Compare the highly considered, comprehensive formulations of ProRenal® multivitamins to well known competitors

Everything you need, Nothing you don’t

Do you ever think about what’s in your kidney multivitamin and why it’s there?

We’ve done the thinking for you!

NutrientProRenal® with

Omega-3ProRenal® Why?

Vitamin D a aVitamin D levels may be low in patients with CKD/ESRD

Zinc, Selenium & Copper a a

Levels of these trace minerals may decline over time in patients with CKD/ESRD

Vitamin C a a

The right amount of vitamin C supports a healthy immune system but too much may lead to kidney stones

Omega-3 fish oil a r

CKD/ESRD patients have a higher risk of heart disease and omega-3 fish oil may be protective for heart health*

Phosphorus r rDifficult for the kidney to process and may be harmful in patients with CKD/ESRD

Potassium r rDifficult for the kidney to process and may be harmful in patients with CKD/ESRD

Vitamin A r rDifficult for the kidney to process and may be harmful in patients with CKD/ESRD

- Included - Excludeda r

Alison Steiber, PhD, RD, LD• Editorial Board of the

Journal of Renal Nutrition

• Council of Renal Nutrition, Executive Research Committee

• Assistant Professor of Nutrition

• Case Western Reserve University

Joel D. Kopple, MD – Chair• Professor of Medicine and

Public Health

• Harbor-UCLA Medical Center

• UCLA School of Medicine and Public Health

• Chair, KDOQI Clinical Practice Guidelines for Nutrition Work Group

• Past President, National Kidney Foundation

Robert Provenzano, MD• Section Head,

Nephrology, St. John’s Hospital

• Associate Clinical Professor Of Medicine

• Wayne State University School of Medicine

• Past President, Renal Physicians Association (RPA)

* Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease.

Nutrient CentrumTM Silver NephrocapTM

Rena-ViteTM

(NephroviteTM)ProRenal®

ProRenal®

with Omega-3

Vitamin D 500 IU No No 1000 IU 1000 IU

Omega-3 fish oil No No No No

330 mg EPA 220 mg DHA1 g total fish

oilIron No No No Yes Yes

Zinc, Selenium & Copper Yes No No Yes Yes

Vitamin A 2500 IU No No No NoPotassium 80 mg No No No NoPhosphorus 110 mg No No No No

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ProRenal® multivitamins are formulated from the latest scientific evidence by a world class advisory board.

ProRenal® and ProRenal® with Omega-3 are designed specifically for kidney health

The material provided in this brochure is for strictly informational and educational purposes only. It is not meant to replace or substitute for the recommendations or advice of your physician or health care provider.

The information contained in this brochure should not be used to diagnose or treat a health problem or disease. Before considering to or taking any multivitamin or supplement, please consult with your physician or healthcare provider first.

The statements contained in this brochure have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent disease.

If you are eating a balanced diet, you may not need to take a daily multivitamin.

Your physician/healthcare provider and Nephroceuticals® have an ongoing financial arrangement aimed at emphasizing educating patients on the need for proper nutrition in chronic heart and kidney disease. Your physician receives a portion

of the sales receipts of the product supply that you order as compensation for providing such nutritional education services. If you have any further questions concerning ProRenal® and ProRenal® with Omega-3 or desire more information about

alternatives to ProRenal® and ProRenal® with Omega-3, please ask your physician.

Not all vitamins are created equal

Take specially formulated ProRenal® multivitamins to support your kidney health!

ProRenal® multivitamins are the only kidney vitamins available without a prescription that include 1000 IU of vitamin D plus 1000 mg of fish oil in ProRenal® with Omega-3.

Why are ProRenal® multivitamins the right choice for me?

Other ingredients: soybean oil, gelatin beeswax, lecithin, glycerin, water, and caramel color. Contains soy and fish (anchovy and sardine).

Other ingredients: microcrystalline celluiose, croscarm eliose sodium, sucrose fatty acid ester, silica and pharmaceutical glaze.

Supplement FactsServing Size: 2 Softgels

Amount Per Serving % Daily Value

Calories 15Calories from Fat 15Total Fat 1 g 2%*Vitamin C (as ascorbic acid) 60 mg 100%Vitamin D (as cholecalciferol) 1,000 IU 250%Vitamin E (as d-alpha-tocopherol) 10 IU 33%Thiamin (as thiamin HCl) 1.5 mg 100%Riboflavin 2 mg 118%Niacin (as niacinamide) 20 mg 100%Vitamin B6 (as pyridoxine HCl) 10 mg 500%Folate (as folic acid) 800 mcg 200%Vitamin B12 (as cyanocobalamin) 2.4 mcg 40%Biotin 30 mcg 10%Pantothenic acid (as D-calcium pantothenate) 5 mg 50%Iron (as ferrous gluconate) 8 mg 44%Zinc (as zinc oxide) 8 mg 53%Selenium (as selenomethionine) 55 mcg 79%Copper (as copper oxide) 0.9 mg 45%Fish Oil 1,000 mg *** EPA (Eicosapentaenoic acid) (330 mg) DHA (Docosahexaenoic acid) (220 mg)

* Percent Daily Values are based on a 2,000 calorie diet.*** Daily value not established.

Supplement FactsServing Size: 1 Tablet

Amount Per Serving % Daily Value

Vitamin C (as ascorbic acid) 60 mg 100%Vitamin D (as cholecalciferol) 1,000 IU 250%Thiamin (as thiamin mononitrate) 1.5 mg 100%Riboflavin 2 mg 118%Niacin 20 mg 100%Vitamin B6 (as pyridoxine HCl) 10 mg 500%Folate (as folic acid) 800 mcg 200%Vitamin B12 (as cyanocobalamin) 2.4 mcg 40%Biotin 30 mcg 10%Pantothenic acid (as D-calcium pantothenate) 5 mg 50%Iron (as ferrous gluconate) † 8 mg 44%Zinc (as zinc oxide) 8 mg 53%Selenium (as selenomethionine) 55 mcg 79%Copper (as copper oxide) 0.9 mg 45%

Take care of your kidneys with two competitively priced choices of ProRenal® daily multivitamins

What’s the deal with fish oil?

Fish oil is made of omega-3 essential fatty acids, EPA and DHA, which are vital for normal tissue, vascular and heart health, but can’t be synthesized by the human body.1 Therefore, it is important to get enough omega-3 fish oil, either by a diet rich in fish or through supplementation.

What are the relevant considerations when choosing an omega-3 supplement?

You should find out where your fish oil originated. For the safest source of omega-3, choose fish oils derived from wild, cold water fish that are low on the food chain, such as sardines and anchovies. Avoid fish oils that are sourced from bottom feeders, scavengers or farm raised fish, which can increase the risk of contaminants including dioxins, PCBs and mercury.

The fish oil in ProRenal® with Omega-3 is sourced from wild sardines and anchovies from the cold waters off Chile, which reduces the risks associated with pesticides or other contaminants.

Make sure the omega-3 fish oil you take has adequate doses of the active components, DHA and EPA. Fish oil supplements can contain as little as 8% of active DHA and EPA, and instead may include inferior fish oils that may not be beneficial to you.

The omega-3 fish oil concentration in ProRenal® with Omega-3 is based on the latest clinical research2 and includes 1000 mg of fish oil, consisting of 330 mg EPA and 220 mg DHA. ProRenal® with Omega-3 is formulated to support the health of your heart and kidneys.

Why is it important for me to limit potassium and phosphorous in my diet?

When your kidneys fail they are unable to handle the potassium and phosphorous you get from your diet, and can build up to high levels in the body. High levels of potassium can cause weakness, tiredness or an abnormal heartbeat which can lead to a heart attack. High levels of phosphorous can cause itching, weak bones or result in unhealthy deposits of calcium in your heart and lungs. Even dialysis is unable to get rid of potassium and phosphorous

effectively so both CKD and ESRD patients need to be careful and discuss with their doctors how much potassium and phosphorous should be in your diet.

Feel confident taking ProRenal® multivitamins as they DO NOT contain any phosphorus or potassium.

Why is my doctor recommending I take a vitamin D supplement?

You are not alone—current research suggests that vitamin D deficiency is a worldwide epidemic effecting over 50% of people of all ages and populations.3 Vitamin D deficiency is widespread due to a variety of reasons including reduced sun exposure, limited food sources with natural vitamin D, and numerous chronic disease conditions.4

Research shows that vitamin D is vital for the healthy functioning of many organs, and kidney patients have a higher risk for being deficient.5 The National Kidney Foundation guidelines suggest taking a multivitamin preparation with vitamin

D for patients with kidney disease.6 In an effort to maintain proper levels of vitamin D in the body, ProRenal®

and ProRenal® with Omega-3 are designed according to recent health guidelines with a daily dose of 1000 IU vitamin D.

When choosing a vitamin D supplement always look for appropriate doses, as too little vitamin D may have no effect and excessive amounts may be harmful.7 Recently, the Institute of Medicine increased the national daily recommendation of vitamin D that should be consumed.8 Since it is difficult to obtain enough vitamin D from food alone, The Endocrine Society recommends taking vitamin D supplements.9 Incorporating a vitamin D supplement, for those who are deficient, as part of a daily routine is one of the few solutions for increasing levels in the body.

ProRenal® and ProRenal® with Omega-3 set a new standard for the industry with 1000 IU of vitamin D included in our complete kidney multivitamins.

1. Mozaffarian, D. Ann Int Med 2011; 155:1602. Kris-Etherton, P. Circulation 2002; 106;27473. Holick, M. N Engl J Med 2007; 4. McGreevy, C. Ann Int Med 2011; 155:820

5. Binkley, N. Rhem Clin N Am2012; 38(1):456. National Kidney Foundation KDOQI7. Sanders, K. JAMA 2010; 303:18158. Institute of Medicine, 20109. Holick, M. J Clin Endocrin Metab 2011; 96:1911

ProRenal® with Omega-3Gluten-free softgels combine a Complete Multivitamin with EPA/DHA rich Omega-3 fish oil and 1000 IU Vitamin D for all kidney patients

ProRenal®

Gluten-free tablets combine a Complete Multivitamin with 1000 IU Vitamin D, but do not contain Omega-3 for ESRD patients

Dr. JohnQ&A with a medical professional

As a preventive measure against the high incidence of cardiovascular disease and heart failure in conjunction with kidney disease, the American Heart Association guidelines recognize that omega-3 fatty acid supplements may reduce the risk of coronary heart disease. ProRenal® with Omega-3 is a multivitamin plus omega-3 supplement for patients concerned with cardiovascular disease.

There may be an associationbetween kidney and heartdisease

CKD is often associated with secondary conditions

There are many other concerns when your kidneys aren’t functioning properly. CKD can be a precursor to fluid overload, sodium and potassium imbalances, absorption inadequacies, bone and mineral disorders and anemia. To address these complications, ProRenal® with Omega-3 and ProRenal® Multivitamin formulations include considered doses of B complex vitamins (B6, B12 and folic acid) and iron for anemia; thiamine, riboflavin, pantothenic acid and niacin for extracting energy from food; vitamin C for tissue health; and vitamin D for bone health.

ProRenal® multivitamins are specially formulated with the restrictions and needs of kidney patients in mind. Kidney patients often require nutritional supplementation of specific vitamins and minerals due to dietary constraints and diminished kidney function. There are some vitamins and minerals that can be harmful or toxic to kidney patients. ProRenal® multivitamins are optimized for you with Everything you need, Nothing you don’t.

Proper supplementation is important for kidney health

Vitamin deficiencies can be common among patients with kidney disease. Leading organizations such as the American Dietitians Association and the National Kidney Foundation recommend considering a multivitamin for patients with CKD and ESRD. Make sure you always discuss the use of any multivitamins with your doctor and decide if ProRenal® and ProRenal® with Omega-3 are right for you.

More than 10%, or over 26 million people in the US over the age of 20 suffer from Chronic Kidney Disease (CKD). With the incidence of CKD on the rise, it is critical to take steps to better support your kidney health. If you are currently a CKD or ESRD (dialysis) patient, take the time to educate yourself on the importance of nutrition and multivitamins in your daily routine.

Chronic Kidney Disease iscommon in adults

Multivitamins may berecommended for patients with CKD/ESRD

Take ProRenal® and

ProRenal® with Omega-3 as part of a strategy to better support your kidney health.