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t-cell receptor signaling

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C D 4 / C D 8 T e x t P P P c-Jun T-Cell Receptor Signaling ATF2 NF-B NFAT Elk1 SRF NFAT IKKs p38 JNK MKK4/7 MKK3/6 VHR Ca 2 + Ca 2 + Ca 2 + IB Degradation MEKK1 Ca 2 + MEK1/2 Raf1 PKC PIP2 ERK1/2 Fyn Fyn ITK Fyb GADS SLP76 PLC GRB2 Ca 2 + Akt PI3K SHP2 P P P P P CARD11 MALT1 BCL10 PAK CDC42 MAP3Ks Calm Rac P ZAP70 Ca 2 + Caln DAG NF-B IB Cell Proliferation and Differentiation NFAT Antigen-Presenting Cell Active Release and Translocation of CTLA4 to Membrane Cytoskeletal Remodelling Endosome Immune Response IL-2 Gene Expression Lck SHP2 CSK Vav P A G TRIM LAT SOS P C D 4 5 CTLA4 CTLA4 C TLA4 CTLA4 SIT CD28 I P 3 R Ag TCR-CD3 Compl ex MHC-II B7-2 B7-1 C a C n T e x t C a C n Ras P IP3 2009 ProteinLounge.com C

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LAT. B7-2. CaCn. B7-1. MHC-II. TRIM. P A G. Ag. GRB2. GADS. CD4/CD8. C D 4 5. SLP76. CD28. ZAP70. Lck. PKC . SIT. CTLA4. SOS. SHP2. SHP2. PI3K. Caln. VHR. MEK1/2. CARD11. Fyb. PLC g. P. I k B. BCL10. MAP3Ks. Fyn. Fyn. PAK. Calm. ITK. JNK. CSK. Akt. p38. - PowerPoint PPT Presentation

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Page 1: T-Cell Receptor Signaling

CD

4/C

D8

Text

P

P

P

c-Jun

T-Cell Receptor Signaling

ATF2 NF-B

NFATElk1SRF

NFAT

IKKs

p38

JNK

MKK4/7

MKK3/6

VHR

Ca2+Ca2+

Ca2+

IBDegradation

IBDegradation

MEKK1

Ca2+

MEK1/2

Raf1

PKC

PIP2

ERK1/2

Fyn

Fyn

ITKFyb

GADS

SLP76

PLC

GRB2

Ca2+

Akt

PI3K

SHP2

P

P

P

P

P

CARD11

MALT1

BCL10PAK

CDC42

MAP3Ks

Calm

Rac

P

ZAP70

Ca2+

CalnCaln

DAG

NF-BIB

Cell Proliferationand DifferentiationCell Proliferation

and Differentiation

NFAT

Antigen-Presenting CellAntigen-Presenting Cell

Active Release andTranslocation of

CTLA4 to Membrane

Active Release andTranslocation of

CTLA4 to Membrane

CytoskeletalRemodellingCytoskeletalRemodelling

EndosomeEndosome

ImmuneResponseImmune

Response

IL-2 GeneExpressionIL-2 Gene

Expression

Lck

SHP2

CSK

Vav

PAG

TRIM

LAT

SOSP

CD45

CTLA

4C

TLA4

CTLA4CTLA4

CT

LA

4C

TL

A4

CTLA4

SIT

CD28

IP3R

Ag

TCR-CD3

ComplexTCR-CD3

Complex

MHC-II

MHC-II

B7-2

B7-1

CaCn

CaCn

Text

CaCn

CaCn

Ras

P

IP3

2009ProteinLounge.com 2009ProteinLounge.comC

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