier moleculesrevolving doorsare

    used to carry large molecules (glucose)across the membrane.

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    Passive

    Osmosis is the diffusion of water.

    Solutions with a higher osmotic

    pressure than body fluids are calledhypertonic.

    Solutions with a osmotic pressure equal

    to body fluids are called isotonic. Solutions with a lower osmotic pressure

    than body fluids are called hypotonic.

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    Passive

    When fluid is forced through amembrane by hydrostatic or blood

    pressure, the mechanism is calledfiltration.

    Edemaexcess tissue fluid.

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    Active

    Active transport is a process that movesparticles through membranes from a

    region of low concentration to highconcentration.

    Equilibrium is never reached.

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    Active

    In endocytosismolecules that are too large to betransported by other means are engulfed by portionof the cell membrane and carried intothe cell

    surrounded by a vesicle.

    1. Pinocytosisis a form in which cells engulf liquids.

    2. Phagocytosisis a form in which the cell takes in

    larger particles, such as a white blood cell engulfinga bacterium.

    3. Receptor-mediated is a form in which receptorsbind specific particles, and they are drawn into thecell.

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    The reverse to endocytosis isexocytosis.

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    3.4 The Cell Cycle

    The series of changes a cell undergoes fromthe time it is formed until it reproduces iscalled the cell cycle.

    The cell cycle is highly regulated. Most cellsdo not divide continually. Cells have amaximum number of times they candivide because of built-in clocks calledtelomeres on the tips of chromosomes.

    Mitosiscell division to form new cells (bodycells).

    Meiosiscell division that forms sex cells(gametes).

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    Mitosis (IPMAT)

    1. Interphase

    2. Prophase

    3. Metaphase

    4. Anaphase

    5. Telophase

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    Mitosis

    Interphase is a period of great metabolicactivity in which the cell grows and

    synthesizes new molecules and organelles.During the S phase of interphase, the DNA ofthe cell is replicated in preparation for celldivision.

    Prophasechromosomes and centriolesbecome visible and the nuclear envelope andthe nucleolus disappear.

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    Metaphasethe chromosomes line up in themiddle of the cell. Spindle fibers are

    connected to the centromeres of eachchromosome.

    Anaphasecentromeres are pulled apart andchromosomes move in opposite directions.

    Telophasechromosomes change back intochromatin. Nuclear envelope and nucleolusre-form. Cell membrane pinches.

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    Cytokinesisis the division of cytoplasm.

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    Cell Death

    Apoptosisis a form of cell death that isactually a normal part of development,

    sculpting organs from overgrown tissues. In the fetus, apoptosis carves away webbing

    between developing fingers and toes.

    Apoptosis follows a sunburn it peels away

    cells so damaged that they might otherwiseturn cancerous.

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    Cancer

    Cancer cells spread to distant areas(metastasize), display excessive

    growth (hyperplasia), and exhibitproperties found in earlier stages(de-differentiation).

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    Work Cited

    Golgi apparatus image.www.sirinet.net/~jgjohnso/cell.html Mitochondria man image.

    www.mitochondria.us/pages/rebep_main.html Mitochondria image.

    www.mitochondria.us/pages/rebep_main.html Cell image.

    www.merck.com/media/mmhe2/figures/fg001_2.gif

    ER image. www.science.siu.edu/plant-biology/PLB117/JPEGs%20CD/0073.JPG Ribosome image.

    //anthro.palomar.edu/biobasis/bio_5.htm

    http://www.sirinet.net/~jgjohnso/cell.htmlhttp://www.mitochondria.us/pages/rebep_main.htmlhttp://www.mitochondria.us/pages/rebep_main.htmlhttp://www.mitochondria.us/pages/rebep_main.htmlhttp://www.mitochondria.us/pages/rebep_main.htmlhttp://www.merck.com/media/mmhe2/figures/fg001_2.gifhttp://www.merck.com/media/mmhe2/figures/fg001_2.gifhttp://www.science.siu.edu/plant-biology/PLB117/JPEGs%20CD/0073.JPGhttp://www.science.siu.edu/plant-biology/PLB117/JPEGs%20CD/0073.JPGhttp://www.science.siu.edu/plant-biology/PLB117/JPEGs%20CD/0073.JPGhttp://www.science.siu.edu/plant-biology/PLB117/JPEGs%20CD/0073.JPGhttp://www.science.siu.edu/plant-biology/PLB117/JPEGs%20CD/0073.JPGhttp://www.science.siu.edu/plant-biology/PLB117/JPEGs%20CD/0073.JPGhttp://www.merck.com/media/mmhe2/figures/fg001_2.gifhttp://www.mitochondria.us/pages/rebep_main.htmlhttp://www.mitochondria.us/pages/rebep_main.htmlhttp://www.sirinet.net/~jgjohnso/cell.html
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    Cell membrane image.www.bioeng.auckland.ac.nz/images/

    Popeye cartoon.

    www.//vilenski.org/science/safari/cellstructure/ribo.html Lysosome image.

    www.people.virginia.edu/~rjh9u/lysosome.html

    Cytoskeleton image.

    www.beyondbooks.com/lif71/4f.asp Animated sheep. www.beyondbooks.com

    http://www.bioeng.auckland.ac.nz/images/http://www.people.virginia.edu/~rjh9u/lysosome.htmlhttp://www.beyondbooks.com/lif71/4f.asphttp://www.beyondbooks.com/http://www.beyondbooks.com/http://www.beyondbooks.com/lif71/4f.asphttp://www.people.virginia.edu/~rjh9u/lysosome.htmlhttp://www.bioeng.auckland.ac.nz/images/
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    Centrosome image.www.faculty.tcc.cc.fl.us/scma/smithh/centrioles.jpg

    Cilia and Flagella image.www.academic.brooklyn.cuny.edu/biology/bio4fv/page/flagella-movement.html

    Nucleus image.www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBook

    CELL2.html

    Carrier Molecule image.www.msad54.k12.me.us/MSAD54Pages/skow/CurrProjects/Biology/CrazyCells/Transport/transport%20proteins.htm

    http://www.faculty.tcc.cc.fl.us/scma/smithh/centrioles.jpghttp://www.faculty.tcc.cc.fl.us/scma/smithh/centrioles.jpghttp://www.academic.brooklyn.cuny.edu/biology/bio4fv/page/flagella-movement.htmlhttp://www.academic.brooklyn.cuny.edu/biology/bio4fv/page/flagella-movement.htmlhttp://www.academic.brooklyn.cuny.edu/biology/bio4fv/page/flagella-movement.htmlhttp://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookCELL2.htmlhttp://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookCELL2.htmlhttp://www.msad54.k12.me.us/MSAD54Pages/skow/CurrProjects/Biology/CrazyCells/Transport/transport%20proteins.htmhttp://www.msad54.k12.me.us/MSAD54Pages/skow/CurrProjects/Biology/CrazyCells/Transport/transport%20proteins.htmhttp://www.msad54.k12.me.us/MSAD54Pages/skow/CurrProjects/Biology/CrazyCells/Transport/transport%20proteins.htmhttp://www.msad54.k12.me.us/MSAD54Pages/skow/CurrProjects/Biology/CrazyCells/Transport/transport%20proteins.htmhttp://www.msad54.k12.me.us/MSAD54Pages/skow/CurrProjects/Biology/CrazyCells/Transport/transport%20proteins.htmhttp://www.msad54.k12.me.us/MSAD54Pages/skow/CurrProjects/Biology/CrazyCells/Transport/transport%20proteins.htmhttp://www.msad54.k12.me.us/MSAD54Pages/skow/CurrProjects/Biology/CrazyCells/Transport/transport%20proteins.htmhttp://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookCELL2.htmlhttp://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookCELL2.htmlhttp://www.academic.brooklyn.cuny.edu/biology/bio4fv/page/flagella-movement.htmlhttp://www.academic.brooklyn.cuny.edu/biology/bio4fv/page/flagella-movement.htmlhttp://www.academic.brooklyn.cuny.edu/biology/bio4fv/page/flagella-movement.htmlhttp://www.academic.brooklyn.cuny.edu/biology/bio4fv/page/flagella-movement.htmlhttp://www.faculty.tcc.cc.fl.us/scma/smithh/centrioles.jpg
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    Edema image. www.nucleusinc.com

    Mitosis image 1stpg.

    http://campus.queens.edu/faculty/jannr/cells/mit%20pics/mitosis%20animal.jpg

    Mitosis image.www.mun.ca/.../BIOL2060/CellBiol17/CB17_19.html

    http://www.nucleusinc.com/http://campus.queens.edu/faculty/jannr/cells/mit%20pics/mitosis%20animal.jpghttp://campus.queens.edu/faculty/jannr/cells/mit%20pics/mitosis%20animal.jpghttp://campus.queens.edu/faculty/jannr/cells/mit%20pics/mitosis%20animal.jpghttp://www.mun.ca/.../BIOL2060/CellBiol17/CB17_19.htmlhttp://www.mun.ca/.../BIOL2060/CellBiol17/CB17_19.htmlhttp://www.mun.ca/.../BIOL2060/CellBiol17/CB17_19.htmlhttp://www.mun.ca/.../BIOL2060/CellBiol17/CB17_19.htmlhttp://campus.queens.edu/faculty/jannr/cells/mit%20pics/mitosis%20animal.jpghttp://campus.queens.edu/faculty/jannr/cells/mit%20pics/mitosis%20animal.jpghttp://campus.queens.edu/faculty/jannr/cells/mit%20pics/mitosis%20animal.jpghttp://www.nucleusinc.com/