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ThoraxThe Journal of the Thoracic Society(President I W B GRANT)

Editors: BENJAMIN B MILSTEIN and ANTHONY SEATON

Contents January 1981 Vol 36 No 1

Editorial: What is the true role of surfactant in the lung? page 1

ORIGINAL ARTICLES

Prognosis of peripheral lung tumours related to size of the primary TOM TREASURE AND J R BELCHER page 5

Immunological and respiratory changes in coffee workers EUGENIJA ZUSKIN, FEDOR VALIC, ANDBOZICA KANCELJAK page 9

Perioperative risk of complete heart block in patients with bifascicular block and prolonged PRinterval FRANK L MIKELL, E KENNETH WEIR, AND ELLIOT CHESLER page 14

Time course of response to prednisolone in chronic airflow obstruction JONATHAN WEBB, T J H CLARK,AND CLAIR CHILVERS page 18

Recovery of plasma corticotrophin and cortisol levels after a three-week course of prednisoloneJONATHAN WEBB AND T J H CLARK page 22

Hepatobronchial fistula caused by hyatid disease J BORRIE AND J H F SHAW page 25

Use of lung pressure-volume curves and helium-sulphur hexafluoride washout to detect emphysema insubjects with mild airflow obstruction R PETRIK PEREIRA, D HUNTER, AND N B PRIDE page 29

Moment analysis of the flow-time curve after breathing gases of different densities M R PARTRIDGE,A C WATSON, AND K B SAUNDERS page 38

Bicuspid mitral bioprosthesis E BODNAR, N L R BOWDEN, P J DRURY, E G J OLSEN, I DURMAZ, ANDD N ROSS page 45

Deposition of pressurised aerosols in the human respiratory tract STEPHEN P NEWMAN, DEMETRI PAVIA,FOLKE MOREN, NOIRIN F SHIEAHAN, AND STEWART W CLARKE page 52

Circulating immune complexes in patients with lung cancer JULIA LOWE, AMADA SEGAL-EIRAS, P B ILES,AND R W BALDWIN page 56

Serum immunoreactive trypsin in cystic fibrosis P DANDONA, MARGARET HODSON, J BELL, L RAMDIAL,I BELDON, AND J C BATTEN page 60

Middle aortic syndrome as a cause of heart failure in children and its management SAIBAL GUPTA,B GOSWAMI, D C GHOSH, AND A N SEN GUPTA page 63

SHORT REPORTS

Intrathoracic chemodectoma with noradrenaline secretion BISHAN K NIGAM, SITEPHEN L HYER,EVELYN J TAYLOR, AND TUPAS GUHA page 66

Infective endocarditis from group C streptococci causing stenosis of both the aortic and mitral valvesM K DAVIES, M A IRELAND, AND'D B CLARKE page 69

Proceedings of the Society of Thoracic and Cardiovascular Surgeons of Great Britain and Irelandpage 72

Notice page 71

ASTM CODEN: THORA 7 36(1)1-80 1981 ISSN 0040"637

Published by British Medical Association, Tavistock Square, London WCIH 9JR and printed in England by Bradleys, Reading & Londo

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CONTENTS 1981

NoI1JANUARY PAGE

Editorial: tisth tueroeWhatacaniiseunthe.....true......role......of....surfactant............in....the.....lung........1.ORIGINAL ARTICLESPrognosis of peripheral lung tumours related to size of the primary TOM TREASURE, JR BELCHER............... 5Immunological and respiratory changes in coffee workerS EUGENIJA ZUSKIN, FEDOR VALIC, B02ICA

KA CLANCELJ .........................................................................................K.......................9..Perioperative risk of complete heart block in patients with bifascicular block and prolonged PR interval

FRANK L MIKELL, E KENNETH WEIR, ELLIOT CHESLER.14......................................................................1Time course of response to prednisolone in chronic airflow obstruction JONATHAN WEBB, TJH CLARK,

CLAIR L E S......................................CHILVER...............................................................18...........Recovery of plasma corticotrophin and cortisol levels after a three-week course of prednisolone JONATHAN

Use of lung pressure-volume curves and helium-sulphur hexafluoride washout to detect emphysema in subjectswith mild airflow obstruction R PETRIK PEREIRA, D HUNTER, NB PRIDE ........................................... 29

Moment analysis of the flow-time curve after breathing gases of different densities MR PARTRIDGE, AC WATSON,KB S U D R......................SAUNDERS.............................................................................38................3

Bicuspid mitral bioprosthesiS E BODNAR, NLR BOWDEN, PJ DRURY, EGJ OLSEN, I DURMAZ, DN ROSS................ 45Deposition of pressurised aerosols in the human respiratory tract STEPHEN P NEWMAN, DEMETRI PAVIA,

FOLKE MOREN, NOiRiN F SHEAHAN, STEWART W CLARKE.................................................................. 52Circulating immune complexes in patients with lung cancer JULIA LOWE, AMADA SEGAL-EIRAS, PB ILES,

RW B L W N.........................BALDWIN............................................................................56.................5Serum immunoreactive trypsin in cystic fibrosiS P DANDONA, MARGARET HODSON, J BELL, L RAMDIAL, I BELDON,

JC B T E............................BATTEN..........................................................................60...................6Middle aortic syndrome as a cause of heart failure in children and its management SAIBAL GUPTA, B GOSWAMI,

DC G O H A E UP A...GH...................H..............AN..............SEN.................GUPTA..........................63.......6SHORT REPORTSIntrathoracic chemodectoma with noradrenaline secretion BISHAN K NIGAM, STEPHEN L HYER, EVELYN J TAYLOR,

TUPA U A.........................................................GUHA................................................66.................6Infective endocarditis from group C streptococci causing stenosis of both the aortic and mitral valves MK

DAVIES, MA IRELAND, DB CLARKE.69..............................................................................................6Proceedings of the Society of Thoracic and Cardiovascular Surgeons of Great Britain and Ireland ................ 72

No 2 FEBRUARY

ORIGINAL ARTICLESRTH Ladnnec 1781-1826. His life and work: a bicentenary appreciation ALEX SAKULA.............................. 81LanecaismdcnnisoyRYKER........his...........medical.....................history....................RY........KEER.............. 91Auscultation of the heart since Laennec BEA AHM.......................BREY.................LEATHAM........................ 95Auscultation of the lung: past lessons, future possibilitieS RAYMOND L MURPHY ...................................... 99Ultrastructural localisation of lactoferrin and glycoprotein in human bronchial glandS DENISE BOWES,

AE C A K B C R I........CLARK,....................................B............C...........RR................N...........108.............0Relationship between asthima and gastro-oesophageal reflUX ROBERT JR GOODALL, JOHN E EARIS, DAVID N COOPER,

ALAN BERNSTEIN, JOHN G TEMPLE.116..........................................................................................1Raised enzyme markers of chronic inflammation in asymptomatic farmers' lung CWG TURTON, G FIRTH,

E GRUNDY, BG RIGDEN, JT SMYTH, M TURNER-WARWICK ...................................................................122Echocardiography in combined discrete and hypertrophic subaortic stenosiS RICHARD CHARLES, CAROLYN

MAKIN, NORMAN COULSHED, DAVID HAMILTON.126.............................................................................2Pattern of carbon dioxide stimulated breathing in patients with chronic airway obstruction CHRISTOPHER S

GARRARD, D J A E...............................DONALD......................................LANE.....................130.........3Tidal expiratory flow patterns in airflow obstruction MJ MORRIS, DJ LANE............................................. 135Assessment of factors influencing the result of sputum cytology in bronchial carcinoma MD CLEE, DJM SINCLAIR 143SHORT REPORTSMucous gland adenoma of the bronchus CW EDWARDS, HR MATTHEWS...................................................147Chronic pericardial effusion after mediastinal radiotherapy STEPHANIE A GOMM, TB STRETTON...................... 149Mitral valve replacement using cold cardioplegia in a patient with sickle cell trait I HUDSON, IA DAVIDSON,

CGA C R G R..........................MCGREGOR...................................................................151.....................Acquired hypertrichosis lanuginosa and carcinoma of the bronchus CD SHEE, VAL GRAHAM......................... 153Pneumomediastinum as a complication of athletic competition EDWIN J MORGAN, DAVID A HENDERSON.........155Congenital bilateral absence of diaphragM NURIA TORAN, JOHN L EMERY.................................................157Co r s o dnerrespondence.................................................................................................159..................5



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No 3 MARCH PAGE

Editorial: Normal and abnormal function of the diaphragm .................... ................................................................. 161ORIGINAL ARTICLESContractile properties and fatigue of the diaphragm in man JOHN MOXHAM, AJR MORRIS, SG SPIRO, RHT EDWARDS,

MALCOLM GREEN.16Limitations of measurement of transdiaphragmatic pressure in detecting diaphragmatic weakness ANDRE DE

TROYER, MARCESTENNEN16Bronchoscopic management of tracheal lesions using the neodynium yttrium aluminium garnet laser L TOTY,

C PERSONNE, A COLCHEN, G VOURC H ....................................................................................................................... 175Intrabronchial metastases from renal carcinoma with recurrent tumour expectoration AG JARIWALLA, A

SEATON, RJM MCCORMACK,AGIBBS,IA CAMPBELL, BH DAVIES....................................................................................................................... 179Endobronchial metastasis from renal adenocarcinoma simulating a foreign body E AMER, J GUY, B VAZE 183Atopy and wheeze in children according to parental atopy and family size JOHN B DAVIS, CHRISTOPHER J BULPITT 185Comparison of radiotherapy alone and radiotherapy with chemotherapy using adriamycin and 5- fluorouracil

in bronchogenic carcinoma G ANDERSON, TJ DEELEY, C SMITH, J JANI................................................................... ........................... 190Clotted false lumen: reappraisal of indications for medical management of acute laortic dissection CJ

SANDERSON, STUART RICH, POLLY A BEERE, CE ANAGNOSTOPOULOS, JAMES M LEVETT, J MARK LAWRENCE............... 194Randomised controllled trial of rehabilitation in chronic respiratory disability AE COCKROFT, MJ SAUNDERS,

G BERRY.20Late respiratory sequelae of blunt chest injury: a preliminary report CHRISTOPHER D HANNING, EILEEN

LEDINGHAM, IAIN MCA LEDINGHAM ........................................................................................................................ 204Pulmonary involvement in primary biliary cirrhosis R RODRIGUEZ-ROISIN, A PARES, M BRUGUERA, J COLL,

C PICADO, A AGUSTI-VIDAL, F BURGOS, J RODES ............................................ ........................................................................... 208Objective in vivo analysis of anti-smoking cigarette filters NOIRiN F SHEAHAN, D PAVIA, JRM BATEMAN, JE AGNEW,

SWCLARKE.213SHORT REPORTSCongenitally corrected transposition of the great arteries with tricuspid incompetence: successful treatment by

xenograft valve replacement in a 15-month-old child ALISTAIR ROSS, CHRISTOPHER LINCOLN 217Progressive generalised scleroderma: respiratory failure from primary chest wall involvement DC RUSSELL,

A MALONEY, ALMUIRI219Proceedings of the Thoracic Society and the British Thoracic Association ..................................................................................... 221Correspondence ...........................7.............................................................

No 4 APRIL

Editorial: Asbestos and public health ........................... ......................................................................... 241ORIGINAL ARTICLESMoses Maimonides' Treatise on Asthma FRED ROSNER ............................................................................ ........................................... 245Simultaneous occurrence of pulmonary interstitial fibrosis and alveolar cell carcinoma in one family

F BEAUMONT, HM JANSEN, JD ELEMA, LP TEN KATE, HJ SLUITER .................................................................................................................. 252Arterial plasma histamine levels at rest, and during and after exercise in patients with asthma: effects of terbu-

taline aerosol SANDRA D ANDERSON, PTB BYE, RE SCHOEFFEL, JP SEALE, KM TAYLOR, L FERRIS ............ .................. 259H2 receptor blockade and bronchial hyperreactivity to histamine in asthma STEPHEN G NOGRADY, CAROL BEVAN 268Comparison between irrigation and conventional treatment for empyema and pneumonectomy space infection

FL ROSENFELDT, D MCGIBNEY, MV BRAIMBRIDGE, DA WATSON ....................................................................................................................... 272Systemic absorption of noxythiolin from the pleural cavity in man and in the rabbit LF ROSENFELDT, JR

GLOVER, DMAROSSY.278Management of pleural sepsis in Nigerian children CHIJIOKE H ANYANWU, MARTIN EGBUE ..................... .............................. 282Pulmonary function abnormalities in Sjogren's syndrome and the sicca complex ILIA SEGAL, GERSHON FINK,

ISRAEL MACHTEY, VIKTOR GURA, SHIMON A SPITZER ......................................................... .............................................................. 286Lobar pressure-volume characteristics of excised human lungs N BEREND, C SKOOG, WM THURLBECK ........................ 290Association of HLA B8 with spontaneous resolution in sarcoidosis MJ SMITH, CWG TURTON, DN MITCHELL, M

TURNER-WARWICK, LM MORRIS, SD LAWLER ....................................................................................................................... 296Time and place for sputum cytology in the diagnosis of lung cancer F HARTVEIT........................................................................... 299Sustained release oral aminophylline in patients with airflow obstruction AP GREENING, E BAILLIE, HR GRIBBIN,

NBPRIDE.303Ketotifen in atopic asthma and exercise-induced asthma IS PETHERAM, J MOXHAM, CW BIERMAN, M MCALLEN

SGSPIRO.308SHORT REPORTSLung bullae, bronchiectasis, and Hashimoto's disease associated with ulcerative colitis treated by colectomy

JM SHNEERSON ................................................................................................................................................................................................................313



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Arteriovenous fistula of the thoracic aorta: report of a case presenting with superior vena caval obstructionEULOGIO MARTINEZ, JOSE MELLER, MOACIR GODOY, JOAO LOURENCO V HERRMANN, ENIO BUFFOLO ............ .................. 315

Correspondence ..............................................................................................

No 5 MAY

Editorial: Development of secondary polycythaemia in chronic airways obstruction .................. .... 321ORIGINAL ARTICLESTreatment of pulmonary infections caused by mycobacteria of the Mycobacterium avium-intracellulare complex

AM HUNTER, IA CAMPBELL, PA JENKINS, AP SMITH .......................................... ............................................................................ 326Homograft aortic valve replacement: seven years' experience with antibiotic-treated valves SK KHANNA, JK

ROSS, JLMONRNR3Allergic bronchopulmonary disease caused by Curvularia lunata and Drechslera hawaiiensis ROSE MCALEER,

DOROTHEA B KROENERT, JANET L ELDER, JH FROUDIST ..................................................................... ................................................. 338Allergic bronchopulmonary fungal disease without clinical asthma JOHN J GLANCY, JANET L ELDER, ROSEMCALEER.345

Surgical treatment of congenital coronary artery fistula STANLEY JOHN, W JOHN PERIANAYAGAM, S MURALID-HARAN, V NANDAKUMAR, RUTH MANSFIELD, S KRISHNASWAMY, IP SUKUMAR, GEORGE CHERIAN ....................... ............ 350

Catheter tip cultures on open-heart surgery patients: associations with site of catheter and age of patientsFREEMAN, N HJERSING, ANITA BURRIDGE ...................................................................................................................... 355

Morphometry of pulmonary arteries from angiograms in chronic obstructive lung disease KEITH HORSFIELD,MICHAELTHOMAS.360

Carbon monoxide in breath in relation to smoking and carboxyhaemoglobin levels NICHOLAS J WALD,MARIANNE IDLE, JILLIAN BOREHAM, ALAN BAILEY ............................................ .................................................................... . .... 366

Intrasubject variability of pulmonary function testing in healthy children ARLENE A HUTCHISON, ANNA ERBEN,LOUISE A MCLENNAN, LOUIS I LANDAU, PETER D PHELAN ....................................................................................................... ............... 370

Inhaled prazosin in asthma PETER J BARNES, PHILIP W IND, COLIN T DOLLERY .....................7............................8..........................378Dose-dependency of theophylline clearance and protein binding JA FLEETHAM, CE BIRD, K NAKATSU, RD WIGLE,PWMMUNT.38

Synergism between ipratropium and theophylline in asthma HARVEY KREISMAN, HAROLD FRANK, NORMANWOLKOVE, MICHAELGENT.387

Operation for repair of obstructed substernocostal (Morgagni) hernia K MOGHISSI ........ ............................................................ 392SHORT REPORTSAmyloid producing tumour of the lung UGUR HACIHANEFIOGLU, ENGIN UZGOREN ........................................................................ 395Pulmonary veno-occlusive disease in unilateral hypertransradiant lung M PAJEWSKI, R REIF, H MANOR, R

STARINSKY, DKATZIR.397Correspondencee400

No 6 JUNE

Editorial: Should corticosteroid aerosols be used in severe chronic asthma? ............................................................. 401ORIGINAL ARTICLESJoseph Skoda 1805-81: a centenary tribute to a pioneer of thoracic medicine ALEX SAKULA ............. ............................. 404Pneumonconiosis of shale miners A SEATON, D LAMB, W RHIND BROWN, G SCLARE, WG MIDDLETON .................. 412Cardiopulmonary function in fibrodysplasia ossificans progressiva JM CONNOR, CC EVANS, DAP EVANS .................. 419Adaptive response to pneumonectomy in puppies WILLIAM THURLBECK, WAYNE GALAUGHER, JOAN MATHERS ...... 424Use of exercise tests in assessment of the functional result of aortocoronary bypass surgery IY LUKSIC, JA RAFFO,

DASG MARY, DA WATSON, PB DEVERALL, RJ LINDEN................................................................................................................. 428Circulating catecholamines in exercise and hyperventilation induced asthma PJ BARNES, MJ BROWN, M

SILVERMAN, CTDOLLERYE435Palliative side-to-side oesophagogastrostomy for unresectable carcinoma of the oesophagus and cardia KOING-

BO KWUN, PAUL A KIRSCHNER............................................................................................. .................. . ...... 441In vitro monocyte maturation as a prediction of survival in squamous cell carcinoma of the lung RICHARD G

DENT, PETERCOLEL446Exponential analysis of lobar pressure-volume characteristics N BEREND, C SKOOG, WM THURLBECK ........L...........1......452Mechanical inefficiency of the thoracic cage in scoliosis RS JONES, JD KENNEDY, F HASHAM, R OWEN, JF TAYLOR 456Oral VP-16-213 in advanced bronchogenic carcinoma and toxic effects when combined with methotrexate

G ANDERSON, F BOWYER, L WILLIAMS........................................... ............. ........................................... . ......... 462Congenital oesophageal stenosis caused by tracheobronchial structures in the oesophageal wall NBN IBRAHIM,SANDRY.465



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No 6 JUNE continued PAGE

Radiographic appearance of mycoplasma pneumonia OC FINNEGAN, SJ FOWLES, RJ WHITE ................ ............................. 469Estimation of arterial oxygen tension in adult subjects using a transcutaneous electrode DCS HUTCHISON,

G ROCCA, DHONEYBOURNE.473SHORT REPORTTrichosporon capitatum causing recurrent fungal endocarditis AG ARNOLD, B GRIBBIN, M DE LEVAL, F MACART-

NEY, MSLACK.478Correspondence.480

No 7 JULY

Editorial: The pulmonary clock ..............................................4................................................................................81ORIGINAL ARTICLESReception of the stethoscope and Laennec's book PJBISHOP..... 487Gastric emptying after oesophagectomy as assessed by plasma paracetamol concentrations P GOLDSTRAW,

P BACH........................................................................................................................................................................................................................493Hydatid cyst of the liver with intrathoracic rupture DS XANTHAKIS, E KATSARAS, M EFTHIMIADIS, G PAPADAKIS,

G VAROUCHAKIS, C ALIG IZAKIS...................................................................................................................................................................................................97Recurrent chest infections, ciliary abnormalities and partial complement deficiency in a Jordanian family

ID STARKE, B CORRIN, PJ SELBY, ADB WEBSTER, M TURNER-WARWICK ...................................... ............................................................. 502Bronchial needle aspiration in the diagnosis of bronchial carcinoma G BUIRSKI, PMA CALVERLEY, NJ DOUGLAS,

D LAMB, M MCINTYRE, MF SUDLOW, H WHITE ........................................................................................................................ 508Serum and sputum a2 macroglobulin in patients with chronic obstructive airways disease DAVID BURNETT,

ROBERT ASTOCKLEY.512Exercise-induced bronchoconstriction as an expression of bronchial hyperreactivity: a study of its mechanisms

in children HERMAN J NEIJENS, TACO WESSELIUS, KAREL F KERREBIJN ....................................... ......................................................... 517Influence of age on response to ipratropium and salbutamol in asthma MI ULLAH, GB NEWMAN, KB SAUNDERS 523Site of action of ipratropium bromide and clinical and physiological determinants of response in patients with

asthma MR PARTRIDGE, KB SAUNDERS ........................................................................................................................ 530Cardiovascular response during severe acute asthma and its treatment in children AT EDMUNDS, S GODFREY 534Management of oesophageal perforation associated with benign stricture and hiatus hernia by oesophagoplasty

and fundoplication DKC COOPER ......................................................................................................................... 541Alveolar proteinosis lung lavage using partial cardiopulmonary bypass ALLAN P FREEDMAN, ANASTASIOS

PELIAS, ROBERT F JOHNSTON, INDER P GOEL, HADI I HAKKI, THEODORE OSLICK, JAMES P SHINNICK ............ .................. 543Ventilatory function test values of healthy adult Jordanians NAIF A SLIMAN, BASEM M DAJANI, HURAIRA MDAJANI.546

SHORT REPORTSOat cell carcinoma of bronchus presenting with somatostatinoma syndrome RR GHOSE, SK GUPTA.............................. 550Progressive lung disease in a malt-worker ME ELLIS, JAR FRIEND ............................. ........................................................ 552Pneumonectomy for massive ventilated lung cysts ED BATEMAN, DE WESTERMAN, RP HEWITSON, AD FERGUSON 554Fulminating chromobacterial septicaemia presenting as respiratory distress syndrome TS LEE, BALLARD DWRIGHT.557

Correspondence .........................................................................................................................560........................Correction ..............................................................................................................................................................................................560

No 8 AUGUST

Editorial: Measurement of bronchial reactivity: a question of interpretation .................................................................................... 561ORIGINAL ARTICLESCauses of pneumonia presenting to a district general hospital RJ WHITE, AD BLAlNEY, K JOY HARRISON, SKRCLARKE.566

Induction of bronchial hypersensitivity: evidence for a role for prostaglandins EH WALTERS, RW PARRISH,C BEVAN, APSMITH.571

Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptomsof asthma EF JUNIPER, PA FRITH, FE HARGREAVE .......................................... .............................................................................. 575

Effect of aerosol and oral fenoterol on histamine and methacholine challenge in asthmatic subjects CM SALOME,_RE SCHOEFFEL, AJ WOOLCOCK............................ : 0

Follow-up study of disability among elderly patients discharged from hospital with exacerbations of chronicbronchitis HEDLEY PEACH, MS PATHY ....................................................................................................................... 585

Surgical management of pericarditis in Zaria, Nigeria OA MABOGUNJE, CO ADESANYA, MS KHWAJA, JH LAWRIE,GM EDINGTON.590..........



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No 8 AUGUST continued PAGE

Hyperventilation or exercise to induce asthma? PM TWEEDDALE, DJ GODDEN IWB GRANT......................................................... 596Small pulmonary arteries in some natives of La Paz, Bolivia D HEATH, P SMITH, J RIOS DALENZ, D WILLIAMS,

PHARRIS.599Hypothalamic-pituitary dysfunction in respiratory hypoxia PETER d'A SEMPLE, GRAHAM H BEASTALL, WALTER S

WATSON, ROBERT HUME 605Circulating immune complexes in tuberculosis N MCI JOHNSON, MW MCNICOL, EJ BURTON-KEE, JF MOWBRAY ...... 610Diurnal variation in airflow obstruction in chronic bronchitis KD DAWKINS, MF MUERS ............................ ............................ 618Effect of tobacco smoke exposure on rat tracheal submucosal glands: an ultrastructural study DJ LEWIS, PRJAKINS.622

Optimal dose of salbutamol respiratory solution: comparison of three doses with plasma levels EH WALTERS,A COCKROFT, T GRIFFITHS, K ROCCHICCIOLI, BH DAVIES ..................................................................................................... .................. 625

Comparison of inhaled and intravenous terbutaline in acute severe asthma SJ WILLIAMS, SJ WINNER, TJHCLARK.629

SHORT REPORTSPleural effusion associated with urinary tract obstruction: support for a hypothesis FW LEUNG, AJ WILLIAMS,PAOOILL.63

Sleep apnoea syndrome caused by neurofibromatosis and superior vena caval obstruction JR STRADLING,S HUDDART, AGARNOLDO634

Familial sarcoidosis presenting with stridor S PRIESTLEY, JC DELANEY.................................................................................... 636Coexisting congenital primary superior vena caval aneurysm and rheumatic mitral stenosis CK MOK, CW CHAN,

RT CLARE, GBONG.638Correspondence.640

No 9 SEPTEMBER

Editorial: The asthma syndrome: inciters, inducers, and host characteristics .................................................................................... 641ORIGINAL ARTICLESImmunohistochemical study of collagen types in human foetal lung and fibrotic lung disease ED BATEMAN,

M TURNER-WARWICK, BC ADELMANN-GRILL ....................................................................................................................... 645Nasal mucociliary clearance and ciliary beat frequency in cystic fibrosis compared with sinusitis and bronchiec-

tasis JONATHAN RUTLAND, PETER J COLE ....................................................................................................................... 654Present outlook in bronchiectasis: clinical and social study and review of factors influencing prognosis DA ELLIS,

PE THORNLEY, AJ WIGHTMAN, M WALKER, J CHALMERS, JW CROFTON ...................................................................................................... 659Antigen of Haemophilus influenzae in bronchial tissue CHRISTOPHER W CLARKE, CATHERINE A HANNANT,

RALPH SCICCHITANO, KEN J DONALD, BARRY JACKSON ..................................................................... .................................................. 665Non-malignant asbestos pleural disease GUNNAR HILLERDAL .................................................................................... 669Management of disrupted sternotomy AC ROY, JRH PENHALL, EWJ CAMERON .................................................................................... 676Rationale for the surgical treatment of pulmonary metastases PETER MARKS, MOHAMED Z FERRAG, HASHMATASHRAF.679

Is cough as effective as chest physiotherapy in the removal of excessive tracheobronchial secretions? JRMBATEMAN, SP NEWMAN, KATHLEEN M DAUNT, NOIRIN F SHEAHAN, D PAVIA, SF CLARKE............................................................ 683

Ferritin, finger clubbing, and lung disease JM SHNEERSON, BM JONES .................................... ................................................ 688SHORT REPORTSLiposarcoma of the mediastinum: report of two cases and review of the literature RJ STANDERFER, SH ARMISTEAD,

MPANETH.693Hydralazine lung BHBAASS695Bilateral congenital coronary artery fistula A SCHNEEWEISS, S RATH, HN NEUFELD ........................................................................ 697Traumatic chylothorax associated with subarachnoid-pleural fistula PAULO CERATTI AZAMBUJA, LUIS SERGIOFRAG.M.NI.699

Chylothorax complicating repair of a left diaphragmatic hernia in a neonate A CZERNIAK, Z DREZNIK,Y NEUMAN, IWOLFSTEIN.701

Myopathy and external pulmonary artery compression caused by sarcoidosis MM KHAN, DS GILL, B MCCONKEY 703Chronic pulmonary histoplasmosis in an Irishman M MADDEN, JD KENNEDY, HT HITCHCOCK, D O'BEIRN.................. 705Proceedings of the Scottish Thoracic Society and the Thoracic Society .......................................... .............................. 707Correspondenc.719

No 10 OCTOBER

Editorial: Mast cells and basophils: effector cells of inflammatory disorders in the lung ............................. ............................ 721



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ORIGINAL ARTICLESA calcium antagonist, nifedipine, modifies exercise-induced asthma PETER Ji BARNES, NICOLA M WILSON,

MORRIS O N..........................................................BROWN.......................................726.................2Histamine dose-response curves in asthma: relevance of the distinction between PC20 and reactivity in character-

ising clinical state A BEAUPRtJAO.......................JL...........................MAL.................................... 731Modulation of histamine-induced bronchoconstriction with inhaled, oral and intravenous clemastine in normal

and asthmatic subjects V HARTMANN, H MAGNUSSEN, JP HOLLE, E SCHULER..........................................737Intravenous salbutamol and aminophylline in asthima: a search for synergy PDJ HANDSLIP, AM DART, BH

DA I S......................................IES....................................................741....................................4Pulmonary aspergillus infection invading the pleura GUNNAR HILLERDAL ...............................................745Prognostic value of pulmonary artery pressure in chronic obstructive pulmonary disease E WEITZENBLUM, C

HIRTH, A DUCOLONE, R MIRHOM, J RASAHOLINJANAHARY, M EHRHART...................................................752Hypoxic and hypercapnic response in asthmatic subjects with previous respiratory failure ARLENE A HUTCHISON,

ANTHONY S Y......................................................L.............N....................Y.............759...............5Nail haemorrhages in native highlanders of the Peruvian AndeS DONALD HEATH, PETER HARRIS, DAVID WILLIA,MS,

HEVER G R............................................KRUGER.....................................................764....................6Hypoxia and the neonatal rabbit lung: neuroendocrine cell numbers, 5-HT fluorescence intensity, and the

relationship to arterial thickness IM KEITH, JA WILL....................................................................767Penetration of piperacillin into bronchial mucosa and SpUtUM GE MARLIN, KR BURGESS, J BURGOYNE, GR

FUNNEL, G I N SS................................MDG...................GU..............NNESS............................774...........7Serum, saliva, and sputum levels of metronidazole in acute exacerabations of chronic bronchitiS D SIEGLER

CM KAYE, SHEENA REILLY, AT WILLIS, MG SANKEY ..........................................................................781Multiple bronchial stenoses: treatment by mechanical dilatation PB ILES.................................................784Effect of oral salbutamol and slow-release aminophylline on exercise tolerance in chronic bronchitiS AG

LEICHITCHGA,,ALAS,GMORGAN,ALET,GJDAADYELLIS,........G...BELL,......C...HASLETT..........G...R...MCHARDY........ 78778Angiotensin converting enzyme in bronchoalveolar lavage fluid in pulmonary sarcoidosis M PERRIN-FAYOLLE,

Y PACHECO, R HARF, B MONTAGNON, N BlOT.................................................................................. 790SHORT REPORTSProlonged wheezing and tracheal compression caused by an aberrant right subclavian artery CH MAAYAN, P

MOGLE, A ,S GO F E....................A.........TAL,....................S.........GODFREY................................793.........9Endobronchial pulp-canal reamer extracted with the fibreoptic bronchoscope CFC RIZZON, LC SEVERO ..........795False aneurysm of the ascending aorta with aortico-right fistula SA PHiOTIOU, TK KAUL, JL MERCER...............796Acute hiatal hernia after Heller's operation my RABAU, I AVIGAD, A CZERNIAK, Y LIBERMAN, I WOLFSTIN .......798Correspondence .......................................................................................................800..................0

No 1 1 NOVEMBER

Editorial: Alveolar response to injury.801............................................................................................0ORIGINAL ARTICLES

Cryptogenic obliterative bronchiolitis in adUltS CW TURTON, G WILLIAMS, M GREEN....................................805Cardiac damage presenting late after road accidentS ALAN F MACKINTOSH, HUGH A FLEMING........................811Low-dose propranolol for the protection of the left ventricle from ischaemic damage A HEDLEY BROWN,

BRETT L KRAUSE, GRAHAM M MORRITT.814.......................................................................................1Plasma cyclic nucleotide levels in exercise-induced asthma JPR HARTLEY, CJ DAVIES, TJ CHARLES, RDH MONIE,

SG NRRGY D W I S N..N.........RGRADY..................................MD.............W.........N..............N.........823.........2Occupational asthma in a factory making flux-cored solder containing colophony P SHERWOOD BURGE,

GERALDINE EDGE, ROSEMARIE HAWKINS, VANESSA WHITE, AJ NEWMAN TAYLOR ........................................828Predicting recovery from acute severe asthma PF JENKINS, GFA BENFIELD, AP SMITH ..................................835Respiratory morbidity and lung function in schoolchildren aged 7 to 11I years in South Wales and the West of

England YANL,SSTLGR...........JWG............YARNELL,..........................AS.........ST..........LEGER.............. 842Respiratory infections and their influence on lung function in children: a multiple regression analysis JWG

YARNELL, E E.......................................AS..............ST...............LEGER.............................847...........4Reproducibility of flow rates measured with low density gas mixtures in exercise-induced bronchospasm

STEPHEN G SPIRO, C WARREN BIERMAN, IAN A PETHERAM ...................................................................852Interrelationship between lung volume, expiratory flow, and lung transfer factor in fibrosing alveolitis

JN P N E..............................PAN..........................................E......................858.............................5Cervical gastrostomy in the surgical treatment of oesophageal cancer by reconstruction with the stomach

JL B R O..........................BARR.......................................................................863..........................6Investigation of alveolar macrophage function using lucigenin-dependent chemiluminescence ANDREW J

WILLIAMS, J CO E.......................................PETER....................................COLE.....................866..........6



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CONTENTS

No 11 NOVEMBER continued PAGE

Postoperative intrapleural BCG in lung cancer: lack of efficacy and possible enhancement of tumour growthW BAKKER, JMA NIJHUIS-HEDDES, AMJ WEVER, A BRUTEL DE LA RIVIERE,EAVANDER VELDE, JH DIJKMAN............... 870

SHORT REPORTSGiardia lamblia in bronchoalveolar lavage fluid WIM J STEVENS, PAUL A VERMEIRE .............................................................. 875Giant cell arteritis limited to large elastic pulmonary arteries SJOERD SC WAGENAAR, CEES JJ WESTERMANN,

BRYAN CORRIN ................................................................................................................................................................................................................876Normal pregnancy and delivery in a woman with severe underlying lung disease ST WEISS, SE WEINBERGER,

JW WEISS, TS JOHNSON ...........................................................................................................................................................................................................878Correspondence ..............................................................................................................................................................................................................880

No 12 DECEMBER

Editorial: Compensating occupational asthma ............................................................................... 881ORIGINAL ARTICLESSurgical treatment of bullous lung disease PD POTGIETER, SR BENATAR, RP HEWITSON, AD FERGUSON 885Surgical treatment of carcinoma of the oesophagus JF DARK, H MOUSALLI, R VAUGHAN ......................................................... 891Benign asbestos pleural effusion: diagnosis and course BWS ROBINSON, AW MUSK .......................................... ............................. 896Reactive mesothelial proliferation: a necropsy study CD SHELDON, AMANDA HERBERT, PJ GALLAGHER ..................... 901Occupational asthma caused by a plastics blowing agent, azodicarbonamide AJM SLOVAK ................................................ 906Experimental cotton-fibre pulmonary embolism in the rat BRIAN JOHNSTON, PAUL SMITH, DONALD HEATH 910Protective value of dust respirators in extrinsic allergic alveolitis: clinical assessment using inhalation provocation

tests DJ HENDRICK, R MARSHALL, JA FAUX, JM KRALL ........................................................................................... ........................... 917Radionuclide determined pulmonary blood volume in ischaemic heart disease WJ HANNAN, J VOJACEK, HM

CONNELL, NG DEWHURST, AL MUIR ....................................................................................................................... 922Determination of mortality risk in obstructive pulmonary syndromes: physical examination compared with

measurement of forced expiratory volume in one second NE PARDEE, RH WINTERBAUER, EH MORGAN, JDALLEN.. . 928

Volume of emphysema P TURNER, WF WHIMSTER ...................................................................................................................... 932Alveolar development after ligation of left pulmonary artery in newborn pig: clinical relevance to unilateral

pulmonary artery SHEILA G HAWORTH, SHEILA A MCKENZIE, MARGARET L FITZPATRICK ................ .................................. 938Automated system for the measurement of airways resistance, lung volumes, and flow-volume loops PiJ

CHOWIENCZYK, PJ REES, TJHCLARK....................................................................................................................... 944SHORT REPORTSOccupational asthma after exposure to a diazonium salt VAL GRAHAM, MJS COE, RJ DAVIES ................................................ 950Impalement wound of the chest A GROSSI, B MEZZACAPO, G BIAGI, G GOTTI .......................................................................................... 952Ventilatory failure after Pasteurella multocida pneumonia PMA CALVERLEY, NJ DOUGLAS, DR BUCHANAN,

AMMWILSON...... 954Riedel's thyroiditis with invasion of the lungs MJ WARD, D DAVIES 956Empyema after internal jugular catheterisation in rheumatoid arthritis VB ANTONY, SA SAHN ............................ 958Correspondence..9.6.0...................................Index ......9.6........1...... ....1.....



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