adalimumab in combination with methotrexate
TRANSCRIPT
PsoriasisAdalimumab in combination with methotrexate.Case Report
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F. Peral Rubio, M.D.Department of DermatologyHospital Universitario Virgen MacarenaSeville, Spain
Adalimumab in combination with methotrexate.Case Report
54-year-old women. Diagnosed of Severe Plaque Psoriasis in
2000. In 2000 did not improve treatment with
PUVA. In 2001 was treated with cyclosporine
showing good response to treatment, but had to be suspended for hypertension.
In 2008 was treated with methotrexate without improvement .
Adalimumab in combination with methotrexate.Case Report
The patient was referred for evaluation because of a psoriasis flare involving extensive plaques on all body surfaces
Physical examination
BSA: 42
PASI:28,80
Adalimumab in combination with methotrexate.Case Report
We decided to start treatment with adalimumab 80 mg at initiation followed by 40 mg one weeks later and 40mg every other week.
Adalimumab in combination with methotrexate.
Case Report.
Laboratory examinations: Complete blood counts : normal Blood chemistries : normal. Tuberculin skin test, with booster
effect was negative. A chest radiograph revealed no signs of
tuberculosis. HBV, HCV, HIV negative. Antinuclear antibodies: negative
Physical examination at 4 weeks
BSA: 36
PASI: 21.30
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Physical examination at 8 weeks
BSA: 33
PASI: 20.40
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Physical examination at 16 weeks
BSA: 30
PASI: 19.40
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Adalimumab in combination with methotrexate.Case Report
The patient had no complete response to treatment, so we decided to combine methotrexate 5mg weekly
Physical examination at 24 weeks
BSA: 1.10
PASI: 2.70
Adalimumab in combination with methotrexate.Case Report
Currently, the patient is treated with adalimumab as monotherapy with good control of psoriasis.
The combination of adalimumab and methotrexate was safe and effective in this case
Psoriasis.Adalimumab in combination with methotrexate.Case Report
www.dermatoblog.com
F. Peral Rubio, M.D.Department of DermatologyHospital Universitario Virgen MacarenaSeville, Spain