Variation WorkshopUniversity of Washington

March 20-21, 2006

Sponsored by the NHLBI

• Overview of Workshop

• Overview of PGAs

• PGA Education Programs

• New Opportunities

Workshop Overview:

Mark Rieder - Finding SNPsDana Crawford - SNP Selection

Debbie Nickerson - SNP GenotypingChris Carlson - Association Analysis

- Tutorials: SNP Resources and Selection- Case Studies - VKORC1 and CRP

PPROGRAMS ROGRAMS FORFOR

GGENOMICENOMIC

AAPPLICATIONSPPLICATIONS

National Heart, Lung, and Blood InstitutesNational Heart, Lung, and Blood InstitutesNational Institute of HealthNational Institute of Health

PGAPGA Mission Mission

• Provide new resources and reagents to link genes to biological function and make these readily available to the NHLBI community.

• Facilitate workshops, courses, and visiting scientist programs to train investigators in the technologies being applied in the PGAs.

• Rapidly disseminate data through the world wide web and public databases.

PGAPGA Programs Programs

PGAPGA Resources/Tools Resources/Tools• Mouse Models of HLBS Disorders • Rat Models of HLBS Disorders

• DNA Variations (SNPs - locations, allele frequencies, genotypes and haplotypes)

• Functionally Conserved Elements (enhancer database)

• Reagents (clones, ES cells, mice, and rats)• Protocols • Bioinformatic Resources (software tools and

databases) • Archives for Microarray and Antibodies

http://www.nhlbi.nih.gov/resources/pga/index.htm

http://www.nhlbi.nih.gov/resources/pga/resource.htm

http://pga.lbl.gov/PGA/PGA_inventory.html

PGA Education Programs - http://www.nhlbi.nih.gov/resources/pga/workshop.htm

• Short Courses• On-line Tutorials• Visiting Scientist Programs

PGA Symposium see http://www.pgasymposium.org

New Opportunities from SeattleSNPs