18/2/2015 UCLBiochemicalandMicrobialEngineering[LBIRC2108]

http://www.uclouvain.be/encours2014LBIRC2108.html 1/2

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BiochemicalandMicrobialEngineering[LBIRC2108]

5.0crditsECTS 30.0h+22.5h 2q >Schedule

Teacher(s) AgathosSpyridon

Language French

Placeofthecourse

LouvainlaNeuve

Onlineresources

Icampus

Mainthemes

From design to scaleup on a pilot scale of microbial and enzymatic processes. Theoretical andmethodological foundations of applied chemical kinetics and design of chemical reactors with thecharacteristics(kineticsandtransportphenomena)ofbiochemicalandmicrobiologicalprocessesinordertosystematizetheprinciplesunderlyingtheanalysisanddesign/sizingofbioreactors.Specifics:

(Micro)biologicalprocessescharacterizedkineticallyandthermodynamically:cellgrowth,itsmeasurementorestimation,useofsubstrate(s),formationofproduct(s).Yields.Productivities.Kineticmodels.Parameterestimation.Themethodologyofmaterialandenergybalancesfortheanalysisofbiotechnologicalsystemsandoftheirperformance.Batch,continuous,semicontinuousreactors.Transportphenomenaappliedtotheanalysisofaeration,agitation,rheology,scaleupandsterilizationofbioreactors.

Aims

a.Contributiondel'activitaurfrentielAA(AAduprogramme)

1.22.12.22.44.14.24.58.5

b.FormulationspcifiquepourcetteactivitdesAAduprogramme

Attheendofthisactivity,thestudentisableto:

1.Applythemethodologyofmaterialbalancestotheanalysisofbiotechnologicalsystems2.Applythemethodologyofenergybalancetotheanalysisofbiotechnologicalsystems3.Applythemethodologyofreactordesigntotheanalysisanddesign/sizingofbioreactors(areaofbiochemicalandmicrobiologicalprocesses)inthespecificcaseofbatchreactors4.Applythemethodologyofreactordesigntotheanalysisanddesign/sizingofbioreactorsinthespecificcaseofCSTR(continuousstirredtankreactor).5.Applythemethodologyofreactordesigntotheanalysisanddesign/sizingofbioreactorsinthespecificcaseofsemicontinuousreactors(fedbatch).6.Applymasstransferphenomenaintheanalysisofdifferentoperations(aeration,agitation,etc.)thatcantakeplaceinbioreactors.7. Apply the phenomena of energy transfer to the analysis of different operations (aeration,agitation,etc.)thatcantakeplaceinbioreactors.

8. Apply the phenomena of transfer of momentum to the analysis of different operations (aeration,agitation,etc.)cantakeplaceinbioreactors.

9.Applythemethodologyofchemicalkineticsappliedtotheanalysisanddesign/sizingofbioreactors(areaofbiochemicalandmicrobiologicalprocesses).

10.Search for real values of constants ''or of other parameters in correlations that are essential to thedesign/sizingofbiologicalreactors.

11.Aspartof thedesignofanewbiologicalreactorpropose inareasonedmanner(with itsadvantagesand limitations) the design of themost appropriate reactor with respect to the industrial context underconsideration.

Evaluationmethods

Writtenexaminationin2parts1.Examinationrequiringshortanswersbutbasedonatheoreticaldevelopment2.Examinationfocusedonproblemsolving

Teachingmethods

1. Lectures, lectures with guided questions, including presentations of concrete examples from industrywith case analysis by the instructor [conventional lectures, interactive presentations using audiovisualequipment(videoprojections,powerpoint)]2. Exercise sessions in teams, guided. These exercises are designed to familiarize the student with themethodology of solving quantitative problems in the design and analysis of bioprocesses:makes use ofcalculationsforsizingorperformance,constructionofflowsheetscombiningunitoperations,searchofrealvalues of constants or other parameters of correlations useful in design or modeling / optimization of

COURSESDESCRIPTIONFOR20142015

18/2/2015 UCLBiochemicalandMicrobialEngineering[LBIRC2108]

http://www.uclouvain.be/encours2014LBIRC2108.html 2/2

bioprocesses.

Theactivitybeginswithafacetofacepresenceonly

Content

Definitions:Definitionsinbioengineeringquantitiesandreactorsmicrobialprocesses'yieldsofbiologicalprocesses in a reactor. Kineticmodels ofmicrobial growth.Modeling of a batch reactor modeling of acontinuous stirred biological system with and without recycling ' twostage continuous stirred systems.Enzymatic process reactors design and performance. Sterilization processes. Scaleup from laboratoryscale throughpilot scale to industrial scale.Bioseparationsengineering. Ideal recoveryprocess:primaryseparation, isolation, purification and polishing. Separation devices in industrial cell culture: continuousperfusionreactorwithcellretention.Advantagesandlimitationsofeachdesigninanindustrialcontext.

Bibliography

Mandatory supports(available on icampus): Notes, slides, chapters and sections specified from thetextbooks "Bioprocess Engineering Principles" by Pauline M. Doran 2nd edition (2013) and "BioprocessEngineering"byMichaelL.Shuler&FikretKargi2ndedition(2002) Other supports: video projections, recommended reading: chapters and sections from the abovetextbooks

Cycleandyearofstudy

>Premireannedemaster[120]bioingnieur:chimieetbioindustries,finalitspcialise

Facultyorentityincharge

>AGRO