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    Introduction

    Research is critical in medicine because itleads to new discoveries and can change

    peoples lives by improving health and well-

    being

    All research starts with an idea or question

    based on personal experiences

    Research shapes the world we live in by

    continually questioning and testing humanknowledge and understanding

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    Research is critical in medicine because it leads to new discoveries and can

    change peoples lives by improving overall health and well-being. All research

    begins with an idea or question based on personal experiences and ends with

    results that may change the way in which various ailments and disease

    processes are diagnosed and treated. Research shapes the world we live in by

    continually questioning and testing human knowledge and understanding.

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    Introduction

    There are many ways in which humansacquire knowledge and gather informationin order to solve problems

    Many questions are answered andproblems solved based on inheritedcustoms, traditions and experiences

    More complex questions may be

    answered through a process of logicalreasoning

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

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    What is Reasoning?

    Inductive - the process of

    developing generalization from

    specific observations

    Deductive - the process of

    developing specific predictions

    from general principles

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    Reasoning combines experience, ones intellectual faculties and formal

    systems of thought. This process can be inductive or deductive. Inductive

    reasoning is the process of developing generalizations from specific

    observations, and deductive reasoning is the process of developing specific

    predictions from general principles. Both are useful in understanding

    phenomena but are limited in the ability to uncover new ideas or discoveries.

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    Scientific Approach

    The most sophisticated method of acquiring

    knowledge that has been developed

    Combines important features of induction

    and deduction together with other methods

    to create a system of acquiring knowledge

    Generally more reliable than other methods

    Approach used most often to perform

    medical research

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    The scientific approach in research is the most sophisticated method of

    acquiring knowledge that has been developed. This approach combines

    important features of induction and deduction together with other methods to

    create a system of acquiring knowledge that is generally more reliable than

    other methods. It is used most often to perform medical research.

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    What is Science?

    Knowledge or a system of knowledgecovering general truths or the operationof general laws as obtained and testedthrough scientific method and concernedwith the physical world and itsphenomena

    The central purpose of science is to

    provide an objective, factual and usefulaccount of the world in which we live

    The Merriam-Webster Dictionary. Springfield, MA: Merriam-Webster, Incorporated, 1993.

    Science involves the observation, identification, description, experimental

    investigation, and theoretical explanation of phenomenon. Science includes a

    series of activities usually restricted to a class of natural phenomena and involves

    methodology applied to an inquiry or study.

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    Three Domains of Science

    Scientific knowledge - knowledge

    verified by scientific methods

    Scientific research - methods used for

    accumulation and verification of

    knowledge

    Scientific theory -systematically

    organized facts to explain phenomena

    Science is thought to exist in three different domains. These domains are

    scientific knowledge, scientific research and scientific theory. Scientific

    knowledge is knowledge verified by scientific methods. Scientific research is a

    series of methods used for accumulation and verification of knowledge.

    Scientific theory is systematically organized facts to explain phenomena.

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    Functions of Science

    There are two primary functions of science:

    Development of theory

    Testing of hypotheses deducted by theory

    Science progresses when new facts lead to

    new theories

    These facts are generally proven with

    research and evidence-based processes

    Abramson, J. Making Sense of Data: A Self-Instruction Manual on the Interpretation of Epidemiological Data. New York, NY:

    Oxford University Press, 1988.

    There are two primary functions of science. These include the development of

    theory and the testing of substantive hypotheses deducted from theory or data.

    Science is thought to progress when new facts lead to new theories, and

    these facts are generally proven with research and evidence-based processes.

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    What is Research?

    A systematic investigation, involving the

    collection of information (data), to solve a

    problem or contribute to knowledge about a

    theory or practice

    Relies on methods and principles that will

    produce credible and verifiable results

    Research helps provide scientificunderstanding and solves practical problems

    The Merriam-Webster Dictionary. Springfield, MA: Merriam-Webster, Incorporated, 1993.

    Research is a systematic investigation, involving the collection of information

    (data), to solve a problem or contribute to knowledge about a theory or

    practice. It applies the scientific approach to the study of a question of interest

    and relies on methods and principles that will produce credible and verifiable

    results. Research helps provide scientific understanding and solves practical

    problems.

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    Steps in Research

    Identify the question or problem

    Conduct a literature review of the question

    Frame a hypothesis

    Develop the study design

    Complete the research

    Analyze the data

    Generate conclusions

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

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    Identify the Question

    Good or poor research is defined by thequestion being asked

    The question should be well understood, andthe problem well defined

    Selecting a question should not be rushed

    If the question is hurried, proceeding in anorderly fashion may be difficult and may

    produce unreliable results

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    It is generally thought within the scientific community that the difference

    between good and poor research is the distinction between asking a good or

    poor question. It is very important that the question being asked is well

    understood and that the problem has been well defined. Selecting a research

    question should not be hurried and many hours may be devoted to selecting the

    appropriate problem to be answered. If either is not clear, proceeding in an

    orderly fashion may be difficult and continuing may produce unreliable

    results.

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    Identify the Question

    Sources for identifying the question or

    problem:

    Personal experiences

    Literature review

    Theories

    Ideas from others

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    The four most common sources for identifying the appropriate question or problem are personal

    experiences, review of previous research (literature review), review of theories, and ideas from

    others. There is a wealth of ideas one can obtain by just observing everyday occurrences. In the

    course of the researchers day, it is normal to experience issues that may raise questions or

    present problems. Posing questions prior to initiating research such as, What if this situationwas approached in a different way? or What would be the outcome if a procedure was

    performed differently? may help define and develop a research question. In order to recognize

    or identify these questions, it is necessary to be aware of recurrent problems and situations that

    are frustrating, bothersome or do not produce reliable or good quality outcomes. It is also

    helpful to continually examine the way in which procedures are performed and how decisions

    that are made affect performance and functions.

    Performing a literature review is another method of developing a question. Reviewing published

    literature may provoke an idea or question by suggesting what areas of a topic should be

    explored further. Questions may also result from inconsistencies found or by the lack of

    published data.

    Continually evaluating developed theories and considering questions raised by others may also

    be a good source for developing questions or ideas. As situations and common practices change

    over time, previously proven theories may no longer produce valid outcomes. Listening to and

    observing problems that others have experienced may raise a question. These questions can be

    researched in order to produce answers and improve practices.

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    Identify the Question

    Criteria for evaluating the question:

    Significance

    Practicality

    Feasibility

    Interest to researcher

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    Not all questions posed may be researchable although they may be thought

    provoking. Generally questions that are philosophically based cannot be

    measured. Questions that are researchable involve variables that can be defined,

    measured and quantified. In some instances it may be necessary to reword the

    question if this occurs.

    It is important to determine the questions feasibility to ensure the

    appropriateness of the study. Some factors that should be considered include, the

    duration or length of time the study will last, the time involved to enroll each

    subject, availability of subjects, cooperation of others, facilities and equipment,

    money, experience of the researcher and ethical concerns. If any of these factors

    pose a problem then it may be necessary to rethink the question.

    Another important factor is the interest level of the question or topic to the

    researcher. Without the researchers dedication to the topic, the study may not be

    successful or worthwhile. Additionally, when developing the question, the topic

    should promote an opportunity for growth and acquired knowledge.

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    Identify the Question

    Form the statement

    Declarative

    Interrogative

    Define the terms in the statement

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    After the question has been examined and clarified, it is necessary to convert it

    to a definitive statement. A good statement will serve as a guide to developing

    the study design. The two common types of statements used are declarative

    (states the problem as a declaration) or interrogative (states the problem as a

    question). Forming the statement helps to define the terms of the study. Once

    the question or problem is stated and finalized, it is necessary to understand

    how the question has been examined in the past.

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    Literature Review

    Determine what published data

    suggests about the question or

    problem

    Clarify the value of the question

    Clarify what is already known

    Provide sources for reference

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    When developing a research protocol the investigator must determine what the

    published data suggest about the question or problem being studied. This will

    help clarify the value of the question, what is already known or proven about

    the topic and which sources that may be used for reference.

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    Primary Sources:

    Journal articles, books, abstracts

    Written by the person(s) who conductedthe research

    Secondary Sources:

    Review articles that summarize research

    Written by someone other than primaryinvestigator

    Literature Review

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    There are several primary sources that may be used for a literature review.

    These include journal articles, books and abstracts written by the person(s)

    who conducted the research. Secondary sources that may be used include

    review articles that summarize previous research. Most source material will

    originate from authors or researchers other than those conducting the initial

    research.

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    Frame a Hypothesis

    The hypothesis is a statement that describes

    the results the researcher expects

    It examines relationships or differences

    The null hypothesis is a statement that

    expects no relationships or differences to

    exist

    A study should be designed to test thehypothesis or null hypothesis

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    The general purpose of a hypothesis is to guide scientific inquiries and often

    follows directly with the question being asked or theory being tested. It

    provides direction to the research design and assists in the collection, analysis

    and interpretation of data. A hypothesis is a tentative prediction or explanation

    of a relationship between two or more variables and describes the results the

    researcher expects to obtain. A null hypothesis is a statement that expects that

    no relationships or differences to exist. Research studies should be designed to

    test the hypothesis or null hypothesis.

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    Frame a Hypothesis

    The nature of the hypothesis willdetermine:

    Sample group for study

    Measuring instruments

    Study design

    Procedures

    Statistical techniques

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    The nature of the hypothesis will determine the sample group for study,

    measuring instruments, study design, procedures, and statistical techniques

    used for data analysis.

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    Develop the Study Design

    A study design is the researchers overall plan

    to obtain the answer(s) to the question being

    asked and the hypothesis being tested

    It spells out strategies to develop information

    that is accurate, objective and meaningful

    It explains methods that will be used to collect

    and analyze data

    It includes time frame to conduct study

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    The study design is the researchers overall plan to obtain the answer(s) to the

    hypothesis being tested. It spells out strategies for developing information that

    is accurate, objective, and meaningful, and explains the methods that will be

    used to collect and analyze data. This should also include the time frame

    necessary or allowed to conduct the study.

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    Develop the Study Design

    Questions that may assist in development:Will there be an intervention or treatment?

    What type of comparisons will be made?

    What procedures will be used to control

    variables?

    When and how many times will data be collected

    from research subjects?In what setting will the study take place?

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    There are several questions that should be asked to assist with study

    development. These include:

    Will there be an intervention or treatment?

    What type of comparisons will be made?

    What procedures will be used to control variables?

    When and how many times are data collected from research subjects?

    What setting will the study take place?

    Answers to these and similar questions will allow all pertinent information to be

    included and collected as part of the study. It will also help to eliminate the

    possibility of omitting valuable resources or other essentials needed to produce

    a reliable outcome.

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    Develop the Study Design

    Characteristics of good study design:

    Appropriateness of question

    Lack of study bias

    Precision of study

    Power of study

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    Appropriateness of the research question, lack of study bias, precision of the

    study and power of the study to change practices are characteristics of a well-

    designed study.

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    Complete Research

    There are several different researchmethods available for data collection

    It is important to choose one that will mostaccurately reflect the question being asked

    Research different methods and choose themost appropriate

    Perform research following the study

    design that was developed and collectappropriate data

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    There are several methods available for data collection that allows for

    completion of a research study. It is important to choose a method that will

    most accurately reflect the question being asked. It may be necessary to

    research different methods and choose the most appropriate one for the study

    being performed. It is also necessary to perform research following the study

    design that was developed and to collect all appropriate data.

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    Complete the Research

    Research methods include:

    Interviews and questionnaires

    Scales and standardized self-report

    measures

    Observational methods

    Biophysiologic measures

    Records and available data sources

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    Commonly used research methods to collect data include interviews and

    questionnaires, scales and standardized self-report measures, observational

    methods, biophysiologic measures and previously documented records and

    available data sources. To complete a research study the developed study

    design should be followed. Methods and protocols should not be changed once

    a study is started.

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    Analyze the Data

    Upon completion of the study, data shouldbe analyzed and measured for quality

    Instruments used should result in measuresthat are relevant, accurate, unbiased,sensitive, one-dimensional and efficient

    Measures that are physical or physiologichave a higher likelihood of success thanother types

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    Upon completion of the study, the data collected should be analyzed and

    measured for quality. An ideal measuring instrument is one that results in

    measures that are relevant, accurate, unbiased, sensitive, one-dimensional and

    efficient. Measures that are physical or physiologic have a higher likelihood of

    success than other types.

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    Data Analysis

    Quality measurements should test for:

    Reliability

    Validity

    Efficiency

    Sensitivity

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    There are several techniques that have been developed to evaluate the quality

    of the measurements used. These measurements should test for reliability,

    validity, efficiency and sensitivity. Analysis of the data may be performed

    quantitatively or qualitatively.

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    Quantitative Data Analysis

    Statistical measurements are techniques thatrender quantitative data meaningful and

    intelligible

    Enables researchers to reduce, summarize,

    organize, evaluate, interpret and

    communicate numerical information

    It may be necessary to seek the assistance of

    someone familiar or trained in the area ofstatistics to perform analysis

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    Statistical measurements are techniques that render quantitative data

    meaningful and intelligible. These techniques enable researchers to reduce,

    summarize, organize, evaluate, interpret and communicate numerical

    information collected during a research study. In order to perform these

    measures appropriately and correctly, it may be necessary to seek the

    assistance of someone familiar or trained in the area of statistics.

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    Statistics are classified as:

    Descriptiveused to describe and

    synthesize data

    (Averages and Percentages)

    Inferentialused to make inferences or

    draw conclusions about a population

    Quantitative Data Analysis

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    Quantitative statistics are generally classified as descriptive (used to describe

    and synthesize data [averages and percentages]) or inferential (used to make

    inferences or draw conclusions about a population).

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    Types of statistical analysis:

    Frequency distributions

    Central tendency (mode, median, mean)

    Sampling distributions

    Paired t-tests

    ANOVA (Analysis ofVariance)

    Quantitative Data Analysis

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    Examples of descriptive measures of statistical analysis include frequency

    distributions and central tendency (mode, median, mean). Inferential measures

    include sampling distributions, paired T-tests and ANOVA (Analysis Of

    Variance) analysis.

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    Is used to impose some order on the body of

    information collected

    Allows for general conclusions to be reached and

    communicated in an understandable format

    Is generally described as having soft endpoints

    There are no uniformly accepted rules but rather

    generally accepted methods

    Qualitative Data Analysis

    Polit DF and Hungler BP. Nursing Research Principles and Methods (Fourth Edition), 1991

    Qualitative analysis is used to impose some order on the body of information

    collected. It allows for general conclusions to be reached and communicated in

    an understandable format. Often this analysis is described as holistic and is

    usually concerned with humans and their environment and complexities. This

    method is sometimes described as having soft endpoints, which may include

    quality of life changes, ability to adapt to different environments and

    environmental influences on individuals. There are no uniformly accepted rules

    for this type of analysis. However, there are several commonly used and accepted

    methods.

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    Generate Conclusions

    Similar to the early phases of research,

    this may be difficult and time-consuming

    Involves organizing the data in order to

    interpret and communicate

    There are no specific techniques or

    methods but rather only simple guidelines

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    This last stage of research involves generating the conclusions. Similar to the

    beginning phase, this may be difficult and time-consuming. It involves

    organizing the gathered and analyzed data in an orderly fashion in order to

    interpret and communicate the results of the study. There are no specific

    techniques or methods but rather only simple guidelines that may be followed.

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    Generate Conclusions

    Aspects of interpreting results include:

    Accuracy

    Meaning

    Importance

    Extent of generalization

    Implications

    Polit, D.Nursing Research Principles and Methods. Philadelphia, PA: J.B. Lippincott Company, 1991.

    Aspects that should be considered when interpreting the results include the

    accuracy, meaning and importance of the findings, the extent to which the

    results can be generalized and the implications that the results will have on

    currently accepted practices and theories. Good quality research should be

    developed into abstract or manuscript form and submitted to the appropriate

    peer reviewed journal for acceptance and publication. This is the most effective

    way to communicate important findings that should be adopted into daily

    practice.

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    Conclusions

    Developing, conducting and

    communicating a research protocol is a

    sophisticated and time-consuming process

    It is important to understand the steps in

    developing a research protocol in order to

    perform an appropriate study and obtain

    reliable results

    Developing, conducting and communicating a research protocol is a

    sophisticated and time-consuming process. It is important to understand the

    steps in developing a research protocol in order to perform an appropriate

    study and obtain reliable results.