elm phospho.elm
Post on 06-Jan-2016
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Eukaryotic Linear Motif
• Collection of small functional sites/motives.
• Examples:
- protein interaction sites
- cell compartment targeting signals
- post-translational modifications sites
- cleavage sites
Functional sites vs. globular domains
Difficult to analyse productively
Why?
There are many of them.
They are short.
No defined structure.
False positive results.
ELM aims:
• Creation of a comprehensive database of eukaryotic linear motifs
• Providing a resource to aid in ELM discovery
Phospho.ELM version 7.0
How to improve ELM as to be useful prediction tool?
Building algorithm for prediction using ELM database.
Searching for the known motifs in given protein.
Evaluation of the results found by ELM.
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