Testicular Anatomy

Sertoli cell

nucleus

Gonadal Differentiation

cortical

medullary

Mullerian and Wolffian Duct Systems

cervix

External Genitalia

Brain Differentiation

testis

testosterone

TE

BRAIN

What does testosterone do developmentally?

Tonic secretion of GnRH in puberty

Summary

Undifferentiated gonad

Y-chromosome:SRYTDF

Embryonic Testis

Sertoli cells

Leydig cells

MIF Mullerian ductregression

testosterone Wollfian duct

DHT

Masculinization ofexternal genitalia

estrogen

Masculinization of the brain