update sunscreen 2015 krisada duangurai m.d
DESCRIPTION
chromophores DNA Collagen Lipid Elastic tissueTRANSCRIPT
Update sunscreen 2015 Krisada Duangurai M.D. chromophores DNA
Collagen Lipid Elastic tissue Transfer of sun light Chromophores
Increase energy in their molecules
Then change molecular structure to new molecules Or change to heat
Mechanism of UV Triggers melanin production,
How UV rays affect skin UVC UVB UVA Visible light IR 290 320 400
800 Wavelength (nm) Epidermis Dermis Hypodermis Causes strong
inflammation and damages cells. Exfoliation cycle is affected. Skin
peeling, allergic reaction, uneven pigmentation etc. Oxidizes
melanin and affects collagen leading to photoaging. Chronic spot
pigmentation, immune suppression, skin cancer etc. Triggers melanin
production, Produces Superoxide, Damages skin cell UVA and UVB UVA
UVB UVA more pigmentation UVA more skin penetration UVA damage by
radical mechanism Agings & Photoagings Pigmentation Cancer
Radical mechanism UVB more sunburn and pigmentation after sunburn
UVB damage to DNA UVB damage by direct actions Erythema Cancer
Direct energy transfer mechanism Sunscreen Sunscreen Chemical
Nonchemical Sunlight UVA UVB
visible light infrared Sunscreen Chemical Nonchemical Mechanism of
inorganic and organic sunscreen Ideal UV Protection From the
different characters of UVA and UVB, the UV technology should be
designed to protect your skin effectively from both UVA and UVB.
Protection of just one type of UV will not be effective. Data on
file, Johnson & Johnson Neutrogena. Evolution of Needs of UVA
Protection
UVB determined to be primarily responsible for skin cancer and skin
aging (collagen breakdown, wrinkling, pigmentation). Protection of
skin immune function correlates with UVA protection and NOT with
SPF. 1970s early 1980s 1980 1990s 2000s Pure UVA found to induce
skin cancer, and adds to UVB induction. Pure UVA found to be
capable of inducing skin aging effects (sagging, wrinkling,
pigmentation). SPF levels in sunscreens increase. Avobenzone
Chemical SS Very unstable Can be stable by combination with
Tinosorb and Mexoryl or DEHN(dialkyl naphthalate) New UVA absorbers
UVA TDSA(Mesoryl SX)
UVA/UVB DTS(Mesoryl XL) MBBT(Tinosorb M) BEMT(Tinosorb S) DEHN
(Corapan TQ- diethylhexyl 2,6-naphthalate) Specific Absorption of
different Sunscreens
Avobenzone Tinosorb S TINOSORBS vs. TINOSORBM
UV spectrum of TINOSORB S recorded using a Perkin Elmer Lambda 16
Spectrometer. The broad-spectrum is due to the special design of
the TINOSORB S molecule. For comparison the UV spectrum of TINOSORB
M is also shown. TINOSORB S is overall more efficient and TINOSORB
M reaches further into the far UV-A range. Ciba Specialty chemicals
Inc. Pub No. PC.UVPS.TB.0212e02 The 3rd Dimension: Biological
protection with Licochalcone
With highly effective natural antioxidant Licochalcone A
(Glycyrrhiza Inflata) Protect the skin cells against free radicals
induced by UVAup to deeper skin layers Highly effective natural
antioxidant Licochalcone A
From plants.... to human cells Licochalcone A is a natural
ingredient from the roots of Chinese Licorice Root Extract
(Glycyrrhiza Inflata). Due to its origin with intensive UV
radiation this plant has developed its own protection mechanism. UV
radiation stimulates the enzyme production which is involved in
release of Licochalcone A. The anti-oxidative efficacy protects the
plant cells against free radicals induced by radiation and is now
used as a highly effective active to protect cells in the deeper
layers of the skin. Bioavailability (penetration profile)
Licochalcone A Bioavailability (penetration profile) 84 % Stratum
12 % Epidermis Licochalcone A penetrates into the deeper layers of
the skin Protect cell agains free radical up to dermis level 4 %
Dermis + Sunscreen Active ingredients Vehicle Chemical ss Physical
ss
Antioxidant Water base Oil base FDA Sunscreen Labeling Guidelines
at a Glance
Sunscreens may be labeled broad-spectrum if they provide protection
against both UVA and UVB radiation according to FDA-sanctioned test
methods. Only broad-spectrum sunscreens with an SPF of 15 or higher
may state that they help protect against skin cancer and early skin
aging if used as directed with other sun protection measures.
Broad-spectrum sunscreens with SPFs of 2-14 must display a warning
that the product has not been shown to help prevent skin cancer or
early skin aging. The terms sunblock, sweatproof and waterproof are
no longer allowed on sunscreen labels. Sunscreens may claim to be
water-resistant, but must specify whether they protect the skin for
40 or 80 minutes of swimming or sweating, based on standard
testing. Sunscreens that are not water-resistant must instruct
consumers to use a water-resistant sunscreen if swimming or
sweating. A company cannot claim that its sunscreen products
provide sun protection for more than two hours without submitting
test results to prove this. The FDA has proposed a regulation that
would require sunscreen products with SPF values higher than 50 to
be labeled SPF 50+. The FDA is seeking additional data before
making a final ruling. Learn more about high-SPF sunscreens. The
FDA is currently reviewing the effectiveness of sunscreen wipes,
powders, towelettes, as well as body washes and shampoo with
sunscreen ingredients. No decisions have been made. For sunscreen
spray products, the agency has requested additional data to
establish effectiveness and to determine whether they present a
safety concern if inhaled unintentionally.* *The Skin Cancer
Foundation recommends applying spray sunscreen in a well-ventilated
room, or outdoors (keeping in mind that the wind may carry some
sunscreen away). Keep your eyes and mouth closed when spraying
sunscreen. When applying to the face, its best to spray the
sunscreen on your hand and then apply to your face by hand. FDA
Sunscreen Labeling Guidelines at a Glance
Sunscreens may be labeled broad-spectrum if they provide protection
against both UVA and UVB radiation according to FDA-sanctioned test
methods. Only broad-spectrum sunscreens with an SPF of 15 or higher
may state that they help protect against skin cancer and early skin
aging if used as directed with other sun protection measures.
Broad-spectrum sunscreens with SPFs of 2-14 must display a warning
that the product has not been shown to help prevent skin cancer or
early skin aging. FDA Sunscreen Labeling Guidelines at a
Glance
The terms sunblock, sweatproof and waterproof are no longer allowed
on sunscreen labels. Sunscreens may claim to be water-resistant,
but must specify whether they protect the skin for 40 or 80 minutes
of swimming or sweating, based on standard testing. Sunscreens that
are not water-resistant must instruct consumers to use a
water-resistant sunscreen if swimming or sweating. A company cannot
claim that its sunscreen products provide sun protection for more
than two hours without submitting test results to prove this. FDA
Sunscreen Labeling Guidelines at a Glance
The FDA has proposed a regulation that would require sunscreen
products with SPF values higher than 50 to be labeled SPF 50+. The
FDA is seeking additional data before making a final ruling. Learn
more about high-SPF sunscreens. The FDA is currently reviewing the
effectiveness of sunscreen wipes, powders, towelettes, as well as
body washes and shampoo with sunscreen ingredients. No decisions
have been made. For sunscreen spray products, the agency has
requested additional data to establish effectiveness and to
determine whether they present a safety concern if inhaled
unintentionally.* What to apply first? medication should always be
the first product applied to a clean, washed face applying a
moisturizer after the medication could actually enhance penetration
of the medication apply a sunscreen with an SPF of 15 or higher
next finally, apply foundation, powder, blush and any other colored
cosmetics