z what’s my story · z then a miracle occurred….. david earnest (former grad student at...
TRANSCRIPT
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What’s my story ? z
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Well how did I get here?
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• Enjoyed science = med school!
High school
• Majored in Premed + Psychology
• Met Jim Smith (from Florida State University)
Bachelors - Penn State
• Fred Stephan and circadian rhythms
• Met Fred Turek from Northwestern
Masters - Psychobiology program at FSU
• Reproductive endocrinology of circadian rhythms
Doctorate Biology Northwestern -
• Sarah Winans Newman - neurobiology of male sex behavior REP program
Post Doc at University of Michigan
z Then a miracle occurred…..
David Earnest
(Former grad student at
Northwestern)
Joan Morell
Faculty member
at Rutgers
Lydia Don
Carlos
Cheryl Sisk
(Former grad
student at FSU)
Invites me to apply for job at Rutgers
Invites me for a talk at
Rochester
At Rochester
I meet
Invites
Joan Morrell for talk
at
Michigan State
Lydia does
Post doc
with…
Jill Schneider
(undergrad at FSU)
Invites me to apply
for a job at Lehigh
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Sex, ageing and clocks
Jennifer Swann
Professor, Lehigh University
Dept Biological Sciences
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My sleep wake
1 2 3 4 5 6 7 8 9 10 11 12 1 2 3 4 5 6 7 8 9 10 11 12
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His sleep wake
1 2 3 4 5 6 7 8 9 10 11 12 1 2 3 4 5 6 7 8 9 10 11 12
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Are we so different?
How do your patterns look?
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Larks and Owls?
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Why melatonin?
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Melatonin exhibits a strong rhythm
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Melatonin profiles of Larks and Owls
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Temperature also shows a rhythm with a peak opposite to melatonin
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Sex difference in circadian markers
Women are advanced compared to men in:
DLM On = Dim Light Melatonin Onset
CBT = Core Body Temperature minimum
DLMO Off = Dim Light Melatonin Offset
Cain et al, J Biol Rhythms . 2010 August ; 25(4): 288–296.
z Sex differences decline with age
Roenneberg, etal Current Biology Vol 14 No 24 R1038
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What time is it?
How do you know this?
Why do you know this?
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All organisms keep time
Microorganisms
Insects
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All of your body keeps
time
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The rhythms do not show the same phase relationship
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What are circadian rhythms?
Circadian = circa+dian (about one day)
Endogenous - generated internally
Entrainable – synchronized to time cues
Zeitgebers: light, food, social cues
The SCN controls circadian rhythms
The suprachiasmatic
nucleus is the “Master
oscillator”.
Sits above the optic chiasm
and receives light from
special receptors in the
retina
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Why study rhythms?
Implications in health and disease
Travel – jet lag
Shift workers: health
professionals, airline pilots
Pathologies – DSPS, blindness
NASA!
z A hamster is housed
in a cage that
contains a running
wheel.
The running wheel
has a switch that
registers every
revolution of the
wheel and sends that
information to a
computer.
The computer puts a
time stamp on each
data point, and
collects the data over
long periods of time.
http://scienceblogs.com/clock/2006/07/clock_tutorial_4_on_methodolog.php
Hamster actograph
And circadian qualities
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1. Light entrainment
2. “Free run”
persistence under
constant conditions
3. Period of free
running rhythm ≠24
hours
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z z Teenagers!
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Seasonal affective disorder z
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Treatment depends on what type you are!
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z z Bright light treatment
resynchronizes rhythms
N Engl J Med 1990; 322:1253-1259
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Entrainment – life on mars
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Mars has a 24.69 hour day
Astronauts must adapt to the day length to
work with equipment
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Can astronauts adapt to 24.68 hour day?
Twenty subjects working in support of the Phoenix Mars Lander at the SOC in Tucson, AZ
Volunteered to work on a Mars schedule
Activity monitored with a wrist motion logger
Melatonin monitored via urine samples
From: Learning to Live on a Mars Day: Fatigue Countermeasures during the Phoenix Mars Lander
Mission Sleep. 2012;35(10):1423-1435. doi:10.5665/sleep.2128
Sleep | © 2012 Associated Professional Sleep Societies, LLC.
Yes they can!
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z In conclusion:
Circadian rhythms are
ubiquitous and important!
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Resources
https://neuron.illinois.edu/units/what-makes-me-tick-tock
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Thank you!