人类疱疹病毒
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人类疱疹病毒. 病原生物学教研室. 疱疹病毒 ( Herpesvirus) 是一类中等大小、结构相似、有包膜的 DNA 病毒。 与人类有关的疱疹病毒 称为人类疱疹病毒( Human herpes virus,HHV) 。. 根据其生物学特性分为： α 疱疹病毒 ：宿主范围广，复制周期短，引起细胞病变迅速，可 在感觉神经节内建立潜伏感染。如 单纯疱疹病毒、 水痘-带状疱疹病毒 ； β 疱疹病毒 ：宿主范围较窄，增殖周期较长，引起感染细胞形成 巨细胞，可在淋巴-网状内皮细胞、分泌腺细胞、 - PowerPoint PPT PresentationTRANSCRIPT
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(Herpesvirus) DNA(Human herpes virus,HHV) - - 67 B EB 8
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HHV 1.DNA20162150200nm100110nm 2.EBVHHV-6HHV-72CPE 3.
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DNA
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HHV
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herpes simplex virusHSVherpes simplex
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HSV
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HSV11gBgCgDgEgGgHgIgJgLgNgMgpGHSV-1HSVgpDgBgDgEFcIgGFcgHgL
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HSV HSVHSV-1HSV-2DNA50%HSV HSV-1: HSV-2:
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HSV HSV CPE HSV
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HSV
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HSV(herpes) HSV 1 2 3 4HSV-2
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62HSV-1HSV-1 HSV-2genital herpes80%HSV-2HSV-1
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HSV HSV-1HSV-2 HSV
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HSV-1HSVHSV
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HSV-2 HSV-2 HSV-2 HSV-2 HSV-2 HSV-2mRNA
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HSV23dCPENTDNA
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; ; PCRHSV
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HSVCFIFANTELISA CFHSV IFAIgMIgGIgA ELISAHSV95%
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HSVDNAgpD HSV-2
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5-()(Ara-A) (acyclovir,ACV) (VACV)HSV IFN
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EB EB1964EpsteinBarr (Burkitt lymphoma) EB(Epstein-Barr virus,EBV) EBVBurkitt
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EBV EBVEBV EBV: EBV(EBNA)(LMP) EBV (EA)EBV(VCA)EBV(MA)
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EBVBBEBVEBVEBV EBVBEBVB
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EBV () EBV90% NTEBVBEBV
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1.(infectious mononucleosis)EBV6 2. (Burkitts lymphoma)6EBVEBVBurkitt 3.(nasopharyngeal carcinoma,NPC)40EBVNPCNPCEBV ()NPCEBV (EAVCAMAEBNA)
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EBV 1 EBVVCA-IgAEA-IgA1:51:102 341:80 EBV DNAEBV
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EBV EBVEBVgp340NTEBVgp340EBV EBV
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1956Smith (Cytomegalovirus,CMV) CMV CMVAIDS
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CMV CMV 1
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CMV2 60%90%CMV --
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1CMVCMVTORCH CMV2()3AIDSCMV4CMVEBVEA5CMVDNACMVDNACMV
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() 48wCPECMV2 () ELISACMVIgMCMVIgMCMVIgMCMV () DNADNACMVPCRCMVDNA
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CMVCMV (Towwne) CMV- CMVCMV
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(VaricellaZoster virus,VZV)
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VZVHSV CPE
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VZVVZV
2
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3920%30%
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14 w40
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VZV
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VZV (VZIg)72hVZIg ()
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6 HHV-66090HHV-6
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624035dHHV-6 HHV-6 HHV-6 HHV-6HIVTHHIVHHV-6HIVHIV
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7 7HHV-7Frenkel 1990CD4+THHV-7HHV-7HHV-646HHV-7
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8 8 (HHV-8) 1994Chang 90%KaposiAIDS (Kaposis sarcomaassociated herpesvirus,KSHV)KSHVHHV-8 HHV-8Kaposi
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123EB