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What’s my story ? z

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Page 1: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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What’s my story ? z

Page 2: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Well how did I get here?

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• Enjoyed science = med school!

High school

• Majored in Premed + Psychology

• Met Jim Smith (from Florida State University)

Bachelors - Penn State

• Fred Stephan and circadian rhythms

• Met Fred Turek from Northwestern

Masters - Psychobiology program at FSU

• Reproductive endocrinology of circadian rhythms

Doctorate Biology Northwestern -

• Sarah Winans Newman - neurobiology of male sex behavior REP program

Post Doc at University of Michigan

Page 3: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

z Then a miracle occurred…..

David Earnest

(Former grad student at

Northwestern)

Joan Morell

Faculty member

at Rutgers

Lydia Don

Carlos

Cheryl Sisk

(Former grad

student at FSU)

Invites me to apply for job at Rutgers

Invites me for a talk at

Rochester

At Rochester

I meet

Invites

Joan Morrell for talk

at

Michigan State

Lydia does

Post doc

with…

Jill Schneider

(undergrad at FSU)

Invites me to apply

for a job at Lehigh

Page 4: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Sex, ageing and clocks

Jennifer Swann

Professor, Lehigh University

Dept Biological Sciences

Page 5: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

z

z z

My sleep wake

1 2 3 4 5 6 7 8 9 10 11 12 1 2 3 4 5 6 7 8 9 10 11 12

Page 6: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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His sleep wake

1 2 3 4 5 6 7 8 9 10 11 12 1 2 3 4 5 6 7 8 9 10 11 12

Page 7: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Are we so different?

How do your patterns look?

Page 8: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Larks and Owls?

Page 9: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Why melatonin?

Page 10: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Melatonin exhibits a strong rhythm

Page 11: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Melatonin profiles of Larks and Owls

Page 12: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Temperature also shows a rhythm with a peak opposite to melatonin

Page 13: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Sex difference in circadian markers

Women are advanced compared to men in:

DLM On = Dim Light Melatonin Onset

CBT = Core Body Temperature minimum

DLMO Off = Dim Light Melatonin Offset

Cain et al, J Biol Rhythms . 2010 August ; 25(4): 288–296.

Page 14: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

z Sex differences decline with age

Roenneberg, etal Current Biology Vol 14 No 24 R1038

Page 15: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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What time is it?

How do you know this?

Why do you know this?

Page 16: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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All organisms keep time

Microorganisms

Insects

Page 17: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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All of your body keeps

time

Page 18: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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The rhythms do not show the same phase relationship

Page 19: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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What are circadian rhythms?

Circadian = circa+dian (about one day)

Endogenous - generated internally

Entrainable – synchronized to time cues

Zeitgebers: light, food, social cues

Page 20: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

The SCN controls circadian rhythms

The suprachiasmatic

nucleus is the “Master

oscillator”.

Sits above the optic chiasm

and receives light from

special receptors in the

retina

Page 21: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Why study rhythms?

Implications in health and disease

Travel – jet lag

Shift workers: health

professionals, airline pilots

Pathologies – DSPS, blindness

NASA!

Page 22: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

z A hamster is housed

in a cage that

contains a running

wheel.

The running wheel

has a switch that

registers every

revolution of the

wheel and sends that

information to a

computer.

The computer puts a

time stamp on each

data point, and

collects the data over

long periods of time.

http://scienceblogs.com/clock/2006/07/clock_tutorial_4_on_methodolog.php

Page 23: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

Hamster actograph

And circadian qualities

DD

D L

1. Light entrainment

2. “Free run”

persistence under

constant conditions

3. Period of free

running rhythm ≠24

hours

Page 24: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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z z Teenagers!

Page 25: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Page 26: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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z

Seasonal affective disorder z

Page 27: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Treatment depends on what type you are!

Page 28: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Page 29: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Page 30: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former
Page 31: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Page 32: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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z z Bright light treatment

resynchronizes rhythms

N Engl J Med 1990; 322:1253-1259

Page 33: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Entrainment – life on mars

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Mars has a 24.69 hour day

Astronauts must adapt to the day length to

work with equipment

Page 34: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Can astronauts adapt to 24.68 hour day?

Twenty subjects working in support of the Phoenix Mars Lander at the SOC in Tucson, AZ

Volunteered to work on a Mars schedule

Activity monitored with a wrist motion logger

Melatonin monitored via urine samples

Page 35: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

From: Learning to Live on a Mars Day: Fatigue Countermeasures during the Phoenix Mars Lander

Mission Sleep. 2012;35(10):1423-1435. doi:10.5665/sleep.2128

Sleep | © 2012 Associated Professional Sleep Societies, LLC.

Yes they can!

Page 36: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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z In conclusion:

Circadian rhythms are

ubiquitous and important!

Page 38: z What’s my story · z Then a miracle occurred….. David Earnest (Former grad student at Northwestern) Joan Morell Faculty member at Rutgers Lydia Don Carlos Cheryl Sisk (Former

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Thank you!