supplementary table s1: primers used for detecting aebp1 ......supplementary table s2: transcription...

Supplementary Table S1: Primers used for detecting Aebp1 and its targets.

Gene Sequence

Aebp1 Forward TTGGAAACGCTGGATCGGTTA

Reverse TGTGTCTCTCTTCTGCGGTAG

Fabp Forward GGGGCCAGGCTTCTATTCC

Reverse GGAGCTGGGTTAGGTATGGG

Efemp1 Forward GCGCTGGTCAAGTCACAGTA

Reverse AAGCATCTGGGACAATGTCAC

Thbs2 Forward CTGGGCATAGGGCCAAGAG

Reverse GCTTGACAATCCTGTTGAGATCA

Fbln5 Forward GCTTGTCGTGGGGACATGAT

Reverse TGGGGTAGTTGGAAGCTGGTA

Lum Forward CTCTTGCCTTGGCATTAGTCG

Reverse GGGGGCAGTTACATTCTGGTG

Mmp2 Forward CAAGTTCCCCGGCGATGTC

Reverse TTCTGGTCAAGGTCACCTGTC

Tgfb2 Forward TCGACATGGATCAGTTTATGCG

Reverse CCCTGGTACTGTTGTAGATGGA

Fbn1 Forward GGACGCCAATTTGGAGGCT

Reverse CTTTCAGCGCATCGTGTCCT

Cd4 Forward AGGTGATGGGACCTACCTCTC

Reverse GGGGCCACCACTTGAACTAC

Supplementary Table S2: Transcription program of AEBP1, as well as its co-regulators. Reg1 Reg2 Support nGRN fisherTest adjustedPvalue AEBP1 JUN 0.168 96745 1.47E-26 6.71E-26 AEBP1 FOS 0.133 76568 6.06E-08 1.26E-07 AEBP1 TNFAIP3 0.092 52657 8.00E-08 1.65E-07 AEBP1 TCF4 0.080 45743 3.97E-13 1.02E-12 AEBP1 FOSB 0.069 39569 2.01E-10 4.74E-10 AEBP1 EHF 0.064 36682 2.01E-05 3.61E-05 AEBP1 PRDM1 0.063 36480 2.91E-29 1.50E-28 AEBP1 HIVEP2 0.054 31168 4.78E-05 8.37E-05 AEBP1 ZNF83 0.052 29755 1.16E-06 2.24E-06 AEBP1 ZFPM2 0.033 18885 4.04E-07 8.02E-07 AEBP1 ARID5B 0.027 15545 3.15E-09 7.03E-09 AEBP1 STAT4 0.026 15065 8.70E-08 1.79E-07 AEBP1 NR4A2 0.025 14592 1.70E-06 3.26E-06 AEBP1 NR4A1 0.025 14386 5.86E-06 1.08E-05 AEBP1 LEF1 0.024 13973 1.62E-09 3.68E-09 AEBP1 PBX1 0.022 12772 4.05E-08 8.57E-08 AEBP1 KLF6 0.021 11990 8.86E-05 1.53E-04 AEBP1 IFI16 0.015 8644 1.50E-07 3.04E-07 AEBP1 MYBL1 0.006 3685 1.06E-04 1.80E-04 AEBP1 FOSL2 0.006 3513 2.04E-04 3.45E-04

AEBP1 program

Regulator link Targeted genes

AEBP1 activation AKR1B10

AEBP1 activation SPP1

AEBP1 activation LUM

AEBP1 activation FABP4

AEBP1 activation CD24

AEBP1 activation EFEMP1

AEBP1 activation CCDC80

AEBP1 activation ITGBL1

AEBP1 activation ACSL4

AEBP1 activation CCL19

AEBP1 activation PROM1

AEBP1 activation MOXD1

AEBP1 activation SVEP1

AEBP1 activation CRISPLD2

AEBP1 activation STMN2

AEBP1 activation DEFB1

AEBP1 activation THBS2

AEBP1 activation FBLN5

AEBP1 activation COL1A1

AEBP1 activation FGFR2

AEBP1 activation DCN

AEBP1 activation VIM

AEBP1 activation DPT

AEBP1 activation CHL1

AEBP1 activation PTPN13

AEBP1 activation FBN1


AEBP1 activation TGFB2

AEBP1 activation JAG1

AEBP1 activation PDE1A

AEBP1 activation RBMS3

AEBP1 activation MTHFD2

AEBP1 activation SRPX2

AEBP1 activation SERPINE2

AEBP1 activation SMOC2

AEBP1 activation CCDC3

AEBP1 activation MMP2

AEBP1 activation ITGAV

AEBP1 activation ANXA2

AEBP1 activation IGKC

AEBP1 activation ACSM1

AEBP1 activation NAV3

AEBP1 activation HSPA4L

AEBP1 activation THY1

AEBP1 activation PRKG1

AEBP1 activation ABCB4

AEBP1 activation CTSK

AEBP1 activation LRRC1

AEBP1 activation FLJ36840



AEBP1 activation FLNA

AEBP1 activation PLCXD3

AEBP1 activation PGM3

AEBP1 activation GABRE

AEBP1 activation LGALS3

AEBP1 activation CDH11

AEBP1 activation PDE5A

AEBP1 activation LAPTM4B

AEBP1 activation MID1IP1

AEBP1 activation LTBP2

AEBP1 activation SPON1

AEBP1 activation INMT

AEBP1 activation CAP2

AEBP1 activation CAPN2

AEBP1 activation BAMBI

AEBP1 activation RANBP17

AEBP1 activation PMP22

AEBP1 activation BAI3

AEBP1 activation CTSE

AEBP1 activation STK17A

AEBP1 activation LPL

AEBP1 activation SLC44A3

AEBP1 activation GSN

AEBP1 activation MCAM

AEBP1 activation STXBP4

AEBP1 activation FMOD

AEBP1 activation PODN

AEBP1 activation PLP2

AEBP1 activation CAPG

AEBP1 activation CACNA1C

AEBP1 activation CCL21

AEBP1 activation CHRDL1

AEBP1 activation KCNA3

AEBP1 activation ENPP5

AEBP1 activation FAM38B

AEBP1 activation S100A14

AEBP1 activation ADAMTSL2

AEBP1 activation IKZF3

AEBP1 activation CD3E

AEBP1 activation ADAMTS12

AEBP1 activation FNDC1

AEBP1 activation NCAM1

AEBP1 activation HDGFRP3

AEBP1 activation GLT8D2

AEBP1 activation RHOH

AEBP1 activation MAPK10

AEBP1 activation LAMC3

AEBP1 activation CLDN7

AEBP1 activation CLDN11

AEBP1 activation SUSD2

AEBP1 activation CCND1

AEBP1 repessing VCAM1

AEBP1 repessing SDS

AEBP1 repessing CYP3A43

AEBP1 repessing MT1X

AEBP1 repessing IFI44L

AEBP1 repessing TIMD4

AEBP1 repessing OAT

AEBP1 repessing CD163

AEBP1 repessing DNAJC12

AEBP1 repessing MARCO

AEBP1 repessing VSIG4

AEBP1 repessing CR1

AEBP1 repessing PPP1R1A

AEBP1 repessing FCER1G

AEBP1 repessing CD4

AEBP1 repessing P2RY13

AEBP1 repessing C1QC

AEBP1 repessing ACADSB

AEBP1 repessing GPR116

AEBP1 repessing SLC16A10

AEBP1 repessing F8

AEBP1 repessing ODZ3

AEBP1 repessing KCNN2

AEBP1 repessing PDCD1LG2

AEBP1 repessing SLC19A2

AEBP1 repessing ITIH3

AEBP1 repessing CD244

AEBP1 repessing EFHD1

AEBP1 repessing KCNJ8

AEBP1 repessing LAIR1

AEBP1 activation program

Category Term PValue Genes FDR

GOTERM_BP_DIRECT

GO:0030198~extracellular matrix organization

4.14E-17

FMOD, COL4A2, LGALS3, ADAMTSL2, LUM, FBN1, EFEMP1, CCDC80, DCN, MMP2, TGFB2, NCAM1, SMOC2, CTSK, LAMC3, CRISPLD2, ITGAV, FBLN5, COL6A3, COL12A1, COL1A1, SPP1

6.45E-14

GOTERM_BP_DIRECT

GO:0022617~extracellular matrix disassembly

1.61E-09

COL4A2, CTSK, GSN, COL6A3, CAPG, FBN1, COL12A1, COL1A1, DCN, MMP2, SPP1

2.51E-06

GOTERM_BP_DIRECT

GO:0030199~collagen fibril organization

9.85E-08

FMOD, LUM, COL12A1, COL1A1, ANXA2, TGFB2, DPT

1.53E-04

GOTERM_BP_DIRECT

GO:0007155~cell adhesion 7.11E-0

7

SVEP1, MCAM, ITGBL1, NCAM1, LAMC3, ITGAV, COL6A3, COL12A1, THBS2, CHL1, SPP1, CDH11, SPON1, DPT

1.11E-03

GOTERM_BP_DIRECT

GO:0001525~angiogenesis 4.70E-0

6 FGFR2, COL4A2, SRPX2, ITGAV, JAG1, MCAM, MMP2, ANXA2, TGFB2, THY1

7.32E-03

GOTERM_BP_DIRECT

GO:0030574~collagen catabolic process

6.96E-05

COL4A2, CTSK, COL6A3, COL12A1, COL1A1, MMP2

1.08E-01

GOTERM_BP_DIRECT

GO:0001957~intramembranous ossification

4.80E-04

CTSK, COL1A1, MMP2 7.44E-

01 GOTERM_BP_DIRECT

GO:0035987~endodermal cell differentiation

4.82E-04

COL4A2, ITGAV, COL12A1, MMP2 7.47E-

01 GOTERM_BP_DIRECT

GO:0030593~neutrophil chemotaxis

5.54E-04

LGALS3, CCL21, CCL19, SPP1, TGFB2 8.59E-

01 GOTERM_BP_DIRECT

GO:0060325~face morphogenesis 9.57E-0

4 CRISPLD2, COL1A1, MMP2, TGFB2

1.48E+00

GOTERM_BP_DIRECT

GO:0007411~axon guidance 9.95E-0

4

NCAM1, FGFR2, COL4A2, CAP2, ITGAV, COL6A3, CD24, CACNA1C, MMP2, CHL1, TGFB2

1.54E+00

GOTERM_BP_DIRECT

GO:0010977~negative regulation of neuron projection development

1.04E-03

STMN2, VIM, EFEMP1, PMP22 1.61E

+00 GOTERM_BP_DIRECT

GO:2000147~positive regulation of cell motility

2.82E-03

CLDN7, CCL21, CCL19 4.31E


GO:0007026~negative regulation of microtubule depolymerization

5.77E-03

STMN2, MID1IP1, HDGFRP3 8.61E


GO:0042632~cholesterol homeostasis

6.15E-03

LPL, ACSM1, FABP4, CD24 9.16E


GO:0001501~skeletal system development

7.74E-03

LGALS3, FBN1, COL12A1, COL1A1, CDH11 1.14E


GO:0031295~T cell costimulation 9.80E-0

3 CD3E, CCL21, CCL19, CD24

1.42E+01

GOTERM_BP_DIRECT

GO:0072139~glomerular parietal epithelial cell differentiation

1.14E-02

PROM1, CD24 1.64E

+01

GOTERM_BP_DIRECT

GO:0051603~proteolysis involved in cellular protein catabolic process

1.27E-02

CTSK, ADAMTS12, CAPN2 1.81E

+01

GOTERM_BP_DIRECT

GO:0006469~negative regulation of protein kinase activity

1.32E-02

PODN, FABP4, DCN, THY1 1.87E

+01

GOTERM_BP_DIRECT

GO:0010718~positive regulation of epithelial to mesenchymal transition

1.53E-02

COL1A1, BAMBI, TGFB2 2.13E

+01

GOTERM_BP_DIRECT

GO:0016477~cell migration 1.68E-0

2 ITGAV, ADAMTS12, CD24, BAMBI, TGFB2

2.32E+01

GOTERM_BP_DIRECT

GO:0001837~epithelial to mesenchymal transition

1.71E-02

FGFR2, FLNA, TGFB2 2.35E

+01

GOTERM_BP_DIRECT

GO:2000768~positive regulation of nephron tubule epithelial cell differentiation

1.71E-02

PROM1, CD24 2.35E

+01

GOTERM_BP_DIRECT

GO:0048050~post-embryonic eye morphogenesis

1.71E-02

EFEMP1, FBN1 2.35E


GO:0071356~cellular response to tumor necrosis factor

1.77E-02

CCL21, CCL19, COL1A1, ADAMTS12 2.43E


GO:0010811~positive regulation of cell-substrate adhesion

2.00E-02

SMOC2, CCDC80, SPP1 2.69E

+01

GOTERM_BP_DIRECT

GO:0010560~positive regulation of glycoprotein biosynthetic process

2.27E-02

CCL21, CCL19 3.01E

+01

GOTERM_BP_DIRECT

GO:0007596~blood coagulation 2.28E-0

2 SERPINE2, ITGAV, PDE1A, PDE5A, COL1A1, PRKG1, FLNA, TGFB2

3.02E+01

GOTERM_BP_DIRECT

GO:0002548~monocyte chemotaxis

2.30E-02

LGALS3, CCL21, CCL19 3.04E


GO:0007566~embryo implantation

2.52E-02

SERPINE2, MMP2, SPP1 3.28E


GO:0001768~establishment of T cell polarity

2.83E-02

CCL21, CCL19 3.61E


GO:0071230~cellular response to amino acid stimulus

3.21E-02

COL1A1, CAPN2, MMP2 3.98E

+01

GOTERM_BP_DIRECT

GO:0071560~cellular response to transforming growth factor beta stimulus

3.21E-02

COL4A2, FBN1, COL1A1 3.98E

+01

GOTERM_BP_DIRECT

GO:2000107~negative regulation of leukocyte apoptotic process

3.39E-02

CCL21, CCL19 4.15E


GO:0072112~glomerular visceral epithelial cell differentiation

3.94E-02

PROM1, CD24 4.65E

+01

GOTERM_BP_DIRECT

GO:0002606~positive regulation of dendritic cell antigen processing and presentation

3.94E-02

CCL21, CCL19 4.65E

+01

GOTERM_BP_DIRECT

GO:0034695~response to prostaglandin E

3.94E-02

CCL21, CCL19 4.65E


GO:0030097~hemopoiesis 4.23E-0

2 PGM3, JAG1, TGFB2

4.89E+01

GOTERM_BP_DIRECT

GO:0060346~bone trabecula formation

4.49E-02

COL1A1, MMP2 5.11E


GO:0016525~negative regulation of angiogenesis

4.92E-02

COL4A2, DCN, THBS2 5.44E


GO:0048048~embryonic eye morphogenesis

5.58E-02

EFEMP1, FBN1 5.91E


GO:0070307~lens fiber cell development

5.58E-02

FGFR2, VIM 5.91E


GO:0090331~negative regulation of platelet aggregation

5.58E-02

SERPINE2, PRKG1 5.91E


GO:0001771~immunological synapse formation

5.58E-02

CCL21, CCL19 5.91E


GO:0006898~receptor-mediated endocytosis

5.67E-02

COL4A2, SUSD2, COL1A1, IGKC 5.97E


GO:0042340~keratan sulfate catabolic process

6.66E-02

FMOD, LUM 6.58E

+01

GOTERM_BP_DIRECT

GO:0071347~cellular response to interleukin-1

6.88E-02

CCL21, CCL19, ADAMTS12 6.70E

+01

GOTERM_BP_DIRECT

GO:0033630~positive regulation of cell adhesion mediated by integrin

7.20E-02

CCL21, TGFB2 6.87E

+01

GOTERM_BP_DIRECT

GO:0051016~barbed-end actin filament capping

7.20E-02

GSN, CAPG 6.87E


GO:0050921~positive regulation of chemotaxis

7.20E-02

CCL21, CCL19 6.87E


GO:0001666~response to hypoxia 8.24E-0

2 CD24, CAPN2, MMP2, TGFB2

7.38E+01

GOTERM_BP_DIRECT

GO:0002407~dendritic cell chemotaxis

8.26E-02

CCL21, CCL19 7.39E


GO:0042325~regulation of phosphorylation

8.26E-02

SRPX2, CD24 7.39E


GO:0014002~astrocyte development

8.78E-02

LAMC3, VIM 7.61E


GO:0048260~positive regulation of receptor-mediated endocytosis

8.78E-02

CCL21, CCL19 7.61E

+01

GOTERM_BP_DIRECT

GO:0050860~negative regulation of T cell receptor signaling pathway

8.78E-02

LGALS3, THY1 7.61E

+01

GOTERM_BP_DIRECT

GO:0032331~negative regulation of chondrocyte differentiation

9.31E-02

EFEMP1, ADAMTS12 7.81E


GO:0007409~axonogenesis 9.94E-0

2 FGFR2, FMOD, LUM

8.04E+01

GOTERM_BP_DIRECT

GO:0007160~cell-matrix adhesion 9.94E-0

2 ITGAV, FBLN5, ADAMTS12

8.04E+01


KEGG_PATHWAY

hsa04510:Focal adhesion 1.36E-0

6

COL4A2, CCND1, LAMC3, ITGAV, COL6A3, COL1A1, MAPK10, CAPN2, THBS2, FLNA, SPP1

1.61E-03

KEGG_PATHWAY

hsa04512:ECM-receptor interaction

3.08E-05

COL4A2, LAMC3, ITGAV, COL6A3, COL1A1, THBS2, SPP1

3.66E-02

KEGG_PATHWAY

hsa05205:Proteoglycans in cancer 2.61E-0

3 CCND1, ITGAV, LUM, DCN, MMP2, FLNA, TGFB2

3.05E+00

KEGG_PATHWAY

hsa04151:PI3K-Akt signaling pathway

2.71E-03

FGFR2, COL4A2, CCND1, LAMC3, ITGAV, COL6A3, COL1A1, THBS2, SPP1

3.17E+00

KEGG_PATHWAY

hsa04670:Leukocyte transendothelial migration

9.57E-03

CLDN7, CLDN11, MMP2, RHOH, THY1 1.08E

+01 KEGG_PATHWAY

hsa05200:Pathways in cancer 2.01E-0

2 FGFR2, COL4A2, CCND1, LAMC3, ITGAV, MAPK10, MMP2, TGFB2

2.14E+01

KEGG_PATHWAY

hsa05222:Small cell lung cancer 2.22E-0

2 COL4A2, CCND1, LAMC3, ITGAV

2.34E+01

KEGG_PATHWAY

hsa04974:Protein digestion and absorption

2.36E-02

COL4A2, COL6A3, COL12A1, COL1A1 2.47E

+01 KEGG_PATHWAY

hsa05146:Amoebiasis 3.91E-0

2 COL4A2, LAMC3, COL1A1, TGFB2

3.77E+01

KEGG_PATHW hsa05210:Colorectal cancer 7.15E-0 CCND1, MAPK10, TGFB2 5.86E

AY 2 +01 KEGG_PATHWAY

hsa05212:Pancreatic cancer 7.56E-0

2 CCND1, MAPK10, TGFB2

6.07E+01

KEGG_PATHWAY

hsa04514:Cell adhesion molecules (CAMs)

7.95E-02

NCAM1, CLDN7, ITGAV, CLDN11 6.26E

+01 KEGG_PATHWAY

hsa03320:PPAR signaling pathway 8.18E-0

2 LPL, FABP4, ACSL4

6.37E+01

AEBP1 repression program

Category Term PValue Genes FDR GOTERM_BP_DIRECT

GO:0042102~positive regulation of T cell proliferation

3.38E-03

VCAM1, CD4, PDCD1LG2 4.07E


GO:0045087~innate immune response

9.63E-03

MARCO, CR1, CD244, FCER1G, CD4, C1QC 1.12E


GO:0006955~immune response 1.52E-0

2 IFI44L, CD4, C1QC, PDCD1LG2

1.71E+01

GOTERM_BP_DIRECT

GO:0002250~adaptive immune response

1.96E-02

LAIR1, CD244, CD4 2.16E


GO:0006953~acute-phase response

6.07E-02

F8, CD163 5.36E


GO:0006958~complement activation, classical pathway

8.90E-02

CR1, C1QC 6.82E

+01 Category Term PValue Genes FDR KEGG_PATHWAY

hsa04610:Complement and coagulation cascades

1.51E-02

CR1, F8, C1QC 1.36E

+01 KEGG_PATHWAY


5.74E-02


+01

AEBP1-JUN program

CoRegulators link Targeted genes

AEBP1 JUN activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1


THBS2


FBLN5


COL1A1


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2


JAG1


PDE1A


RBMS3


MTHFD2


SRPX2

AEBP1 JUN activati SERPINE2

on


SMOC2


CCDC3


MMP2


ITGAV


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2


BAMBI


RANBP17


PMP22


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD


PODN


PLP2


CAPG


CACNA1C


CCL21

AEBP1 JUN activati CHRDL1

on


KCNA3


ENPP5


FAM38B


S100A14


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1


CYP2B6


GSTM1


CCL20


APOA4


CCL2


IGFBP1


THBS1


IL8


IL7R


LYZ


EMP1


PDK4


RGS4


HLA-DRA


GEM


CFHR5


HLA-DPA1


ANXA1


RGS5


NUCB2


ENPP2


HKDC1


VNN3


ADAMTS1


OIT3


GBA3


MME


CYR61


HLA-DQB1

AEBP1 JUN activati ACTA2

on


PRAMEF10


CYBB


IFI44L


HYOU1


ALDH1L1


PCK1


IL6


BIRC3


BBOX1


IL1RL1


NPR3


ITK


RGS2


CTGF


GDF15


FGL2


FST


HSD17B7P2


ANXA3


CRHBP


AADAT


INPP4B


WEE1


TM4SF1


VNN2


DDIT4


PTGS2


FAM102B


ERRFI1


MSR1


ABI3BP


RANBP3L


AKT3


STK17B


GZMK


SYNPO2


TFRC


NEDD9


PTPRC


SLC5A1


CDH19


CALCRL


GPR128


PAPPA2


INSIG1


TXNIP


CD36


DUSP1

AEBP1 JUN activati GFPT1

on


GJA1


SCGN


TSPAN13


ADAMTS4


TAT


CPE


DOCK11


TNFRSF21


KLB


MAML2


HPGD


LCP1


RAB8B


RASD1


SOD2


ARHGDIB


AOAH


SC5DL


PLAC8


ERO1LB


EVI2B


GPR37


CD53


ANGPTL1


SLFN11


MMP19


ATAD2


ARL5B


S100A11


SESN3


LIPA


ALDOC


RNF122


IER3


CR1


TFPI2


S100A12


CTSS


GSTM5


CD44


SLC25A15


GADD45G


CD4


PLEK2


LOC646982


LIFR


CA13


ELTD1

AEBP1 JUN activati PLEK

on


FPR1


SERPINB1


RND2


PECAM1


IYD


RND3


CD86


FYB


CXCL2


TIMP3


TNC


CEP170


LDLR


DOCK8


LTBP1


ZSWIM6


PCDH18


TRIB1


MGAT4A


LOX


EPB41L2


KCNMA1


PIK3R3


IL1B


ICA1


IQGAP1


CTH


TGFBR3


SAMD9L


TIPARP


SOCS2


GCLM


TLR1


HSPA2


NCF2


OSMR


AKAP12


TP53INP1


IDI1


IL1RAP


SCN9A


CD48


IGSF6


SAMD9


OBFC2A


GPR116


SLFN5


OSBPL11

AEBP1 JUN activati PPT1

on


ACE2


EDNRB


SMPD3


TCP11L2


GPR34


LHFP


SERPINB8


SLC2A9


F8


HHIP


MYO5A


CXCL1


INHBA


SLC20A1


KLRB1


FGF21


SLC38A2


FLT1


SPG20


GBP5


PTPRB


RAB31


GPD2


DOCK2


CHORDC1


PRC1


VCL


IL1RN


SLC7A7


TACSTD2


CCR1


ADAMTS5


TLR4


KLRC4


SKAP2


MMD


ODZ3


WARS


RNF152


CAV1


CTTNBP2NL


ANGPT2


CXCL16


EHD3


SELL


SLC9A9


PRKCH


PLA2G4A

AEBP1 JUN activati CLIC2

on


CD83


AQP3


BMP10


GNA13


SLA


F2RL1


S100P


VGLL3


KCNN2


OSGIN2


ATP8A1


PLCB1


TMEM71


SLC31A2


NEBL


STK38L


MMP8


RAB27B


GMFG


PDCD1LG2


PELI1


DOPEY2


CPEB4


GPM6A


EDN1


CXCL9


OGN


GPR56


RASSF2


GREB1


NUSAP1


IL18RAP


ITGAX


IKZF1


GLA


TXK


RRAGD


EPB41L3


PS1TP4


TLR2


GGTA1


MFSD1


SEMA3D


ANGPTL2


SLC19A2


PCDHB16


SLC8A1


NRG4

AEBP1 JUN activati EEF1E1

on


CNN2


GIMAP4


COX11


PCDHB15


GRAP


SLAMF6


SMC2


ITIH3


PCDH17


FRMD4B


LRRK2


FILIP1


CMKLR1


IL10RA


CD93


PGM2


TGFB1


PDE4B


LMOD1


CRISP3


MAPRE1


ME2


VAV3


ARSK


RBMS2


SCAMP1


TMEM106C


SLC11A1


MOSPD1


UCP2


DUSP10


RGS16


SH2D1A


PELI2


CLEC4E


RBMS1


P2RY14


RNF157


PRICKLE2


MYO9A


ALOX5AP


EFNB2


DUSP5


RET


SLC6A6


ARRDC2


CD55

AEBP1 JUN repessing

SDS

AEBP1 JUN repessi CYP3A43

ng

AEBP1 JUN repessing

MT1X

AEBP1 JUN repessing

IFI44L

AEBP1 JUN repessing

TIMD4

AEBP1 JUN repessing

OAT

AEBP1 JUN repessing

VCAM1

AEBP1 JUN repessing

CD163

AEBP1 JUN repessing

DNAJC12

AEBP1 JUN repessing

MARCO

AEBP1 JUN repessing

VSIG4

AEBP1 JUN repessing

CR1

AEBP1 JUN repessing

PPP1R1A

AEBP1 JUN repessing

FCER1G

AEBP1 JUN repessing

CD4

AEBP1 JUN repessing

P2RY13

AEBP1 JUN repessing

C1QC

AEBP1 JUN repessing

ACADSB

AEBP1 JUN repessing

GPR116

AEBP1 JUN repessing

SLC16A10

AEBP1 JUN repessing

F8

AEBP1 JUN repessing

ODZ3

AEBP1 JUN repessing

KCNN2

AEBP1 JUN repessing

PDCD1LG2

AEBP1 JUN repessing

SLC19A2

AEBP1 JUN repessing

ITIH3

AEBP1 JUN repessing

CD244

AEBP1 JUN repessing

EFHD1

AEBP1 JUN repessing

KCNJ8

AEBP1 JUN repessing

LAIR1

AEBP1 JUN repessing

SPINK1

AEBP1 JUN repessing

DDX3Y

AEBP1 JUN repessing

MT1M

AEBP1 JUN repessing

HAMP

AEBP1 JUN repessing

PLA2G2A

AEBP1 JUN repessing

CCDC80

AEBP1 JUN repessing

CYP1A1

AEBP1 JUN repessing

GPX2

AEBP1 JUN repessing

CFHR3

AEBP1 JUN repessing

MUC6

AEBP1 JUN repessing

ELOVL7

AEBP1 JUN repessing

IGFBP5

AEBP1 JUN repessing

F13A1

AEBP1 JUN repessing

LOXL4

AEBP1 JUN repessing

STMN2

AEBP1 JUN repessing

LAMA2

AEBP1 JUN repessing

INHBE

AEBP1 JUN repessing

EDIL3

AEBP1 JUN repessing

CXCL6

AEBP1 JUN repessing

CDC6

AEBP1 JUN repessi ACSS2

ng

AEBP1 JUN repessing

PTPN13

AEBP1 JUN repessing

PTCH2

AEBP1 JUN repessing

G0S2

AEBP1 JUN repessing

SRPX2

AEBP1 JUN repessing

TOP2A

AEBP1 JUN repessing

NAT8

AEBP1 JUN repessing

MBL2

AEBP1 JUN repessing

ABCA9

AEBP1 JUN repessing

WSB1

AEBP1 JUN repessing

UROC1

AEBP1 JUN repessing

SLC38A1

AEBP1 JUN repessing

SRD5A2

AEBP1 JUN repessing

IGKC

AEBP1 JUN repessing

LOC389834

AEBP1 JUN repessing

ACSM1

AEBP1 JUN repessing

NAV3

AEBP1 JUN repessing

SDF2L1

AEBP1 JUN repessing

ABCA10

AEBP1 JUN repessing

RNPC3

AEBP1 JUN repessing

KLHL5

AEBP1 JUN repessing

PRKG1

AEBP1 JUN repessing

PDGFRB

AEBP1 JUN repessing

ABCB4

AEBP1 JUN repessing

CTSK

AEBP1 JUN repessing

SLC22A7

AEBP1 JUN repessing

FLNA

AEBP1 JUN repessing

SEMA3C

AEBP1 JUN repessing

ODZ1

AEBP1 JUN repessing

PLCXD3

AEBP1 JUN repessing

PGM3

AEBP1 JUN repessing

KCNK5

AEBP1 JUN repessing

TRIM55

AEBP1 JUN repessing

AKR1C3

AEBP1 JUN repessing

TPX2

AEBP1 JUN repessing

PLAT

AEBP1 JUN repessing

PKLR

AEBP1 JUN repessing

RTP3

AEBP1 JUN repessing

LGALS3

AEBP1 JUN repessing

ARHGAP10

AEBP1 JUN repessing

CCNL1

AEBP1 JUN repessing

UNC5CL

AEBP1 JUN repessing

SLC17A3

AEBP1 JUN repessing

HIST1H1B

AEBP1 JUN repessing

DTL

AEBP1 JUN repessing

SGEF

AEBP1 JUN repessing

MOGAT1

AEBP1 JUN repessing

CTPS

AEBP1 JUN repessing

CCDC14

AEBP1 JUN repessi SH3YL1

ng

AEBP1 JUN repessing

MX1

AEBP1 JUN repessing

ZYG11A

AEBP1 JUN repessing

EFNA1

AEBP1 JUN repessing

DGAT2

AEBP1 JUN repessing

GALNTL2

AEBP1 JUN repessing

IL6R

AEBP1 JUN repessing

VLDLR

AEBP1 JUN repessing

CCL18

AEBP1 JUN repessing

SEC14L4

AEBP1 JUN repessing

UNC93A

AEBP1 JUN repessing

LOC644714

AEBP1 JUN repessing

NFASC

AEBP1 JUN repessing

SYT7

AEBP1 JUN repessing

TNFSF14

AEBP1 JUN repessing

ARL4D

AEBP1 JUN repessing

BAI3

AEBP1 JUN repessing

AMACR

AEBP1 JUN repessing

ZNF28

AEBP1 JUN repessing

ECHDC2

AEBP1 JUN repessing

PCOLCE2

AEBP1 JUN repessing

CYP4X1

AEBP1 JUN repessing

NT5E

AEBP1 JUN repessing

REPS1

AEBP1 JUN repessing

DTX4

AEBP1 JUN repessing

FMO4

AEBP1 JUN repessing

SNRPA1

AEBP1 JUN repessing

SPATA18

AEBP1 JUN repessing

SLFN13

AEBP1 JUN repessing

ZNF594

AEBP1 JUN repessing

VEPH1

AEBP1 JUN repessing

PLA1A

AEBP1 JUN repessing

BST2

AEBP1 JUN repessing

CACNA1C

AEBP1 JUN repessing

CENPC1

AEBP1 JUN repessing

TMEM37

AEBP1 JUN repessing

GLT1D1

AEBP1 JUN repessing

F12

AEBP1 JUN repessing

ASPM

AEBP1 JUN repessing

TNFAIP8

AEBP1 JUN repessing

GSTZ1

AEBP1 JUN repessing

SCARNA9

AEBP1 JUN repessing

GSTA3

AEBP1 JUN repessing

LOC221442

AEBP1 JUN repessing

GAS2

AEBP1 JUN repessing

ALDH7A1

AEBP1 JUN repessing

SNORA28

AEBP1 JUN repessing

ABCG5

AEBP1 JUN repessing

TMEM176A

AEBP1 JUN repessi LRRC7

ng

AEBP1 JUN repessing

GSTP1

AEBP1 JUN repessing

CNTN3

AEBP1 JUN repessing

SLC12A8

AEBP1 JUN repessing

PLEKHA3

AEBP1 JUN repessing

LPIN2

AEBP1 JUN repessing

GPT

AEBP1 JUN repessing

GLUD1

AEBP1 JUN repessing

S100A14

AEBP1 JUN repessing

TESC

AEBP1 JUN repessing

HGFAC

AEBP1 JUN repessing

CYP21A2

AEBP1 JUN repessing

TMEM144

AEBP1 JUN repessing

HELLS

AEBP1 JUN repessing

RBP5

AEBP1 JUN repessing

RAB15

AEBP1 JUN repessing

MIF

AEBP1 JUN repessing

GPR133

AEBP1 JUN repessing

PLCE1

AEBP1 JUN repessing

GLYCTK

AEBP1 JUN repessing

LOC388796

AEBP1 JUN repessing

GCDH

AEBP1 JUN repessing

SLC5A9

AEBP1 JUN repessing

FUNDC2

AEBP1 JUN repessing

PRODH2

AEBP1 JUN repessing

KCNE1

AEBP1 JUN repessing

RPS27L

AEBP1 JUN repessing

HDGFRP3

AEBP1 JUN repessing

TOM1L1

AEBP1 JUN repessing

A2M

AEBP1 JUN repessing

MAPK10

AEBP1 JUN repessing

ABCC6

AEBP1 JUN repessing

KIF4A

AEBP1 JUN repessing

CISH

AEBP1 JUN repessing

TMPRSS6

AEBP1 JUN repessing

COQ10A

AEBP1 JUN repessing

MGC16384

AEBP1 JUN repessing

POLE2

AEBP1 JUN repessing

TTC21B

AEBP1 JUN repessing

CCDC52

AEBP1 JUN repessing

CLDN7

AEBP1 JUN repessing

NXF1

AEBP1 JUN repessing

FLJ32742

AEBP1 JUN repessing

TNFAIP2

AEBP1 JUN repessing

AMPD1

AEBP1 JUN repessing

MALT1

AEBP1 JUN repessing

APOBEC3B

AEBP1 JUN repessing

STXBP1

AEBP1 JUN repessing

MUC20

AEBP1 JUN repessi LOC646870

ng

AEBP1 JUN repessing

CCND1

AEBP1 JUN repessing

SNORA74A

AEBP1 JUN repessing

KCNS3

AEBP1 JUN repessing

FAHD2A

AEBP1-JUN activation program


GOTERM_BP_DIRECT


4.39E-16

FMOD, BMP10, LTBP1, ADAMTSL2, LUM, TNC, MMP8, DCN, MMP2, ABI3BP, TGFB1, TGFB2, SMOC2, CD44, ITGAX, CRISPLD2, ITGAV, COL6A3, COL12A1, LOX, THBS1, SPP1, CYR61, COL4A2, LGALS3, MMP19, EFEMP1, FBN1, CCDC80, CTSS, NCAM1, CTSK, LAMC3, FBLN5, PECAM1, COL1A1, ADAMTS5, ADAMTS4

7.77E-13

GOTERM_BP_DIRECT


2

HLA-DQB1, CXCL1, TNFRSF21, ENPP2, CCR1, TLR1, SUSD2, CXCL2, TLR2, CXCL9, TLR4, IFI44L, IL7R, CCL20, CCL21, IL1RAP, CD4, IGKC, THBS1, DEFB1, ARHGDIB, FYB, IL18RAP, IL1RL1, CMKLR1, IL1RN, CCL19, GEM, CTSS, PDCD1LG2, IGSF6, CD86, TGFBR3, HLA-DPA1, HLA-DRA

3.34E-09

GOTERM_BP_DIRECT


3.15E-09

COL4A2, FBN1, MMP19, MMP8, CTSS, DCN, MMP2, CTSK, CD44, GSN, CAPG, COL6A3, COL12A1, COL1A1, ADAMTS5, LCP1, SPP1, ADAMTS4

5.54E-06

GOTERM_BP_DIRECT

GO:0006954~inflammatory response

8.82E-09

CXCL1, TNFRSF21, CCL2, PTGS2, CCR1, CRHBP, TLR1, CXCL2, F2RL1, CXCL9, TLR2, TGFB1, SLC11A1, CCL20, CCL21, AOAH, IL1RAP, SCN9A, IL1B, THBS1, SPP1, IL6, GBP5, IL18RAP, LIPA, ANXA1, LYZ, CCL19, S100A12, CYBB

1.55E-05

GOTERM_BP_DIRECT


8

GNA13, CAV1, F2RL1, PRKG1, TGFB1, SLC7A7, TGFB2, VCL, CD48, CD44, SERPINE2, ITGAX, ITGAV, PDE1A, THBS1, ANGPT2, TFPI2, DOCK11, EHD3, KCNMA1, SLC8A1, VAV3, PLEK, SELL, F8, PRKCH, DOCK8, FLNA, WEE1, PLA2G4A, CD36, PECAM1, PDE5A, COL1A1

1.27E-04

GOTERM_BP_DIRECT


7

BMP10, CCL2, CCR1, TNC, PCDHB15, NEDD9, ITGBL1, VCL, ITGAX, CTGF, ITGAV, COL6A3, COL12A1, THBS1, THBS2, SPP1, DPT, SPON1, CYR61, SVEP1, SELL, EFNB2, MCAM, NCAM1,

3.80E-04

RND3, CD36, LAMC3, PECAM1, CHL1, CDH11

GOTERM_BP_DIRECT


7

PTPRB, FGFR2, COL4A2, CAV1, CCL2, FLT1, VAV3, PTGS2, MMP19, JAG1, MCAM, MMP2, ANXA2, TGFB2, THY1, WARS, SRPX2, CTGF, ITGAV, CALCRL, ANGPT2

4.87E-04

GOTERM_BP_DIRECT


3.65E-07

VAV3, CCL2, LGALS3, CCL20, CCL21, PDE4B, EDN1, CCL19, IL1B, SPP1, TGFB2, S100A12

6.43E-04

GOTERM_BP_DIRECT


6

HLA-DQB1, CAV1, CD86, CD3E, CCL21, EFNB2, CCL19, CD4, HLA-DPA1, CD24, PDCD1LG2, HLA-DRA

3.17E-03

GOTERM_BP_DIRECT

GO:0007165~signal transduction 2.47E-0

6

GNA13, SLC20A1, CRHBP, TLR1, FST, TLR2, GJA1, CD53, PRKG1, SKAP2, IQGAP1, CTGF, IL1B, PLCB1, ANGPT2, AKT3, CYR61, RET, PRKCH, CLIC2, FGF21, GEM, ARRDC2, RND2, CD83, PDE5A, INPP4B, RASD1, CHL1, CXCL1, PLCXD3, CCL2, CXCL9, FPR1, NEDD9, IL7R, SMOC2, CCL20, PDE1A, CD4, FYB, ITK, CAP2, IL1RL1, S100A11, ANXA1, MAPK10, PECAM1, IGFBP1, GDF15

4.35E-03

GOTERM_BP_DIRECT


4.30E-06

IL6, CCL2, FLT1, LGALS3, CCL20, CCL21, ANXA1, CCL19, S100A12

7.58E-03

GOTERM_BP_DIRECT

GO:0006935~chemotaxis 4.65E-0

6

CXCL1, PLP2, CCL2, CMKLR1, ENPP2, CCR1, CXCL2, CXCL9, FPR1, DOCK2, CCL20, CXCL16, DEFB1, CYR61

8.19E-03

GOTERM_BP_DIRECT

GO:0033280~response to vitamin D

6.65E-06

PLA2G4A, PTGS2, IL1B, CD4, TGFB1, AQP3, SPP1

1.17E-02

GOTERM_BP_DIRECT

GO:0007166~cell surface receptor signaling pathway

1.28E-05

KLRB1, PTPRC, CCL2, IL18RAP, CD3E, CCR1, EDN1, ANXA1, LIFR, TSPAN13, GEM, CD53, BIRC3, IL7R, IGSF6, INHBA, EDNRB, CD36, TACSTD2, CD4, CALCRL, SMPD3

2.25E-02

GOTERM_BP_DIRECT


5

KCNMA1, CAV1, CCL2, FLT1, CAPN2, MMP2, TGFB1, DDIT4, TGFB2, TFRC, UCP2, IL1B, TGFBR3, CD24, THBS1, ANGPT2

3.78E-02

GOTERM_BP_DIRECT


3.66E-05

FMOD, LUM, COL12A1, COL1A1, LOX, ANXA2, TGFB2, DPT

6.44E-02

GOTERM_BP_DIRECT

GO:0010628~positive regulation of gene expression

3.76E-05

CAV1, IL6, ACTA2, CD3E, TNC, VIM, TLR2, GJA1, TLR4, IL7R, TGFB1, TGFB2, SLC11A1, INHBA, CD44, GSN, CTGF, IL1B

6.63E-02

GOTERM_BP_DIRECT


5.35E-05

PTPRC, IL6, CD3E, ANXA1, CCL19, IL1B, CD4, HLA-DPA1, PDCD1LG2

9.43E-02

GOTERM_BP_DIRECT

GO:0032729~positive regulation of interferon-gamma production

5.95E-05

SLC11A1, CD3E, PDE4B, SLAMF6, IL1B, TLR4, HLA-DPA1, TXK

1.05E-01

GOTERM_BP_DIRECT

GO:0051592~response to calcium ion

6.08E-05

TXNIP, KCNMA1, PLA2G4A, CAV1, IL6, CCND1, DUSP1, THBS1, AQP3

1.07E-01

GOTERM_BP_DIRECT

GO:0045860~positive regulation of protein kinase activity

8.04E-05

PTPRC, CCL21, RASSF2, MMD, CCL19, CD4, IQGAP1, CYR61

1.42E-01

GOTERM_BP_DIRECT

GO:0045730~respiratory burst 8.81E-0

5 SLC11A1, CD55, CYBB, NCF2, CD24

1.55E-01

GOTERM_BP_D GO:0050900~leukocyte migration 9.33E-0 CD48, CAV1, ITGAX, CD44, SELL, ITGAV, 1.64E-

IRECT 5 PDE4B, PECAM1, F2RL1, COL1A1, ANGPT2, SLC7A7

01

GOTERM_BP_DIRECT

GO:0032496~response to lipopolysaccharide

9.62E-05

CXCL1, TNFRSF21, PELI1, PTGS2, CXCL2, EDN1, CXCL9, DUSP10, TLR4, DCN, S100A14, TRIB1, SLC11A1, PLA2G4A, IL10RA

1.69E-01

GOTERM_BP_DIRECT

GO:0007267~cell-cell signaling 1.05E-0

4

FGFR2, GRAP, CCR1, EFNB2, EDN1, CXCL9, GJA1, FGF21, TGFB2, INHBA, CD86, SH2D1A, CCL20, CCL21, CTGF, IL1B, GDF15, CYR61

1.86E-01

GOTERM_BP_DIRECT

GO:0046718~viral entry into host cell

1.45E-04

NCAM1, CR1, CD55, CD86, TFRC, LDLR, ITGAV, EFNB2, ACE2, CD4

2.55E-01

GOTERM_BP_DIRECT

GO:0031100~organ regeneration 1.55E-0

4 CAV1, CCND1, CCL2, LIFR, TGFBR3, ANGPT2, TGFB1, LCP1, ANXA3

2.72E-01

GOTERM_BP_DIRECT


1.84E-04

CCL21, F2RL1, CCL19, THBS1, TGFB1 3.24E-

01

GOTERM_BP_DIRECT

GO:0070374~positive regulation of ERK1 and ERK2 cascade

1.89E-04

FGFR2, IL6, CCL2, CCR1, F2RL1, CCL19, TLR4, FGF21, CD36, CD44, CCL20, CCL21, CTGF, IL1B

3.33E-01

GOTERM_BP_DIRECT

GO:0070098~chemokine-mediated signaling pathway

2.12E-04

CXCL1, CCL2, CCL20, CMKLR1, CCL21, CCR1, CXCL2, CXCL9, CCL19

3.73E-01

GOTERM_BP_DIRECT

GO:0090023~positive regulation of neutrophil chemotaxis

2.56E-04

CXCL1, CCL21, EDN1, CXCL2, CCL19, IL1B 4.50E-

01

GOTERM_BP_DIRECT

GO:0030335~positive regulation of cell migration

2.98E-04

RET, FLT1, CCR1, EDN1, F2RL1, MCAM, TGFB1, ITGAV, CXCL16, SEMA3D, COL1A1, THBS1, CYR61, ATP8A1

5.24E-01

GOTERM_BP_DIRECT

GO:0042742~defense response to bacterium

3.35E-04

SLC11A1, CLEC4E, CCL20, LYZ, TLR4, IGKC, S100A14, ADAMTS5, ANXA3, PLAC8, ADAMTS4, S100A12

5.88E-01

GOTERM_BP_DIRECT


3.74E-04

INHBA, COL4A2, ITGAV, MMP8, COL12A1, MMP2

6.57E-01

GOTERM_BP_DIRECT


3.78E-04

COL4A2, CTSK, MMP19, COL6A3, MMP8, COL12A1, COL1A1, CTSS, MMP2

6.64E-01

GOTERM_BP_DIRECT

GO:0046330~positive regulation of JNK cascade

4.10E-04

CTGF, CCL21, GADD45G, RASSF2, F2RL1, CCL19, TLR4, PLCB1

7.20E-01

GOTERM_BP_DIRECT

GO:0016049~cell growth 4.10E-0

4 IL6, ITGAV, EDN1, TGFBR3, IL7R, TGFB1, EMP1, TGFB2

7.20E-01

GOTERM_BP_DIRECT


4.37E-04

TNFRSF21, IL6, CCL2, CCL20, CCL21, CRHBP, EDN1, CCL19, COL1A1, ADAMTS12

7.67E-01

GOTERM_BP_DIRECT

GO:0032355~response to estradiol

4.81E-04

TXNIP, CCND1, DUSP1, SOCS2, PTGS2, CTGF, ANXA1, IL1B, CD4, COL1A1, TGFB1

8.44E-01

GOTERM_BP_DIRECT


5.16E-04

FGFR2, NRG4, TLR1, F2RL1, TLR2, TLR4, SH2D1A, CLEC4E, PDE1A, IL1RAP, IL1B, PELI2, CD4, IGKC, DEFB1, TXNIP, ITK, CRISP3, CR1, PELI1, VAV3, KLB, NCF2, LGALS3, ANXA1, SLAMF6, MAPK10, CTSS, BIRC3, S100A12, NCAM1, DUSP5, CTSK, CYBB, CD86, CD55, CD36, TXK

9.06E-01

GOTERM_BP_DIRECT

GO:0030168~platelet activation 6.55E-0

4

GNA13, IL6, PLA2G4A, VAV3, CD36, PLEK, PECAM1, F8, PRKCH, COL1A1, THBS1, TGFB1, FLNA, TGFB2, VCL

1.15E+00

GOTERM_BP_DIRECT

GO:0050702~interleukin-1 beta secretion

6.67E-04

CD36, GBP5, F2RL1, TLR4 1.17E

+00

GOTERM_BP_DIRECT

GO:0007204~positive regulation of cytosolic calcium ion concentration

7.11E-04

GNA13, EDNRB, CD55, CD36, CCR1, EDN1, F2RL1, IL1B, GJA1, CD24, CACNA1C

1.25E+00

GOTERM_BP_DIRECT

GO:0050852~T cell receptor signaling pathway

7.34E-04

FYB, HLA-DQB1, TNFRSF21, ITK, PTPRC, CD3E, PDE4B, CD4, HLA-DPA1, TXK, HLA-DRA, THY1

1.29E+00

GOTERM_BP_DIRECT

GO:0002576~platelet degranulation

7.51E-04

CD36, PLEK, PECAM1, F8, THBS1, FLNA, TGFB1, TGFB2, VCL

1.31E+00

GOTERM_BP_DIRECT

GO:0042493~response to drug 7.95E-0

4

TXNIP, LPL, SLC8A1, IL6, RET, CAV1, VAV3, PTGS2, ANXA1, GCLM, TGFB1, TGFB2, ABCB4, INHBA, CCND1, CD86, COL1A1, LOX, THBS1

1.39E+00

GOTERM_BP_DIRECT


9.50E-04

PTPRC, IL6, PODN, SOCS2, GADD45G, FABP4, DCN, TRIB1, THY1

1.66E+00

GOTERM_BP_DIRECT


9.68E-04

HYOU1, COL4A2, MSR1, CD36, TFRC, LDLR, ENPP2, CXCL16, SUSD2, PPT1, COL1A1, IGKC

1.69E+00

GOTERM_BP_DIRECT

GO:0071223~cellular response to lipoteichoic acid

9.83E-04

CD36, CCL20, TLR2, TLR4 1.72E


GO:0048812~neuron projection morphogenesis

1.09E-03

EPB41L3, GPM6A, LIFR, ZSWIM6, GJA1, LRRK2, WEE1

1.91E+00

GOTERM_BP_DIRECT


3 CRISPLD2, TIPARP, COL1A1, MMP2, TGFB1, TGFB2

1.96E+00

GOTERM_BP_DIRECT

GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling

1.14E-03

PELI1, CTH, CD36, SLC20A1, CCL21, F2RL1, CCL19, GJA1, PELI2, BIRC3, FLNA, S100A12

1.98E+00

GOTERM_BP_DIRECT

GO:0009749~response to glucose 1.18E-0

3 TXNIP, LPL, SLC8A1, CTGF, GJA1, THBS1, ANGPT2, TGFB1

2.06E+00

GOTERM_BP_DIRECT

GO:0071346~cellular response to interferon-gamma

1.35E-03

CCL2, GBP5, CCL20, CCL21, EDN1, CCL19, HLA-DPA1

2.35E+00

GOTERM_BP_DIRECT

GO:0042116~macrophage activation

1.38E-03

SLC11A1, CD93, TLR1, TLR4 2.40E



1.38E-03

DOCK2, CCL21, CCL19, DOCK8 2.40E


GO:0050729~positive regulation of inflammatory response

1.40E-03

LPL, CCL2, IL1RL1, TLR2, FABP4, TLR4, CTSS, S100A12

2.43E+00

GOTERM_BP_DIRECT

GO:0002224~toll-like receptor signaling pathway

1.51E-03

PELI1, CTSK, CD36, TLR1, TLR2, PELI2, TLR4, MAPK10, CTSS, BIRC3

2.63E+00

GOTERM_BP_DIRECT

GO:0019221~cytokine-mediated signaling pathway

1.55E-03

HLA-DQB1, PLP2, IL6, CCL2, PODN, SOCS2, CCR1, IL1RN, LIFR, DCN, NCAM1, CD44, IL10RA, IL1RAP, IL1B, HLA-DPA1, HLA-DRA

2.69E+00

GOTERM_BP_DIRECT

GO:0042346~positive regulation of NF-kappaB import into nucleus

1.59E-03

PTGS2, TLR2, CCL19, IL1B, TLR4 2.77E


GO:0043406~positive regulation of MAP kinase activity

1.81E-03

FLT1, EDN1, PDE5A, CD24, LRRK2, TGFB1, S100A12

3.14E+00

GOTERM_BP_DIRECT

GO:0042535~positive regulation of tumor necrosis factor biosynthetic process

1.86E-03

TLR1, TLR2, TLR4, THBS1 3.24E

+00

GOTERM_BP_DIRECT


1.88E-03

SMOC2, CCDC80, THBS1, ABI3BP, SPP1, CYR61

3.26E+00

GOTERM_BP_DIRECT

GO:0001816~cytokine production 1.89E-0

3 ITK, LIPA, FABP4, CD4, TXK

3.28E+00

GOTERM_BP_DIRECT

GO:0007568~aging 2.16E-0

3 EDNRB, PLA2G4A, IL6, CD86, CCL2, TFRC, GSN, UCP2, IL1B, DCN, TIMP3, TGFB1

3.74E+00

GOTERM_BP_DIRECT

GO:0032570~response to progesterone

2.37E-03

TXNIP, CAV1, CCL2, THBS1, TGFB1, TGFB2 4.10E


GO:0051384~response to glucocorticoid

2.59E-03

PLA2G4A, CAV1, IL6, DUSP1, PTGS2, IL1RN, TAT, ANXA3

4.47E+00

GOTERM_BP_DIRECT

GO:0071260~cellular response to mechanical stimulus

2.78E-03

CAV1, SLC38A2, PTGS2, IL1B, GJA1, CNN2, TLR4, COL1A1

4.80E+00

GOTERM_BP_DIRECT

GO:0045086~positive regulation of interleukin-2 biosynthetic process

3.12E-03

CD86, CD3E, IL1B, CD4 5.36E

+00

GOTERM_BP_DIRECT

GO:0051770~positive regulation of nitric-oxide synthase biosynthetic process

3.12E-03

CCL2, CCL20, TLR2, TLR4 5.36E

+00

GOTERM_BP_DIRECT

GO:0060389~pathway-restricted SMAD protein phosphorylation

3.12E-03

BMP10, TGFBR3, TGFB1, TGFB2 5.36E


GO:0034142~toll-like receptor 4 signaling pathway

3.20E-03

PELI1, CD36, TLR1, TLR2, PELI2, TLR4, MAPK10, BIRC3, S100A14

5.49E+00

GOTERM_BP_DIRECT

GO:0008284~positive regulation of cell proliferation

3.21E-03

FGFR2, CLDN7, IL6, FLT1, KLB, PRC1, OSMR, TNC, EFEMP1, EDN1, LIFR, FGF21, PRAMEF10, TGFB1, PLAC8, TGFB2, EDNRB, CD86, PLA2G4A, CTGF, ITGAV, BAMBI

5.51E+00

GOTERM_BP_DIRECT

GO:0002244~hematopoietic progenitor cell differentiation

3.34E-03

PTPRC, INHBA, PLEK, FST, SAMD9L, TGFB1, SMPD3

5.73E+00

GOTERM_BP_DIRECT

GO:0007229~integrin-mediated signaling pathway

3.43E-03

VAV3, ITGAX, PLEK, CTGF, ITGAV, NEDD9, ADAMTS1, TXK

5.87E+00

GOTERM_BP_DIRECT

GO:0032735~positive regulation of interleukin-12 production

3.48E-03

CD36, TLR2, CCL19, TLR4, PLCB1 5.95E


GO:0000188~inactivation of MAPK activity

3.48E-03

DUSP5, CAV1, DUSP1, RGS4, DUSP10 5.95E


GO:0045429~positive regulation of nitric oxide biosynthetic process

3.62E-03

IL6, PTGS2, EDN1, TLR2, IL1B, TLR4 6.20E


GO:0042476~odontogenesis 3.98E-0

3 FGFR2, MYO5A, INHBA, AQP3, TGFB2

6.79E+00

GOTERM_BP_DIRECT

GO:0006928~movement of cell or subcellular component

4.18E-03

GNA13, PTGS2, ENPP2, VIM, FPR1, VNN2, ARHGDIB, VCL

7.11E+00

GOTERM_BP_DIRECT


4.23E-03

APOA4, LPL, ACSM1, CAV1, LDLR, FABP4, CD24

7.20E+00

GOTERM_BP_DIRECT

GO:0035690~cellular response to drug

4.57E-03

CCL2, TFRC, CRHBP, PDE4B, EDN1, IL1B, FGF21

7.75E+00

GOTERM_BP_DIRECT

GO:0010744~positive regulation of macrophage derived foam cell differentiation

4.79E-03

LPL, MSR1, CD36, PRKCH 8.12E

+00

GOTERM_BP_DIRECT

GO:0043552~positive regulation of phosphatidylinositol 3-kinase

5.14E-03

VAV3, FLT1, CCL21, CCL19, TGFB1 8.68E

+00

activity GOTERM_BP_DIRECT


5.29E-03

DOCK2, CCL21, CCL19 8.92E


GO:0035634~response to stilbenoid

5.29E-03

APOA4, CD36, IL1B 8.92E

+00

GOTERM_BP_DIRECT

GO:1900227~positive regulation of NLRP3 inflammasome complex assembly

5.29E-03

CD36, GBP5, TLR4 8.92E

+00

GOTERM_BP_DIRECT


5.78E-03

COL4A2, CAV1, EDN1, FBN1, COL1A1, TGFB1 9.72E

+00

GOTERM_BP_DIRECT

GO:0030301~cholesterol transport

5.80E-03

CAV1, MSR1, CD36, LDLR 9.74E


GO:0071222~cellular response to lipopolysaccharide

5.89E-03

EDNRB, IL6, CD86, CD36, CCL2, CCL20, CXCL16, PDE4B, TLR4

9.88E+00

GOTERM_BP_DIRECT

GO:0030217~T cell differentiation 6.50E-0

3 PTPRC, IKZF1, CD4, IL7R, RHOH

1.08E+01

GOTERM_BP_DIRECT

GO:0031663~lipopolysaccharide-mediated signaling pathway

6.50E-03

CCL2, TLR2, IL1B, TLR4, TGFB1 1.08E


GO:0072593~reactive oxygen species metabolic process

7.26E-03

CTGF, PDK4, LRRK2, DDIT4, CYR61 1.20E



3 FLT1, CTGF, ITGAV, TGFBR3, ADAMTS12, CD24, THBS1, BAMBI, TGFB1, LCP1, TGFB2

1.23E+01

GOTERM_BP_DIRECT


7.81E-03

CTSK, COL1A1, MMP2 1.29E

+01

GOTERM_BP_DIRECT

GO:0031394~positive regulation of prostaglandin biosynthetic process

7.81E-03

PLA2G4A, PTGS2, ANXA1 1.29E

+01

GOTERM_BP_DIRECT

GO:0001558~regulation of cell growth

7.96E-03

EPB41L3, TFRC, SOCS2, CTGF, FBLN5, PAPPA2, CYR61

1.31E+01

GOTERM_BP_DIRECT

GO:0006796~phosphate-containing compound metabolic process

8.16E-03

PTPRB, SLC20A1, ENPP2, TGFB1 1.34E


GO:0006885~regulation of pH 8.16E-0

3 SLC9A9, EDNRB, EDN1, PDK4

1.34E+01

GOTERM_BP_DIRECT

GO:0042060~wound healing 8.49E-0

3 SLC11A1, CCL20, TNC, IL1B, LOX, DCN, TGFB2

1.39E+01

GOTERM_BP_DIRECT


8.49E-03

IL6, CCL2, CCL20, CCL21, EDN1, CCL19, ADAMTS12

1.39E+01

GOTERM_BP_DIRECT

GO:0009408~response to heat 8.72E-0

3 PLA2G4A, IL6, CCL2, HSPA2, IL1B, TP53INP1

1.43E+01

GOTERM_BP_DIRECT


8.95E-03

FGFR2, TGFBR3, FLNA, TGFB1, TGFB2 1.47E


GO:0038124~toll-like receptor TLR6:TLR2 signaling pathway

9.04E-03

PELI1, CD36, TLR1, TLR2, PELI2, TLR4, MAPK10

1.48E+01

GOTERM_BP_DIRECT


9.04E-03


1.48E+01

GOTERM_BP_DIRECT

GO:0009967~positive regulation of signal transduction

9.41E-03

SH2D1A, VAV3, SOCS2, GRAP, SKAP2, SLA 1.53E

+01 GOTERM_BP_D GO:0070542~response to fatty 9.52E-0 CD36, PTGS2, UCP2, CTGF 1.55E

IRECT acid 3 +01

GOTERM_BP_DIRECT

GO:0006468~protein phosphorylation

9.83E-03

FYB, RET, CCL2, PDK4, STK17B, MMD, PRKCH, MAPK10, STK17A, PRKG1, TGFB1, TRIB1, TGFB2, CCND1, GMFG, RASSF2, TXK, LRRK2, STK38L, AKT3

1.60E+01

GOTERM_BP_DIRECT


1.02E-02


1.65E+01

GOTERM_BP_DIRECT

GO:0034141~positive regulation of toll-like receptor 3 signaling pathway

1.08E-02

PELI1, CAV1, F2RL1 1.74E

+01

GOTERM_BP_DIRECT


1.08E-02

SLC11A1, CCL21, CCL19 1.74E

+01

GOTERM_BP_DIRECT

GO:0060452~positive regulation of cardiac muscle contraction

1.08E-02

RGS2, CTGF, ACE2 1.74E



1.08E-02

CCL21, TGFBR3, CCL19 1.74E


GO:0010886~positive regulation of cholesterol storage

1.08E-02

LPL, MSR1, CD36 1.74E


GO:0060395~SMAD protein signal transduction

1.17E-02

BMP10, INHBA, VIM, GDF15, TGFB1, TGFB2 1.87E


GO:0009612~response to mechanical stimulus

1.17E-02

TXNIP, CCL2, TNC, DCN, ANGPT2, TIMP3 1.87E


GO:0009611~response to wounding

1.17E-02

CCL2, CTGF, CCR1, TNC, TGFB1, TGFB2 1.87E


GO:0006909~phagocytosis 1.19E-0

2 SLC11A1, CD93, PECAM1, ANXA1, ANXA3

1.91E+01

GOTERM_BP_DIRECT

GO:0048661~positive regulation of smooth muscle cell proliferation

1.25E-02

FGFR2, IL6, FLT1, PTGS2, EDN1, CALCRL 2.00E

+01

GOTERM_BP_DIRECT

GO:0008285~negative regulation of cell proliferation

1.39E-02

CXCL1, IL6, PODN, PTGS2, IL1RL1, S100A11, TGFB1, TGFB2, SOD2, WARS, INHBA, SERPINE2, EEF1E1, IL1B, ADAMTS1, PMP22, TP53INP1, DPT

2.19E+01

GOTERM_BP_DIRECT

GO:0031340~positive regulation of vesicle fusion

1.41E-02

PLA2G4A, ANXA1, ANXA2 2.22E


GO:0031622~positive regulation of fever generation

1.41E-02

PLA2G4A, PTGS2, IL1B 2.22E

+01

GOTERM_BP_DIRECT

GO:0060907~positive regulation of macrophage cytokine production

1.41E-02

CD36, TLR2, TLR4 2.22E

+01

GOTERM_BP_DIRECT

GO:0060087~relaxation of vascular smooth muscle

1.41E-02

KCNMA1, RGS2, PRKG1 2.22E


GO:0009617~response to bacterium

1.44E-02

SLC11A1, CAV1, CCL2, DEFB1 2.25E


GO:0042246~tissue regeneration 1.44E-0

2 GSN, TXK, IGFBP1, TIMP3

2.25E+01

GOTERM_BP_DIRECT

GO:0002755~MyD88-dependent toll-like receptor signaling pathway

1.52E-02


2.36E+01

GOTERM_BP_DIRECT

GO:0044281~small molecule metabolic process

1.52E-02

PTGS2, LDLR, SLC44A3, SLC5A1, ARSK, GSTM5, BBOX1, IQGAP1, GSTM1, APOA4, OGN, CD44, CTGF, INSIG1, PLCB1, AADAT, TAT, PGM2, CTH, CD36, AKR1B10, INPP4B, TNFRSF21, FMOD, CAV1, CYP2B6, CA13, ALDOC, LUM, PPT1, DCN, SLC19A2, GCLM, ALOX5AP, ACSL4, PIK3R3, GPD2, LPL, PDK4, INMT, IYD, ABCB4, PCK1, GBA3, PLA2G4A, ACSM1, GLA, UCP2, EEF1E1, FABP4, IDI1, CACNA1C, SLC25A15, HPGD, SMPD3

2.37E+01

GOTERM_BP_DIRECT


1.53E-02

COL4A2, CCL2, DCN, THBS1, ANGPT2, THBS2 2.38E



1.54E-02

LGALS3, CMKLR1, RASSF2, FBN1, COL12A1, COL1A1, NPR3, ADAMTS4, CDH11

2.39E+01

GOTERM_BP_DIRECT

GO:0008277~regulation of G-protein coupled receptor protein signaling pathway

1.55E-02

RGS2, RGS4, RGS5, RGS16, PLCB1 2.41E

+01

GOTERM_BP_DIRECT

GO:0050731~positive regulation of peptidyl-tyrosine phosphorylation

1.60E-02

IL6, CD36, CD44, ENPP2, CD3E, CD4, TGFB1 2.47E

+01

GOTERM_BP_DIRECT

GO:0007264~small GTPase mediated signal transduction

1.70E-02

FGFR2, NRG4, PRC1, MYO9A, IQGAP1, DOCK2, RAB27B, DOCK11, ARL5B, RHOH, ARHGDIB, VAV3, RAB8B, KLB, NCF2, GEM, DOCK8, FLNA, NCAM1, DUSP5, RND2, RND3, CYBB, RAB31, MAPRE1, LRRK2, RASD1

2.61E+01

GOTERM_BP_DIRECT

GO:0035556~intracellular signal transduction

1.78E-02

CXCL1, FYB, ITK, NRG4, PLEK2, CD3E, IL1RL1, STK17B, PRKCH, STK17A, DUSP1, CTGF, TGFBR3, PLCB1, LRRK2, STK38L, AKT3

2.72E+01

GOTERM_BP_DIRECT

GO:0019934~cGMP-mediated signaling

1.79E-02

EDNRB, CD36, PRKG1 2.73E

+01

GOTERM_BP_DIRECT

GO:0001960~negative regulation of cytokine-mediated signaling pathway

1.79E-02

PTPRC, CAV1, IL1RN 2.73E

+01

GOTERM_BP_DIRECT

GO:0032609~interferon-gamma production

1.79E-02

ITK, TLR4, TXK 2.73E


GO:0030728~ovulation 1.79E-0

2 PTGS2, IL1B, HPGD

2.73E+01

GOTERM_BP_DIRECT

GO:0001542~ovulation from ovarian follicle

1.79E-02

PLA2G4A, MMP19, ADAMTS1 2.73E


GO:0070493~thrombin receptor signaling pathway

1.79E-02

PLEK, F2RL1, HPGD 2.73E



1.82E-02

SERPINE2, PTGS2, IL1B, MMP2, SPP1 2.77E


GO:0008217~regulation of blood pressure

2.08E-02

EDNRB, PTGS2, ACTA2, NPR3, CACNA1C, SOD2

3.10E+01

GOTERM_BP_DIRECT

GO:0043434~response to peptide hormone

2.12E-02

CTGF, ANXA1, IL1B, GJA1, COL1A1 3.15E

+01 GOTERM_BP_D GO:0010759~positive regulation 2.20E-0 CCL2, CMKLR1, THBS1 3.25E

IRECT of macrophage chemotaxis 2 +01

GOTERM_BP_DIRECT

GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway

2.27E-02

ITK, RET, FLT1, CD3E, ANGPTL1, CD4, TXK 3.32E

+01

GOTERM_BP_DIRECT

GO:0032760~positive regulation of tumor necrosis factor production

2.28E-02

CD36, CCL2, TLR2, CCL19, TLR4 3.34E

+01

GOTERM_BP_DIRECT


2.45E-02

IL6, CD36, TLR2, IL1B, TLR4 3.54E


GO:0071549~cellular response to dexamethasone stimulus

2.50E-02

IL6, CCL2, ERRFI1, TGFB1 3.60E

+01

GOTERM_BP_DIRECT

GO:0010862~positive regulation of pathway-restricted SMAD protein phosphorylation

2.62E-02

BMP10, INHBA, GDF15, TGFB1, TGFB2 3.74E

+01

GOTERM_BP_DIRECT

GO:0045744~negative regulation of G-protein coupled receptor protein signaling pathway

2.65E-02

PLEK, RGS2, RGS4 3.77E

+01

GOTERM_BP_DIRECT

GO:0009058~biosynthetic process 2.65E-0

2 AADAT, ALDH1L1, TAT

3.77E+01

GOTERM_BP_DIRECT

GO:0010763~positive regulation of fibroblast migration

2.65E-02

SLC8A1, THBS1, TGFB1 3.77E



2.80E-02

CPEB4, COL1A1, CAPN2, RRAGD, MMP2 3.94E


GO:0014070~response to organic cyclic compound

2.99E-02

EDNRB, CD83, LUM, LIFR, ANGPT2 4.15E


GO:0014823~response to activity 2.99E-0

2 CCL2, EDN1, FGF21, ANGPT2, PCK1

4.15E+01

GOTERM_BP_DIRECT

GO:0048247~lymphocyte chemotaxis

3.02E-02

CCL2, CCL20, CCL21, CCL19 4.18E


GO:0036066~protein O-linked fucosylation

3.13E-02

THBS1, ADAMTS5, SPON1 4.29E


GO:0032700~negative regulation of interleukin-17 production

3.13E-02

TLR2, TLR4, TGFB1 4.29E


GO:0055119~relaxation of cardiac muscle

3.13E-02

SLC8A1, RGS2, PDE5A 4.29E



3.13E-02

FMOD, OGN, LUM 4.29E

+01

GOTERM_BP_DIRECT


3.30E-02

CTSK, ADAMTS12, CTSS, CAPN2 4.46E

+01

GOTERM_BP_DIRECT

GO:0050873~brown fat cell differentiation

3.30E-02

RGS2, PTGS2, FABP4, PLAC8 4.46E

+01

GOTERM_BP_DIRECT

GO:0051092~positive regulation of NF-kappaB transcription factor activity

3.44E-02

IL6, CTH, TLR2, PRKCH, IL1B, TLR4, TGFB1, S100A12

4.61E+01

GOTERM_BP_DIRECT

GO:0001934~positive regulation of protein phosphorylation

3.44E-02

EDNRB, CCND1, IL1B, PELI2, LRRK2, TGFB1, ANXA2, CYR61

4.61E+01

GOTERM_BP_DIRECT

GO:0000187~activation of MAPK activity

3.50E-02

DUSP5, FPR1, IL1B, TLR4, MAPK10, THBS1, LRRK2

4.67E+01

GOTERM_BP_DIRECT

GO:0042542~response to hydrogen peroxide

3.60E-02

TXNIP, PLA2G4A, SLC8A1, DUSP1, COL1A1 4.76E


GO:0006536~glutamate metabolic process

3.64E-02

AADAT, TAT, GCLM 4.80E


GO:0019372~lipoxygenase pathway

3.64E-02

PTGS2, ALOX5AP, HPGD 4.80E

+01

GOTERM_BP_DIRECT


3.64E-02

RET, CCL21, TGFB2 4.80E

+01

GOTERM_BP_DIRECT

GO:0042554~superoxide anion generation

3.64E-02

CYBB, NCF2, EDN1 4.80E

+01

GOTERM_BP_DIRECT

GO:0086064~cell communication by electrical coupling involved in cardiac conduction

3.64E-02

SLC8A1, GJA1, CACNA1C 4.80E

+01

GOTERM_BP_DIRECT

GO:0060038~cardiac muscle cell proliferation

3.64E-02

BMP10, TGFBR3, TGFB2 4.80E

+01

GOTERM_BP_DIRECT

GO:0030968~endoplasmic reticulum unfolded protein response

3.65E-02

HYOU1, CTH, CCND1, CCL2, GFPT1, IGFBP1, FGF21

4.81E+01

GOTERM_BP_DIRECT

GO:0050727~regulation of inflammatory response

3.82E-02

PTGS2, ANXA1, ACE2, ADAMTS12, BIRC3 4.97E


GO:0006936~muscle contraction 3.95E-0

2 SLC8A1, ACTA2, ANXA1, GJA1, LMOD1, ANXA2, VCL

5.08E+01

GOTERM_BP_DIRECT

GO:0032869~cellular response to insulin stimulus

4.06E-02

MYO5A, RAB31, CCL2, UCP2, GFPT1, ERRFI1 5.18E

+01

GOTERM_BP_DIRECT

GO:0007179~transforming growth factor beta receptor signaling pathway

4.09E-02

CCL2, LTBP2, TGFBR3, BAMBI, GDF15, HPGD, TGFB1, TGFB2

5.21E+01

GOTERM_BP_DIRECT


4.19E-02

CMKLR1, TLR2, THBS1 5.29E


GO:0001817~regulation of cytokine production

4.19E-02

CD83, ACE2, IQGAP1 5.29E



4.19E-02

CD83, PDE4B, ANXA1 5.29E



4.19E-02



GO:0048246~macrophage chemotaxis

4.19E-02

EDNRB, CCL2, LGALS3 5.29E


GO:0060347~heart trabecula formation

4.19E-02

BMP10, TGFBR3, ADAMTS1 5.29E

+01

GOTERM_BP_DIRECT

GO:0043537~negative regulation of blood vessel endothelial cell migration

4.19E-02

THBS1, ANGPT2, TGFB1 5.29E

+01

GOTERM_BP_DIRECT

GO:2001241~positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

4.19E-02

INHBA, RET, TGFB2 5.29E

+01

GOTERM_BP_DIRECT

GO:0048662~negative regulation of smooth muscle cell proliferation

4.21E-02

OGN, CAV1, NPR3, TRIB1 5.32E

+01 GOTERM_BP_D GO:0010718~positive regulation 4.21E-0 COL1A1, BAMBI, TGFB1, TGFB2 5.32E

IRECT of epithelial to mesenchymal transition

2 +01

GOTERM_BP_DIRECT

GO:0071407~cellular response to organic cyclic compound

4.52E-02

MSR1, CCL2, TIPARP, IL1B, TGFB1 5.58E


GO:0042130~negative regulation of T cell proliferation

4.54E-02

TNFRSF21, PELI1, PDE5A, TGFB1 5.59E


GO:0007601~visual perception 4.54E-0

2 MYO5A, LAMC3, TACSTD2, LUM, EFEMP1, PPT1, COL1A1, RGS16, MYO9A, TIMP3

5.59E+01

GOTERM_BP_DIRECT

GO:0042127~regulation of cell proliferation

4.59E-02

TXNIP, TNFRSF21, ITK, TFRC, CXCL2, ACE2, CXCL9, TXK, JAG1

5.63E+01

GOTERM_BP_DIRECT

GO:0032633~interleukin-4 production

4.66E-02

ITK, TXK 5.69E


GO:0046477~glycosylceramide catabolic process

4.66E-02

GBA3, GLA 5.69E


GO:0034381~plasma lipoprotein particle clearance

4.66E-02

MSR1, CD36 5.69E


GO:0060401~cytosolic calcium ion transport

4.66E-02

SLC8A1, CTGF 5.69E


GO:0007497~posterior midgut development

4.66E-02

EDNRB, RET 5.69E

+01

GOTERM_BP_DIRECT

GO:0048002~antigen processing and presentation of peptide antigen

4.66E-02

SLC11A1, CTSS 5.69E

+01

GOTERM_BP_DIRECT

GO:0042495~detection of triacyl bacterial lipopeptide

4.66E-02

TLR1, TLR2 5.69E



4.66E-02

PROM1, CD24 5.69E


GO:0035810~positive regulation of urine volume

4.76E-02

EDNRB, EDN1, NPR3 5.76E


GO:0090026~positive regulation of monocyte chemotaxis

4.76E-02

CCL2, CCR1, S100A14 5.76E



4.76E-02

CCL21, CCR1, CCL19 5.76E


GO:0006959~humoral immune response

4.77E-02

TNFRSF21, CD83, IL6, SH2D1A, CCL2 5.78E


GO:0006952~defense response 4.77E-0

2 CD48, CRISP3, INHBA, CD83, CXCL9

5.78E+01

GOTERM_BP_DIRECT


4.88E-02



GO:0030073~insulin secretion 4.88E-0

2 MYO5A, IL1RN, ANXA1, CACNA1C

5.86E+01

GOTERM_BP_DIRECT

GO:1904030~negative regulation of cyclin-dependent protein kinase activity

5.03E-02

PODN, SOCS2, GMFG, DCN, TRIB1 5.97E

+01

GOTERM_BP_DIRECT


5.13E-02

TNFRSF21, ITK, SH2D1A, CD86, ANXA1, CD4, TXK, CTSS

6.05E+01

GOTERM_BP_DIRECT

GO:0043065~positive regulation of apoptotic process

5.18E-02

TXNIP, KCNMA1, IL6, VAV3, PTGS2, STK17A, TGFB1, PLA2G4A, DUSP1, EEF1E1, GADD45G, RASSF2, IL1B

6.08E+01

GOTERM_BP_DIRECT

GO:2001237~negative regulation of extrinsic apoptotic signaling pathway

5.24E-02

LGALS3, ITGAV, THBS1, GCLM 6.13E

+01

GOTERM_BP_DIRECT


5.35E-02

CCL21, CCL19, PPT1 6.21E



5.35E-02

LAMC3, VIM, TLR4 6.21E


GO:0010613~positive regulation of cardiac muscle hypertrophy

5.35E-02

BMP10, EDN1, PDE5A 6.21E


GO:0002690~positive regulation of leukocyte chemotaxis

5.35E-02

IL6, F2RL1, CXCL9 6.21E


GO:0019233~sensory perception of pain

5.56E-02

EDNRB, PTGS2, EDN1, SCN9A, MME 6.35E


GO:0006968~cellular defense response

5.56E-02

KLRC4, ITK, SH2D1A, NCF2, CXCL9 6.35E


GO:0009409~response to cold 5.60E-0

2 LPL, IL6, HSPA2, PLAC8

6.38E+01

GOTERM_BP_DIRECT

GO:0030890~positive regulation of B cell proliferation

5.60E-02

PTPRC, PELI1, VAV3, TLR4 6.38E


GO:0050870~positive regulation of T cell activation

5.97E-02

CCL2, HLA-DPA1, THY1 6.62E


GO:0042310~vasoconstriction 5.97E-0

2 EDNRB, CAV1, EDN1

6.62E+01

GOTERM_BP_DIRECT

GO:0036120~cellular response to platelet-derived growth factor stimulus

5.97E-02

CCL2, ERRFI1, IQGAP1 6.62E

+01

GOTERM_BP_DIRECT

GO:0031623~receptor internalization

5.98E-02

CAV1, RAB31, CD36, CALCRL 6.63E


GO:0046426~negative regulation of JAK-STAT cascade

5.98E-02

CAV1, PODN, SOCS2, DCN 6.63E


GO:0043200~response to amino acid

5.98E-02

IL6, CCL2, CTGF, EDN1 6.63E


GO:0006811~ion transport 6.14E-0

2 SLC9A9, PLP2, CYBB, SLC8A1, SLC38A2, SLC20A1, SLC6A6, SLC7A7

6.72E+01

GOTERM_BP_DIRECT

GO:0010508~positive regulation of autophagy

6.37E-02

RNF152, DCN, LRRK2, TP53INP1 6.87E


GO:0000165~MAPK cascade 6.42E-0

2 NCAM1, FGFR2, DUSP5, CAV1, NRG4, RET, CCL2, KLB, IL1B, LRRK2, TGFB1

6.89E+01

GOTERM_BP_DIRECT

GO:0043547~positive regulation of GTPase activity

6.45E-02

CCL2, VAV3, CCL19, DOCK8, RGS16, MYO9A, IQGAP1, THY1, DOCK2, CCL20, RGS2, RGS4, RGS5, PLCB1, LRRK2, DOCK11, ERRFI1, ARHGDIB

6.91E+01

GOTERM_BP_DIRECT

GO:0048535~lymph node development

6.62E-02

IKZF1, IL7R, TGFB1 7.01E


GO:0007263~nitric oxide mediated signal transduction

6.62E-02

CD36, FPR1, RASD1 7.01E


GO:1901741~positive regulation of myoblast fusion

6.62E-02

CXCL9, CD53, GDF15 7.01E

+01 GOTERM_BP_D GO:0006801~superoxide 6.62E-0 CYBB, NCF2, SOD2 7.01E

IRECT metabolic process 2 +01 GOTERM_BP_DIRECT

GO:0006629~lipid metabolic process

6.68E-02

CD36, LDLR, AOAH, IL1RN, MID1IP1, ACSL4, ABCB4

7.04E+01

GOTERM_BP_DIRECT

GO:0045599~negative regulation of fat cell differentiation

6.77E-02

IL6, INSIG1, JAG1, TGFB1 7.09E



2 CD44, CTGF, ITGAV, FBLN5, ADAMTS12, VCL

7.16E+01

GOTERM_BP_DIRECT

GO:0030308~negative regulation of cell growth

6.89E-02

BMP10, INHBA, SERPINE2, GJA1, PPT1, TGFB1, TGFB2

7.16E+01

GOTERM_BP_DIRECT

GO:0035583~sequestering of TGFbeta in extracellular matrix

6.91E-02

LTBP1, FBN1 7.17E

+01

GOTERM_BP_DIRECT

GO:0007181~transforming growth factor beta receptor complex assembly

6.91E-02

FMOD, TGFBR3 7.17E

+01

GOTERM_BP_DIRECT

GO:0001865~NK T cell differentiation

6.91E-02

ITK, TXK 7.17E


GO:0044691~tooth eruption 6.91E-0

2 ADAMTS1, COL1A1

7.17E+01

GOTERM_BP_DIRECT


6.91E-02

PROM1, CD24 7.17E

+01

GOTERM_BP_DIRECT

GO:0014829~vascular smooth muscle contraction

6.91E-02

SLC8A1, ACTA2 7.17E


GO:0071727~cellular response to triacyl bacterial lipopeptide

6.91E-02

TLR1, TLR2 7.17E


GO:0070487~monocyte aggregation

6.91E-02

CD44, IL1B 7.17E


GO:0002730~regulation of dendritic cell cytokine production

6.91E-02

TLR2, TLR4 7.17E


GO:0033688~regulation of osteoblast proliferation

6.91E-02

FGFR2, NPR3 7.17E



6.91E-02

EFEMP1, FBN1 7.17E


GO:0061092~positive regulation of phospholipid translocation

6.91E-02

ATP8A1, ABCB4 7.17E


GO:1903598~positive regulation of gap junction assembly

6.91E-02

CAV1, ACE2 7.17E


GO:0010572~positive regulation of platelet activation

6.91E-02

PLEK, TLR4 7.17E


GO:0032507~maintenance of protein location in cell

6.91E-02

CAV1, CD4 7.17E

+01

GOTERM_BP_DIRECT

GO:0048010~vascular endothelial growth factor receptor signaling pathway

6.98E-02

NCAM1, FGFR2, DUSP5, CYBB, CAV1, NRG4, VAV3, CCL2, FLT1, KLB, NCF2, ITGAV

7.21E+01

GOTERM_BP_DIRECT


7.19E-02

IL6, TFRC, IL1RN, F8 7.31E


GO:0050829~defense response to Gram-negative bacterium

7.19E-02

SLC11A1, IL6, TLR4, CD4 7.31E

+01 GOTERM_BP_D GO:0055074~calcium ion 7.29E-0 CAV1, SLC8A1, S100A14 7.36E

IRECT homeostasis 2 +01 GOTERM_BP_DIRECT

GO:0032722~positive regulation of chemokine production

7.29E-02

IL6, TLR2, TLR4 7.36E

+01

GOTERM_BP_DIRECT

GO:0010881~regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

7.29E-02

SLC8A1, CLIC2, CACNA1C 7.36E

+01

GOTERM_BP_DIRECT

GO:0010596~negative regulation of endothelial cell migration

7.29E-02

BMP10, DCN, THBS1 7.36E


GO:0006874~cellular calcium ion homeostasis

7.40E-02

CAV1, CCL2, CCR1, CCL19, INPP4B, TGFB1 7.42E


GO:0010629~negative regulation of gene expression

7.56E-02

CD3E, CTGF, CCR1, TIPARP, GJA1, TGFB1, TGFB2

7.50E+01

GOTERM_BP_DIRECT


7.97E-02



GO:0033198~response to ATP 7.97E-0

2 SLC8A1, SELL, IL1B

7.69E+01

GOTERM_BP_DIRECT

GO:0045786~negative regulation of cell cycle

8.04E-02

INHBA, PTGS2, HPGD, TGFB1 7.72E


GO:0051607~defense response to virus

8.28E-02

PTPRC, IL6, CD86, F2RL1, CXCL9, IFI44L, SLFN11, DDIT4

7.82E+01

GOTERM_BP_DIRECT

GO:0030334~regulation of cell migration

8.32E-02

GNA13, SERPINE2, ENPP2, JAG1, TGFB1 7.84E


GO:0019229~regulation of vasoconstriction

8.68E-02

EDN1, ACE2, CACNA1C 7.98E


GO:0046697~decidualization 8.68E-0

2 PLA2G4A, PTGS2, SPP1

7.98E+01

GOTERM_BP_DIRECT

GO:0071398~cellular response to fatty acid

8.68E-02

EDN1, PDK4, IL1B 7.98E


GO:0035335~peptidyl-tyrosine dephosphorylation

8.77E-02

PTPRB, DUSP5, PTPRC, DUSP1, DUSP10, PTPN13

8.01E+01

GOTERM_BP_DIRECT

GO:0043408~regulation of MAPK cascade

8.94E-02

BMP10, INHBA, CD24, GDF15 8.08E


GO:0048468~cell development 8.94E-0

2 BMP10, INHBA, GDF15, TGFB1

8.08E+01

GOTERM_BP_DIRECT

GO:0060326~cell chemotaxis 8.94E-0

2 CXCL1, CCL21, CXCL2, CXCL9

8.08E+01

GOTERM_BP_DIRECT

GO:0006687~glycosphingolipid metabolic process

8.94E-02

GBA3, GLA, ARSK, SMPD3 8.08E


GO:0051900~regulation of mitochondrial depolarization

9.10E-02

LRRK2, GCLM 8.14E


GO:0060298~positive regulation of sarcomere organization

9.10E-02

BMP10, EDN1 8.14E


GO:0034371~chylomicron remodeling

9.10E-02

APOA4, LPL 8.14E


GO:0030072~peptide hormone secretion

9.10E-02

EDN1, SMPD3 8.14E


GO:0010574~regulation of vascular endothelial growth factor

9.10E-02

IL6, CCL2 8.14E

+01

production GOTERM_BP_DIRECT

GO:0003104~positive regulation of glomerular filtration

9.10E-02

F2RL1, GJA1 8.14E

+01

GOTERM_BP_DIRECT


9.10E-02

CCL21, CCL19 8.14E

+01

GOTERM_BP_DIRECT

GO:0060083~smooth muscle contraction involved in micturition

9.10E-02

KCNMA1, CACNA1C 8.14E


GO:0038165~oncostatin-M-mediated signaling pathway

9.10E-02

OSMR, LIFR 8.14E


GO:0006534~cysteine metabolic process

9.10E-02

CTH, GCLM 8.14E


GO:0071726~cellular response to diacyl bacterial lipopeptide

9.10E-02

CD36, TLR2 8.14E


GO:0070508~cholesterol import 9.10E-0

2 CD36, LDLR

8.14E+01

GOTERM_BP_DIRECT

GO:1903169~regulation of calcium ion transmembrane transport

9.10E-02

TSPAN13, LRRK2 8.14E

+01

GOTERM_BP_DIRECT

GO:0014826~vein smooth muscle contraction

9.10E-02

EDNRB, EDN1 8.14E


GO:0001915~negative regulation of T cell mediated cytotoxicity

9.10E-02

PTPRC, IL7R 8.14E

+01

GOTERM_BP_DIRECT

GO:0032269~negative regulation of cellular protein metabolic process

9.10E-02

EDNRB, EDN1 8.14E

+01

GOTERM_BP_DIRECT

GO:0001554~luteolysis 9.10E-0

2 PLA2G4A, MMP19

8.14E+01

GOTERM_BP_DIRECT

GO:0071345~cellular response to cytokine stimulus

9.40E-02

CD86, IL18RAP, MME 8.25E


GO:0045879~negative regulation of smoothened signaling pathway

9.40E-02

SERPINE2, CD3E, HHIP 8.25E


GO:0034394~protein localization to cell surface

9.40E-02

FBLN5, FLNA, VCL 8.25E

+01

GOTERM_BP_DIRECT

GO:0007187~G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

9.41E-02

CCL2, CCR1, ANXA1, CALCRL 8.25E

+01

GOTERM_BP_DIRECT

GO:0009267~cellular response to starvation

9.41E-02

CAV1, PDK4, RRAGD, LRRK2 8.25E

+01

GOTERM_BP_DIRECT

GO:0006810~transport 9.47E-0

2

LAPTM4B, MYO5A, GABRE, SLC20A1, UCP2, SLC6A6, GJA1, FABP4, CLIC2, AQP3, SLC7A7, ABCB4

8.27E+01

Category Term PValue Genes FDR KEGG_PATHWAY

hsa05144:Malaria 1.52E-0

8 KLRB1, CR1, IL6, CD36, CCL2, PECAM1, TLR2, IL1B, TLR4, THBS1, THBS2, TGFB1, TGFB2

1.95E-05

KEGG_PATHWAY

hsa05323:Rheumatoid arthritis 1.56E-0

6

HLA-DQB1, IL6, CCL2, FLT1, TLR2, TLR4, TGFB1, TGFB2, CTSK, CD86, CCL20, IL1B, HLA-DPA1, HLA-DRA

2.01E-03

KEGG_PATHWAY

hsa04640:Hematopoietic cell lineage

8.28E-06

CR1, IL6, CD3E, MME, IL7R, CD55, CD36, CD44, TFRC, IL1B, CD4, CD24, HLA-DRA

1.06E-02

KEGG_PATHWAY

hsa05145:Toxoplasmosis 1.16E-0

5

HLA-DQB1, LDLR, TLR2, TLR4, MAPK10, BIRC3, TGFB1, TGFB2, HSPA2, LAMC3, IL10RA, HLA-DPA1, PIK3R3, AKT3, HLA-DRA

1.49E-02

KEGG_PATHWAY


5

COL4A2, CAV1, VAV3, FLT1, TNC, MAPK10, BIRC3, CAPN2, FLNA, VCL, CCND1, LAMC3, ITGAV, COL6A3, COL1A1, THBS1, PIK3R3, THBS2, AKT3, SPP1

1.74E-02

KEGG_PATHWAY

hsa05140:Leishmaniasis 4.87E-0

5 HLA-DQB1, CR1, PTGS2, NCF2, TLR2, IL1B, TLR4, HLA-DPA1, TGFB1, TGFB2, HLA-DRA

6.25E-02

KEGG_PATHWAY


5

COL4A2, IL6, TLR2, TLR4, TGFB1, VCL, TGFB2, LAMC3, IL1B, SERPINB1, COL1A1, PIK3R3, PLCB1

1.02E-01

KEGG_PATHWAY

hsa05152:Tuberculosis 8.50E-0

5

HLA-DQB1, CR1, IL6, TLR1, TLR2, TLR4, MAPK10, CTSS, TGFB1, TGFB2, ITGAX, CLEC4E, IL10RA, IL1B, HLA-DPA1, AKT3, HLA-DRA

1.09E-01

KEGG_PATHWAY

hsa05321:Inflammatory bowel disease (IBD)

1.18E-04

HLA-DQB1, IL6, IL18RAP, TLR2, IL1B, TLR4, HLA-DPA1, TGFB1, TGFB2, HLA-DRA

1.52E-01

KEGG_PATHWAY

hsa04060:Cytokine-cytokine receptor interaction

1.87E-04

TNFRSF21, IL6, CCL2, FLT1, IL18RAP, OSMR, CCR1, LIFR, CXCL9, CCL19, IL7R, TGFB1, TGFB2, CCL20, CCL21, IL10RA, CXCL16, IL1RAP, IL1B

2.39E-01

KEGG_PATHWAY


2.23E-04

ITK, CLDN7, CYBB, VAV3, NCF2, PECAM1, TXK, CLDN11, PIK3R3, MMP2, RHOH, THY1, VCL

2.86E-01

KEGG_PATHWAY


2.77E-04

COL4A2, CD36, CD44, LAMC3, ITGAV, TNC, COL6A3, COL1A1, THBS1, THBS2, SPP1

3.54E-01

KEGG_PATHWAY

hsa05142:Chagas disease (American trypanosomiasis)

2.89E-04

IL6, CCL2, CD3E, TLR2, IL1B, TLR4, MAPK10, PLCB1, PIK3R3, TGFB1, AKT3, TGFB2

3.70E-01

KEGG_PATHWAY


4

CAV1, LUM, TLR2, TLR4, DCN, TIMP3, MMP2, IQGAP1, FLNA, TGFB1, TGFB2, CCND1, CD44, ITGAV, THBS1, PIK3R3, AKT3

4.02E-01

KEGG_PATHWAY

hsa04668:TNF signaling pathway 3.14E-0

4 CXCL1, IL6, CCL2, PTGS2, CCL20, EDN1, CXCL2, IL1B, MAPK10, BIRC3, PIK3R3, AKT3

4.02E-01

KEGG_PATHWAY

hsa04620:Toll-like receptor signaling pathway

3.41E-04

CTSK, IL6, CD86, TLR1, TLR2, CXCL9, IL1B, TLR4, MAPK10, PIK3R3, AKT3, SPP1

4.37E-01

KEGG_PATHWAY

hsa04145:Phagosome 7.18E-0

4

HLA-DQB1, CYBB, MSR1, CD36, TFRC, NCF2, ITGAV, TLR2, TLR4, HLA-DPA1, CTSS, THBS1, THBS2, HLA-DRA

9.17E-01

KEGG_PATHWAY


7.21E-04

FGFR2, COL4A2, IL6, FLT1, OSMR, TNC, TLR2, TLR4, FGF21, IL7R, DDIT4, PCK1, CCND1, LAMC3, ITGAV, COL6A3, COL1A1, THBS1, PIK3R3, THBS2, ANGPT2, AKT3, SPP1

9.21E-01

KEGG_PATHWAY

hsa05134:Legionellosis 1.13E-0

3 CXCL1, CR1, IL6, HSPA2, CXCL2, TLR2, IL1B, TLR4

1.44E+00

KEGG_PATHWAY


1.20E-03

HLA-DQB1, NCAM1, PTPRC, CLDN7, CD86, SELL, ITGAV, PECAM1, HLA-DPA1, CD4,

1.53E+00

CLDN11, PDCD1LG2, HLA-DRA

KEGG_PATHWAY

hsa04062:Chemokine signaling pathway

1.41E-03

CXCL1, ITK, CCL2, VAV3, CCR1, CXCL2, CXCL9, CCL19, DOCK2, CCL20, CCL21, CXCL16, PLCB1, PIK3R3, AKT3

1.80E+00

KEGG_PATHWAY

hsa04066:HIF-1 signaling pathway 2.78E-0

3 CYBB, IL6, FLT1, TFRC, HKDC1, EDN1, TLR4, PIK3R3, ANGPT2, AKT3

3.51E+00

KEGG_PATHWAY

hsa05332:Graft-versus-host disease

2.90E-03

HLA-DQB1, IL6, CD86, IL1B, HLA-DPA1, HLA-DRA

3.67E+00

KEGG_PATHWAY


4.69E-03

COL4A2, SLC8A1, SLC38A2, COL6A3, ACE2, COL12A1, MME, COL1A1, SLC7A7

5.85E+00

KEGG_PATHWAY

hsa04068:FoxO signaling pathway 6.62E-0

3 IL6, CCND1, GADD45G, MAPK10, PIK3R3, IL7R, TGFB1, AKT3, TGFB2, PCK1, SOD2

8.18E+00

KEGG_PATHWAY

hsa05416:Viral myocarditis 7.25E-0

3 HLA-DQB1, CD55, CAV1, CD86, CCND1, HLA-DPA1, HLA-DRA

8.92E+00

KEGG_PATHWAY

hsa04940:Type I diabetes mellitus 8.35E-0

3 HLA-DQB1, CD86, CPE, IL1B, HLA-DPA1, HLA-DRA

1.02E+01

KEGG_PATHWAY

hsa04350:TGF-beta signaling pathway

1.26E-02

INHBA, LTBP1, FST, DCN, THBS1, BAMBI, TGFB1, TGFB2

1.51E+01

KEGG_PATHWAY

hsa04672:Intestinal immune network for IgA production

1.33E-02

HLA-DQB1, IL6, CD86, HLA-DPA1, TGFB1, HLA-DRA

1.58E+01

KEGG_PATHWAY


2 COL4A2, CCND1, PTGS2, LAMC3, ITGAV, BIRC3, PIK3R3, AKT3

1.69E+01

KEGG_PATHWAY

hsa04010:MAPK signaling pathway

2.20E-02

FGFR2, DUSP10, FGF21, MAPK10, FLNA, TGFB1, TGFB2, DUSP5, PLA2G4A, HSPA2, DUSP1, GADD45G, IL1B, CACNA1C, AKT3

2.48E+01

KEGG_PATHWAY

hsa04022:cGMP-PKG signaling pathway

2.51E-02

GNA13, KCNMA1, EDNRB, SLC8A1, RGS2, PDE5A, PRKG1, PLCB1, PIK3R3, CACNA1C, AKT3

2.79E+01

KEGG_PATHWAY

hsa04612:Antigen processing and presentation

2.73E-02

KLRC4, HLA-DQB1, HSPA2, CD4, HLA-DPA1, CTSS, HLA-DRA

2.99E+01

KEGG_PATHWAY

hsa04750:Inflammatory mediator regulation of TRP channels

2.75E-02

PLA2G4A, IL1RAP, F2RL1, PRKCH, IL1B, MAPK10, PLCB1, PIK3R3

3.01E+01

KEGG_PATHWAY

hsa04270:Vascular smooth muscle contraction

2.78E-02

GNA13, KCNMA1, PLA2G4A, ACTA2, PRKCH, CALCRL, PRKG1, PLCB1, CACNA1C

3.03E+01

KEGG_PATHWAY


2

GNA13, FGFR2, COL4A2, IL6, RET, PTGS2, MAPK10, FGF21, BIRC3, MMP2, TGFB1, TGFB2, EDNRB, CCND1, LAMC3, ITGAV, HHIP, PLCB1, PIK3R3, AKT3

3.15E+01

KEGG_PATHWAY

hsa05164:Influenza A 3.84E-0

2

HLA-DQB1, IL6, CCL2, HSPA2, IL1B, TLR4, HLA-DPA1, MAPK10, PIK3R3, AKT3, HLA-DRA

3.95E+01

KEGG_PATHWAY

hsa05210:Colorectal cancer 3.92E-0

2 CCND1, MAPK10, PIK3R3, TGFB1, AKT3, TGFB2

4.01E+01

KEGG_PATHWAY

hsa05132:Salmonella infection 3.96E-0

2 CXCL1, IL6, CXCL2, IL1B, TLR4, MAPK10, FLNA

4.05E+01

KEGG_PATHWAY

hsa04380:Osteoclast differentiation

4.35E-02

CTSK, CYBB, NCF2, IL1B, MAPK10, PIK3R3, TGFB1, AKT3, TGFB2

4.35E+01

KEGG_PATHWAY


2 CCND1, MAPK10, PIK3R3, TGFB1, AKT3, TGFB2

4.39E+01

KEGG_PATHWAY

hsa05162:Measles 4.52E-0

2 IL6, SH2D1A, HSPA2, CD3E, TLR2, IL1B, TLR4, PIK3R3, AKT3

4.48E+01

KEGG_PATHWAY

hsa04930:Type II diabetes mellitus

5.67E-02

SOCS2, HKDC1, MAPK10, PIK3R3, CACNA1C 5.27E

+01 KEGG_PATHWAY

hsa00052:Galactose metabolism 6.13E-0

2 PGM2, GLA, HKDC1, AKR1B10

5.56E+01

KEGG_PATHWAY

hsa04630:Jak-STAT signaling pathway

7.32E-02

IL6, CCND1, SOCS2, OSMR, IL10RA, LIFR, PIK3R3, IL7R, AKT3

6.23E+01

KEGG_PATHWAY

hsa04142:Lysosome 7.43E-0

2 LAPTM4B, SLC11A1, CTSK, LIPA, GLA, CTSE, PPT1, CTSS

6.29E+01

KEGG_PATHWAY

hsa05340:Primary immunodeficiency

7.71E-02

PTPRC, CD3E, CD4, IL7R 6.43E

+01 KEGG_PATHWAY

hsa05143:African trypanosomiasis 7.71E-0

2 IL6, F2RL1, IL1B, PLCB1

6.43E+01

KEGG_PATHWAY

hsa04621:NOD-like receptor signaling pathway

8.47E-02

IL6, CCL2, IL1B, MAPK10, BIRC3 6.79E

+01 KEGG_PATHWAY

hsa04660:T cell receptor signaling pathway

8.90E-02

ITK, PTPRC, VAV3, CD3E, CD4, PIK3R3, AKT3 6.98E

+01 KEGG_PATHWAY

hsa04923:Regulation of lipolysis in adipocytes

8.91E-02

PTGS2, FABP4, PRKG1, PIK3R3, AKT3 6.98E

+01 AEBP1-JUN repression program


GOTERM_BP_DIRECT


1.35E-04

ACADSB, GLUD1, ACSS2, SLC19A2, KCNS3, AKR1C3, CYP3A43, GSTZ1, ELOVL7, SRD5A2, NT5E, GCDH, GSTA3, MT1M, CYP1A1, CYP21A2, AMACR, STXBP1, LPIN2, MT1X, ABCB4, AMPD1, ALDH7A1, ACSM1, PLCE1, ABCG5, DGAT2, PKLR, PLA2G2A, GPT, G0S2, UROC1, CACNA1C, OAT, GSTP1

2.15E-01

GOTERM_BP_DIRECT

GO:0006805~xenobiotic metabolic process

2.57E-03

CYP3A43, ACSM1, GSTA3, CYP1A1, CYP21A2, GSTZ1, ACSS2, GSTP1

4.03E+00

GOTERM_BP_DIRECT


4.68E-03

DTX4, MBL2, F12, CR1, CD244, LGALS3, BST2, MALT1, MAPK10, C1QC, MIF, APOBEC3B, MARCO, CTSK, FCER1G, PDGFRB, CD4, IGKC, MX1

7.22E+00

GOTERM_BP_DIRECT

GO:0055114~oxidation-reduction process

6.55E-03

CYP1A1, CYP21A2, GLUD1, F8, FMO4, VCAM1, CYP3A43, GPX2, AKR1C3, CYP4X1, ALDH7A1, PRODH2, LOXL4, SRD5A2

9.97E+00

GOTERM_BP_DIRECT


8.72E-03

MBL2, F8, IL6R, CD163 1.31E


GO:0006813~potassium ion transport

9.14E-03

KCNS3, SLC12A8, KCNJ8, KCNK5, KCNN2 1.36E


GO:0044255~cellular lipid metabolic process

9.83E-03

CYP1A1, DGAT2, AMACR, ELOVL7, G0S2, LPIN2, ABCB4

1.46E+01

GOTERM_BP_DIRECT


2 HAMP, SEMA3C, TNFSF14, IFI44L, CD4, CXCL6, IGKC, C1QC, CCL18, PDCD1LG2

1.50E+01

GOTERM_BP_D GO:0007584~response to nutrient 1.04E-0 AKR1C3, VCAM1, ABCG5, PKLR, VLDLR 1.54E

IRECT 2 +01 GOTERM_BP_DIRECT


1.08E-02

A2M, F13A1, F8, STXBP1, FLNA 1.60E



1.29E-02

MBL2, HAMP, FCER1G, CXCL6, IGKC, S100A14

1.87E+01

GOTERM_BP_DIRECT

GO:0007597~blood coagulation, intrinsic pathway

1.46E-02

F12, A2M, F8 2.10E


GO:0006749~glutathione metabolic process

1.58E-02

NAT8, GSTA3, GSTZ1, GSTP1 2.25E


GO:0045926~negative regulation of growth

1.62E-02

MT1M, MT1X, IGFBP5 2.30E


GO:0042730~fibrinolysis 1.97E-0

2 PLAT, F12, TMPRSS6

2.72E+01

GOTERM_BP_DIRECT


2 NAT8, CCND1, ABCG5, CYP1A1, SEMA3C, SRD5A2, VLDLR, ABCC6, ABCB4

2.85E+01

GOTERM_BP_DIRECT

GO:0045737~positive regulation of cyclin-dependent protein serine/threonine kinase activity

2.34E-02

CDC6, CCND1, CCNL1 3.15E

+01

GOTERM_BP_DIRECT

GO:0008652~cellular amino acid biosynthetic process

2.54E-02

GLUD1, GPT, OAT 3.37E



2.54E-02

MBL2, CR1, IGKC, C1QC 3.37E



2 PLAT, F12, CD244, KIF4A, A2M, F13A1, F8, FCER1G, PRKG1, FLNA, MIF

4.09E+01

GOTERM_BP_DIRECT

GO:0019432~triglyceride biosynthetic process

3.35E-02

MOGAT1, DGAT2, ELOVL7, LPIN2 4.20E


GO:1903825~organic acid transmembrane transport

4.08E-02

SLC17A3, SLC38A1 4.86E


GO:0006651~diacylglycerol biosynthetic process

4.08E-02

MOGAT1, PLCE1 4.86E


GO:0050830~defense response to Gram-positive bacterium

4.29E-02

MBL2, TNFAIP8, PLA2G2A, IL6R 5.04E


GO:1901687~glutathione derivative biosynthetic process

4.32E-02

GSTA3, GSTZ1, GSTP1 5.06E


GO:0016042~lipid catabolic process

4.58E-02

PLCXD3, PLCE1, PLA2G2A, PLA1A 5.27E


GO:0055088~lipid homeostasis 5.08E-0

2 GCDH, ACADSB, ABCB4

5.65E+01

GOTERM_BP_DIRECT

GO:0034641~cellular nitrogen compound metabolic process

5.20E-02

GCDH, ALDH7A1, ACADSB, GLUD1, GSTZ1, GPT, UROC1, OAT

5.74E+01

GOTERM_BP_DIRECT

GO:0006493~protein O-linked glycosylation

5.50E-02

PGM3, MUC20, KCNE1, MUC6 5.95E

+01

GOTERM_BP_DIRECT


5.99E-02

EFNA1, CD4, IL6R, MIF 6.28E

+01

GOTERM_BP_DIRECT

GO:0050796~regulation of insulin secretion

5.99E-02

KCNS3, STXBP1, SYT7, CACNA1C 6.28E


GO:0042866~pyruvate biosynthetic process

6.06E-02

SDS, PKLR 6.32E

+01

GOTERM_BP_DIRECT

GO:0008584~male gonad development

6.51E-02

AKR1C3, TESC, SRD5A2, ASPM 6.59E



6.72E-02

LGALS3, IL6R, CCL18 6.71E



7.36E-02

MARCO, LOXL4, IGKC, CD163, VLDLR 7.05E



2 VCAM1, PDGFRB, CXCL6

7.32E+01

GOTERM_BP_DIRECT

GO:0009308~amine metabolic process

7.99E-02

VCAM1, CYP1A1 7.36E



8.36E-02

APOBEC3B, BST2, KCNJ8, IFI44L, MX1 7.52E


GO:0006956~complement activation

8.83E-02

MBL2, IGKC, C1QC 7.72E


GO:0006112~energy reserve metabolic process

8.95E-02

KCNS3, PKLR, STXBP1, CACNA1C 7.76E



9.15E-02

PLCE1, EFNA1, MUC20, MAPK10 7.84E


GO:0006071~glycerol metabolic process

9.89E-02

MOGAT1, DGAT2 8.11E



4.07E-05

PLAT, MBL2, F12, CR1, A2M, F13A1, F8, C1QC 5.10E-

02 KEGG_PATHWAY

hsa02010:ABC transporters 3.02E-0

3 ABCA10, ABCA9, ABCG5, ABCC6, ABCB4

3.72E+00

KEGG_PATHWAY

hsa00561:Glycerolipid metabolism

8.65E-03

GLYCTK, MOGAT1, ALDH7A1, DGAT2, LPIN2 1.03E

+01 KEGG_PATHWAY

hsa01130:Biosynthesis of antibiotics

8.86E-03

GLYCTK, GCDH, PGM3, ALDH7A1, SDS, PKLR, ACSS2, OAT, AMPD1

1.06E+01

KEGG_PATHWAY

hsa01100:Metabolic pathways 3.86E-0

2

GCDH, ACADSB, CYP1A1, CYP21A2, GLUD1, AMACR, LPIN2, ACSS2, AMPD1, AKR1C3, GLYCTK, ACSM1, PLCE1, ALDH7A1, DGAT2, POLE2, SDS, PKLR, PLA2G2A, PRODH2, GSTZ1, GPT, UROC1, NT5E, OAT

3.89E+01

KEGG_PATHWAY

hsa00140:Steroid hormone biosynthesis

4.54E-02

AKR1C3, CYP1A1, CYP21A2, SRD5A2 4.42E

+01 KEGG_PATHWAY

hsa04976:Bile secretion 6.93E-0

2 ABCG5, SLC22A7, KCNN2, ABCB4

5.94E+01

KEGG_PATHWAY

hsa01230:Biosynthesis of amino acids

8.18E-02

ALDH7A1, SDS, PKLR, GPT 6.57E

+01 KEGG_PATHWAY

hsa05204:Chemical carcinogenesis

9.78E-02

CYP3A43, GSTA3, CYP1A1, GSTP1 7.25E

+01

AEBP1-FOS program


AEBP1 FOS activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1


THBS2


FBLN5


COL1A1


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1

AEBP1 FOS activati COL6A3

on


TGFB2


JAG1


PDE1A


RBMS3


MTHFD2


SRPX2


SERPINE2


SMOC2


CCDC3


MMP2


ITGAV


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2


BAMBI


RANBP17


PMP22


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM

AEBP1 FOS activati STXBP4

on


FMOD


PODN


PLP2


CAPG


CACNA1C


CCL21


CHRDL1


KCNA3


ENPP5


FAM38B


S100A14


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1


CYP2B6


CYP2B7P1


SAA1


CXCL13


MT1M


GSTA2


IGJ


SLITRK3


SDS


CYP3A43


ARSE


SERPINE1


MT1F


SPARCL1


LPA


HLA-DRA


CRP


GSTT1


LRG1


SLC2A3


MME


MT1X

AEBP1 FOS activati TIMD4

on


ARRDC3


SLCO4C1


AGXT2


SULT1E1


OAT


HLA-DPB1


CRHBP


CNDP1


AADAT


S100A8


GFRA1


DNAJC12


VIL1


PHLDA1


PSAT1


DDC


ZFAND5


CALCRL


MT1E


MPEG1


KCNE4


PROZ


EBP


STAB2


KLB


HIST1H2BM


FRZB


PLTP


DNASE1L3


DHRS2


MS4A4A


HYDIN


NEXN


HBEGF


PPP1R1A


FCER1G


GADD45G


CA13


PFKFB3


GPT2


MTHFD2L


PECAM1


IYD


HIST1H4B


LAPTM5


CLEC4G


FCN2


C1QC

AEBP1 FOS activati PKHD1L1

on


SOCS3


SLC1A3


GAS2L3


ACADSB


S100A9


MS4A6A


SCN9A


MRO


APOD


SLCO1A2


SLC16A10


MSRB3


CASP1


ODZ2


TSPAN7


CTSC


ALG3


PDLIM3


LRP2


GBP4


TACSTD2


GMPPB


FCGR2B


ODZ3


CHRNA4


CSF1R


KDR


SLC9A9


IL2RG


IFRD1


CD200


AQP3


FAM102A


RHOB


PANK1


APOLD1


MVD


GADD45B


ACADS


FAM59A


GYG2


IKZF1


USP2


FGF23


FAM49A


GCDH


SLC2A12


SDC4

AEBP1 FOS activati SSTR1

on


KLRG1


ITIH3


CD244


SH3RF2


SUSD4


IER2


LHFPL2


FOLR2


MAP3K5


GIMAP5


UCP2


TMPRSS6


PIM1


RBMS1


OLR1


FZD7


CES7


AXL


LAIR1


SLC7A8


CYP17A1


CD80


MEP1B

AEBP1 FOS repessing

SDS

AEBP1 FOS repessing

CYP3A43

AEBP1 FOS repessing

MT1X

AEBP1 FOS repessing

IFI44L

AEBP1 FOS repessing

TIMD4

AEBP1 FOS repessing

OAT

AEBP1 FOS repessing

VCAM1

AEBP1 FOS repessing

CD163

AEBP1 FOS repessing

DNAJC12

AEBP1 FOS repessing

MARCO

AEBP1 FOS repessing

VSIG4

AEBP1 FOS repessing

CR1

AEBP1 FOS repessing

PPP1R1A

AEBP1 FOS repessing

FCER1G

AEBP1 FOS repessing

CD4

AEBP1 FOS repessing

P2RY13

AEBP1 FOS repessing

C1QC

AEBP1 FOS repessing

ACADSB

AEBP1 FOS repessing

GPR116

AEBP1 FOS repessing

SLC16A10

AEBP1 FOS repessing

F8

AEBP1 FOS repessing

ODZ3

AEBP1 FOS repessing

KCNN2

AEBP1 FOS repessing

PDCD1LG2

AEBP1 FOS repessing

SLC19A2

AEBP1 FOS repessi ITIH3

ng

AEBP1 FOS repessing

CD244

AEBP1 FOS repessing

EFHD1

AEBP1 FOS repessing

KCNJ8

AEBP1 FOS repessing

LAIR1

AEBP1 FOS repessing

AKR1B10

AEBP1 FOS repessing

CYP3A7

AEBP1 FOS repessing

SPP1

AEBP1 FOS repessing

CFTR

AEBP1 FOS repessing

CYP1A2

AEBP1 FOS repessing

FABP4

AEBP1 FOS repessing

TSPAN8

AEBP1 FOS repessing

BICC1

AEBP1 FOS repessing

CD24

AEBP1 FOS repessing

CXCL10

AEBP1 FOS repessing

MMP7

AEBP1 FOS repessing

CHI3L1

AEBP1 FOS repessing

USP9Y

AEBP1 FOS repessing

CDH6

AEBP1 FOS repessing

LGALS4

AEBP1 FOS repessing

LYZ

AEBP1 FOS repessing

SCN7A

AEBP1 FOS repessing

ITGBL1

AEBP1 FOS repessing

HAO2

AEBP1 FOS repessing

ITGA2

AEBP1 FOS repessing

STEAP4

AEBP1 FOS repessing

SLC12A2

AEBP1 FOS repessing

VWF

AEBP1 FOS repessing

CCL19

AEBP1 FOS repessing

ITGB8

AEBP1 FOS repessing

PROM1

AEBP1 FOS repessing

GPC3

AEBP1 FOS repessing

SQLE

AEBP1 FOS repessing

FASN

AEBP1 FOS repessing

ANTXR1

AEBP1 FOS repessing

MOXD1

AEBP1 FOS repessing

SVEP1

AEBP1 FOS repessing

HMGCS1

AEBP1 FOS repessing

GPAM

AEBP1 FOS repessing

VTCN1

AEBP1 FOS repessing

DEFB1

AEBP1 FOS repessing

CFHR4

AEBP1 FOS repessing

HAS2

AEBP1 FOS repessing

PDGFD

AEBP1 FOS repessing

AKR1C2

AEBP1 FOS repessing

DHODH

AEBP1 FOS repessing

COL1A2

AEBP1 FOS repessing

CHST4

AEBP1 FOS repessing

FBLN5

AEBP1 FOS repessi ANK3

ng

AEBP1 FOS repessing

COL1A1

AEBP1 FOS repessing

TMEM45B

AEBP1 FOS repessing

SC4MOL

AEBP1 FOS repessing

ANXA13

AEBP1 FOS repessing

LXN

AEBP1 FOS repessing

GLS

AEBP1 FOS repessing

FADS1

AEBP1 FOS repessing

FGFR2

AEBP1 FOS repessing

GK

AEBP1 FOS repessing

DNAH5

AEBP1 FOS repessing

DCN

AEBP1 FOS repessing

SLIT2

AEBP1 FOS repessing

GLS2

AEBP1 FOS repessing

DPT

AEBP1 FOS repessing

GGH

AEBP1 FOS repessing

PTPN13

AEBP1 FOS repessing

ANXA3

AEBP1 FOS repessing

KIAA1324L

AEBP1 FOS repessing

WDR72

AEBP1 FOS repessing

SORT1

AEBP1 FOS repessing

SCRN1

AEBP1 FOS repessing

FBN1

AEBP1 FOS repessing

COL6A3

AEBP1 FOS repessing

ADRA1A

AEBP1 FOS repessing

COL14A1

AEBP1 FOS repessing

P4HA1

AEBP1 FOS repessing

UGCG

AEBP1 FOS repessing

CCDC102B

AEBP1 FOS repessing

CLEC2D

AEBP1 FOS repessing

IL32

AEBP1 FOS repessing

S100A10

AEBP1 FOS repessing

JAG1

AEBP1 FOS repessing

FAM102B

AEBP1 FOS repessing

HPS5

AEBP1 FOS repessing

PDE1A

AEBP1 FOS repessing

RBMS3

AEBP1 FOS repessing

SCD

AEBP1 FOS repessing

IFI6

AEBP1 FOS repessing

AASS

AEBP1 FOS repessing

SLC17A4

AEBP1 FOS repessing

PLK2

AEBP1 FOS repessing

HSPH1

AEBP1 FOS repessing

ABCB11

AEBP1 FOS repessing

SRPX2

AEBP1 FOS repessing

DAO

AEBP1 FOS repessing

CCDC68

AEBP1 FOS repessing

SERPINE2

AEBP1 FOS repessing

GFPT2

AEBP1 FOS repessi DTNA

ng

AEBP1 FOS repessing

CYP3A5

AEBP1 FOS repessing

HGF

AEBP1 FOS repessing

CRYAB

AEBP1 FOS repessing

ADAM9

AEBP1 FOS repessing

ANXA2P2

AEBP1 FOS repessing

TGM2

AEBP1 FOS repessing

GPR64

AEBP1 FOS repessing

SLC16A7

AEBP1 FOS repessing

MAP1B

AEBP1 FOS repessing

GALNT2

AEBP1 FOS repessing

TMEM156

AEBP1 FOS repessing

DNAJB4

AEBP1 FOS repessing

NAT2

AEBP1 FOS repessing

ITGAV

AEBP1 FOS repessing

PFKFB1

AEBP1 FOS repessing

SLC38A1

AEBP1 FOS repessing

GABRP

AEBP1 FOS repessing

IFI44

AEBP1 FOS repessing

DIO1

AEBP1 FOS repessing

SLC22A15

AEBP1 FOS repessing

ANXA2

AEBP1 FOS repessing

ACSM1

AEBP1 FOS repessing

TPM1

AEBP1 FOS repessing

LPAL2

AEBP1 FOS repessing

GPR174

AEBP1 FOS repessing

DGKH

AEBP1 FOS repessing

NAV3

AEBP1 FOS repessing

GPRC5B

AEBP1 FOS repessing

HSPA4L

AEBP1 FOS repessing

RAPGEF5

AEBP1 FOS repessing

IL18

AEBP1 FOS repessing

TRPC1

AEBP1 FOS repessing

KCNJ15

AEBP1 FOS repessing

ART4

AEBP1 FOS repessing

ENTPD1

AEBP1 FOS repessing

UGT2A3

AEBP1 FOS repessing

RRM2

AEBP1 FOS repessing

THY1

AEBP1 FOS repessing

WNK3

AEBP1 FOS repessing

CD96

AEBP1 FOS repessing

ABCA10

AEBP1 FOS repessing

FDPS

AEBP1 FOS repessing

MANEA

AEBP1 FOS repessing

TUSC3

AEBP1 FOS repessing

KLHL5

AEBP1 FOS repessing

PRKG1

AEBP1 FOS repessing

PIGR

AEBP1 FOS repessing

TMEM154

AEBP1 FOS repessi CYP39A1

ng

AEBP1 FOS repessing

STARD4

AEBP1 FOS repessing

LIPH

AEBP1 FOS repessing

AMICA1

AEBP1 FOS repessing

SULF1

AEBP1 FOS repessing

KCNB1

AEBP1 FOS repessing

CTSK

AEBP1 FOS repessing

SPIRE1

AEBP1 FOS repessing

LRRC1

AEBP1 FOS repessing

FLJ36840

AEBP1 FOS repessing

SLC25A30

AEBP1 FOS repessing

COL12A1

AEBP1 FOS repessing

COL4A2

AEBP1 FOS repessing

LIPG

AEBP1 FOS repessing

FLNA

AEBP1 FOS repessing

FER

AEBP1 FOS repessing

EDNRA

AEBP1 FOS repessing

POF1B

AEBP1 FOS repessing

DPP4

AEBP1 FOS repessing

PGM3

AEBP1 FOS repessing

PPP1R3B

AEBP1 FOS repessing

FMN1

AEBP1 FOS repessing

UGT2B17

AEBP1 FOS repessing

SLC16A4

AEBP1 FOS repessing

PRLR

AEBP1 FOS repessing

PBK

AEBP1 FOS repessing

GABRE

AEBP1 FOS repessing

DHCR7

AEBP1 FOS repessing

EPB41L4A

AEBP1 FOS repessing

CHML

AEBP1 FOS repessing

PLAT

AEBP1 FOS repessing

SSR1

AEBP1 FOS repessing

CPD

AEBP1 FOS repessing

MAMDC2

AEBP1 FOS repessing

LGALS3

AEBP1 FOS repessing

ENO3

AEBP1 FOS repessing

CDH11

AEBP1 FOS repessing

ENAH

AEBP1 FOS repessing

AURKA

AEBP1 FOS repessing

OGFRL1

AEBP1 FOS repessing

SLC39A10

AEBP1 FOS repessing

RND2

AEBP1 FOS repessing

IL1R2

AEBP1 FOS repessing

SLC25A36

AEBP1 FOS repessing

SMC6

AEBP1 FOS repessing

CYP4F12

AEBP1 FOS repessing

PIGW

AEBP1 FOS repessing

ZFYVE16

AEBP1 FOS repessing

HOOK1

AEBP1 FOS repessi SRGAP1

ng

AEBP1 FOS repessing

PDE5A

AEBP1 FOS repessing

PALMD

AEBP1 FOS repessing

KRT19

AEBP1 FOS repessing

NEDD4L

AEBP1 FOS repessing

LOX

AEBP1 FOS repessing

PLA2R1

AEBP1 FOS repessing

ARHGAP15

AEBP1 FOS repessing

MID1IP1

AEBP1 FOS repessing

MUM1L1

AEBP1 FOS repessing

ELOVL2

AEBP1 FOS repessing

GBP3

AEBP1 FOS repessing

BCL2L11

AEBP1 FOS repessing

TIGD2

AEBP1 FOS repessing

ROCK2

AEBP1 FOS repessing

NAALADL2

AEBP1 FOS repessing

RASA2

AEBP1 FOS repessing

PRKD1

AEBP1 FOS repessing

ST3GAL6

AEBP1 FOS repessing

TMEM100

AEBP1 FOS repessing

ECT2

AEBP1 FOS repessing

TGFBI

AEBP1 FOS repessing

INMT

AEBP1 FOS repessing

HSPB8

AEBP1 FOS repessing

PLSCR1

AEBP1 FOS repessing

OSMR

AEBP1 FOS repessing

TNFRSF11B

AEBP1 FOS repessing

CAP2

AEBP1 FOS repessing

OCLM

AEBP1 FOS repessing

SH3BGRL

AEBP1 FOS repessing

GPHN

AEBP1 FOS repessing

ALPK2

AEBP1 FOS repessing

AHI1

AEBP1 FOS repessing

AHSA2

AEBP1 FOS repessing

SSX2IP

AEBP1 FOS repessing

VLDLR

AEBP1 FOS repessing

ODF2L

AEBP1 FOS repessing

DNHD1

AEBP1 FOS repessing

SLC15A1

AEBP1 FOS repessing

EPSTI1

AEBP1 FOS repessing

TAS2R14

AEBP1 FOS repessing

CAPN2

AEBP1 FOS repessing

DNAJC10

AEBP1 FOS repessing

BAMBI

AEBP1 FOS repessing

SLC7A1

AEBP1 FOS repessing

ITGA3

AEBP1 FOS repessing

SLFN5

AEBP1 FOS repessing

MAP2

AEBP1 FOS repessing

DHRS7

AEBP1 FOS repessi CKAP2

ng

AEBP1 FOS repessing

TES

AEBP1 FOS repessing

ANXA5

AEBP1 FOS repessing

PIK3C2G

AEBP1 FOS repessing

RNASE1

AEBP1 FOS repessing

ITGB3

AEBP1 FOS repessing

LEAP2

AEBP1 FOS repessing

HIST1H3A

AEBP1 FOS repessing

FKBP14

AEBP1 FOS repessing

ABCG2

AEBP1 FOS repessing

PRKCE

AEBP1 FOS repessing

ZNF28

AEBP1 FOS repessing

CTSE

AEBP1 FOS repessing

NQO1

AEBP1 FOS repessing

STK17A

AEBP1 FOS repessing

METTL7B

AEBP1 FOS repessing

ATF7IP2

AEBP1 FOS repessing

GPR180

AEBP1 FOS repessing

SLPI

AEBP1 FOS repessing

SPCS3

AEBP1 FOS repessing

CD302

AEBP1 FOS repessing

CA12

AEBP1 FOS repessing

SLC44A3

AEBP1 FOS repessing

PUS7L

AEBP1 FOS repessing

RGS9

AEBP1 FOS repessing

DNAJB14

AEBP1 FOS repessing

PEG10

AEBP1 FOS repessing

NEDD4

AEBP1 FOS repessing

MCTP2

AEBP1 FOS repessing

SMC4

AEBP1 FOS repessing

FAM3B

AEBP1 FOS repessing

TP53BP2

AEBP1 FOS repessing

CCR2

AEBP1 FOS repessing

ZNF320

AEBP1 FOS repessing

GCA

AEBP1 FOS repessing

CD34

AEBP1 FOS repessing

MCAM

AEBP1 FOS repessing

ARRDC4

AEBP1 FOS repessing

FMOD

AEBP1 FOS repessing

MBOAT1

AEBP1 FOS repessing

ATRNL1

AEBP1 FOS repessing

IFT80

AEBP1 FOS repessing

DHX36

AEBP1 FOS repessing

TAS2R50

AEBP1 FOS repessing

CAPG

AEBP1 FOS repessing

TM6SF1

AEBP1 FOS repessing

IFIT3

AEBP1 FOS repessing

FLJ16734

AEBP1 FOS repessing

DMXL2

AEBP1 FOS repessi OSBPL3

ng

AEBP1 FOS repessing

ZNF260

AEBP1 FOS repessing

SLAMF7

AEBP1 FOS repessing

SLC30A10

AEBP1 FOS repessing

CACNA1C

AEBP1 FOS repessing

ZC3H6

AEBP1 FOS repessing

KIAA0020

AEBP1 FOS repessing

OAS1

AEBP1 FOS repessing

FZD6

AEBP1 FOS repessing

EXT1

AEBP1 FOS repessing

NUDT4

AEBP1 FOS repessing

APBB1IP

AEBP1 FOS repessing

PDCD4

AEBP1 FOS repessing

SAMD12

AEBP1 FOS repessing

PCSK9

AEBP1 FOS repessing

GAS2

AEBP1 FOS repessing

ZRANB2

AEBP1 FOS repessing

ST14

AEBP1 FOS repessing

PODXL

AEBP1 FOS repessing

SPSB1

AEBP1 FOS repessing

SHBG

AEBP1 FOS repessing

LOC440993

AEBP1 FOS repessing

DCUN1D1

AEBP1 FOS repessing

HIST1H4L

AEBP1 FOS repessing

NBEAL1

AEBP1 FOS repessing

OSGIN2

AEBP1 FOS repessing

ACLY

AEBP1 FOS repessing

TMPRSS3

AEBP1 FOS repessing

ARL6IP5

AEBP1 FOS repessing

JUB

AEBP1 FOS repessing

JAK2

AEBP1 FOS repessing

GK3P

AEBP1 FOS repessing

ACACA

AEBP1 FOS repessing

FLJ36116

AEBP1 FOS repessing

PGAP1

AEBP1 FOS repessing

FAM98A

AEBP1 FOS repessing

PLEKHA3

AEBP1 FOS repessing

ENPP5

AEBP1 FOS repessing

COX7B

AEBP1 FOS repessing

LPIN2

AEBP1 FOS repessing

CCDC76

AEBP1 FOS repessing

MVK

AEBP1 FOS repessing

EDN1

AEBP1 FOS repessing

ARHGAP11A

AEBP1 FOS repessing

CENPI

AEBP1 FOS repessing

FGL1

AEBP1 FOS repessing

FAM38B

AEBP1 FOS repessing

TAS2R13

AEBP1 FOS repessing

GPR56

AEBP1 FOS repessi S100A14

ng

AEBP1 FOS repessing

ABCB1

AEBP1 FOS repessing

TESC

AEBP1 FOS repessing

PFKP

AEBP1 FOS repessing

ADAMTSL2

AEBP1 FOS repessing

IKZF3

AEBP1 FOS repessing

BMPR2

AEBP1 FOS repessing

CD9

AEBP1 FOS repessing

DOCK5

AEBP1 FOS repessing

LRRC19

AEBP1 FOS repessing

TLR2

AEBP1 FOS repessing

TXN

AEBP1 FOS repessing

ADAMTS12

AEBP1 FOS repessing

FNDC1

AEBP1 FOS repessing

ERGIC2

AEBP1 FOS repessing

ATP6V1C1

AEBP1 FOS repessing

ANGPTL2

AEBP1 FOS repessing

CD1C

AEBP1 FOS repessing

FBLN1

AEBP1 FOS repessing

TIA1

AEBP1 FOS repessing

PLCE1

AEBP1 FOS repessing

CP110

AEBP1 FOS repessing

KRT18

AEBP1 FOS repessing

TMC4

AEBP1 FOS repessing

SLC5A9

AEBP1 FOS repessing

ZNF484

AEBP1 FOS repessing

DKK3

AEBP1 FOS repessing

CALU

AEBP1 FOS repessing

NCAM1

AEBP1 FOS repessing

ERBB2

AEBP1 FOS repessing

SLC38A6

AEBP1 FOS repessing

FAS

AEBP1 FOS repessing

HDGFRP3

AEBP1 FOS repessing

TAGLN2

AEBP1 FOS repessing

ERO1L

AEBP1 FOS repessing

PNPLA8

AEBP1 FOS repessing

KNDC1

AEBP1 FOS repessing

HIST1H4H

AEBP1 FOS repessing

RNF43

AEBP1 FOS repessing

TRAT1

AEBP1 FOS repessing

FLJ31958

AEBP1 FOS repessing

PPIL4

AEBP1 FOS repessing

LRRN1

AEBP1 FOS repessing

SGCB

AEBP1 FOS repessing

CRLF3

AEBP1 FOS repessing

VPS26A

AEBP1 FOS repessing

CACNA1D

AEBP1 FOS repessing

CHAC1

AEBP1 FOS repessing

ZMAT3

AEBP1 FOS repessi NTS

ng

AEBP1 FOS repessing

CCL28

AEBP1 FOS repessing

PCDH20

AEBP1 FOS repessing

LAMA3

AEBP1 FOS repessing

TAS2R4

AEBP1 FOS repessing

PRSS23

AEBP1 FOS repessing

PARP6

AEBP1 FOS repessing

ENC1

AEBP1 FOS repessing

VEGFC

AEBP1 FOS repessing

ME2

AEBP1 FOS repessing

EIF2S1

AEBP1 FOS repessing

TTTY10

AEBP1 FOS repessing

FLJ13197

AEBP1 FOS repessing

ADRBK2

AEBP1 FOS repessing

MPHOSPH6

AEBP1 FOS repessing

HOMER1

AEBP1 FOS repessing

IMPA2

AEBP1 FOS repessing

TMEM106C

AEBP1 FOS repessing

PDZK1IP1

AEBP1 FOS repessing

MDN1

AEBP1 FOS repessing

SLC11A1

AEBP1 FOS repessing

SLC16A14

AEBP1 FOS repessing

WRN

AEBP1 FOS repessing

STEAP2

AEBP1 FOS repessing

WWC1

AEBP1 FOS repessing

GPX3

AEBP1 FOS repessing

COQ10A

AEBP1 FOS repessing

ITGB3BP

AEBP1 FOS repessing

KCND3

AEBP1 FOS repessing

PRPF39

AEBP1 FOS repessing

S100A6

AEBP1 FOS repessing

PRMT6

AEBP1 FOS repessing

LTBP3

AEBP1 FOS repessing

ADAM19

AEBP1 FOS repessing

FZD3

AEBP1 FOS repessing

CTBS

AEBP1 FOS repessing

ZNF767

AEBP1 FOS repessing

KPNA5

AEBP1 FOS repessing

CLDN11

AEBP1 FOS repessing

SUSD2

AEBP1 FOS repessing

SNX2

AEBP1 FOS repessing

SMCHD1

AEBP1 FOS repessing

TRPM7

AEBP1 FOS repessing

KBTBD2

AEBP1 FOS repessing

AMPD1

AEBP1 FOS repessing

MALT1

AEBP1 FOS repessing

APOBEC3B

AEBP1 FOS repessing

BAIAP2L1

AEBP1 FOS repessing

STXBP1

AEBP1 FOS repessi DEPDC6

ng

AEBP1 FOS repessing

FLJ10213

AEBP1 FOS repessing

FNDC3B

AEBP1 FOS repessing

ZNF542

AEBP1 FOS repessing

TAGAP

AEBP1 FOS repessing

RHOBTB3

AEBP1-FOS activation program


GOTERM_BP_DIRECT


1.05E-13

FMOD, ADAMTSL2, LUM, DCN, SDC4, MMP2, TGFB2, SMOC2, CRISPLD2, ITGAV, COL6A3, SERPINE1, COL12A1, SPP1, COL4A2, LGALS3, EFEMP1, FBN1, CCDC80, TMPRSS6, KDR, NCAM1, CTSK, LAMC3, FBLN5, PECAM1, COL1A1

1.75E-10

GOTERM_BP_DIRECT


9

FGFR2, COL4A2, APOLD1, JAG1, STAB2, MCAM, TMPRSS6, MMP2, ANXA2, KDR, TGFB2, THY1, APOD, SRPX2, ITGAV, SERPINE1, RHOB, CALCRL

1.34E-05

GOTERM_BP_DIRECT


2.89E-06

S100A8, LGALS3, SAA1, CCL21, S100A9, FCER1G, CCL19, SPP1, TGFB2

4.82E-03

GOTERM_BP_DIRECT


5.31E-06


8.85E-03

GOTERM_BP_DIRECT


8.47E-06

FMOD, ACADSB, ARSE, MVD, SLC44A3, CYP2B6, PFKFB3, CA13, LUM, DCN, SDC4, CYP3A43, LPA, SLCO1A2, SLC2A3, MT1E, SULT1E1, ACSL4, GPT2, MT1F, AADAT, GCDH, EBP, DDC, LPL, GSTA2, MT1M, ACADS, GSTT1, GYG2, STAB2, MT1X, INMT, ABCB4, IYD, ACSM1, CYP17A1, UCP2, PANK1, AKR1B10, FABP4, AGXT2, CACNA1C, PSAT1, LRP2, OAT

1.41E-02

GOTERM_BP_DIRECT


1.50E-05


2.49E-02

GOTERM_BP_DIRECT


4

SVEP1, STAB2, MCAM, ITGBL1, NCAM1, LAMC3, ITGAV, PECAM1, COL6A3, RHOB, COL12A1, THBS2, CHL1, SPP1, CDH11, SPON1, DPT

3.03E-01

GOTERM_BP_DIRECT


2.27E-04

COL4A2, LPA, FOLR2, OLR1, SAA1, SUSD2, COL1A1, STAB2, IGKC, LRP2

3.78E-01

GOTERM_BP_DIRECT


3.88E-04

FGFR2, CD244, S100A8, S100A9, C1QC, MAP3K5, SAA1, FCN2, PDE1A, FCER1G, IL2RG, CASP1, IGKC, DEFB1, CSF1R, KLB,

6.44E-01

LGALS3, AXL, FGF23, MAPK10, NCAM1, CTSK, KLRG1, CD80, HBEGF, SUSD4

GOTERM_BP_DIRECT


4.04E-04

S100A8, OLR1, CRHBP, CRP, S100A9, AXL, CCL19, KLRG1, FOLR2, CCL21, CXCL13, SCN9A, MEP1B, SPP1, CSF1R

6.71E-01

GOTERM_BP_DIRECT


4 CD80, CD3E, CCL21, CCL19, CD24, HLA-DPB1, HLA-DRA

1.01E+00

GOTERM_BP_DIRECT


7.96E-04

CLDN7, CCL21, CCL19, CSF1R 1.32E


GO:0071276~cellular response to cadmium ion

9.85E-04

GSN, MT1E, MT1X, MT1F 1.63E

+00

GOTERM_BP_DIRECT


3

FGFR2, COL4A2, CAP2, KLB, FGF23, MMP2, TGFB2, NCAM1, ITGAV, COL6A3, RHOB, GFRA1, HBEGF, IL2RG, CD24, CACNA1C, CHL1, CSF1R

1.72E+00

GOTERM_BP_DIRECT


1.09E-03

PODN, PPP1R1A, GADD45G, FABP4, DCN, GADD45B, THY1

1.81E+00

GOTERM_BP_DIRECT


1.11E-03

MAP3K5, CCL21, GADD45G, CCL19, GADD45B, FZD7

1.83E+00

GOTERM_BP_DIRECT


1.20E-03

S100A8, LAMC3, VIM, S100A9 1.98E


GO:0071294~cellular response to zinc ion

1.44E-03

MT1M, MT1E, MT1X, MT1F 2.38E



2.02E-03



GO:0051493~regulation of cytoskeleton organization

2.35E-03

S100A8, S100A9, CAPN2, NEXN 3.84E



2.52E-03

EBP, ARSE, LGALS3, FBN1, COL12A1, COL1A1, FRZB, CDH11

4.12E+00

GOTERM_BP_DIRECT


2.64E-03



GO:0010038~response to metal ion

2.71E-03


+00

GOTERM_BP_DIRECT


3

CD244, OLR1, SLC7A8, PRKG1, FLNA, TGFB2, SERPINE2, ITGAV, PECAM1, SERPINE1, PDE5A, PROZ, PDE1A, RHOB, FCER1G, COL1A1

4.76E+00

GOTERM_BP_DIRECT


3 SOCS3, UCP2, APOLD1, CHRNA4, CD24, CAPN2, CASP1, MMP2, TGFB2

4.82E+00

GOTERM_BP_DIRECT


3.47E-03


5.62E+00

GOTERM_BP_DIRECT

GO:0050900~leukocyte migration 4.95E-0

3 CD244, OLR1, ITGAV, PECAM1, SLC7A8, FCER1G, COL1A1

7.93E+00

GOTERM_BP_DIRECT


5.62E-03

COL4A2, ITGAV, COL12A1, MMP2 8.96E



6.06E-03

LPA, APOD, MID1IP1, ACSL4, LRP2, PLTP, ABCB4

9.63E+00

GOTERM_BP_DIRECT

GO:0048015~phosphatidylinositol-mediated signaling

6.06E-03

FGFR2, KLB, CD80, GSN, FGF23, HBEGF, CSF1R

9.63E+00

GOTERM_BP_DIRECT


3 PGM3, EBP, JAG1, CSF1R, TGFB2

1.16E+01

GOTERM_BP_DIRECT


7.57E-03

CTSK, CTSC, ADAMTS12, CAPN2 1.19E

+01

GOTERM_BP_DIRECT


3

FCGR2B, CXCL13, CCL21, SUSD2, CCL19, PKHD1L1, IL2RG, CTSC, IGKC, DEFB1, C1QC, HLA-DRA

1.19E+01

GOTERM_BP_DIRECT


3 SAA1, PECAM1, SERPINE1, AXL, RHOB, FCER1G, COL1A1, FLNA, TGFB2

1.48E+01

GOTERM_BP_DIRECT


9.81E-03

S100A8, CXCL13, S100A9, FCER1G, STAB2, IGKC, S100A14

1.51E+01

GOTERM_BP_DIRECT

GO:0050776~regulation of immune response

1.05E-02

LAIR1, KLRG1, FCGR2B, CD3E, COL1A1, IGKC, CD200

1.61E+01

GOTERM_BP_DIRECT



1.65E+01

GOTERM_BP_DIRECT


2 GCDH, ACADSB, ACADS, ABCB4

1.77E+01

GOTERM_BP_DIRECT


1.16E-02




1.29E-02

GSN, VIL1, CAPG 1.94E


GO:0000186~activation of MAPKK activity

1.31E-02

NCAM1, FGFR2, MAP3K5, KLB, GADD45G, FGF23, HBEGF, IL2RG, GADD45B

1.97E+01

GOTERM_BP_DIRECT

GO:0042157~lipoprotein metabolic process

1.45E-02

LPL, LPA, OLR1, APOLD1 2.17E



1.56E-02

LPL, S100A8, SERPINE1, S100A9, FABP4 2.31E



1.78E-02

LGALS3, FOLR2, CCL21, CCL19 2.59E


GO:0048469~cell maturation 1.90E-0

2 CCL21, AXL, CCL19, KDR

2.74E+01

GOTERM_BP_DIRECT


1.93E-02

CCL21, SERPINE1, CCL19 2.77E


GO:0030307~positive regulation of cell growth

2.32E-02

S100A8, S100A9, HBEGF, ACSL4, TGFB2 3.23E

+01

GOTERM_BP_DIRECT

GO:0033539~fatty acid beta-oxidation using acyl-CoA dehydrogenase

2.42E-02

GCDH, ACADSB, ACADS 3.35E

+01

GOTERM_BP_DIRECT


2.61E-02

NCAM1, CD80, ITGAV, CLEC4G, AXL 3.57E

+01

GOTERM_BP_DIRECT

GO:2000098~negative regulation of smooth muscle cell-matrix adhesion

2.69E-02

APOD, SERPINE1 3.65E

+01

GOTERM_BP_DIRECT

GO:0070488~neutrophil aggregation

2.69E-02

S100A8, S100A9 3.65E



2.69E-02

PROM1, CD24 3.65E

+01 GOTERM_BP_D GO:0045601~regulation of 2.69E-0 APOLD1, KDR 3.65E

IRECT endothelial cell differentiation 2 +01 GOTERM_BP_DIRECT

GO:0032602~chemokine production

2.69E-02

S100A8, S100A9 3.65E


GO:0038095~Fc-epsilon receptor signaling pathway

2.76E-02

NCAM1, FGFR2, KLB, CD80, FGF23, FCER1G, HBEGF, IL2RG, MAPK10, IGKC

3.72E+01

GOTERM_BP_DIRECT

GO:0006508~proteolysis 2.81E-0

2

CTSK, LPA, OLR1, ADAMTSL2, CNDP1, MME, MEP1B, CTSC, CAPN2, CASP1, TMPRSS6, MMP2

3.78E+01

GOTERM_BP_DIRECT

GO:0006775~fat-soluble vitamin metabolic process

2.85E-02

LPL, AKR1B10, SDC4, LRP2 3.82E



2.95E-02



GO:0007173~epidermal growth factor receptor signaling pathway

3.17E-02

NCAM1, FGFR2, KLB, CD80, VIL1, PDE1A, EFEMP1, FGF23, HBEGF, IL2RG

4.15E+01

GOTERM_BP_DIRECT

GO:0042730~fibrinolysis 3.23E-0

2 SERPINE1, TMPRSS6, ANXA2

4.21E+01

GOTERM_BP_DIRECT


3.26E-02

AADAT, GCDH, DDC, ACADSB, AGXT2, PSAT1, OAT, GPT2, INMT, IYD

4.24E+01

GOTERM_BP_DIRECT


3.35E-02

ITGAV, VIL1, HBEGF, COL1A1, MCAM, KDR, CSF1R

4.33E+01

GOTERM_BP_DIRECT


3.43E-02

CYP3A43, GSTA2, ACSM1, CYP17A1, CYP2B6, GSTT1, SULT1E1

4.41E+01

GOTERM_BP_DIRECT

GO:0030900~forebrain development

3.66E-02

IKZF1, SSTR1, PRKG1, LRP2 4.62E

+01

GOTERM_BP_DIRECT


3.73E-02

NCAM1, FGFR2, KLB, ITGAV, AXL, FGF23, HBEGF, IL2RG, KDR

4.70E+01

GOTERM_BP_DIRECT


2 S100A8, S100A9, FABP4

4.78E+01

GOTERM_BP_DIRECT

GO:0008202~steroid metabolic process

3.83E-02

CYP17A1, CYP2B6, AKR1B10, SULT1E1 4.78E


GO:0006766~vitamin metabolic process

3.96E-02

LPL, SLC2A3, PANK1, AKR1B10, SDC4, LRP2 4.90E

+01

GOTERM_BP_DIRECT


4.00E-02

PROM1, CD24 4.94E

+01

GOTERM_BP_DIRECT


4.00E-02

EFEMP1, FBN1 4.94E



4.13E-02

CCL21, CRHBP, CCL19, COL1A1, ADAMTS12 5.05E



4.14E-02

PSAT1, OAT, GPT2 5.05E


GO:0007586~digestion 4.76E-0

2 SSTR1, AKR1B10, CTSE, MEP1B

5.56E+01

GOTERM_BP_DIRECT

GO:0030212~hyaluronan metabolic process

4.79E-02

PIM1, ITIH3, STAB2 5.58E


GO:0001523~retinoid metabolic process

4.96E-02

LPL, AKR1B10, SDC4, LRP2 5.71E

+01 GOTERM_BP_D GO:0008284~positive regulation 4.98E-0 FGFR2, CLDN7, KLB, FOLR2, MVD, ITGAV, 5.73E

IRECT of cell proliferation 2 EFEMP1, HBEGF, BAMBI, KDR, CSF1R, TGFB2 +01 GOTERM_BP_DIRECT


2 SLC9A9, PLP2, SLC1A3, SLC16A10, SLC7A8, CHRNA4

5.80E+01

GOTERM_BP_DIRECT

GO:0002793~positive regulation of peptide secretion

5.30E-02

S100A8, S100A9 5.97E

+01

GOTERM_BP_DIRECT


5.30E-02

CCL21, CCL19 5.97E

+01

GOTERM_BP_DIRECT

GO:0032119~sequestering of zinc ion

5.30E-02

S100A8, S100A9 5.97E



2 FGFR2, AQP3, TGFB2

6.08E+01

GOTERM_BP_DIRECT


5.79E-02




5.82E-02

SAA1, CCL21, CCL19 6.32E


GO:0006730~one-carbon metabolic process

6.19E-02

MTHFD2, MTHFD2L, CA13 6.55E


GO:0010757~negative regulation of plasminogen activation

6.58E-02

SERPINE2, SERPINE1 6.78E


GO:0009396~folic acid-containing compound biosynthetic process

6.58E-02

MTHFD2, MTHFD2L 6.78E



6.58E-02

CCL21, CCL19 6.78E


GO:0006869~lipid transport 6.68E-0

2 LPA, APOD, APOLD1, PLTP

6.84E+01

GOTERM_BP_DIRECT


2

EBP, CD244, PLCXD3, CAP2, SPARCL1, CRHBP, S100A9, AXL, MAPK10, PRKG1, SMOC2, FCGR2B, PECAM1, PDE1A, PDE5A, CHRNA4, HBEGF, IL2RG, CASP1, CHL1, CSF1R

6.97E+01

GOTERM_BP_DIRECT


6.91E-02

SERPINE2, RHOB, JAG1, NEXN 6.97E


GO:0030855~epithelial cell differentiation

6.91E-02

FGFR2, GSTA2, LGALS3, VIL1 6.97E

+01

GOTERM_BP_DIRECT


7.32E-02


+01

GOTERM_BP_DIRECT

GO:0030203~glycosaminoglycan metabolic process

7.63E-02

FMOD, LUM, DCN, STAB2, SDC4 7.33E



2 LPL, CYP17A1, CCND1, SLC1A3, APOD, SOCS3, COL1A1, TGFB2, ABCB4

7.37E+01

GOTERM_BP_DIRECT

GO:0007568~aging 7.84E-0

2 APOD, SOCS3, GSN, UCP2, CTSC, DCN

7.43E+01

GOTERM_BP_DIRECT

GO:0090080~positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

7.85E-02

KLB, FGF23 7.44E

+01

GOTERM_BP_DIRECT

GO:0045627~positive regulation of T-helper 1 cell differentiation

7.85E-02

CD80, CCL19 7.44E

+01

GOTERM_BP_DIRECT

GO:0061037~negative regulation of cartilage development

7.85E-02

FRZB, TGFB2 7.44E



7.85E-02

CCL21, CCL19 7.44E

+01

GOTERM_BP_DIRECT

GO:0006488~dolichol-linked oligosaccharide biosynthetic process

7.88E-02

GMPPB, PGM3, MVD, ALG3 7.45E

+01

GOTERM_BP_DIRECT


7.99E-02

FGFR2, CCL21, FGF23, CCL19, KDR, CSF1R 7.50E



8.10E-02




2 S100A8, DCN, SDC4, TGFB2

7.57E+01

GOTERM_BP_DIRECT

GO:0018108~peptidyl-tyrosine phosphorylation

8.19E-02

FGFR2, EFEMP1, AXL, KDR, CSF1R 7.59E



2 ITGAV, ADAMTS12, CD24, BAMBI, SDC4, TGFB2

7.64E+01

GOTERM_BP_DIRECT

GO:0006911~phagocytosis, engulfment

8.50E-02

GSN, FCER1G, IGKC 7.73E


GO:0060333~interferon-gamma-mediated signaling pathway

8.64E-02

NCAM1, SOCS3, HLA-DPB1, HLA-DRA 7.78E


GO:0001974~blood vessel remodeling

8.91E-02

AXL, JAG1, TGFB2 7.89E


GO:1901998~toxin transport 8.91E-0

2 SLC7A8, MEP1B, CASP1

7.89E+01

GOTERM_BP_DIRECT

GO:0045010~actin nucleation 9.09E-0

2 GSN, VIL1

7.96E+01

GOTERM_BP_DIRECT


9.09E-02

PROM1, CD24 7.96E


GO:0021879~forebrain neuron differentiation

9.09E-02

CSF1R, PHLDA1 7.96E



9.09E-02

CCL21, CCL19 7.96E

+01

GOTERM_BP_DIRECT


9.09E-02

CCL21, CCL19 7.96E

+01

GOTERM_BP_DIRECT

GO:0045576~mast cell activation 9.09E-0

2 FCER1G, RHOH

7.96E+01

GOTERM_BP_DIRECT

GO:0051014~actin filament severing

9.09E-02

GSN, VIL1 7.96E



9.33E-02

PODN, SOCS3, DCN 8.04E



9.33E-02



GO:0050890~cognition 9.33E-0

2 CHRNA4, CHL1, HLA-DRA

8.04E+01

GOTERM_BP_DIRECT

GO:0034446~substrate adhesion-dependent cell spreading

9.75E-02

ITGAV, AXL, FZD7 8.19E

+01

GOTERM_BP_DIRECT

GO:0008219~cell death 9.75E-0

2 OLR1, PMP22, TGFB2

8.19E+01

GOTERM_BP_DIRECT

GO:0005975~carbohydrate metabolic process

9.78E-02

FMOD, KLB, SLC2A3, PFKFB3, LUM, GYG2, DCN, STAB2, SDC4

8.20E+01

GOTERM_BP_DIRECT


9.81E-02

S100A8, SOCS3, CXCL13, DCN, CASP1, S100A14

8.21E+01



8.31E-04

COL4A2, LAMC3, ITGAV, COL6A3, COL1A1, SDC4, THBS2, SPP1

1.04E+00

KEGG_PATHWAY


8.31E-04

COL4A2, SLC16A10, COL6A3, SLC7A8, COL12A1, MME, MEP1B, COL1A1

1.04E+00

KEGG_PATHWAY


3

COL4A2, CCND1, LAMC3, ITGAV, COL6A3, COL1A1, MAPK10, CAPN2, THBS2, FLNA, SPP1, KDR

1.25E+00

KEGG_PATHWAY


3 CCND1, ITGAV, LUM, HBEGF, DCN, SDC4, MMP2, FZD7, FLNA, KDR, TGFB2

3.18E+00

KEGG_PATHWAY


3.56E-03

NCAM1, CLDN7, CD80, ITGAV, PECAM1, CLDN11, HLA-DPB1, SDC4, HLA-DRA

4.38E+00

KEGG_PATHWAY


1.87E-02

FGFR2, COL4A2, FGF23, KDR, CCND1, LAMC3, ITGAV, COL6A3, IL2RG, COL1A1, THBS2, SPP1, CSF1R

2.11E+01

KEGG_PATHWAY


2 LPL, OLR1, FABP4, ACSL4, PLTP

3.22E+01

KEGG_PATHWAY

hsa00380:Tryptophan metabolism 3.33E-0

2 AADAT, GCDH, DDC, INMT

3.46E+01

KEGG_PATHWAY

hsa00071:Fatty acid degradation 4.24E-0

2 GCDH, ACADSB, ACADS, ACSL4

4.19E+01

KEGG_PATHWAY

hsa04978:Mineral absorption 4.74E-0

2 MT1M, MT1E, MT1X, MT1F

4.56E+01

KEGG_PATHWAY


5.78E-02

CLDN7, PECAM1, CLDN11, MMP2, RHOH, THY1

5.26E+01

KEGG_PATHWAY

hsa05150:Staphylococcus aureus infection

6.10E-02

FCGR2B, HLA-DPB1, C1QC, HLA-DRA 5.46E

+01 KEGG_PATHWAY


6.34E-02

CD3E, MME, CD24, CSF1R, HLA-DRA 5.61E

+01 KEGG_PATHWAY


2 CTSK, CD80, HLA-DPB1, TGFB2, HLA-DRA

5.73E+01

KEGG_PATHWAY


2 CCND1, CD80, HLA-DPB1, HLA-DRA

6.47E+01

KEGG_PATHWAY


8.03E-02

CTSK, FCGR2B, SOCS3, MAPK10, CSF1R, TGFB2

6.50E+01

KEGG_PATHWAY

hsa04010:MAPK signaling pathway

8.06E-02

FGFR2, MAP3K5, GADD45G, FGF23, MAPK10, GADD45B, CACNA1C, FLNA, TGFB2

6.52E+01

KEGG_PATHWAY

hsa05322:Systemic lupus erythematosus

8.87E-02

HIST1H2BM, CD80, HIST1H4B, HLA-DPB1, C1QC, HLA-DRA

6.88E+01

KEGG_PATHWAY

hsa05310:Asthma 9.26E-0

2 FCER1G, HLA-DPB1, HLA-DRA

7.05E+01

AEBP1-FOS repression

program Category Term PValue Genes FDR

GOTERM_BP_DIRECT


1.20E-09

FMOD, ADAMTSL2, LTBP3, MMP7, ITGB3, DCN, VCAM1, TNFRSF11B, ITGB8, ITGAV, COL6A3, TGFBI, COL12A1, LOX, SPP1, ADAM9, COL4A2, LGALS3, FBN1, ITGA2, ITGA3, NCAM1, VWF, CTSK, FBLN1, COL14A1, LAMA3, FBLN5, COL1A2, COL1A1

2.09E-06

GOTERM_BP_DIRECT


8

ITGB3BP, IL32, ITGB3, FER, ITGBL1, CDH6, VCAM1, CD96, CD9, ITGB8, ITGAV, TGFBI, COL6A3, COL12A1, SSX2IP, ENTPD1, SPP1, DPT, ADAM9, SVEP1, LGALS4, PODXL, ITGA2, CHST4, SLAMF7, PRKCE, MCAM, NCAM1, VWF, LAMA3, HAS2, CDH11

1.29E-04

GOTERM_BP_DIRECT


5.60E-06

FMOD, COL14A1, P4HA1, COL1A2, COL12A1, COL1A1, LOX, ANXA2, DPT

9.76E-03

GOTERM_BP_DIRECT


1.00E-05

COL4A2, FBN1, MMP7, DCN, CTSK, LAMA3, COL14A1, CAPG, COL6A3, COL1A2, COL12A1, COL1A1, SPP1, ADAM9

1.74E-02

GOTERM_BP_DIRECT


4.31E-05

CYP3A5, IMPA2, CYP3A7, SLC44A3, CYP3A43, CYP39A1, GPC3, ST3GAL6, ELOVL2, DAO, NQO1, PIK3C2G, NUDT4, ABCB11, CHAC1, CA12, UGCG, STXBP1, PFKP, CYP1A2, LPIN2, PRKD1, PNPLA8, PLCE1, SQLE, AKR1B10, RRM2, HAO2, TXN, MVK, EXT1, OAT, GPAM, FMOD, ACADSB, COX7B, PFKFB1, HMGCS1, AASS, DCN, SLC19A2, GLS2, GPHN, DHCR7, DHODH, FASN, ENO3, FADS1, KCNB1, SCD, NAT2, ACACA, FDPS, ABCB1, ACLY, CYP4F12, INMT, MT1X, ABCG2, AMPD1, ACSM1, GLS, LIPG, MBOAT1, FABP4, LIPH, DIO1, GK, CACNA1C, CACNA1D

7.52E-02

GOTERM_BP_DIRECT


4 VCAM1, CD34, ITGB8, ITGAV, FBLN5, ITGA2, ITGA3, ADAMTS12, ITGB3, BCL2L11, ADAM9

1.96E-01

GOTERM_BP_DIRECT


1.18E-04

STEAP4, ME2, CYP3A7, DNAJC10, OSGIN2, AASS, CYP3A43, VCAM1, AKR1C2, CYP39A1, P4HA1, DHCR7, GPX3, DHODH, DAO, LOX, NQO1, FADS1, SCD, F8, CYP4F12, CYP1A2, MOXD1, DHRS7, CHML, SQLE, RRM2, AKR1B10, TXN, DIO1, STEAP2

2.05E-01

GOTERM_BP_DIRECT


4

CD244, HPS5, ITGB3, PRKG1, APBB1IP, CALU, CD9, SERPINE2, ITGAV, PDE1A, FCER1G, ENTPD1, PLAT, F8, ITGA2, DGKH, ITGA3, HGF, PRKCE, ANXA5, FLNA, VEGFC, VWF, HIST1H3A, PDE5A, COL1A2, JAK2, COL1A1

2.23E-01

GOTERM_BP_DIRECT

GO:0030195~negative regulation of blood coagulation

1.65E-04

SERPINE2, CD34, EDN1, TSPAN8, ANXA5 2.87E-

01 GOTERM_BP_DIRECT

GO:2000650~negative regulation of sodium ion transmembrane

2.97E-04

NEDD4, PCSK9, NEDD4L, PRKCE 5.16E-

01

transporter activity GOTERM_BP_DIRECT

GO:0006695~cholesterol biosynthetic process

3.90E-04

SQLE, DHCR7, FDPS, HMGCS1, ACLY, MVK, CFTR

6.78E-01

GOTERM_BP_DIRECT


4

F8, DGKH, ITGB3, HGF, PRKCE, APBB1IP, FLNA, FZD6, CALU, CD9, PLSCR1, VEGFC, VWF, COL1A2, FCER1G, COL1A1

6.90E-01

GOTERM_BP_DIRECT


5.72E-04

COL4A2, CTSK, COL14A1, COL6A3, COL1A2, MMP7, COL12A1, COL1A1, ADAM9

9.92E-01

GOTERM_BP_DIRECT


6.33E-04

EDN1, FER, CYP1A2, DCN, S100A14, VCAM1, EDNRA, SLC11A1, TNFRSF11B, KCNJ8, CCR2, SLPI, JAK2, FAS

1.10E+00

GOTERM_BP_DIRECT

GO:0007507~heart development 8.18E-0

4

TP53BP2, ERBB2, FBN1, EDN1, ITGA3, BICC1, DNAH5, VCAM1, EDNRA, PLCE1, KCNJ8, ADAM19, LOX, VLDLR

1.42E+00

GOTERM_BP_DIRECT


1.12E-03

PRKD1, FBLN1, ITGB8, ITGAV, FCER1G, ITGA2, ITGA3, ITGB3, ADAM9

1.94E+00

GOTERM_BP_DIRECT


1.12E-03

CD9, VEGFC, VWF, F8, STXBP1, HGF, ITGB3, FLNA, CALU

1.94E+00

GOTERM_BP_DIRECT


3

IL1R2, IL18, SUSD2, TLR2, CCL19, IL32, CHST4, IFI44L, CCL28, C1QC, PDCD1LG2, CXCL10, CD96, TNFRSF11B, CCR2, SLPI, CD4, FAS, DEFB1, IFI6

2.13E+00

GOTERM_BP_DIRECT


1.55E-03

SCD, ELOVL2, ACACA, FASN, ACLY, GK, LPIN2, GPAM

2.67E+00

GOTERM_BP_DIRECT


1.99E-03

EDNRA, IL18, CCR2, TLR2, FABP4, ITGA2, JAK2, GPRC5B

3.42E+00

GOTERM_BP_DIRECT

GO:0048333~mesodermal cell differentiation

2.23E-03

FGFR2, ITGA2, ITGA3, ITGB3 3.82E


GO:0051290~protein heterotetramerization

2.47E-03

HIST1H4L, RRM2, HIST1H3A, S100A10, ANXA2, HIST1H4H

4.22E+00

GOTERM_BP_DIRECT

GO:0003094~glomerular filtration 2.92E-0

3 EDNRA, CD34, SULF1, MCAM

4.97E+00

GOTERM_BP_DIRECT

GO:0007568~aging 3.49E-0

3

EDNRA, VCAM1, CRYAB, EIF2S1, CCR2, MMP7, ADRA1A, ENO3, DCN, FAS, WRN, NQO1

5.91E+00

GOTERM_BP_DIRECT


4.14E-03

KCNB1, GFPT2, PFKFB1, ACACA, FASN, STXBP1, ACLY, CACNA1C, CACNA1D

6.98E+00

GOTERM_BP_DIRECT

GO:0010595~positive regulation of endothelial cell migration

4.72E-03

PRKD1, ROCK2, EDN1, BMPR2, ITGB3, ANXA3

7.92E+00

GOTERM_BP_DIRECT

GO:0042482~positive regulation of odontogenesis

5.98E-03

EDNRA, CD34, EDN1 9.92E


GO:0045785~positive regulation of cell adhesion

6.28E-03

ITGAV, ERBB2, TGM2, ITGA2, APBB1IP, TPM1

1.04E+01

GOTERM_BP_DIRECT


3

HMGCS1, GGH, MMP7, ITGA2, ITGA3, ABCB1, ABCG2, VEGFC, TNFRSF11B, DHODH, ADRA1A, ENO3, COL1A1, FAS, LOX, GK, VLDLR

1.42E+01

GOTERM_BP_DIRECT

GO:1901016~regulation of potassium ion transmembrane

8.82E-03

NEDD4, NEDD4L, CACNA1D 1.43E

+01

transporter activity

GOTERM_BP_DIRECT

GO:0007167~enzyme linked receptor protein signaling pathway

8.82E-03

ERBB2, CD4, JAK2 1.43E

+01

GOTERM_BP_DIRECT


3 CD244, CD34, ITGAV, PODXL, COL1A2, FCER1G, ITGA3, COL1A1, ITGB3

1.44E+01

GOTERM_BP_DIRECT

GO:0031589~cell-substrate adhesion

9.68E-03

VWF, ITGAV, ITGA2, ITGB3 1.56E

+01

GOTERM_BP_DIRECT


3

FGFR2, COL4A2, IL18, JAG1, MCAM, THY1, ANXA2, PRKD1, VEGFC, SRPX2, ITGAV, TGFBI, TMEM100

1.58E+01

GOTERM_BP_DIRECT


2

PIK3C2G, USP9Y, ITGAV, PODXL, WWC1, JAK2, ADAMTS12, CD24, ITGB3, BAMBI, SRGAP1

1.79E+01

GOTERM_BP_DIRECT


1.13E-02

EDN1, CHI3L1, CCL19, HAS2, FAS, ADAMTS12, VLDLR

1.80E+01

GOTERM_BP_DIRECT

GO:0072089~stem cell proliferation

1.21E-02

RNF43, CD34, ABCB1 1.92E

+01

GOTERM_BP_DIRECT


1.30E-02

EDNRA, PLCE1, CCR2, EDN1, ADRA1A, JAK2, CD24, CACNA1C, CCL28

2.04E+01

GOTERM_BP_DIRECT


1.31E-02

FADS1, SCD, HAO2, ELOVL2, ACACA, FASN, HMGCS1, ACLY, GK, LPIN2, GPAM

2.05E+01

GOTERM_BP_DIRECT

GO:0006814~sodium ion transport

1.36E-02

SLC12A2, SLC17A4, SLC38A6, SLC5A9, NEDD4L, SCN7A, SLC38A1

2.12E+01

GOTERM_BP_DIRECT


1.46E-02

MARCO, HSPH1, COL4A2, SUSD2, COL1A2, COL1A1, PLA2R1, TMPRSS3, CD163, VLDLR

2.27E+01

GOTERM_BP_DIRECT

GO:0001580~detection of chemical stimulus involved in sensory perception of bitter taste

1.47E-02

TAS2R13, TAS2R50, TAS2R14, TAS2R4, PIGR 2.28E

+01

GOTERM_BP_DIRECT

GO:0030324~lung development 1.52E-0

2 FGFR2, GPC3, DHCR7, CHI3L1, ITGA3, LOX, CYP1A2

2.35E+01

GOTERM_BP_DIRECT

GO:0031325~positive regulation of cellular metabolic process

1.59E-02

ACACA, FASN, ACLY 2.44E



1.80E-02

NCAM1, CR1, ITGAV, ITGA2, CD4, ITGB3, DPP4

2.71E+01

GOTERM_BP_DIRECT


2

ITGB3BP, S100A6, CD244, IMPA2, TAS2R4, ERBB2, TLR2, ADRBK2, PRKG1, APBB1IP, CXCL10, EDNRA, TNFRSF11B, ANK3, ZFYVE16, PDE1A, CD4, FAS, RASA2, GABRP, DTNA, CAP2, TP53BP2, PRKCE, ANXA5, TRAT1, RND2, PRKD1, VEGFC, NTS, CD34, PDE5A, TXN, ADRA1A, JAK2, ANTXR1, EXT1, VLDLR

2.84E+01

GOTERM_BP_DIRECT

GO:0072661~protein targeting to plasma membrane

1.92E-02

TESC, ANK3, KCNB1, ANXA2 2.86E



1.95E-02

COL4A2, ROCK2, CCR2, SULF1, DCN, CXCL10 2.91E

+01 GOTERM_BP_D GO:0043589~skin morphogenesis 2.01E-0 COL1A2, ITGA2, COL1A1 2.98E

IRECT 2 +01

GOTERM_BP_DIRECT

GO:0035338~long-chain fatty-acyl-CoA biosynthetic process

2.07E-02

SCD, ELOVL2, ACACA, FASN, ACLY 3.05E

+01

GOTERM_BP_DIRECT

GO:0046777~protein autophosphorylation

2.53E-02

FGFR2, PRKD1, TRPM7, EIF2S1, ERBB2, WNK3, AURKA, JAK2, FER, THY1

3.60E+01

GOTERM_BP_DIRECT


2.70E-02

LAIR1, CD244, NEDD4, VTCN1, CD1C, CD4, JAK2, SLAMF7, TRAT1

3.79E+01

GOTERM_BP_DIRECT


2.94E-02

COL4A2, LAMA3, ITGAV, COL12A1 4.06E


GO:0006636~unsaturated fatty acid biosynthetic process

2.98E-02

FADS1, SCD, ELOVL2 4.09E

+01

GOTERM_BP_DIRECT


3.31E-02

PLSCR1, SLC11A1, FBLN1, TESC, CD34, ITGB8, ROCK2, ANK3, IL18, CCR2, TLR2, ITGA3

4.44E+01

GOTERM_BP_DIRECT


3.38E-02

VCAM1, EDN1, CHI3L1, CCL19, HAS2, COL1A1, ADAMTS12

4.51E+01

GOTERM_BP_DIRECT


3.42E-02

COL4A2, EDN1, FBN1, PDGFD, COL1A1 4.54E

+01

GOTERM_BP_DIRECT


3.49E-02

ITGAV, PODXL, EDN1, HAS2, JAK2, PDGFD, FER, COL1A1, HGF, MCAM

4.61E+01

GOTERM_BP_DIRECT

GO:0006828~manganese ion transport

3.51E-02

TRPC1, SLC11A1, SLC30A10 4.64E

+01

GOTERM_BP_DIRECT

GO:0051281~positive regulation of release of sequestered calcium ion into cytosol

3.54E-02

EDNRA, TRPC1, CXCL10, THY1 4.67E

+01

GOTERM_BP_DIRECT

GO:0048008~platelet-derived growth factor receptor signaling pathway

3.54E-02

PLAT, JAK2, PDGFD, FER 4.67E

+01

GOTERM_BP_DIRECT


3.60E-02

CYP3A43, CYP3A5, ACSM1, CYP39A1, CYP3A7, CHAC1, NAT2, CYP4F12, CYP1A2, NQO1

4.72E+01

GOTERM_BP_DIRECT

GO:0043086~negative regulation of catalytic activity

3.64E-02

ANXA5, NQO1, ANXA3, ANXA2, CALU, ANXA2P2

4.76E+01

GOTERM_BP_DIRECT


2 SLC11A1, ERBB2, LOX, DCN, ITGB3, TPM1

5.11E+01

GOTERM_BP_DIRECT

GO:0071773~cellular response to BMP stimulus

4.55E-02

KCND3, BMPR2, ADAMTS12, TMEM100 5.56E

+01

GOTERM_BP_DIRECT

GO:0007205~protein kinase C-activating G-protein coupled receptor signaling pathway

4.55E-02

EDNRA, PLCE1, EDN1, DGKH 5.56E

+01

GOTERM_BP_DIRECT

GO:0043651~linoleic acid metabolic process

4.69E-02

PNPLA8, FADS1, ELOVL2 5.67E


GO:0043277~apoptotic cell clearance

4.69E-02

MARCO, ITGAV, TGM2 5.67E



4.75E-02

IFIT3, APOBEC3B, PLSCR1, KCNJ8, IFI44L, OAS1, GBP3, GPAM, CXCL10

5.72E+01

GOTERM_BP_D GO:0043410~positive regulation 4.85E-0 FGFR2, TNFRSF11B, WWC1, ADRA1A, FAS, 5.79E

IRECT of MAPK cascade 2 PRKCE +01 GOTERM_BP_DIRECT


4.90E-02

ERBB2, EDN1, PDE5A, PDGFD, CD24 5.83E


GO:0010634~positive regulation of epithelial cell migration

4.92E-02

BMPR2, ITGA2, ITGA3, PRKCE 5.85E


GO:0010766~negative regulation of sodium ion transport

4.96E-02

SERPINE2, NEDD4 5.88E


GO:1904037~positive regulation of epithelial cell apoptotic process

4.96E-02

TIA1, SORT1 5.88E


GO:2000439~positive regulation of monocyte extravasation

4.96E-02

CCR2, PDGFD 5.88E



4.96E-02

PROM1, CD24 5.88E


GO:0050748~negative regulation of lipoprotein metabolic process

4.96E-02

ITGAV, ITGB3 5.88E


GO:0097461~ferric iron import into cell

4.96E-02

STEAP4, STEAP2 5.88E

+01

GOTERM_BP_DIRECT


2

FGFR2, TRPC1, COL4A2, ENAH, CAP2, ROCK2, ERBB2, ITGA2, ITGB3, SLIT2, NCAM1, ANK3, ITGAV, COL6A3, JAK2, CD24, CACNA1C, EXT1, CACNA1D, SRGAP1, RASA2

6.05E+01

GOTERM_BP_DIRECT

GO:0007585~respiratory gaseous exchange

5.30E-02

EDNRA, TAS2R4, EDN1, CFTR 6.13E



5.32E-02

CCR2, S100A14, CXCL10 6.14E



5.46E-02

VCAM1, VTCN1, CCL19, CD4, PDCD1LG2 6.24E



5.57E-02

TNFRSF11B, LGALS3, FBN1, COL1A2, COL12A1, COL1A1, EXT1, CDH11

6.32E+01

GOTERM_BP_DIRECT


5.57E-02

VCAM1, CD96, LAIR1, CD34, CLEC2D, COL1A2, SLAMF7, COL1A1

6.32E+01

GOTERM_BP_DIRECT


2 ITGAV, EDN1, PRMT6, ADRA1A, ITGB3

6.44E+01

GOTERM_BP_DIRECT

GO:0051592~response to calcium ion

5.76E-02

TRPC1, NEDD4, ANXA5, HOMER1, ADAM9 6.44E


GO:0034765~regulation of ion transmembrane transport

6.30E-02

KCNJ15, KCND3, NEDD4, KCNJ8, KCNB1, NEDD4L, SCN7A

6.78E+01

GOTERM_BP_DIRECT


2 AKR1C2, CYP39A1, SLC15A1, AKR1B10, CTSE

6.82E+01

GOTERM_BP_DIRECT


6.38E-02

NCAM1, VCAM1, IFIT3, IL1R2, NEDD4, CCR2, LRRC19, OAS1, JAK2, KPNA5, FER, DCN, IFI6

6.83E+01

GOTERM_BP_DIRECT

GO:0006939~smooth muscle contraction

6.67E-02

EDNRA, ROCK2, ADRA1A 7.00E



6.67E-02

CCR2, MALT1, THY1 7.00E



6.95E-02

ITGA3, JAK2, PRKCE, SPP1 7.15E



6.95E-02

CD9, NEDD4, FCER1G, ADRBK2 7.15E

+01

GOTERM_BP_DIRECT

GO:0014068~positive regulation of phosphatidylinositol 3-kinase signaling

7.01E-02

NEDD4, JAK2, PDGFD, DCN, HGF 7.18E

+01

GOTERM_BP_DIRECT

GO:0030336~negative regulation of cell migration

7.32E-02

CCR2, SULF1, TPM1, SLIT2, SRGAP1, THY1 7.34E

+01

GOTERM_BP_DIRECT


7.34E-02

PROM1, CD24 7.35E

+01

GOTERM_BP_DIRECT

GO:0060139~positive regulation of apoptotic process by virus

7.34E-02

CCR2, BCL2L11 7.35E


GO:0042977~activation of JAK2 kinase activity

7.34E-02

PRLR, JAK2 7.35E


GO:1901509~regulation of endothelial tube morphogenesis

7.34E-02

ADAMTS12, CXCL10 7.35E

+01

GOTERM_BP_DIRECT

GO:0045715~negative regulation of low-density lipoprotein particle receptor biosynthetic process

7.34E-02

ITGAV, ITGB3 7.35E

+01

GOTERM_BP_DIRECT

GO:0006543~glutamine catabolic process

7.34E-02

GLS2, GLS 7.35E

+01

GOTERM_BP_DIRECT


7.39E-02

ITGAV, FER, ITGB3, ANTXR1 7.38E

+01

GOTERM_BP_DIRECT


7.69E-02

NTS, CRYAB, AURKA, CD4, COL1A1, CYP1A2, NQO1

7.52E+01

GOTERM_BP_DIRECT

GO:0006633~fatty acid biosynthetic process

7.85E-02

ACSM1, ACACA, FASN, ACLY 7.59E



8.04E-02

ACSM1, LIPG, PCSK9, FABP4, CD24 7.68E


GO:0009948~anterior/posterior axis specification

8.12E-02

GPC3, PGAP1, AURKA 7.71E


GO:0045807~positive regulation of endocytosis

8.12E-02

GPC3, CCL19, NEDD4L 7.71E


GO:0071285~cellular response to lithium ion

8.12E-02

NTS, FABP4, FAS 7.71E


GO:0030155~regulation of cell adhesion

8.32E-02

LAMA3, PRLR, ROCK2, IL18 7.80E



8.40E-02

LGALS3, EDN1, FCER1G, CCL19, SPP1 7.83E



2 FGFR2, FMOD, S100A6, ANK3, MAP2, LRRN1

7.86E+01

GOTERM_BP_DIRECT

GO:0001822~kidney development 8.78E-0

2 KCNJ8, SULF1, PCSK9, HAS2, DCN, BCL2L11

7.98E+01

GOTERM_BP_DIRECT

GO:0016337~single organismal cell-cell adhesion

8.78E-02

COL14A1, SRPX2, CD34, CD24, SLIT2, THY1 7.98E


GO:0034080~CENP-A containing nucleosome assembly

8.80E-02

ITGB3BP, HIST1H4L, CENPI, HIST1H4H 7.99E


GO:0006986~response to unfolded protein

8.80E-02

HSPH1, CHAC1, HSPA4L, DNAJB4 7.99E

+01 GOTERM_BP_D GO:0055085~transmembrane 8.86E-0 TRPC1, SLC16A14, ABCA10, TUSC3, 8.02E

IRECT transport 2 SLC12A2, SLC44A3, SLC15A1, SLC39A10, TRPM7, SLC16A10, SLC22A15, ABCB1, CFTR, ABCG2, ATP6V1C1, SLC11A1, SLC16A7, EIF2S1, SLC7A1, SLC25A36, SLC5A9, NEDD4L, SLC38A1

+01

GOTERM_BP_DIRECT


8.88E-02

CKAP2, MID1IP1, HDGFRP3 8.02E



9.29E-02

FBLN1, PRLR, SERPINE2, SPP1 8.17E



2 ABCA10, CFHR4, OSBPL3, STARD4, VLDLR

8.25E+01

GOTERM_BP_DIRECT


9.60E-02

PRKD1, PLK2, CCL19, MALT1, PRKCE, GPRC5B, ECT2, FLNA

8.28E+01

GOTERM_BP_DIRECT


9.65E-02

CD4, SPP1, CXCL10 8.30E


GO:0032369~negative regulation of lipid transport

9.67E-02

ITGAV, ITGB3 8.30E


GO:0045619~regulation of lymphocyte differentiation

9.67E-02

IKZF3, FAS 8.30E


GO:0001920~negative regulation of receptor recycling

9.67E-02

PCSK9, TRAT1 8.30E


GO:0006084~acetyl-CoA metabolic process

9.67E-02

ACACA, FASN 8.30E


GO:0001821~histamine secretion 9.67E-0

2 EDNRA, EDN1

8.30E+01

GOTERM_BP_DIRECT

GO:0072006~nephron development

9.67E-02

ITGA3, JAG1 8.30E


GO:0032387~negative regulation of intracellular transport

9.67E-02

CRYAB, MAP1B 8.30E

+01

GOTERM_BP_DIRECT


9.78E-02

NCAM1, FGFR2, PRKD1, VEGFC, ROCK2, ITGAV, ERBB2, SULF1, BMPR2, JAK2, ITGB3, RASA2

8.34E+01


KEGG_PATHWAY


9.06E-05

VWF, COL4A2, LAMA3, ITGB8, ITGAV, COL6A3, COL1A2, ITGA2, ITGA3, COL1A1, ITGB3, SPP1

1.16E-01

KEGG_PATHWAY


5

COL4A2, ROCK2, ERBB2, ITGA2, ITGA3, ITGB3, HGF, CAPN2, FLNA, VEGFC, VWF, LAMA3, ITGB8, ITGAV, COL6A3, COL1A2, COL1A1, PDGFD, SPP1

1.20E-01

KEGG_PATHWAY


1.46E-03

CD9, IL1R2, CR1, CD34, CD1C, ITGA2, CD4, ITGA3, CD24, ITGB3

1.86E+00

KEGG_PATHWAY


3

ROCK2, ERBB2, TLR2, ITGA2, FZD3, DCN, ITGB3, HGF, PDCD4, FLNA, FZD6, PLCE1, GPC3, ANK3, ITGAV, FAS

2.04E+00

KEGG_PATHWAY

hsa05410:Hypertrophic cardiomyopathy (HCM)

3.26E-03

ITGB8, ITGAV, ITGA2, ITGA3, ITGB3, CACNA1C, CACNA1D, TPM1, SGCB

4.10E+00

KEGG_PATHW hsa05414:Dilated cardiomyopathy 5.15E-0 ITGB8, ITGAV, ITGA2, ITGA3, ITGB3, 6.41E

AY 3 CACNA1C, CACNA1D, TPM1, SGCB +00 KEGG_PATHWAY


6.36E-03

COL4A2, COL14A1, SLC15A1, SLC16A10, COL6A3, COL1A2, COL12A1, COL1A1, DPP4

7.87E+00

KEGG_PATHWAY


6.86E-03

FGFR2, COL4A2, OSMR, TLR2, ITGA2, ITGA3, HGF, ITGB3, BCL2L11, VEGFC, VWF, LAMA3, PRLR, ITGB8, ITGAV, COL6A3, COL1A2, JAK2, COL1A1, PDGFD, SPP1

8.45E+00

KEGG_PATHWAY

hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC)

7.22E-03

ITGB8, ITGAV, ITGA2, ITGA3, ITGB3, CACNA1C, CACNA1D, SGCB

8.88E+00

KEGG_PATHWAY


7.99E-03

HMGCS1, FDPS, PFKP, AASS, ACLY, AMPD1, PGM3, SDS, SQLE, GFPT2, HAO2, ENO3, DAO, MVK, OAT

9.78E+00

KEGG_PATHWAY


1.09E-02

AKR1B10, MBOAT1, LIPG, DGKH, GK, LPIN2, GPAM

1.31E+01

KEGG_PATHWAY

hsa01212:Fatty acid metabolism 1.78E-0

2 ACADSB, FADS1, SCD, ELOVL2, ACACA, FASN

2.06E+01

KEGG_PATHWAY


3.69E-02

CYP3A5, AKR1C2, UGT2B17, CYP3A7, CYP1A2, UGT2A3

3.83E+01

KEGG_PATHWAY


4.20E-02

CYP3A43, CYP3A5, UGT2B17, CYP3A7, NAT2, CYP1A2, UGT2A3

4.23E+01

KEGG_PATHWAY

hsa04727:GABAergic synapse 4.42E-0

2 GLS2, GABRE, GPHN, GLS, SLC38A1, CACNA1C, CACNA1D

4.40E+01

KEGG_PATHWAY


2 ABCA10, ABCB11, ABCB1, CFTR, ABCG2

4.88E+01

KEGG_PATHWAY

hsa04742:Taste transduction 5.07E-0

2 TAS2R13, TAS2R50, TAS2R14, TAS2R4, PDE1A

4.88E+01

KEGG_PATHWAY

hsa04611:Platelet activation 5.18E-0

2 VWF, ROCK2, COL1A2, FCER1G, ITGA2, COL1A1, ITGB3, PRKG1, APBB1IP

4.95E+01

KEGG_PATHWAY


6.22E-02

IL1R2, VEGFC, TNFRSF11B, PRLR, OSMR, IL18, CCR2, BMPR2, CCL19, FAS, HGF, CCL28, CXCL10

5.62E+01

KEGG_PATHWAY


2 VCAM1, CR1, IL18, TLR2, HGF

6.07E+01

KEGG_PATHWAY

hsa04724:Glutamatergic synapse 7.17E-0

2 GLS2, TRPC1, GLS, ADRBK2, SLC38A1, HOMER1, CACNA1C, CACNA1D

6.15E+01

KEGG_PATHWAY


8.39E-02

NCAM1, VCAM1, CD34, ITGB8, VTCN1, ITGAV, CD4, CLDN11, PDCD1LG2

6.75E+01

AEBP1-TNFAIP3 program


AEBP1 TNFAIP3 activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1


THBS2


FBLN5


COL1A1


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2

AEBP1 TNFAIP3 activati JAG1

on


PDE1A


RBMS3


MTHFD2


SRPX2


SERPINE2


SMOC2


CCDC3


MMP2


ITGAV


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2


BAMBI


RANBP17


PMP22


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD

AEBP1 TNFAIP3 activati PODN

on


PLP2


CAPG


CACNA1C


CCL21


CHRDL1


KCNA3


ENPP5


FAM38B


S100A14


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1


INSIG1


HPGD


SERPINB1


RAB27A


CXCL1


TLR4


GNA13


TMEM71


ARRDC2

AEBP1 TNFAIP3 repessing

SDS


CYP3A43


MT1X


IFI44L


TIMD4


OAT


VCAM1


CD163


DNAJC12


MARCO


VSIG4


CR1


PPP1R1A


FCER1G


CD4

AEBP1 TNFAIP3 repessi P2RY13

ng


C1QC


ACADSB


GPR116


SLC16A10


F8


ODZ3


KCNN2


PDCD1LG2


SLC19A2


ITIH3


CD244


EFHD1


KCNJ8


LAIR1


KCNE1


FAHD2A

AEBP1-TNFAIP3 activation program


GOTERM_BP_DIRECT


2.45E-16


3.55E-13

GOTERM_BP_DIRECT


3.61E-09


5.69E-06

GOTERM_BP_DIRECT


1.61E-07


2.53E-04

GOTERM_BP_DIRECT


6


2.89E-03

GOTERM_BP_DIRECT



1.45E-02

GOTERM_BP_DIRECT


1.03E-04


1.62E-01

GOTERM_BP_DIRECT


5.64E-04


01 GOTERM_BP_DIRECT


6.12E-04


01 GOTERM_BP_DIRECT


7.54E-04

LGALS3, CCL21, CCL19, SPP1, TGFB2 1.18E




1.89E+00

GOTERM_BP_DIRECT


1.32E-03


+00

GOTERM_BP_DIRECT


3


2.89E+00

GOTERM_BP_DIRECT


3.32E-03




3 GNA13, SERPINE2, ITGAV, PDE1A, PDE5A, COL1A1, PRKG1, FLNA, TGFB2, RAB27A

5.43E+00

GOTERM_BP_DIRECT


4.34E-03

LAMC3, VIM, TLR4 6.62E



6.76E-03




7.70E-03




1.03E-02




1.05E-02

CXCL1, CCL21, CCL19 1.53E




1.76E+01

GOTERM_BP_DIRECT


1.24E-02

PROM1, CD24 1.78E

+01

GOTERM_BP_DIRECT


1.49E-02


+01

GOTERM_BP_DIRECT


1.49E-02

CD3E, GSN, VIM, TLR4, TGFB2, RAB27A 2.10E



1.64E-02


+01

GOTERM_BP_DIRECT


1.78E-02


+01

GOTERM_BP_DIRECT


1.85E-02

EFEMP1, FBN1 2.55E


GO:2000768~positive regulation of nephron tubule epithelial cell

1.85E-02

PROM1, CD24 2.55E

+01

differentiation GOTERM_BP_DIRECT


1.99E-02




2 CXCL1, CCL21, SUSD2, CCL19, TLR4, IGKC, DEFB1

2.83E+01

GOTERM_BP_DIRECT


2.20E-02





2.95E+01

GOTERM_BP_DIRECT

GO:0006605~protein targeting 2.21E-0

2 LTBP2, STXBP4, RAB27A

2.97E+01

GOTERM_BP_DIRECT


2.33E-02


+01

GOTERM_BP_DIRECT


2.46E-02

CCL21, CCL19 3.25E

+01

GOTERM_BP_DIRECT


2.68E-02




2.93E-02




3.07E-02

CCL21, CCL19 3.88E



3.67E-02

CCL21, CCL19 4.45E

+01

GOTERM_BP_DIRECT


3.72E-02


+01

GOTERM_BP_DIRECT


3.72E-02




4.27E-02

PROM1, CD24 4.97E

+01

GOTERM_BP_DIRECT


4.27E-02

CCL21, CCL19 4.97E

+01

GOTERM_BP_DIRECT


4.27E-02

CCL21, CCL19 4.97E



4.87E-02

COL1A1, MMP2 5.44E



2 PGM3, JAG1, TGFB2

5.46E+01

GOTERM_BP_DIRECT


5.05E-02

CCL21, CCL19, TLR4 5.58E

+01

GOTERM_BP_DIRECT


5.19E-02

LTBP2, BAMBI, HPGD, TGFB2 5.68E

+01

GOTERM_BP_DIRECT

GO:0048489~synaptic vesicle transport

5.46E-02

FGFR2, RAB27A 5.87E



5.68E-02


+01

GOTERM_BP_DIRECT


6.05E-02

CCL21, CCL19 6.26E



6.05E-02

EFEMP1, FBN1 6.26E



6.05E-02

FGFR2, VIM 6.26E



6.05E-02




6.86E-02

CXCL1, CCL21, CCL19 6.74E



6.90E-02




7.03E-02

GNA13, SERPINE2, JAG1 6.83E



7.21E-02

LPL, FABP4, TLR4 6.92E



7.21E-02

FMOD, LUM 6.92E



7.79E-02

GSN, CAPG 7.21E



7.79E-02

CCL21, CCL19 7.21E

+01

GOTERM_BP_DIRECT


7.79E-02

CCL21, TGFB2 7.21E

+01

GOTERM_BP_DIRECT


7.93E-02




8.83E-02

FGFR2, CCL21, CCL19, TLR4 7.67E



8.93E-02

CCL21, CCL19 7.71E



8.93E-02

SRPX2, CD24 7.71E

+01

GOTERM_BP_DIRECT


9.50E-02

LGALS3, THY1 7.92E

+01

GOTERM_BP_DIRECT


9.50E-02

CCL21, CCL19 7.92E




8.07E+01


KEGG_PATHWAY


6


4.14E-03

KEGG_PATHWAY


5.41E-05


6.44E-02

KEGG_PATHWAY


4 CCND1, ITGAV, LUM, TLR4, DCN, MMP2, FLNA, TGFB2

9.72E-01

KEGG_PATHW hsa04151:PI3K-Akt signaling 1.28E-0 FGFR2, COL4A2, CCND1, LAMC3, ITGAV, 1.52E

AY pathway 3 COL6A3, TLR4, COL1A1, THBS2, SPP1 +00 KEGG_PATHWAY


3 COL4A2, LAMC3, SERPINB1, TLR4, COL1A1, TGFB2

1.61E+00

KEGG_PATHWAY


2 FGFR2, GNA13, COL4A2, CCND1, LAMC3, ITGAV, MAPK10, MMP2, TGFB2

1.21E+01

KEGG_PATHWAY


1.34E-02


+01 KEGG_PATHWAY


2 CXCL1, TLR4, MAPK10, FLNA

2.77E+01

KEGG_PATHWAY



2.92E+01

KEGG_PATHWAY


3.04E-02


+01 KEGG_PATHWAY


4.76E-02

CD3E, TLR4, MAPK10, TGFB2 4.41E

+01 KEGG_PATHWAY


4.99E-02

CTSK, TLR4, MAPK10, SPP1 4.56E

+01 KEGG_PATHWAY


2 TLR4, THBS2, TGFB2

4.97E+01

KEGG_PATHWAY


2 LAMC3, TLR4, MAPK10, TGFB2

5.49E+01

KEGG_PATHWAY



6.51E+01

KEGG_PATHWAY



6.72E+01

KEGG_PATHWAY


2 LPL, FABP4, ACSL4

7.02E+01

KEGG_PATHWAY


9.95E-02


+01 AEBP1-TNFAIP3 repression program



3.93E-03




1.34E-02





2.10E+01

GOTERM_BP_DIRECT


2.27E-02

LAIR1, CD244, CD4 2.49E

+01

GOTERM_BP_DIRECT

GO:1901379~regulation of potassium ion transmembrane transport

2.44E-02

KCNN2, KCNE1 2.65E

+01

GOTERM_BP_DIRECT


6.54E-02

F8, CD163 5.70E



9.57E-02

CR1, C1QC 7.15E

+01 Category Term PValue Genes FDR

KEGG_PATHWAY


1.67E-02

CR1, F8, C1QC 1.49E

+01 KEGG_PATHWAY


6.29E-02


+01

AEBP1-TCF4 program


AEBP1 TCF4 activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1


THBS2


FBLN5


COL1A1


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2


JAG1


PDE1A


RBMS3


MTHFD2


SRPX2


SERPINE2


SMOC2


CCDC3


MMP2


ITGAV


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1

AEBP1 TCF4 activati ABCB4

on


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2


BAMBI


RANBP17


PMP22


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD


PODN


PLP2


CAPG


CACNA1C


CCL21


CHRDL1


KCNA3


ENPP5


FAM38B


S100A14


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3

AEBP1 TCF4 activati GLT8D2

on


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1


GAS2L3


CTSC

AEBP1 TCF4 repessing

SDS


CYP3A43


MT1X


IFI44L


TIMD4


OAT


VCAM1


CD163


DNAJC12


MARCO


VSIG4


CR1


PPP1R1A


FCER1G


CD4


P2RY13


C1QC


ACADSB


GPR116


SLC16A10


F8


ODZ3


KCNN2


PDCD1LG2


SLC19A2


ITIH3


CD244


EFHD1


KCNJ8


LAIR1

AEBP1-TCF4 activation program


GOTERM_BP_DIRECT


6.57E-17


1.78E-13

GOTERM_BP_DIRECT


1.99E-09


3.09E-06

GOTERM_BP_DIRECT


1.12E-07


1.74E-04

GOTERM_BP_DIRECT


7


1.42E-03

GOTERM_BP_DIRECT



8.73E-03

GOTERM_BP_D GO:0030574~collagen catabolic 7.70E-0 COL4A2, CTSK, COL6A3, COL12A1, COL1A1, 1.20E-

IRECT process 5 MMP2 01 GOTERM_BP_DIRECT


5.00E-04


01 GOTERM_BP_DIRECT


5.12E-04


01 GOTERM_BP_DIRECT


6.00E-04


01

GOTERM_BP_DIRECT


7.02E-04


+00

GOTERM_BP_DIRECT



1.57E+00

GOTERM_BP_DIRECT


1.11E-03


+00

GOTERM_BP_DIRECT


3


1.81E+00

GOTERM_BP_DIRECT


2.94E-03




6.01E-03




6.52E-03




8.33E-03





1.50E+01

GOTERM_BP_DIRECT


1.17E-02

PROM1, CD24 1.67E



1.40E-02


+01

GOTERM_BP_DIRECT


1.59E-02


+01

GOTERM_BP_DIRECT


1.74E-02

PROM1, CD24 2.40E

+01

GOTERM_BP_DIRECT


1.74E-02

EFEMP1, FBN1 2.40E



1.78E-02





2.47E+01

GOTERM_BP_DIRECT


1.87E-02




2.08E-02



GO:0010560~positive regulation of glycoprotein biosynthetic

2.32E-02

CCL21, CCL19 3.06E

+01

process GOTERM_BP_DIRECT


2.39E-02





3.29E+01

GOTERM_BP_DIRECT


2.62E-02




2.89E-02

CCL21, CCL19 3.67E

+01

GOTERM_BP_DIRECT


3.33E-02


+01

GOTERM_BP_DIRECT


3.33E-02




3.46E-02

CCL21, CCL19 4.22E



4.02E-02

PROM1, CD24 4.73E

+01

GOTERM_BP_DIRECT


4.02E-02

CCL21, CCL19 4.73E

+01

GOTERM_BP_DIRECT


4.02E-02

CCL21, CCL19 4.73E



2 PGM3, JAG1, TGFB2

5.03E+01

GOTERM_BP_DIRECT


4.59E-02

COL1A1, MMP2 5.19E



5.10E-02




2 CCL21, SUSD2, CCL19, CTSC, IGKC, DEFB1

5.67E+01

GOTERM_BP_DIRECT


5.70E-02




5.70E-02

FGFR2, VIM 5.99E



5.70E-02

CCL21, CCL19 5.99E



5.70E-02

EFEMP1, FBN1 5.99E



5.97E-02




6.80E-02

FMOD, LUM 6.66E



7.14E-02




7.35E-02

CCL21, CCL19 6.95E


GO:0033630~positive regulation of cell adhesion mediated by

7.35E-02

CCL21, TGFB2 6.95E

+01

integrin GOTERM_BP_DIRECT


7.35E-02

GSN, CAPG 6.95E



8.43E-02

CCL21, CCL19 7.46E



8.43E-02

SRPX2, CD24 7.46E




7.56E+01

GOTERM_BP_DIRECT


8.96E-02

LAMC3, VIM 7.69E

+01

GOTERM_BP_DIRECT


8.96E-02

LGALS3, THY1 7.69E

+01

GOTERM_BP_DIRECT


8.96E-02

CCL21, CCL19 7.69E



9.50E-02



KEGG_PATHWAY


6


1.97E-03

KEGG_PATHWAY


3.47E-05


4.11E-02

KEGG_PATHWAY



3.38E+00

KEGG_PATHWAY


3.09E-03


3.60E+00

KEGG_PATHWAY


1.03E-02


+01 KEGG_PATHWAY



2.34E+01

KEGG_PATHWAY



2.45E+01

KEGG_PATHWAY


2.49E-02


+01 KEGG_PATHWAY



3.93E+01

KEGG_PATHWAY


2 LAPTM4B, CTSK, CTSE, CTSC

5.02E+01

KEGG_PATHWAY



5.99E+01

KEGG_PATHWAY



6.20E+01

KEGG_PATHWAY


8.34E-02


+01 KEGG_PATHWAY


2 LPL, FABP4, ACSL4

6.50E+01

AEBP1-TCF4

repression program Category Term PValue Genes FDR GOTERM_BP_DIRECT


3.38E-03




9.63E-03





1.71E+01

GOTERM_BP_DIRECT


1.96E-02

LAIR1, CD244, CD4 2.16E



6.07E-02

F8, CD163 5.36E



8.90E-02

CR1, C1QC 6.82E



1.51E-02

CR1, F8, C1QC 1.36E

+01 KEGG_PATHWAY


5.74E-02


+01

AEBP1-EHF program


AEBP1 EHF activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1


THBS2


FBLN5


COL1A1


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2


JAG1


PDE1A


RBMS3


MTHFD2


SRPX2


SERPINE2


SMOC2


CCDC3


MMP2

AEBP1 EHF activati ITGAV

on


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2


BAMBI


RANBP17


PMP22


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD


PODN


PLP2


CAPG


CACNA1C


CCL21


CHRDL1


KCNA3


ENPP5


FAM38B

AEBP1 EHF activati S100A14

on


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1


KRT23


CFTR


BICC1


MMP7


PKHD1


CDH6


SPARCL1


ITGA2


VWF


ITGB8


GPC3


MUC6


ANTXR1


ELOVL7


LOXL4


VTCN1


GCNT4


PDGFD


FADS1


NPNT


KRT7


KCNJ16


MAP1B


FRZB


LIPH


KRT19


MGAT4A


TGFBI


NFASC


MSRB3


NQO1


FAM3B


SPATA18

AEBP1 EHF activati CD34

on


VEPH1


GRHL2


FZD6


ST14


PODXL


RAB25


GULP1


PFKP


CAPN6


SLC5A9


DKK3


HIST1H4H


LRRN1


NTS


LAMA3


PDZK1IP1


FZD7


STXBP1

AEBP1 EHF repessing

SDS

AEBP1 EHF repessing

CYP3A43

AEBP1 EHF repessing

MT1X

AEBP1 EHF repessing

IFI44L

AEBP1 EHF repessing

TIMD4

AEBP1 EHF repessing

OAT

AEBP1 EHF repessing

VCAM1

AEBP1 EHF repessing

CD163

AEBP1 EHF repessing

DNAJC12

AEBP1 EHF repessing

MARCO

AEBP1 EHF repessing

VSIG4

AEBP1 EHF repessing

CR1

AEBP1 EHF repessing

PPP1R1A

AEBP1 EHF repessing

FCER1G

AEBP1 EHF repessing

CD4

AEBP1 EHF repessing

P2RY13

AEBP1 EHF repessing

C1QC

AEBP1 EHF repessing

ACADSB

AEBP1 EHF repessing

GPR116

AEBP1 EHF repessing

SLC16A10

AEBP1 EHF repessing

F8

AEBP1 EHF repessing

ODZ3

AEBP1 EHF repessing

KCNN2

AEBP1 EHF repessing

PDCD1LG2

AEBP1 EHF repessing

SLC19A2

AEBP1 EHF repessing

ITIH3

AEBP1 EHF repessing

CD244

AEBP1 EHF repessing

EFHD1

AEBP1 EHF repessing

KCNJ8

AEBP1 EHF repessing

LAIR1

AEBP1 EHF repessi CLEC4M

ng

AEBP1 EHF repessing

AGXT2

AEBP1 EHF repessing

CNDP1

AEBP1 EHF repessing

CD36

AEBP1 EHF repessing

DHRS2

AEBP1 EHF repessing

IYD

AEBP1 EHF repessing

MS4A6A

AEBP1 EHF repessing

DUSP10

AEBP1-EHF activation program


GOTERM_BP_DIRECT


9.19E-21

FMOD, ADAMTSL2, LUM, NPNT, MMP7, DCN, MMP2, TGFB2, SMOC2, ITGB8, CRISPLD2, ITGAV, COL6A3, TGFBI, COL12A1, SPP1, COL4A2, LGALS3, EFEMP1, FBN1, CCDC80, ITGA2, NCAM1, VWF, CTSK, LAMA3, LAMC3, FBLN5, COL1A1

1.48E-17

GOTERM_BP_DIRECT


1

SVEP1, PODXL, ITGA2, MCAM, GRHL2, CDH6, ITGBL1, NCAM1, VWF, LAMA3, LAMC3, ITGB8, ITGAV, COL6A3, TGFBI, COL12A1, THBS2, CHL1, SPP1, DPT, CDH11, SPON1

1.38E-07

GOTERM_BP_DIRECT


5.67E-10

COL4A2, CTSK, LAMA3, GSN, COL6A3, CAPG, FBN1, MMP7, COL12A1, COL1A1, DCN, MMP2, SPP1

9.11E-07

GOTERM_BP_DIRECT


1.18E-06


1.90E-03

GOTERM_BP_DIRECT


5 FGFR2, COL4A2, SRPX2, ITGAV, TGFBI, JAG1, MCAM, MMP2, ANXA2, TGFB2, THY1

3.71E-02

GOTERM_BP_DIRECT


4.84E-05

COL4A2, CTSK, COL6A3, MMP7, COL12A1, COL1A1, MMP2

7.78E-02

GOTERM_BP_DIRECT


8.30E-05

COL4A2, LAMA3, ITGAV, COL12A1, MMP2 1.33E-

01 GOTERM_BP_DIRECT


4 CD34, ITGB8, ITGAV, FBLN5, NPNT, ITGA2, ADAMTS12

2.59E-01

GOTERM_BP_DIRECT


1.11E-03


+00

GOTERM_BP_DIRECT


3

NCAM1, FGFR2, COL4A2, CAP2, ITGAV, COL6A3, NFASC, ITGA2, CD24, CACNA1C, MMP2, CHL1, TGFB2

4.10E+00

GOTERM_BP_DIRECT


2.62E-03


+00

GOTERM_BP_DIRECT



4.99E+00

GOTERM_BP_DIRECT


3.46E-03




4.37E-03

SMOC2, NPNT, CCDC80, SPP1 6.80E


GO:0034329~cell junction assembly

4.79E-03

LAMA3, GRHL2, FLNA, CDH11, CDH6 7.43E



6.41E-03




6.77E-03

LGALS3, FBN1, COL12A1, COL1A1, FRZB, CDH11

1.03E+01

GOTERM_BP_DIRECT


8.91E-03

COL4A2, FBN1, PDGFD, COL1A1 1.34E

+01

GOTERM_BP_DIRECT


8.91E-03

PDGFD, COL1A1, CAPN2, MMP2 1.34E



9.20E-03

SRPX2, CD34, PKHD1, CD24, THY1 1.38E



9.89E-03

CCL21, NPNT, CCL19, COL1A1, ADAMTS12 1.48E



1.05E-02

VWF, ITGAV, ITGA2 1.56E



1.29E-02




2 PGM3, CD34, JAG1, TGFB2

1.96E+01

GOTERM_BP_DIRECT

GO:0045879~negative regulation of smoothened signaling pathway

1.55E-02

GPC3, SERPINE2, CD3E 2.23E



2 ITGAV, PODXL, ADAMTS12, CD24, BAMBI, TGFB2

2.41E+01

GOTERM_BP_DIRECT

GO:0035759~mesangial cell-matrix adhesion

1.74E-02

CD34, CCL21 2.45E



1.74E-02

PROM1, CD24 2.45E



1.91E-02


+01

GOTERM_BP_DIRECT


2.59E-02

PROM1, CD24 3.44E

+01

GOTERM_BP_DIRECT


2.59E-02

EFEMP1, FBN1 3.44E

+01

GOTERM_BP_DIRECT

GO:0060672~epithelial cell morphogenesis involved in placental branching

2.59E-02

ST14, GRHL2 3.44E

+01

GOTERM_BP_DIRECT


2.80E-02


+01

GOTERM_BP_D GO:0007596~blood coagulation 2.84E-0 VWF, SERPINE2, ITGAV, PDE1A, PDE5A, 3.71E

IRECT 2 ITGA2, COL1A1, PRKG1, FLNA, TGFB2 +01 GOTERM_BP_DIRECT



3.84E+01

GOTERM_BP_DIRECT


3.34E-02

ITGA2, RAB25, TGFB2 4.21E

+01

GOTERM_BP_DIRECT


3.34E-02


+01

GOTERM_BP_DIRECT


3.44E-02

CCL21, CCL19 4.30E

+01

GOTERM_BP_DIRECT

GO:0006493~protein O-linked glycosylation

3.59E-02

GCNT4, PGM3, MUC6, SPON1 4.44E



3.59E-02

VWF, STXBP1, FLNA, TGFB2 4.44E



3.72E-02



GO:0006911~phagocytosis, engulfment

3.92E-02

GULP1, GSN, IGKC 4.74E



3.93E-02




4.28E-02

CCL21, CCL19 5.05E


GO:0061042~vascular wound healing

4.28E-02

CD34, MCAM 5.05E


GO:0060070~canonical Wnt signaling pathway

4.40E-02

CCND1, FRZB, FZD7, FZD6 5.15E



4.40E-02

COL4A2, SUSD2, LOXL4, COL1A1, IGKC 5.15E


GO:0051781~positive regulation of cell division

4.53E-02

FGFR2, PDGFD, TGFB2 5.25E

+01

GOTERM_BP_DIRECT


4.53E-02

ITGAV, ANTXR1, FZD7 5.25E

+01

GOTERM_BP_DIRECT

GO:0045184~establishment of protein localization

4.53E-02

NPNT, ITGA2, FLNA 5.25E


GO:0007162~negative regulation of cell adhesion

4.74E-02

CLDN7, PODXL, TGFBI 5.42E



2 FGFR2, FMOD, LUM, LRRN1

5.44E+01

GOTERM_BP_DIRECT


4.88E-02

FGFR2, CLDN7, PKHD1, ITGAV, EFEMP1, RAB25, PDGFD, BAMBI, TGFB2

5.53E+01

GOTERM_BP_DIRECT


4.96E-02



GO:0061037~negative regulation of cartilage development

5.12E-02

FRZB, TGFB2 5.70E


GO:0010694~positive regulation of alkaline phosphatase activity

5.12E-02

NPNT, ITGA2 5.70E

+01 GOTERM_BP_D GO:0031346~positive regulation 5.12E-0 EFEMP1, ITGA2 5.70E

IRECT of cell projection organization 2 +01 GOTERM_BP_DIRECT


5.12E-02

CCL21, CCL19 5.70E



5.25E-02

CD34, ITGB8, CD3E, GSN, VIM, TGFB2 5.80E



5.40E-02



GO:0043010~camera-type eye development

5.40E-02

EFEMP1, FBN1, GRHL2 5.90E

+01

GOTERM_BP_DIRECT


5.94E-02

CCL21, CCL19 6.27E

+01

GOTERM_BP_DIRECT


5.94E-02

CCL21, CCL19 6.27E



5.94E-02

PROM1, CD24 6.27E


GO:0072015~glomerular visceral epithelial cell development

5.94E-02

PODXL, JAG1 6.27E


GO:0060463~lung lobe morphogenesis

5.94E-02

FGFR2, GRHL2 6.27E



6.05E-02

FGFR2, CCL21, NPNT, CCL19, PDGFD 6.33E



2 LPL, CCND1, MMP7, ITGA2, COL1A1, TGFB2, ABCB4

6.70E+01

GOTERM_BP_DIRECT


6.76E-02

COL1A1, MMP2 6.76E



6.80E-02

LPL, GPC3, AKR1B10 6.77E



6.92E-02

ITGAV, PODXL, PDGFD, COL1A1, MCAM 6.84E



2 ITGA2, CD24, CAPN2, MMP2, TGFB2

6.90E+01

GOTERM_BP_DIRECT

GO:0048103~somatic stem cell division

7.58E-02

FZD7, TGFB2 7.18E


GO:0043589~skin morphogenesis 7.58E-0

2 ITGA2, COL1A1

7.18E+01

GOTERM_BP_DIRECT


2 CD34, ITGAV, PODXL, COL1A1

7.42E+01

GOTERM_BP_DIRECT


8.30E-02

PDE5A, PDGFD, CD24 7.52E



8.38E-02




8.38E-02

CCL21, CCL19 7.55E



8.38E-02

EFEMP1, FBN1 7.55E



8.38E-02

FGFR2, VIM 7.55E

+01 GOTERM_BP_D GO:0030203~glycosaminoglycan 8.41E-0 FMOD, GPC3, LUM, DCN 7.56E

IRECT metabolic process 2 +01 GOTERM_BP_DIRECT


8.41E-02

CCND1, NTS, COL1A1, NQO1 7.56E


GO:0050680~negative regulation of epithelial cell proliferation

8.56E-02

FGFR2, GPC3, TGFB2 7.63E



8.82E-02

CD3E, VTCN1, CCL19 7.74E



9.09E-02

CCL21, CCL19, FZD7 7.84E



9.18E-02

FGFR2, ITGA2 7.87E


GO:0051965~positive regulation of synapse assembly

9.36E-02

SRPX2, LRRN1, THBS2 7.94E



9.36E-02

FGFR2, ITGA2, PDGFD 7.94E



2 LAMC3, LUM, TGFBI, EFEMP1, COL1A1

7.99E+01

GOTERM_BP_DIRECT

GO:0010629~negative regulation of gene expression

9.59E-02

CD34, ITGB8, CD3E, TGFB2 8.02E



9.90E-02

LPL, GPC3, AKR1B10 8.13E



2 CD34, MCAM

8.15E+01

GOTERM_BP_DIRECT


9.97E-02

FMOD, LUM 8.15E



9.97E-02

SERPINE2, CD34 8.15E


KEGG_PATHWAY


9

COL4A2, ITGA2, MAPK10, CAPN2, FLNA, VWF, CCND1, LAMA3, ITGB8, LAMC3, ITGAV, COL6A3, PDGFD, COL1A1, THBS2, SPP1

2.55E-06

KEGG_PATHWAY


1.72E-08

VWF, COL4A2, LAMA3, ITGB8, LAMC3, ITGAV, COL6A3, ITGA2, COL1A1, THBS2, SPP1

2.09E-05

KEGG_PATHWAY


5 CCND1, GPC3, ITGAV, LUM, ITGA2, DCN, MMP2, FZD7, FLNA, TGFB2, FZD6

4.21E-02

KEGG_PATHWAY


4.79E-05

FGFR2, VWF, COL4A2, CCND1, LAMA3, LAMC3, ITGB8, ITGAV, COL6A3, ITGA2, COL1A1, PDGFD, THBS2, SPP1

5.80E-02

KEGG_PATHWAY


6.55E-04

NCAM1, CLDN7, CD34, ITGB8, VTCN1, ITGAV, NFASC, CLDN11

7.92E-01

KEGG_PATHWAY


3 COL4A2, CCND1, LAMA3, LAMC3, ITGAV, ITGA2

2.23E+00

KEGG_PATHWAY


3

FGFR2, COL4A2, CCND1, LAMA3, LAMC3, ITGAV, ITGA2, MAPK10, MMP2, FZD7, TGFB2, FZD6

2.80E+00

KEGG_PATHWAY


8.74E-03

ITGB8, ITGAV, ITGA2, CACNA1C, TGFB2 1.01E

+01 KEGG_PATHW hsa05414:Dilated cardiomyopathy 1.13E-0 ITGB8, ITGAV, ITGA2, CACNA1C, TGFB2 1.28E


hsa04310:Wnt signaling pathway 1.39E-0

2 CCND1, MMP7, MAPK10, BAMBI, FZD7, FZD6

1.56E+01

KEGG_PATHWAY


2 COL4A2, LAMA3, LAMC3, COL1A1, TGFB2

2.60E+01

KEGG_PATHWAY


3.45E-02


+01

KEGG_PATHWAY


3.77E-02

ITGB8, ITGAV, ITGA2, CACNA1C 3.73E

+01

KEGG_PATHWAY


5.88E-02

CD34, CD3E, ITGA2, CD24 5.21E

+01 KEGG_PATHWAY


6.22E-02


+01 KEGG_PATHWAY

hsa04810:Regulation of actin cytoskeleton

6.89E-02

FGFR2, ITGB8, GSN, ITGAV, ITGA2, PDGFD 5.79E

+01 AEBP1-EHF repression program



1.31E-03

MARCO, CR1, CD244, CD36, FCER1G, CD4, C1QC, CLEC4M

1.71E+00

GOTERM_BP_DIRECT


2.62E-03

LAIR1, CD244, CD4, CLEC4M 3.39E



5.50E-03




1.14E-02

CR1, CD4, CLEC4M 1.39E

+01

GOTERM_BP_DIRECT

GO:0071404~cellular response to low-density lipoprotein particle stimulus

1.74E-02

CD36, FCER1G 2.06E

+01

GOTERM_BP_DIRECT


2.41E-02

CYP3A43, VCAM1, DHRS2, F8, IYD 2.74E



2.48E-02

ACADSB, AGXT2, OAT, IYD 2.81E



2.70E-02

MARCO, CD36 3.02E




3.24E+01

GOTERM_BP_DIRECT


3.53E-02

MARCO, CD36, CD163 3.76E



4.28E-02

CYP3A43, ACADSB, CD36, AGXT2, OAT, SLC19A2, MT1X, IYD

4.37E+01

GOTERM_BP_DIRECT


4.79E-02

VCAM1, KCNJ8, DUSP10 4.75E


GO:0007159~leukocyte cell-cell adhesion

5.14E-02

VCAM1, CLEC4M 5.00E



2 CD36, F8, FCER1G

5.96E+01

GOTERM_BP_DIRECT


2 CD244, CD36, F8, FCER1G

6.14E+01

GOTERM_BP_DIRECT


7.16E-02

CD36, FCER1G 6.23E



7.70E-02

F8, CD163 6.51E

+01

GOTERM_BP_DIRECT


8.60E-02

CD36, FCER1G 6.93E

+01

GOTERM_BP_DIRECT


8.78E-02

CD36, FCER1G 7.01E



2 VCAM1, CR1, CD36

1.27E+01

KEGG_PATHWAY


2.56E-02

CR1, F8, C1QC 2.29E

+01 KEGG_PATHWAY


3.75E-02

CR1, CD36, CD4 3.19E

+01 KEGG_PATHWAY


9.30E-02


+01

AEBP1-PRDM1 program


AEBP1 PRDM1 activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1


THBS2


FBLN5


COL1A1


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2


JAG1


PDE1A


RBMS3


MTHFD2


SRPX2


SERPINE2


SMOC2


CCDC3


MMP2

AEBP1 PRDM1 activati ITGAV

on


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2


BAMBI


RANBP17


PMP22


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD


PODN


PLP2


CAPG


CACNA1C


CCL21


CHRDL1


KCNA3


ENPP5


FAM38B

AEBP1 PRDM1 activati S100A14

on


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1


B3GNT5


MMRN1


SLC35C1


APOA5


RNASE6


SLC4A7


C3AR1


CALCRL


CECR1


GAS2L3


SESN1


ST8SIA4


RAVER2


LY86


CTSC


PIK3CG


TMPRSS2


HIST1H4L


KCNN2


CD97


FAM49A


SLC19A2

AEBP1 PRDM1 repessing

SDS


CYP3A43


MT1X


IFI44L


TIMD4


OAT


VCAM1


CD163


DNAJC12


MARCO


VSIG4

AEBP1 PRDM1 repessi CR1

ng


PPP1R1A


FCER1G


CD4


P2RY13


C1QC


ACADSB


GPR116


SLC16A10


F8


ODZ3


KCNN2


PDCD1LG2


SLC19A2


ITIH3


CD244


EFHD1


KCNJ8


LAIR1


UPB1


CX3CR1

AEBP1-PRDM1 activation program


GOTERM_BP_DIRECT


2.84E-15

FMOD, COL4A2, LGALS3, ADAMTSL2, LUM, FBN1, EFEMP1, CCDC80, DCN, MMP2, TGFB2, NCAM1, SMOC2, CTSK, LAMC3, CRISPLD2, ITGAV, FBLN5, COL6A3, COL12A1, COL1A1,

4.56E-12

SPP1 GOTERM_BP_DIRECT


1.07E-08


1.70E-05

GOTERM_BP_DIRECT


3.11E-07


4.93E-04

GOTERM_BP_DIRECT


7

PIK3CG, FGFR2, COL4A2, SRPX2, ITGAV, JAG1, CALCRL, MCAM, MMP2, ANXA2, TGFB2, THY1

5.94E-04

GOTERM_BP_DIRECT


6

SVEP1, MCAM, MMRN1, ITGBL1, NCAM1, LAMC3, ITGAV, COL6A3, COL12A1, THBS2, CHL1, SPP1, CDH11, SPON1, DPT

1.84E-03

GOTERM_BP_DIRECT


9.44E-05

PIK3CG, LGALS3, CCL21, CCL19, SPP1, TGFB2 1.49E-

01 GOTERM_BP_DIRECT


1.73E-04


2.74E-01

GOTERM_BP_DIRECT


7.04E-04




8.45E-04




1.08E-03

LPL, ACSM1, APOA5, FABP4, CD24 1.69E

+00

GOTERM_BP_DIRECT


1.16E-03


+00

GOTERM_BP_DIRECT


3

NCAM1, FGFR2, COL4A2, CAP2, ITGAV, ST8SIA4, COL6A3, CD24, CACNA1C, MMP2, CHL1, TGFB2

2.00E+00

GOTERM_BP_DIRECT



2.61E+00

GOTERM_BP_DIRECT


1.82E-03




4.12E-03




4.73E-03

PIK3CG, CCL21, CCL19 7.23E



5.39E-03

CCL21, APOA5, CCL19 8.19E



3 PIK3CG, SERPINE2, ITGAV, PDE1A, PDE5A, COL1A1, PRKG1, MMRN1, FLNA, TGFB2

1.10E+01

GOTERM_BP_DIRECT


8.37E-03




1.29E-02

C3AR1, CCL21, CCL19 1.86E



1.38E-02

PROM1, CD24 1.98E



1.49E-02





2.31E+01

GOTERM_BP_DIRECT

GO:0019433~triglyceride catabolic process

1.83E-02

LPL, APOA5, FABP4 2.54E

+01

GOTERM_BP_DIRECT


2.07E-02

PROM1, CD24 2.82E

+01

GOTERM_BP_DIRECT


2.07E-02

EFEMP1, FBN1 2.82E



2.15E-02

TMPRSS2, COL4A2, SUSD2, COL1A1, IGKC 2.91E

+01

GOTERM_BP_DIRECT


2.19E-02


+01

GOTERM_BP_DIRECT


2.20E-02




2.45E-02



GO:0055118~negative regulation of cardiac muscle contraction

2.75E-02

PIK3CG, PDE5A 3.57E

+01

GOTERM_BP_DIRECT


2.75E-02

CCL21, CCL19 3.57E

+01

GOTERM_BP_DIRECT


2.86E-02




2.93E-02





3.96E+01

GOTERM_BP_DIRECT


3.29E-02




3.43E-02

CCL21, CCL19 4.24E


GO:0060219~camera-type eye photoreceptor cell differentiation

3.43E-02

PROM1, SLC4A7 4.24E



3.59E-02




4.10E-02

CCL21, CCL19 4.84E



4.55E-02


+01

GOTERM_BP_DIRECT


4.55E-02


+01

GOTERM_BP_DIRECT


4.76E-02

PROM1, CD24 5.38E

+01

GOTERM_BP_DIRECT


4.76E-02

CCL21, CCL19 5.38E

+01

GOTERM_BP_DIRECT


4.76E-02

CCL21, CCL19 5.38E

+01

GOTERM_BP_DIRECT


2 LAMC3, LUM, EFEMP1, SLC4A7, COL1A1

5.50E+01

GOTERM_BP_DIRECT


5.42E-02

COL1A1, MMP2 5.86E

+01

GOTERM_BP_DIRECT


5.53E-02

PIK3CG, C3AR1, CD24, CACNA1C 5.94E

+01

GOTERM_BP_DIRECT


5.60E-02

PIK3CG, PDE5A, CD24 5.98E



2 PGM3, JAG1, TGFB2

6.22E+01

GOTERM_BP_DIRECT

GO:0034372~very-low-density lipoprotein particle remodeling

6.08E-02

LPL, APOA5 6.29E



6.33E-02

FGFR2, C3AR1, CALCRL 6.45E



2 PIK3CG, COL1A1, MMRN1, FLNA, TGFB2

6.53E+01

GOTERM_BP_DIRECT


6.73E-02

FGFR2, VIM 6.68E



6.73E-02




6.73E-02

EFEMP1, FBN1 6.68E



6.73E-02

CCL21, CCL19 6.68E



6.91E-02



GO:0016540~protein autoprocessing

7.38E-02

TMPRSS2, CTSE 7.03E


GO:0045723~positive regulation of fatty acid biosynthetic process

7.38E-02

APOA5, MID1IP1 7.03E



8.03E-02

FMOD, LUM 7.34E



8.67E-02

CCL21, CCL19 7.62E



8.67E-02

GSN, CAPG 7.62E

+01

GOTERM_BP_DIRECT


8.67E-02

CCL21, TGFB2 7.62E

+01

GOTERM_BP_DIRECT

GO:0097284~hepatocyte apoptotic process

9.30E-02

PIK3CG, GSN 7.87E



2 CCL21, SUSD2, CCL19, CTSC, IGKC, DEFB1

7.88E+01

GOTERM_BP_DIRECT


9.36E-02

PGM3, SLC35C1, ST8SIA4 7.89E

+01

GOTERM_BP_DIRECT


9.58E-02


+01

GOTERM_BP_DIRECT


9.93E-02

SRPX2, CD24 8.09E


KEGG_PATHWAY


6

PIK3CG, COL4A2, CCND1, LAMC3, ITGAV, COL6A3, COL1A1, MAPK10, CAPN2, THBS2, FLNA, SPP1

1.78E-03

KEGG_PATHWAY


1.08E-04


1.31E-01

KEGG_PATHWAY


3 PIK3CG, CCND1, ITGAV, LUM, DCN, MMP2, FLNA, TGFB2

2.04E+00

KEGG_PATHWAY


3.07E-03

PIK3CG, FGFR2, COL4A2, CCND1, LAMC3, ITGAV, COL6A3, COL1A1, THBS2, SPP1

3.65E+00

KEGG_PATHWAY


3.75E-03

PIK3CG, CLDN7, CLDN11, MMP2, RHOH, THY1

4.44E+00

KEGG_PATHWAY


3 PIK3CG, COL4A2, CCND1, LAMC3, ITGAV

7.69E+00

KEGG_PATHWAY


2 PIK3CG, COL4A2, LAMC3, COL1A1, TGFB2

1.58E+01

KEGG_PATHWAY


2 PIK3CG, CCND1, MAPK10, TGFB2

1.90E+01

KEGG_PATHWAY


2 PIK3CG, CCND1, MAPK10, TGFB2

2.05E+01

KEGG_PATHWAY


2 LPL, APOA5, FABP4, ACSL4

2.28E+01

KEGG_PATHWAY


2 PIK3CG, FGFR2, COL4A2, CCND1, LAMC3, ITGAV, MAPK10, MMP2, TGFB2

2.32E+01

KEGG_PATHWAY


4.14E-02


+01 KEGG_PATHWAY


6.41E-02

PIK3CG, CD3E, MAPK10, TGFB2 5.51E

+01 KEGG_PATHWAY


6.71E-02

PIK3CG, MAPK10, CACNA1C 5.68E

+01 KEGG_PATHWAY


6.71E-02

PIK3CG, CTSK, MAPK10, SPP1 5.68E

+01 KEGG_PATHWAY


2 PIK3CG, LAMC3, MAPK10, TGFB2

6.64E+01

KEGG_PATHWAY


8.76E-02

PIK3CG, FABP4, PRKG1 6.70E

+01 KEGG_PATHWAY


2 LAPTM4B, CTSK, CTSE, CTSC

6.86E+01

AEBP1-PRDM1 repression program



3.93E-03




1.34E-02


+01 GOTERM_BP_D GO:0006955~immune response 1.87E-0 IFI44L, CD4, C1QC, PDCD1LG2 2.10E



2.27E-02

LAIR1, CD244, CD4 2.49E



6.54E-02

F8, CD163 5.71E



9.57E-02

CR1, C1QC 7.16E



1.84E-02

CR1, F8, C1QC 1.67E

+01 KEGG_PATHWAY


6.86E-02


+01

AEBP1-HIVEP2 program


AEBP1 HIVEP2 activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1


THBS2


FBLN5


COL1A1


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2


JAG1


PDE1A


RBMS3


MTHFD2


SRPX2


SERPINE2


SMOC2


CCDC3


MMP2


ITGAV


ANXA2


IGKC


ACSM1

AEBP1 HIVEP2 activati NAV3

on


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2


BAMBI


RANBP17


PMP22


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD


PODN


PLP2


CAPG


CACNA1C


CCL21


CHRDL1


KCNA3


ENPP5


FAM38B


S100A14


ADAMTSL2


IKZF3


CD3E

AEBP1 HIVEP2 activati ADAMTS12

on


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1

AEBP1 HIVEP2 repessing

SDS


CYP3A43


MT1X


IFI44L


TIMD4


OAT


VCAM1


CD163


DNAJC12


MARCO


VSIG4


CR1


PPP1R1A


FCER1G


CD4


P2RY13


C1QC


ACADSB


GPR116


SLC16A10


F8


ODZ3


KCNN2


PDCD1LG2


SLC19A2


ITIH3


CD244


EFHD1


KCNJ8


LAIR1

AEBP1-HIVEP2 activation program


GOTERM_BP_DIRECT


4.14E-17


6.45E-14

GOTERM_BP_DIRECT


1.61E-09


2.51E-06

GOTERM_BP_DIRECT


9.85E-08


1.53E-04

GOTERM_BP_DIRECT


7 SVEP1, MCAM, ITGBL1, NCAM1, LAMC3, ITGAV, COL6A3, COL12A1, THBS2, CHL1,

1.11E-03

SPP1, CDH11, SPON1, DPT GOTERM_BP_DIRECT



7.32E-03

GOTERM_BP_DIRECT


6.96E-05


1.08E-01

GOTERM_BP_DIRECT


4.80E-04


01 GOTERM_BP_DIRECT


4.82E-04


01 GOTERM_BP_DIRECT


5.54E-04


01 GOTERM_BP_DIRECT



1.48E+00

GOTERM_BP_DIRECT


4


1.54E+00

GOTERM_BP_DIRECT


1.04E-03




2.82E-03




5.77E-03




6.15E-03




7.74E-03





1.42E+01

GOTERM_BP_DIRECT


1.14E-02

PROM1, CD24 1.64E

+01

GOTERM_BP_DIRECT


1.27E-02


+01

GOTERM_BP_DIRECT


1.32E-02


+01

GOTERM_BP_DIRECT


1.53E-02


+01

GOTERM_BP_DIRECT



2.32E+01

GOTERM_BP_DIRECT


1.71E-02


+01

GOTERM_BP_DIRECT


1.71E-02

PROM1, CD24 2.35E

+01

GOTERM_BP_DIRECT


1.71E-02

EFEMP1, FBN1 2.35E



1.77E-02


+01

GOTERM_BP_DIRECT


2.00E-02


+01

GOTERM_BP_DIRECT


2.27E-02

CCL21, CCL19 3.01E

+01

GOTERM_BP_DIRECT



3.02E+01

GOTERM_BP_DIRECT


2.30E-02




2.52E-02




2.83E-02

CCL21, CCL19 3.61E

+01

GOTERM_BP_DIRECT


3.21E-02


+01

GOTERM_BP_DIRECT


3.21E-02




3.39E-02

CCL21, CCL19 4.15E



3.94E-02

PROM1, CD24 4.65E

+01

GOTERM_BP_DIRECT


3.94E-02

CCL21, CCL19 4.65E

+01

GOTERM_BP_DIRECT


3.94E-02

CCL21, CCL19 4.65E



2 PGM3, JAG1, TGFB2

4.89E+01

GOTERM_BP_DIRECT


4.49E-02

COL1A1, MMP2 5.11E



4.92E-02




5.58E-02




5.58E-02

CCL21, CCL19 5.91E



5.58E-02

EFEMP1, FBN1 5.91E



5.58E-02

FGFR2, VIM 5.91E



5.67E-02




6.66E-02

FMOD, LUM 6.58E



6.88E-02




7.20E-02

GSN, CAPG 6.87E

+01

GOTERM_BP_DIRECT


7.20E-02

CCL21, TGFB2 6.87E

+01

GOTERM_BP_DIRECT


7.20E-02

CCL21, CCL19 6.87E




7.38E+01

GOTERM_BP_DIRECT


8.26E-02

SRPX2, CD24 7.39E



8.26E-02

CCL21, CCL19 7.39E



8.78E-02

CCL21, CCL19 7.61E



8.78E-02

LAMC3, VIM 7.61E

+01

GOTERM_BP_DIRECT


8.78E-02

LGALS3, THY1 7.61E

+01

GOTERM_BP_DIRECT


9.31E-02




2 ITGAV, FBLN5, ADAMTS12

8.04E+01

GOTERM_BP_DIRECT


2 FGFR2, FMOD, LUM

8.04E+01


KEGG_PATHWAY


6


1.61E-03

KEGG_PATHWAY


3.08E-05


3.66E-02

KEGG_PATHWAY



3.05E+00

KEGG_PATHWAY


2.71E-03


3.17E+00

KEGG_PATHWAY


9.57E-03


+01 KEGG_PATHWAY



2.14E+01

KEGG_PATHWAY



2.34E+01

KEGG_PATHWAY


2.36E-02


+01 KEGG_PATHWAY



3.77E+01

KEGG_PATHWAY



5.86E+01

KEGG_PATHWAY



6.07E+01

KEGG_PATHW hsa04514:Cell adhesion molecules 7.95E-0 NCAM1, CLDN7, ITGAV, CLDN11 6.26E

AY (CAMs) 2 +01 KEGG_PATHWAY


2 LPL, FABP4, ACSL4

6.37E+01

AEBP1-HIVEP2 repression program



3.38E-03




9.63E-03





1.71E+01

GOTERM_BP_DIRECT


1.96E-02

LAIR1, CD244, CD4 2.16E



6.07E-02

F8, CD163 5.36E



8.90E-02

CR1, C1QC 6.82E



1.51E-02

CR1, F8, C1QC 1.36E

+01 KEGG_PATHWAY


5.74E-02


+01

AEBP1-ZNF83 program


AEBP1 ZNF83 activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1


THBS2


FBLN5


COL1A1


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2


JAG1


PDE1A


RBMS3


MTHFD2


SRPX2


SERPINE2


SMOC2

AEBP1 ZNF83 activati CCDC3

on


MMP2


ITGAV


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2


BAMBI


RANBP17


PMP22


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD


PODN


PLP2


CAPG


CACNA1C


CCL21


CHRDL1


KCNA3

AEBP1 ZNF83 activati ENPP5

on


FAM38B


S100A14


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1


LAMA2


CLEC2D


SLC17A4


CCDC14


DNAJC10


SPCS3


ZNF320


MBOAT1


ZNF594


DCUN1D1


CNTN3


CCDC76


TIA1


ZNF767

AEBP1 ZNF83 repessing

SDS


CYP3A43


MT1X


IFI44L


TIMD4


OAT


VCAM1


CD163


DNAJC12


MARCO


VSIG4


CR1


PPP1R1A


FCER1G


CD4


P2RY13


C1QC

AEBP1 ZNF83 repessi ACADSB

ng


GPR116


SLC16A10


F8


ODZ3


KCNN2


PDCD1LG2


SLC19A2


ITIH3


CD244


EFHD1


KCNJ8


LAIR1


IL6


CETP


FCGR2B


RHOB


ACADS


IGFALS


DUSP5

AEBP1-ZNF83 activation program


GOTERM_BP_DIRECT


3.90E-17

FMOD, COL4A2, LGALS3, ADAMTSL2, LUM, FBN1, EFEMP1, CCDC80, DCN, MMP2, TGFB2, NCAM1, LAMA2, SMOC2, CTSK, LAMC3, CRISPLD2, ITGAV, FBLN5, COL6A3, COL12A1, COL1A1, SPP1

6.09E-14

GOTERM_BP_D GO:0022617~extracellular matrix 5.27E-0 COL4A2, CTSK, GSN, COL6A3, CAPG, FBN1, 8.25E-

IRECT disassembly 9 COL12A1, COL1A1, DCN, MMP2, SPP1 06

GOTERM_BP_DIRECT


8

SVEP1, MCAM, ITGBL1, NCAM1, LAMA2, LAMC3, ITGAV, COL6A3, COL12A1, CNTN3, THBS2, CHL1, SPP1, CDH11, SPON1, DPT

1.14E-04

GOTERM_BP_DIRECT


2.02E-07


3.16E-04

GOTERM_BP_DIRECT



1.98E-02

GOTERM_BP_DIRECT


1.23E-04


1.92E-01

GOTERM_BP_DIRECT


6.09E-04


01 GOTERM_BP_DIRECT


6.84E-04


+00

GOTERM_BP_DIRECT


4

LAMA2, NCAM1, FGFR2, COL4A2, CAP2, ITGAV, COL6A3, CD24, CACNA1C, MMP2, CHL1, TGFB2

1.08E+00

GOTERM_BP_DIRECT


8.71E-04





2.10E+00

GOTERM_BP_DIRECT


1.47E-03




3.57E-03




7.28E-03




8.56E-03




1.17E-02




1.29E-02

PROM1, CD24 1.83E




1.92E+01

GOTERM_BP_DIRECT


1.60E-02


+01

GOTERM_BP_DIRECT


1.82E-02


+01

GOTERM_BP_DIRECT


1.92E-02


+01

GOTERM_BP_DIRECT


1.93E-02

EFEMP1, FBN1 2.62E

+01

GOTERM_BP_DIRECT


1.93E-02

PROM1, CD24 2.62E

+01

GOTERM_BP_D GO:0001837~epithelial to 2.14E-0 FGFR2, FLNA, TGFB2 2.87E

IRECT mesenchymal transition 2 +01 GOTERM_BP_DIRECT


2.43E-02





3.26E+01

GOTERM_BP_DIRECT


2.50E-02


+01

GOTERM_BP_DIRECT


2.56E-02

CCL21, CCL19 3.33E

+01

GOTERM_BP_DIRECT


2.88E-02




3.14E-02




3.19E-02

CCL21, CCL19 3.97E



3.81E-02

CCL21, CCL19 4.56E

+01

GOTERM_BP_DIRECT


3.99E-02


+01

GOTERM_BP_DIRECT


3.99E-02





4.73E+01

GOTERM_BP_DIRECT


4.44E-02

PROM1, CD24 5.08E



4.44E-02

CCL21, CCL19 5.08E

+01

GOTERM_BP_DIRECT


4.44E-02

CCL21, CCL19 5.08E

+01

GOTERM_BP_DIRECT


5.05E-02

COL1A1, MMP2 5.55E



2 PGM3, JAG1, TGFB2

5.69E+01

GOTERM_BP_DIRECT


5.80E-02

CD3E, CLEC2D, COL1A1, IGKC 6.07E



6.08E-02




6.28E-02

CCL21, CCL19 6.37E



6.28E-02

FGFR2, VIM 6.37E



6.28E-02




6.28E-02

EFEMP1, FBN1 6.37E

+01 GOTERM_BP_D GO:0042340~keratan sulfate 7.48E-0 FMOD, LUM 7.04E

IRECT catabolic process 2 +01 GOTERM_BP_DIRECT


7.52E-02

LAMA2, SERPINE2, JAG1 7.05E



7.55E-02




8.08E-02

GSN, CAPG 7.32E



8.08E-02

CCL21, CCL19 7.32E

+01

GOTERM_BP_DIRECT


8.08E-02

CCL21, TGFB2 7.32E

+01

GOTERM_BP_DIRECT


8.47E-02




9.27E-02

CCL21, CCL19 7.81E



9.27E-02

SRPX2, CD24 7.81E



9.85E-02

LAMC3, VIM 8.02E



9.85E-02

CCL21, CCL19 8.02E

+01

GOTERM_BP_DIRECT


9.85E-02

LGALS3, THY1 8.02E

+01


KEGG_PATHWAY


7

LAMA2, COL4A2, CCND1, LAMC3, ITGAV, COL6A3, COL1A1, MAPK10, CAPN2, THBS2, FLNA, SPP1

3.94E-04

KEGG_PATHWAY


3.86E-06

LAMA2, COL4A2, LAMC3, ITGAV, COL6A3, COL1A1, THBS2, SPP1

4.59E-03

KEGG_PATHWAY


1.12E-03

LAMA2, FGFR2, COL4A2, CCND1, LAMC3, ITGAV, COL6A3, COL1A1, THBS2, SPP1

1.32E+00

KEGG_PATHWAY



4.53E+00

KEGG_PATHWAY


3 LAMA2, COL4A2, CCND1, LAMC3, ITGAV

4.64E+00

KEGG_PATHWAY


3 LAMA2, COL4A2, LAMC3, COL1A1, TGFB2

9.87E+00

KEGG_PATHWAY


3 LAMA2, FGFR2, COL4A2, CCND1, LAMC3, ITGAV, MAPK10, MMP2, TGFB2

1.09E+01

KEGG_PATHWAY


1.25E-02


+01 KEGG_PATHWAY


2.89E-02


+01 KEGG_PATHWAY


2 LAMA2, LAMC3, MAPK10, TGFB2

5.32E+01

KEGG_PATHWAY


7.52E-02

LPL, AKR1B10, MBOAT1 6.06E

+01

KEGG_PATHWAY



6.39E+01

KEGG_PATHWAY



6.59E+01

KEGG_PATHWAY


2 LPL, FABP4, ACSL4

6.89E+01

KEGG_PATHWAY


9.54E-02


+01 AEBP1-ZNF83 repression program



1.83E-04

VCAM1, IL6, CD4, PDCD1LG2 2.46E-

01 GOTERM_BP_DIRECT


3 ACADSB, ACADS, CETP

2.79E+00

GOTERM_BP_DIRECT


2.88E-03

IL6, F8, CD163 3.80E



3 FCGR2B, IFI44L, CD4, C1QC, PDCD1LG2

5.73E+00

GOTERM_BP_DIRECT


6.49E-03

DUSP5, MARCO, CR1, CD244, FCER1G, CD4, C1QC

8.38E+00

GOTERM_BP_DIRECT


3 IL6, F8, RHOB, FCER1G

1.09E+01

GOTERM_BP_DIRECT


2.87E-02

VCAM1, LAIR1, FCGR2B 3.24E



3.11E-02

LAIR1, CD244, CD4 3.46E

+01

GOTERM_BP_DIRECT


3.45E-02

ACADSB, ACADS 3.77E

+01

GOTERM_BP_DIRECT


3.53E-02

MARCO, CETP, CD163 3.83E



3.83E-02

IL6, KCNJ8, IFI44L 4.08E



2 CD244, F8, RHOB, FCER1G

6.23E+01

GOTERM_BP_DIRECT

GO:0050829~defense response to Gram-negative bacterium

7.70E-02

IL6, CD4 6.59E



8.78E-02

IL6, FCER1G 7.09E



2 VCAM1, CR1, IL6

1.14E+01

KEGG_PATHWAY


2 CR1, IL6, FCGR2B, FCER1G

1.94E+01

KEGG_PATHWAY


2.18E-02

CR1, F8, C1QC 2.08E

+01 KEGG_PATHW hsa04640:Hematopoietic cell 3.22E-0 CR1, IL6, CD4 2.92E

AY lineage 2 +01 KEGG_PATHWAY


8.05E-02


+01

AEBP1-ZFPM2 program


AEBP1 ZFPM2 activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1


THBS2


FBLN5


COL1A1


FGFR2


DCN

AEBP1 ZFPM2 activati VIM

on


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2


JAG1


PDE1A


RBMS3


MTHFD2


SRPX2


SERPINE2


SMOC2


CCDC3


MMP2


ITGAV


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2


BAMBI


RANBP17


PMP22


BAI3


CTSE

AEBP1 ZFPM2 activati STK17A

on


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD


PODN


PLP2


CAPG


CACNA1C


CCL21


CHRDL1


KCNA3


ENPP5


FAM38B


S100A14


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1


SLC12A2


EPHA3


F13A1


GLS


SLIT2


KDELR3


OLFML1


SLC38A1


ENTPD1


RERG


EPB41L4A


NEDD4L


ECT2


ITGA3


EXT1


CCNB2


ARL15

AEBP1 ZFPM2 activati FMNL2

on


PDK1

AEBP1 ZFPM2 repessing

SDS


CYP3A43


MT1X


IFI44L


TIMD4


OAT


VCAM1


CD163


DNAJC12


MARCO


VSIG4


CR1


PPP1R1A


FCER1G


CD4


P2RY13


C1QC


ACADSB


GPR116


SLC16A10


F8


ODZ3


KCNN2


PDCD1LG2


SLC19A2


ITIH3


CD244


EFHD1


KCNJ8


LAIR1


MT1E


FTCD


ACY3

AEBP1-ZFPM2 activation program


GOTERM_BP_DIRECT


1.10E-16

FMOD, COL4A2, LGALS3, ADAMTSL2, LUM, FBN1, EFEMP1, CCDC80, ITGA3, DCN, MMP2, TGFB2, NCAM1, SMOC2, CTSK, LAMC3, CRISPLD2, ITGAV, FBLN5, COL6A3, COL12A1, COL1A1, SPP1

1.78E-13

GOTERM_BP_DIRECT


8.28E-09


1.31E-05

GOTERM_BP_DIRECT


7

SVEP1, MCAM, EPHA3, ITGBL1, NCAM1, LAMC3, ITGAV, COL6A3, COL12A1, ENTPD1, THBS2, CHL1, SPP1, CDH11, SPON1, DPT

2.15E-04

GOTERM_BP_DIRECT


2.66E-07


4.22E-04

GOTERM_BP_DIRECT



2.91E-02

GOTERM_BP_DIRECT


5

NCAM1, FGFR2, COL4A2, CAP2, ITGAV, COL6A3, CD24, CACNA1C, EXT1, MMP2, CHL1, SLIT2, TGFB2, EPHA3

1.08E-01

GOTERM_BP_DIRECT


1.53E-04


2.43E-01

GOTERM_BP_DIRECT


6.68E-04




7.82E-04




1.03E-03


+00

GOTERM_BP_DIRECT



2.43E+00

GOTERM_BP_DIRECT


1.68E-03


+00

GOTERM_BP_DIRECT


3

SERPINE2, ITGAV, F13A1, PDE1A, PDE5A, ITGA3, COL1A1, PRKG1, ENTPD1, FLNA, TGFB2

2.89E+00

GOTERM_BP_DIRECT


2.14E-03

SMOC2, CCDC80, ITGA3, SPP1 3.34E



2.31E-03

LGALS3, FBN1, COL12A1, COL1A1, EXT1, CDH11

3.59E+00

GOTERM_BP_DIRECT


3.91E-03




3 ITGAV, ADAMTS12, CD24, BAMBI, TGFB2, EPHA3

9.26E+00

GOTERM_BP_DIRECT


7.95E-03




9.70E-03




1.35E-02

PROM1, CD24 1.94E




2.17E+01

GOTERM_BP_DIRECT


1.74E-02


+01

GOTERM_BP_DIRECT


2.02E-02

PROM1, CD24 2.76E

+01

GOTERM_BP_DIRECT


2.02E-02

EFEMP1, FBN1 2.76E



2.05E-02


+01

GOTERM_BP_DIRECT


2.09E-02


+01

GOTERM_BP_DIRECT

GO:0010976~positive regulation of neuron projection development

2.18E-02

SERPINE2, STMN2, ITGA3, EPHA3 2.95E



2.33E-02




2 ITGAV, FBLN5, ITGA3, ADAMTS12

3.33E+01

GOTERM_BP_DIRECT


2.59E-02

SRPX2, CD24, SLIT2, THY1 3.40E


GO:0072006~nephron development

2.68E-02

ITGA3, JAG1 3.50E

+01

GOTERM_BP_DIRECT


2.68E-02

CCL21, CCL19 3.50E

+01

GOTERM_BP_DIRECT


2.73E-02




3.13E-02




3.34E-02

CCL21, CCL19 4.16E



3.42E-02




3.99E-02

CCL21, CCL19 4.76E


GO:0060763~mammary duct terminal end bud growth

3.99E-02

SLC12A2, SLIT2 4.76E



4.34E-02


+01

GOTERM_BP_DIRECT


4.34E-02


+01

GOTERM_BP_DIRECT


4.59E-02

FMOD, LUM, DCN, EXT1 5.26E



4.64E-02

PROM1, CD24 5.29E



4.64E-02

CCL21, CCL19 5.29E

+01

GOTERM_BP_DIRECT


4.64E-02

CCL21, CCL19 5.29E

+01

GOTERM_BP_DIRECT

GO:0030308~negative regulation of cell growth

4.99E-02

RERG, SERPINE2, SLIT2, TGFB2 5.56E


GO:0035385~Roundabout signaling pathway

5.29E-02

FMOD, SLIT2 5.77E



5.29E-02

COL1A1, MMP2 5.77E



5.32E-02

RERG, PODN, SERPINE2, PMP22, SLIT2, TGFB2, DPT

5.80E+01

GOTERM_BP_DIRECT


2 PGM3, JAG1, TGFB2

6.05E+01

GOTERM_BP_DIRECT


6.37E-02

LTBP2, NEDD4L, BAMBI, TGFB2 6.48E

+01

GOTERM_BP_DIRECT


6.56E-02

EFEMP1, FBN1 6.59E



6.56E-02




6.56E-02

FGFR2, VIM 6.59E



6.56E-02

CCL21, CCL19 6.59E



6.60E-02


+01

GOTERM_BP_DIRECT


2 LPL, CCND1, ITGA3, COL1A1, TGFB2, ABCB4

6.90E+01

GOTERM_BP_DIRECT


7.20E-02

FGFR2, ITGA3 6.94E



7.26E-02

CD3E, GSN, VIM, ITGA3, TGFB2 6.97E


GO:0048846~axon extension involved in axon guidance

7.82E-02

FMOD, SLIT2 7.25E



7.82E-02

FMOD, LUM 7.25E



8.40E-02




8.45E-02

CCL21, CCL19 7.53E

+01

GOTERM_BP_DIRECT


8.45E-02

CCL21, TGFB2 7.53E

+01

GOTERM_BP_DIRECT


8.45E-02

GSN, CAPG 7.53E

+01

GOTERM_BP_DIRECT


8.79E-02

CCL21, CCL19, ECT2, FLNA 7.68E

+01

GOTERM_BP_DIRECT

GO:0030512~negative regulation of transforming growth factor beta receptor signaling pathway

9.15E-02

ADAMTSL2, NEDD4L, BAMBI 7.82E

+01

GOTERM_BP_DIRECT


9.15E-02



GO:0001503~ossification 9.57E-0

2 CHRDL1, EXT1, CDH11

7.97E+01

GOTERM_BP_DIRECT


9.68E-02

SRPX2, CD24 8.01E


GO:0035640~exploration behavior

9.68E-02

ITGA3, CHL1 8.01E



9.68E-02

CCL21, CCL19 8.01E



9.78E-02

SLC12A2, NEDD4L, SLC38A1 8.05E


KEGG_PATHWAY


6

COL4A2, CCND1, LAMC3, ITGAV, COL6A3, ITGA3, COL1A1, MAPK10, CAPN2, THBS2, FLNA, SPP1

2.10E-03

KEGG_PATHWAY


1.12E-05

COL4A2, LAMC3, ITGAV, COL6A3, ITGA3, COL1A1, THBS2, SPP1

1.35E-02

KEGG_PATHWAY


3.44E-03

FGFR2, COL4A2, CCND1, LAMC3, ITGAV, COL6A3, ITGA3, COL1A1, THBS2, SPP1

4.06E+00

KEGG_PATHWAY


3 COL4A2, CCND1, LAMC3, ITGAV, ITGA3

8.10E+00

KEGG_PATHWAY



9.69E+00

KEGG_PATHWAY


2.13E-02


+01 KEGG_PATHWAY


2 FGFR2, COL4A2, CCND1, LAMC3, ITGAV, ITGA3, MAPK10, MMP2, TGFB2

2.50E+01

KEGG_PATHWAY


3.27E-02

ITGAV, ITGA3, CACNA1C, TGFB2 3.30E

+01 KEGG_PATHWAY

hsa04727:GABAergic synapse 3.60E-0

2 GABRE, GLS, SLC38A1, CACNA1C

3.57E+01

KEGG_PATHWAY

hsa05414:Dilated cardiomyopathy 3.95E-0

2 ITGAV, ITGA3, CACNA1C, TGFB2

3.85E+01

KEGG_PATHWAY


4.31E-02


+01 KEGG_PATHWAY



5.81E+01

AEBP1-ZFPM2 repression program



4.23E-03




1.56E-02





2.27E+01

GOTERM_BP_DIRECT


2.17E-02

CYP3A43, ACADSB, ACY3, FTCD, MT1E, OAT, SLC19A2, MT1X

2.37E+01

GOTERM_BP_DIRECT


2.43E-02

LAIR1, CD244, CD4 2.62E



2.53E-02

MT1E, MT1X 2.71E



2.86E-02

MT1E, MT1X 3.01E



3.19E-02

MT1E, MT1X 3.30E



3.52E-02

MT1E, MT1X 3.58E



6.77E-02

F8, CD163 5.79E



9.91E-02

CR1, C1QC 7.24E



1.84E-02

CR1, F8, C1QC 1.64E

+01 KEGG_PATHWAY


6.86E-02


+01

AEBP1-FOSB program

CoRegulators link Targeted genes AEBP1 FOSB activati AKR1B10

on

AEBP1 FOSB activation

SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1


THBS2


FBLN5


COL1A1


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2


JAG1


PDE1A


RBMS3


MTHFD2


SRPX2


SERPINE2


SMOC2


CCDC3


MMP2


ITGAV


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840

AEBP1 FOSB activati COL12A1

on


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2


BAMBI


RANBP17


PMP22


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD


PODN


PLP2


CAPG


CACNA1C


CCL21


CHRDL1


KCNA3


ENPP5


FAM38B


S100A14


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3

AEBP1 FOSB activati CLDN7

on


CLDN11


SUSD2


CCND1


SPINK1


CYP2B6


CYP2B7P1


CXCL13


CYP3A4


PZP


UPP2


CCL20


AVPR1A


CCL2


CYP3A43


MGP


HLA-DQA1


LYZ


RGS1


CD69


SPARCL1


GPNMB


RGS4


LPA


HLA-DRA


CFHR5


C7


GNMT


LRG1


CD5L


CXCR4


SLC2A3


RGS5


CPN1


VNN3


OIT3


CHST9


GBA3


CLEC4M


MME


IGFBP5


SULT1C2


HLA-DQB1


G6PC


HYOU1


TIMD4


SLC1A2


PCK1


MYOM1

AEBP1 FOSB activati ARRDC3

on


CD74


IL6


BBOX1


AGXT2


VCAM1


HLA-DPB1


B3GNT5


MFAP4


ITK


CTGF


GGH


COL4A1


HSD17B7P2


ANXA3


CRHBP


CNDP1


AADAT


S100A8


INPP4B


MMRN1


WEE1


CD163


VNN2


P4HA1


ERRFI1


GFRA1


TIMP1


FREM2


IGF1


ABI3BP


VIL1


PHLDA1


PSAT1


RNASE6


FLRT3


GZMK


ZFAND5


SYNPO2


PTPRC


VNN1


MARCO


CH25H


C3AR1


SLC5A1


CDH19


CALCRL


HLA-DMB


NRG1

AEBP1 FOSB activati MT1E

on


FCGR2A


OLFML1


MPEG1


UGDH


INSIG1


DNAJB4


KCNE4


CD36


STAB2


GABRP


DNAJC3


ZC3H13


GFPT1


GJA1


SCGN


IGFBP2


ADAMTS4


CPA3


SELENBP1


LY6E


CPVL


GREM2


LSS


MYH11


VSNL1


DOCK11


MCTP1


KLB


MAML2


BCHE


HPGD


CD96


HIST1H2BM


RASD1


SIPA1L2


FRZB


PLTP


SLC1A1


TMEM154


ARHGDIB


DNASE1L3


SC5DL


HIST1H3B


EVI2B


CD53


ANGPTL1


SLFN11


PLXDC2

AEBP1 FOSB activati ARL5B

on


S100A11


VSIG4


ALDOC


RNF122


NNMT


IER3


CR1


TFPI2


PPP1R1A


CTSS


ALPL


DOCK10


CD44


GADD45G


CCL5


PRELP


LIFR


CA13


PFKFB3


TMED6


SEC61G


MID1


FPR1


SERPINB1


RND2


PECAM1


IYD


SLC25A36


CYFIP2


FYB


P2RY13


NCKAP1L


CNTN4


DOCK8


ATP1B3


CLEC4G


CD226


ZSWIM6


PCDH18


TRIB1


FCN2


C1QC


PKHD1L1


POSTN


EPB41L2


CECR1


PIK3R3


IL1B

AEBP1 FOSB activati HORMAD2

on


ICA1


SLC1A3


IQGAP1


TGFBR3


SAMD9L


TIPARP


SOCS2


GCLM


SGCE


MX2


PSD3


TLR1


HSPA2


ACADSB


CD3G


NCF2


SESN1


FLJ42289


TP53INP1


PLXNC1


IFI30


SFRP5


C1QB


MS4A6A


IL1RAP


SCN9A


CD48


IGSF6


OBFC2A


MRO


APOD


SLFN5


SLCO1A2


OSBPL11


ST8SIA4


UCA1


BMP5


PPT1


ACE2


PAG1


EDNRB


SLC16A10


PDE7B


PRICKLE1


MSRB3


SLC25A33


LHFP


CD2

AEBP1 FOSB activati RAVER2

on


LY86


SLCO2A1


CD52


SERPINB8


F8


MYO5A


LYSMD3


CXCL1


AREG


RFTN2


TSPAN7


KLRB1


RASGRP1


ALG3


FLT1


CCL4


REPS1


CETP


PDLIM3


LOC654433


LRP2


SPG20


MCTP2


PTPRB


RAB31


PDP2


DOCK2


HMCN1


CHORDC1


VCL


PIK3CG


TACSTD2


CCR1


GMPPB


CD84


TLR4


MMD


ARL4C


ODZ3


WARS


RNF152


C1QA


CTTNBP2NL


SMOC1


SRPX


GPR137B


CSF1R


CXCL16

AEBP1 FOSB activati EHD3

on


KDR


SLC9A9


PSTPIP2


PRKCH


PLA2G4A


CD180


CLIC2


IL2RG


IFRD1


CD200


CD83


AQP3


GNA13


F2RL1


S100P


APBB1IP


VGLL3


TMPRSS2


SHBG


CPXM2


GPR65


FAM102A


RHOB


ATP8A1


PLCB1


PANK1


TMEM71


APOLD1


SLC31A2


NEBL


MMP8


MVD


ACTG2


PDCD1LG2


PELI1


HPS3


DOPEY2


CPEB4


GPM6A


EDN1


OGN


LCP2


GREB1


NUSAP1


IL18RAP


FAM59A


EMR1


ITGAX

AEBP1 FOSB activati GYG2

on


IKZF1


TSPYL5


CD97


TXK


EPB41L3


PS1TP4


LRRC19


TLR2


GGTA1


ACP5


HLA-DQB2


DUOX2


PCDHB16


ANGPTL4


EEF1E1


GPR109B


CALU


PCDHB15


SLC2A12


GRAP


KLRG1


ITIH3


GREM1


CD244


PCDH17


SH3RF2


SUSD4


FRMD4B


IGFALS


LRRK2


LRP1B


CMKLR1


IL10RA


CD93


LMOD1


IFITM2


CRISP3


MAPRE1


IL13RA2


VAV3


IMPA1


AKR1B1


ADRBK2


FOLR2


SLC11A1


MOSPD1


GIMAP5


UCP2

AEBP1 FOSB activati EFHD1

on


TNFSF8


PIM1


SH2D1A


TTLL7


PELI2


CLEC4E


RBMS1


P2RY14


INPP5D


OLR1


PRICKLE2


FZD7


ALOX5AP


EFNB2


SUSD1


DUSP5


RET


AXL


LAIR1


SLC7A8


SLC6A6


ARRDC2


CD80


HCK


MEP1B


CD55

AEBP1 FOSB repessing

SDS


CYP3A43


MT1X


IFI44L


TIMD4


OAT


VCAM1


CD163


DNAJC12


MARCO


VSIG4


CR1


PPP1R1A


FCER1G


CD4


P2RY13


C1QC


ACADSB


GPR116


SLC16A10


F8


ODZ3

AEBP1 FOSB repessi KCNN2

ng


PDCD1LG2


SLC19A2


ITIH3


CD244


EFHD1


KCNJ8


LAIR1


AKR1B10


DDX3Y


RPS4Y1


CYP3A7


GSTM1


KRT23


EIF1AY


UTY


SPP1


CFTR


CYP1A2


LUM


CYP7A1


PLA2G2A


BICC1


THRSP


CD24


CXCL10


APOA4


MMP7


EFEMP1


PKHD1


HBB


USP9Y


CDH6


LGALS4


CYP1A1


HIST1H3I


MT1H


HAO2


ACSL4


ITGA2


ASPN


SLC12A2


FCN3


CCL19


ITGB8


PROM1


EPHA3


GPC3


CLGN

AEBP1 FOSB repessi GPX2

ng


CFHR3


FASN


ANTXR1


PDGFRA


FADS2


FAP


MT1G


MOXD1


SVEP1


F13A1


SLC5A6


PRAMEF10


LOXL4


STMN2


DEFB1


CYP2C19


PDGFD


CYBRD1


AKR1C2


LAMA2


THBS2


CRIM1


DHODH


COL1A2


SLCO4C1


COL1A1


TMEM45B


LXN


INHBE


FADS1


FGFR2


XPNPEP2


NPNT


DNAH5


DCN


SLIT2


GLS2


COL3A1


ELOVL6


DPT


KRT7


ACSS2


PTPN13


SULT1B1


KCNJ16


KIAA1324L


WDR72


SORT1

AEBP1 FOSB repessi SCRN1

ng


FBN1


COL6A3


ADRA1A


TGFB2


DDIT4


CCDC102B


CLEC2D


IL32


S100A10


PDE1A


RBMS3


HMGCR


PPP1R3C


SCD


IFI6


AASS


SLC17A4


ABCB11


SRPX2


DAO


CCDC68


TOP2A


SERPINE2


NAT8


DTNA


DDC


CYP3A5


SMOC2


CRYAB


ANXA2P2


TGM2


MBL2


KDELR3


MAP1B


MMP2


GALNT2


WSB1


CLIC6


NAT2


UROC1


ITGAV


EBP


SLC38A1


IFI44


DIO1


SLC22A15


ANXA2


IGSF9

AEBP1 FOSB repessi IGKC

ng


SELE


ACSM1


TPM1


PDE3A


LPAL2


GPR174


DGKH


NAV3


SDF2L1


GBP2


GPRC5B


ADAM28


HSPA4L


RAPGEF5


ME1


TRPC1


KCNJ15


ENTPD1


UGT2A3


UPB1


THY1


WNK3


PTGIS


USP53


ABCA10


FDPS


RNPC3


AGXT2L1


GPC4


TUSC3


KLHL5


PRKG1


PIGR


PDGFRB


CYP39A1


CDC42EP3


ABCB4


SULF1


KCNB1


GCC2


NLGN4Y


CTSK


SPIRE1


LRRC1


FDFT1


FLJ36840


SLC22A7


SLC25A30

AEBP1 FOSB repessi COL12A1

ng


COL4A2


LIPG


FLNA


NSUN6


RASEF


FER


EDNRA


LIPA


SULT1A2


ODZ1


SNRPN


PLCXD3


PGM3


ASPA


CLSTN2


KCNK5


PPP1R3B


PRKAA2


TRIM55


UGT2B17


DSG1


PBK


CACNA2D1


GABRE


DHCR7


HAL


PLAT


PKLR


CPD


MAMDC2


RTP3


ABCC4


LGALS3


ENO3


CDH11


ENAH


SLC39A10


SLC17A1


ARHGAP10


CCNL1


UNC5CL


IL1R2


SLC17A3


SMC6


TYMS


ZFYVE16


PDE5A


PALMD

AEBP1 FOSB repessi KRT19

ng


MOGAT1


NEDD4L


ITGA6


LAPTM4B


PLA2R1


NBLA00301


MID1IP1


MUM1L1


CTPS


ELOVL2


GBP3


TIGD2


ROCK2


RAB3B


DLEU2


ROBO1


RBBP8


ECT2


TGFBI


INMT


ZYG11A


TNFRSF11B


CAP2


OCLM


EFNA1


DGAT2


ALPK2


AHI1


DNAH14


GALNTL2


AHSA2


SSX2IP


FOLH1


VLDLR


SEC14L4


DNHD1


KCNT2


SLC15A1


GSTM3


EPSTI1


DNAJC10


PDE11A


SLC7A1


RANBP17


ITGA3


MAP2


LOC644714


NFASC

AEBP1 FOSB repessi DHRS7

ng


HEG1


CKAP2


SYT7


AMDHD1


ANXA5


PIK3C2G


DPYSL3


ITGB3


HIST1H3A


SLC2A9


ARL4D


AMACR


ZNF28


CTSE


NQO1


STK17A


METTL7B


SLC25A18


GOLT1B


GPR180


RASGRP3


LPL


PCOLCE2


CYP4X1


NT5E


CA12


SLC44A3


RGS9


GSN


PEG10


TM4SF5


PPP2R1B


SMC4


FMO4


CYP26A1


CCR2


PPM1L


FLJ44896


SPATA18


RPPH1


CD34


ARRDC4


FMOD


MBOAT1


IFT80


ZNF594


PODN


TAS2R50

AEBP1 FOSB repessi CAPG

ng


TM6SF1


IFIT3


VEPH1


FLJ16734


DMXL2


FLRT2


SLC30A10


RABGGTB


CACNA1C


KIAA0020


PLA2G5


CENPC1


ANKRD18A


GRHL2


OAS1


TMEM37


FXYD1


GABRB3


LOC440944


JMJD5


CCL21


EXT1


GSTA3


SAMD12


PCSK9


GAS2


ZRANB2


SNORA28


FAM111B


SPSB1


TTN


HIST1H4L


ABCG5


NBEAL1


OAS2


OSGIN2


RAB25


TMEM176A


GP1BB


ACLY


TMPRSS3


MAPK4


ANKRD26


JUB


GSTP1


GK3P


BCAT1


ACACA

AEBP1 FOSB repessi FLJ36116

ng


AKAP7


FAM98A


CTNNAL1


EPHA4


PLA2G4C


EXOC5


PLEKHA3


SLC6A12


LPIN2


METT5D1


GPT


FXYD2


CCDC76


GLUD1


ATR


MVK


ARHGAP11A


GPR52


LITAF


FAM38B


TAS2R13


S100A14


ABCB1


TESC


UTP15


HGFAC


PFKP


CYP21A2


ADAMTSL2


CAPN6


IKZF3


RNASE2


CHEK1


ADAMTS12


FNDC1


PILRB


FGF23


HSPC072


ATP6V1C1


TM6SF2


PAQR5


PCOLCE


ANGPTL2


FBLN1


BLNK


PLCE1


GLYCTK


SLC5A9

AEBP1 FOSB repessi ZNF484

ng


KCNE1


DKK3


COX11


OR52K3P


SLC38A6


HDGFRP3


GLT8D2


TAGLN2


NID2


TOM1L1


ALOX12P2


A2M


RNF43


TRAT1


FLJ31958


ABCC6


GRM8


PDPR


IMPAD1


CACNA1D


CCL28


PCDH20


EMB


LAMA3


TAS2R4


PARP6


ENC1


KIF4A


TTTY10


FLJ13197


KAL1


MRE11A


HOMER1


ENPEP


IMPA2


PDZK1IP1


PPIF


SLC16A14


WRN


STEAP2


WWC1


CX3CR1


LRRC31


CSAD


TMPRSS6


COQ10A


KCND3


LTBP3

AEBP1 FOSB repessi ADAM19

ng


FZD3


POLE2


B3GNT3


TTC21B


ZNF767


KPNA5


CDKN3


FMNL2


FLJ32742


CLDN11


SUSD2


ALDH1A3


TRPM7


AMPD1


MALT1


APOBEC3B


STXBP1


ADAMTS17


DEPDC6


FNDC5


LOC646870


FLJ10213


ZNF542


CYP17A1


CMYA5


SULT1A1


TTC6


FAHD2A

AEBP1-FOSB activation program


GOTERM_BP_DIRECT


2.57E-11

FMOD, ADAMTSL2, LUM, MMP8, POSTN, DCN, MMP2, ABI3BP, TGFB2, TIMP1, VCAM1, SMOC2, CD44, ITGAX, CRISPLD2, ITGAV, COL6A3, COL12A1, SPP1, COL4A2, COL4A1, LGALS3, EFEMP1, FBN1, CCDC80, CTSS, KDR, NCAM1, CTSK, LAMC3, FBLN5, PECAM1, COL1A1, MFAP4, ADAMTS4

4.54E-08

GOTERM_BP_DIRECT


0

HLA-DQB1, CXCL1, HLA-DQB2, IFITM2, CCR1, TLR1, SUSD2, TLR2, GPR65, TLR4, HLA-DMB, CCL4, C1QC, CD96, CCL20, CCL21, IL1RAP, IL2RG, IGKC, DEFB1, ARHGDIB, FYB, IL18RAP, CMKLR1, CCL19, PKHD1L1, CTSS, HLA-DQA1, PDCD1LG2, TNFSF8, IGSF6, RGS1, CXCL13, TGFBR3, LCP2, HLA-DRA

2.21E-07

GOTERM_BP_DIRECT


0

GNA13, CD244, ATP1B3, F2RL1, SLC7A8, PRKG1, MMRN1, APBB1IP, CD74, TGFB2, VCL, CALU, TIMP1, CD48, CD44, SERPINE2, ITGAX, RASGRP1, ITGAV, PDE1A, CD2, RHOB, INPP5D, TFPI2, DOCK11, EHD3, PIK3CG, VAV3, OLR1, F8, PRKCH, IGF1, DOCK8, FLNA, WEE1, CD84, PLA2G4A, CD36, PDE5A, PECAM1, HIST1H3B, COL1A1, LCP2

6.49E-07

GOTERM_BP_DIRECT


3.70E-10

CXCL1, C3AR1, CCL2, S100A8, LY86, CCR1, CRHBP, TLR1, F2RL1, TLR2, CCL5, CCL4, SLC11A1, CCL20, FOLR2, CXCR4, CCL21, IL1RAP, SCN9A, VNN1, IL1B, SPP1, CSF1R, PIK3CG, IL6, IL18RAP, OLR1, HCK, AXL, LYZ, CCL19, CD5L, CD180, KLRG1, CXCL13, MEP1B

6.56E-07

GOTERM_BP_DIRECT


4.67E-09

PIK3CG, VAV3, CCL2, S100A8, LGALS3, EDN1, CCL19, NCKAP1L, CCL5, CCL4, TGFB2, CCL20, CCL21, IL1B, SPP1

8.27E-06

GOTERM_BP_DIRECT


9

PLXNC1, CCL2, CCR1, PCDHB15, POSTN, MMRN1, CCL4, ITGBL1, VCL, VCAM1, CD96, SRPX, ITGAX, CTGF, ITGAV, COL6A3, COL12A1, RHOB, GPNMB, THBS2, SPP1, DPT, SPON1, SVEP1, HCK, EFNB2, IGFALS, STAB2,

9.11E-06

MCAM, NCAM1, CD36, LAMC3, PECAM1, MFAP4, CD226, CHL1, CDH11

GOTERM_BP_DIRECT


7.09E-09

HLA-DQB1, HLA-DQB2, CCL2, PODN, IFITM2, CCR1, DUOX2, LRRC19, IFI30, DCN, GREM2, VCAM1, CD44, IL10RA, IL1RAP, IL1B, HLA-DPB1, MX2, CSF1R, IL13RA2, FLRT3, PLP2, IL6, SOCS2, HCK, LIFR, MID1, HLA-DQA1, NCAM1, HLA-DRA

1.26E-05

GOTERM_BP_DIRECT


2.66E-08

S100A8, LY86, F2RL1, TLR1, TLR2, TLR4, C1QC, MARCO, SH2D1A, CLEC4E, IL1RAP, IL1B, VNN1, PELI2, NRG1, PIK3CG, CRISP3, CD3G, NCF2, CTSS, CLEC4M, CD84, C1QA, NCAM1, C1QB, CTSK, CD36, KLRG1, CD80, TXK, SUSD4, LCP2, FGFR2, C7, CD244, FCN2, RASGRP1, PDE1A, IL2RG, IGKC, DEFB1, CSF1R, ITK, PELI1, CR1, VAV3, LGALS3, KLB, HCK, AXL, NCKAP1L, MAPK10, CD180, DUSP5, CD55, CYFIP2, FCGR2A

4.72E-05

GOTERM_BP_DIRECT


8.52E-08

TMPRSS2, COL4A2, COL4A1, OLR1, LRP1B, SUSD2, CD5L, PPT1, STAB2, CD163, MARCO, HYOU1, CD36, LPA, FOLR2, CXCL16, CETP, COL1A1, IGKC, LRP2

1.51E-04

GOTERM_BP_DIRECT


7

PTPRB, FGFR2, PIK3CG, COL4A2, CCL2, FLT1, VAV3, APOLD1, JAG1, STAB2, MCAM, MMP2, ANXA2, KDR, TGFB2, THY1, WARS, SRPX2, APOD, CTGF, ITGAV, RHOB, CALCRL, ANGPTL4

1.94E-04

GOTERM_BP_DIRECT


7

GNA13, IMPA1, CRHBP, TLR1, TLR2, GJA1, CD53, PRKG1, IQGAP1, CTGF, IL1B, PLCB1, PAG1, IL13RA2, RET, SPARCL1, PRKCH, IGFALS, CLIC2, ARRDC2, RND2, CD83, PDE5A, INPP4B, RASD1, CD226, CHL1, CXCL1, CD244, PLCXD3, CCL2, FPR1, ADRBK2, GREM1, CCL4, APBB1IP, CD74, SMOC2, CCL20, CD69, SMOC1, RASGRP1, PDE1A, IL2RG, INPP5D, GABRP, CSF1R, FYB, ITK, CAP2, AXL, S100A11, IGF1, MAPK10, TNFSF8, SFRP5, PDE7B, RGS1, PECAM1, IGFBP2, IGFBP5

3.56E-04

GOTERM_BP_DIRECT


3.68E-07

COL4A2, COL4A1, FBN1, MMP8, CTSS, DCN, MMP2, TIMP1, CTSK, CD44, GSN, CAPG, COL6A3, COL12A1, COL1A1, SPP1, ADAMTS4

6.51E-04

GOTERM_BP_DIRECT


5.79E-07

GNA13, PIK3CG, C3AR1, CCR1, EDN1, F2RL1, GJA1, CD52, EDNRB, CD55, CD36, CXCR4, CXCL13, AVPR1A, IL1B, CD24, CACNA1C

1.03E-03

GOTERM_BP_DIRECT


6

GNA13, PIK3CG, IL6, VAV3, F8, AXL, PRKCH, IGF1, MMRN1, APBB1IP, FLNA, CALU, VCL, TIMP1, TGFB2, PLA2G4A, CD36, RASGRP1, PECAM1, RHOB, COL1A1, LCP2

2.48E-03

GOTERM_BP_DIRECT


6

HLA-DQB1, HLA-DQB2, CD3G, CD3E, EFNB2, CCL19, HLA-DQA1, PDCD1LG2, CD80, CCL21, CD24, HLA-DPB1, HLA-DRA

3.55E-03

GOTERM_BP_DIRECT


2.03E-06

FGFR2, IL6, CCL2, CCR1, F2RL1, CCL19, TLR4, CCL5, CCL4, CD74, KDR, CD36, CD44, CCL20, CCL21, CTGF, RASGRP1, IL1B, CSF1R

3.59E-03

GOTERM_BP_DIRECT


2.03E-06

IL6, CCL2, FLT1, LGALS3, FOLR2, CCL20, CCL21, CCL19, CCL5, CCL4

3.59E-03

GOTERM_BP_DIRECT

GO:0002544~chronic inflammatory response

4.44E-06

VCAM1, S100A8, CXCL13, GJA1, VNN1, CCL5 7.87E-

03

GOTERM_BP_DIRECT


4.78E-06

VCAM1, PTPRC, IL6, CD3E, NCKAP1L, CCL19, IL1B, HLA-DPB1, HLA-DMB, CCL5, PDCD1LG2

8.47E-03

GOTERM_BP_DIRECT


4.98E-06

CXCL1, C3AR1, CCL21, EDN1, NCKAP1L, CCL19, IL1B, CD74

8.81E-03

GOTERM_BP_DIRECT


6

CD244, ATP1B3, OLR1, F2RL1, SLC7A8, CD74, CD84, CD48, ITGAX, CD44, ITGAV, PECAM1, CD2, INPP5D, COL1A1

1.15E-02

GOTERM_BP_DIRECT


1.58E-05

FMOD, P4HA1, LUM, COL12A1, COL1A1, GREM1, ANXA2, TGFB2, DPT

2.80E-02

GOTERM_BP_DIRECT


2.07E-05

VCAM1, IL6, CCL2, CCL20, CCL21, CRHBP, EDN1, CCL19, POSTN, COL1A1, ADAMTS12, CCL5, CCL4

3.67E-02

GOTERM_BP_DIRECT


2.76E-05

CXCL1, CCL2, CCL20, CMKLR1, CXCR4, CXCL13, CCL21, CCR1, CCL19, CCL5, CCL4

4.89E-02

GOTERM_BP_DIRECT


3.67E-05

FLRT3, PTPRC, IL6, PODN, SOCS2, PPP1R1A, GADD45G, LRRC19, FABP4, DCN, TRIB1, THY1

6.50E-02

GOTERM_BP_DIRECT


5 PIK3CG, ITK, S100A8, RASGRP1, FABP4, TXK, CD226

6.69E-02

GOTERM_BP_DIRECT


4.70E-05

PIK3CG, CXCR4, CCL21, CCR1, CCL19, CCL5 8.31E-

02

GOTERM_BP_DIRECT

GO:0060333~interferon-gamma-mediated signaling pathway

7.25E-05

NCAM1, HLA-DQB1, VCAM1, HLA-DQB2, CD44, HCK, IFI30, HLA-DPB1, MID1, HLA-DQA1, HLA-DRA

1.28E-01

GOTERM_BP_DIRECT

GO:0050852~T cell receptor signaling pathway

9.49E-05

HLA-DQB1, FYB, PTPRC, HLA-DQB2, ITK, CD3G, CD3E, HLA-DQA1, THY1, TXK, INPP5D, HLA-DPB1, PAG1, HLA-DRA, LCP2

1.68E-01

GOTERM_BP_DIRECT


1.38E-04

NCAM1, CR1, CD55, CD80, CXCR4, ITGAV, CLEC4G, EFNB2, AXL, ACE2, CLEC4M

2.44E-01

GOTERM_BP_DIRECT

GO:0007267~cell-cell signaling 1.42E-0

4

FGFR2, GRAP, CCR1, EFNB2, EDN1, GJA1, CCL5, GREM1, CCL4, TGFB2, TNFSF8, C1QA, SH2D1A, CD80, CCL20, CCL21, CTGF, CXCL13, IL1B, AREG

2.52E-01

GOTERM_BP_DIRECT


4

CXCL1, PLP2, C3AR1, DOCK2, CCL2, CCL20, CMKLR1, CXCL16, CCR1, FPR1, NCKAP1L, CCL5, DEFB1

3.06E-01

GOTERM_BP_DIRECT

GO:0045730~respiratory burst 1.94E-0

4 SLC11A1, CD55, NCF2, CD52, CD24

3.44E-01

GOTERM_BP_DIRECT


2.01E-04

RET, FLT1, CCR1, EDN1, VIL1, F2RL1, IGF1, ACP5, MCAM, CCL5, KDR, ITGAV, CXCL16, COL1A1, ATP8A1, CSF1R

3.55E-01

GOTERM_BP_DIRECT

GO:0007166~cell surface receptor signaling pathway

2.39E-04

KLRB1, PTPRC, CCL2, IL18RAP, CD3G, CD3E, CCR1, EDN1, LIFR, TSPAN7, CD53, MARCO, IGSF6, EDNRB, KLRG1, CD36, LY6E, CXCL13, TACSTD2, CD2, GFRA1, CALCRL

4.23E-01

GOTERM_BP_DIRECT


2.41E-04

ALPL, CXCL1, PELI1, S100A8, EDN1, ACP5, IGF1, TLR4, DCN, S100A14, TRIB1, VCAM1, SLC11A1, PLA2G4A, CXCL13, IL10RA

4.26E-01

GOTERM_BP_DIRECT


2.50E-04

CTGF, CCL21, RASGRP1, GADD45G, F2RL1, CCL19, TLR4, PLCB1, FZD7

4.41E-01

GOTERM_BP_DIRECT


2.82E-04

FGFR2, C3AR1, IL6, FLT1, EDN1, AKR1B1, IGF1, CALCRL, CCL5

4.97E-01

GOTERM_BP_DIRECT


3.28E-04

CD36, CCL2, RASGRP1, CD2, TLR2, CCL19, TLR4, CCL4

5.79E-01

GOTERM_BP_DIRECT

GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway

3.54E-04

ITK, RET, FLT1, CD3E, HCK, ANGPTL1, TXK, NRG1, CSF1R, KDR, LCP2

6.24E-01

GOTERM_BP_DIRECT

GO:0051770~positive regulation of nitric-oxide synthase biosynthetic process

4.02E-04

CCL2, CCL20, TLR2, TLR4, KDR 7.10E-

01

GOTERM_BP_DIRECT

GO:0051384~response to glucocorticoid

4.51E-04

ALPL, PLA2G4A, IL6, BCHE, IGF1, AREG, IGFBP2, CCL5, ANXA3, CPN1

7.95E-01

GOTERM_BP_DIRECT


5.94E-04

ALPL, LGALS3, CMKLR1, FBN1, IGF1, COL12A1, POSTN, COL1A1, FRZB, BMP5, PRELP, ADAMTS4, CDH11

1.05E+00

GOTERM_BP_DIRECT


6.51E-04

CD36, PECAM1, F8, IGF1, MMRN1, FLNA, TGFB2, CALU, TIMP1, VCL

1.15E+00

GOTERM_BP_DIRECT


4

CCL2, FLT1, APOLD1, IGF1, POSTN, CAPN2, MMP2, TGFB2, VCAM1, CXCR4, UCP2, IL1B, TGFBR3, CD24, ANGPTL4

1.21E+00

GOTERM_BP_DIRECT


7.73E-04

SLC11A1, CCL21, CCL19, CD74 1.36E

+00

GOTERM_BP_DIRECT

GO:0009408~response to heat 8.89E-0

4 PLA2G4A, IL6, CCL2, HSPA2, IGF1, IL1B, DNAJB4, TP53INP1

1.56E+00

GOTERM_BP_DIRECT


9.99E-04

LPL, CCL2, S100A8, TLR2, FABP4, TLR4, CTSS, CCL5, CCL4

1.75E+00

GOTERM_BP_DIRECT

GO:0060907~positive regulation of macrophage cytokine production

1.21E-03

CD36, TLR2, TLR4, CD74 2.12E

+00

GOTERM_BP_DIRECT

GO:0007568~aging 1.23E-0

3

IL6, CCL2, IGF1, DCN, CCL5, TIMP1, VCAM1, EDNRB, PLA2G4A, APOD, UCP2, GSN, IL1B, IGFBP2

2.15E+00

GOTERM_BP_DIRECT


1.33E-03

CCL2, CCL20, CCL21, CCL19, CCL5, CCL4 2.33E

+00 GOTERM_BP_D GO:0071347~cellular response to 1.43E-0 IL6, CCL2, CCL20, CCL21, EDN1, CCL19, 2.51E

IRECT interleukin-1 3 ADAMTS12, CCL5, CCL4 +00 GOTERM_BP_DIRECT


1.43E-03

COL4A2, CTSK, COL4A1, COL6A3, MMP8, COL12A1, COL1A1, CTSS, MMP2

2.51E+00

GOTERM_BP_DIRECT

GO:0019886~antigen processing and presentation of exogenous peptide antigen via MHC class II

1.48E-03

HLA-DQB1, HLA-DQB2, CTSE, IFI30, CTSS, HLA-DPB1, HLA-DMB, HLA-DQA1, CD74, HLA-DRA

2.58E+00

GOTERM_BP_DIRECT


1.56E-03

CTSK, ADAMTS12, CTSS, DNAJC3, CAPN2, CPVL

2.72E+00

GOTERM_BP_DIRECT


1.66E-03

CYP3A4, IMPA1, PDP2, SLC44A3, SLC5A1, DUOX2, LSS, BBOX1, IQGAP1, CYP3A43, OGN, LPA, CD44, SLC2A3, CTGF, CH25H, INSIG1, CETP, PLCB1, AADAT, PIK3CG, PRELP, G6PC, CD36, PANK1, AKR1B10, CHST9, INPP4B, FMOD, ACADSB, MVD, CYP2B6, CA13, PFKFB3, ALDOC, LUM, UGDH, UPP2, ACP5, PPT1, DCN, GCLM, SLCO1A2, ALOX5AP, MT1E, SULT1C2, GNMT, INPP5D, PIK3R3, ACSL4, ANGPTL4, LPL, GYG2, STAB2, INMT, PCK1, IYD, ABCB4, GBA3, PLA2G4A, ACSM1, UCP2, EEF1E1, AKR1B1, FABP4, AGXT2, LRP2, PSAT1, CACNA1C, HPGD, NNMT

2.90E+00

GOTERM_BP_DIRECT

GO:0071223~cellular response to lipoteichoic acid

1.78E-03

CD36, CCL20, TLR2, TLR4 3.10E

+00

GOTERM_BP_DIRECT


1.79E-03

SLC11A1, S100A8, CLEC4E, CCL20, CXCL13, LYZ, TLR4, STAB2, IGKC, S100A14, ANXA3, ADAMTS4

3.12E+00

GOTERM_BP_DIRECT


1.84E-03

C1QA, C7, C1QB, CR1, CD55, SUSD4, IGKC, C1QC

3.21E+00

GOTERM_BP_DIRECT


2.01E-03

KLRB1, VCAM1, CD96, LAIR1, SH2D1A, CD3G, KLRG1, CD3E, COL1A1, IGKC, CD200, CD226

3.50E+00

GOTERM_BP_DIRECT

GO:0014068~positive regulation of phosphatidylinositol 3-kinase signaling

2.02E-03

FLT1, F2RL1, IGF1, DCN, CCL5, NRG1, KDR, TGFB2

3.52E+00

GOTERM_BP_DIRECT


2.05E-03

FGFR2, CLDN7, MVD, EDN1, GREM1, TSPYL5, TGFB2, TIMP1, EDNRB, FOLR2, CTGF, ITGAV, CSF1R, IL6, FLT1, KLB, HCK, EFEMP1, LIFR, IGF1, KDR, PLA2G4A, SLC25A33, AVPR1A, AREG, BAMBI

3.57E+00

GOTERM_BP_DIRECT

GO:0031663~lipopolysaccharide-mediated signaling pathway

2.10E-03

CCL2, HCK, TLR2, IL1B, TLR4, CCL5 3.65E


GO:0010759~positive regulation of macrophage chemotaxis

2.48E-03

C3AR1, CCL2, CMKLR1, CCL5 4.31E


GO:0042116~macrophage activation

2.48E-03

SLC11A1, CD93, TLR1, TLR4 4.31E



2.48E-03

DOCK2, CCL21, CCL19, DOCK8 4.31E


GO:0051897~positive regulation of protein kinase B signaling

2.74E-03

PIK3CG, IL6, CCL21, AXL, CCL19, IGF1, NRG1, TSPYL5, IGFBP5

4.74E+00

GOTERM_BP_DIRECT


2.80E-03

ALPL, PLA2G4A, IL1B, AQP3, SPP1 4.85E


GO:0048812~neuron projection morphogenesis

3.08E-03

EPB41L3, GPM6A, LIFR, ZSWIM6, GJA1, LRRK2, WEE1

5.31E+00

GOTERM_BP_DIRECT

GO:0042346~positive regulation of NF-kappaB import into nucleus

3.35E-03

TLR2, CCL19, IL1B, TLR4, GREM1 5.77E


GO:0006928~movement of cell or subcellular component

3.42E-03

GNA13, VIM, FPR1, IGF1, VNN1, CCL4, VNN2, ARHGDIB, VCL

5.89E+00

GOTERM_BP_DIRECT

GO:0071346~cellular response to interferon-gamma

3.76E-03

CCL2, CCL20, CCL21, EDN1, CCL19, CCL5, CCL4

6.44E+00

GOTERM_BP_DIRECT

GO:0030890~positive regulation of B cell proliferation

4.04E-03

PTPRC, PELI1, VAV3, NCKAP1L, TLR4, CD74 6.91E


GO:0045766~positive regulation of angiogenesis

4.11E-03

C3AR1, FLT1, LRG1, RHOB, IL1B, GREM1, CCL5, ANXA3, KDR, ANGPTL4

7.04E+00

GOTERM_BP_DIRECT


4.36E-03

FMOD, OGN, LUM, PRELP 7.45E


GO:0032252~secretory granule localization

4.82E-03

PIK3CG, MYO5A, RASGRP1 8.21E

+00

GOTERM_BP_DIRECT


4.82E-03

CCL21, CCL19, IGF1 8.21E

+00

GOTERM_BP_DIRECT

GO:0070779~D-aspartate import 4.82E-0

3 SLC1A2, SLC1A3, SLC1A1

8.21E+00

GOTERM_BP_DIRECT


4.97E-03

PIK3CG, FLT1, RASGRP1, EDN1, PDE5A, CD24, LRRK2

8.45E+00

GOTERM_BP_DIRECT

GO:0061098~positive regulation of protein tyrosine kinase activity

5.41E-03

CD24, GREM1, CCL5, NRG1, CSF1R 9.15E


GO:0015939~pantothenate metabolic process

5.55E-03

PANK1, VNN1, VNN2, VNN3 9.38E

+00

GOTERM_BP_DIRECT


5.55E-03

RET, CCL21, NCKAP1L, TGFB2 9.38E

+00

GOTERM_BP_DIRECT

GO:0071407~cellular response to organic cyclic compound

5.93E-03

ALPL, P2RY13, CCL2, TIPARP, IL1B, CCL5, IGFBP5

1.00E+01

GOTERM_BP_DIRECT

GO:0071222~cellular response to lipopolysaccharide

6.20E-03

EDNRB, IL6, CD36, CCL2, CCL20, CD80, CXCL16, AXL, TLR4, CD180

1.04E+01

GOTERM_BP_DIRECT

GO:0044344~cellular response to fibroblast growth factor stimulus

6.25E-03

CCL2, CD44, POSTN, COL1A1, CCL5 1.05E


GO:0006952~defense response 6.46E-0

3 CD84, CD48, CRISP3, CD83, RNASE6, MX2, CD74

1.08E+01

GOTERM_BP_DIRECT


6.91E-03

MARCO, CD36, ITGAV, AXL 1.16E



6.91E-03

CLDN7, CCL21, CCL19, CSF1R 1.16E


GO:0048246~macrophage chemotaxis

6.91E-03

EDNRB, CCL2, LGALS3, CCL5 1.16E

+01

GOTERM_BP_DIRECT


7.02E-03

FLRT3, PODN, SOCS2, LRRC19, DCN, DNAJC3, TRIB1

1.17E+01

GOTERM_BP_DIRECT


7.17E-03

COL4A2, ITGAV, MMP8, COL12A1, MMP2 1.20E



7.17E-03

CD36, TLR2, CCL19, TLR4, PLCB1 1.20E

+01

GOTERM_BP_DIRECT


3

FGFR2, PLXNC1, MMP2, TGFB2, RASGRP1, ITGAV, COL6A3, RHOB, IL2RG, CD24, NRG1, CSF1R, PTPRC, COL4A2, VAV3, COL4A1, CAP2, KLB, EFNB2, NCAM1, DUSP5, ST8SIA4, MYH11, GFRA1, CNTN4, CACNA1C, CHL1

1.26E+01

GOTERM_BP_DIRECT

GO:0032729~positive regulation of interferon-gamma production

7.74E-03

SLC11A1, CD3E, IL1B, TLR4, TXK, HLA-DPB1 1.28E


GO:0051938~L-glutamate import 7.89E-0

3 SLC1A2, SLC1A3, SLC1A1

1.31E+01

GOTERM_BP_DIRECT


7.89E-03

DOCK2, CCL21, CCL19 1.31E


GO:0032869~cellular response to insulin stimulus

8.40E-03

MYO5A, RAB31, CCL2, SLC25A33, UCP2, GFPT1, IGF1, ERRFI1

1.39E+01

GOTERM_BP_DIRECT

GO:0030307~positive regulation of cell growth

8.40E-03

S100A8, SLC25A33, CXCL16, AVPR1A, IGF1, ACSL4, NRG1, TGFB2

1.39E+01

GOTERM_BP_DIRECT

GO:0002526~acute inflammatory response

8.46E-03

VCAM1, S100A8, VNN1, DEFB1 1.40E



8.46E-03

CCL2, CCR1, CCL5, S100A14 1.40E


GO:0045429~positive regulation of nitric oxide biosynthetic process

8.53E-03

IL6, EDN1, TLR2, IL1B, AGXT2, TLR4 1.41E



8.57E-03

CYP3A4, CD36, LPA, APOD, CH25H, MID1IP1, ACSL4, LRP2, PLTP, ABCB4

1.41E+01

GOTERM_BP_DIRECT

GO:0045860~positive regulation of protein kinase activity

9.37E-03

PTPRC, CCL21, MMD, CCL19, IQGAP1, LCP2 1.54E


GO:0019722~calcium-mediated signaling

9.37E-03

MCTP2, CXCR4, EDN1, AVPR1A, LRRK2, MCTP1

1.54E+01

GOTERM_BP_DIRECT

GO:0043434~response to peptide hormone

9.37E-03

CTGF, IL1B, GJA1, COL1A1, AREG, TIMP1 1.54E


GO:0042110~T cell activation 9.37E-0

3 PIK3CG, ITK, CD3G, CD80, CD3E, CD2

1.54E+01

GOTERM_BP_DIRECT


1.02E-02

S100A8, LAMC3, VIM, TLR4 1.66E



1.16E-02



GO:1990314~cellular response to insulin-like growth factor stimulus

1.16E-02

SLC25A33, FBN1, IGF1 1.87E


GO:0046822~regulation of nucleocytoplasmic transport

1.16E-02

IER3, INPP4B, MX2 1.87E


GO:0006956~complement activation

1.22E-02

C1QA, C7, C1QB, FCN2, IGKC, C1QC 1.96E

+01

GOTERM_BP_DIRECT

GO:0005975~carbohydrate metabolic process

1.23E-02

FMOD, KLB, PFKFB3, SLC5A1, LUM, ALDOC, UGDH, GYG2, DCN, STAB2, PRELP, PCK1, GBA3, OGN, G6PC, CD44, SLC2A3, CHST9, AKR1B1

1.96E+01

GOTERM_BP_DIRECT


1.23E-02

IL6, CD36, CD44, CD80, CD3E, IGF1, NRG1, CD74

1.96E+01

GOTERM_BP_DIRECT


1.33E-02

COL4A2, EDN1, FBN1, POSTN, COL1A1, CCL5 2.11E

+01

GOTERM_BP_DIRECT


1.33E-02

COL4A1, CPEB4, COL1A1, CCL5, CAPN2, MMP2

2.11E+01

GOTERM_BP_DIRECT


2 LPA, APOD, APOLD1, CETP, OSBPL11, PLTP, SLCO2A1

2.30E+01

GOTERM_BP_DIRECT


2

LPL, IL6, RET, VAV3, GGH, NCKAP1L, CCL5, GCLM, TGFB2, ABCB4, SLC1A2, CCND1, SLC1A3, APOD, BCHE, COL1A1, IGFBP2, NNMT

2.32E+01

GOTERM_BP_DIRECT

GO:0007156~homophilic cell adhesion via plasma membrane adhesion molecules

1.48E-02

CD84, RET, FREM2, PCDHB16, CDH19, PCDHB15, PCDH17, CD200, CD226, CDH11, PCDH18

2.32E+01

GOTERM_BP_DIRECT

GO:2000727~positive regulation of cardiac muscle cell differentiation

1.59E-02

EFNB2, GREM1, NRG1 2.48E

+01

GOTERM_BP_DIRECT

GO:0048251~elastic fiber assembly

1.59E-02

FBLN5, MYH11, MFAP4 2.48E



1.59E-02

CCL21, TGFBR3, CCL19 2.48E



2 CRISPLD2, TIPARP, COL1A1, MMP2, TGFB2

2.51E+01

GOTERM_BP_DIRECT


1.72E-02

FGFR2, VAV3, FLT1, CCL2, KLB, NCF2, AXL, NCKAP1L, KDR, DUSP5, NCAM1, ITGAV, RASGRP1, CYFIP2, IL2RG, NRG1

2.64E+01

GOTERM_BP_DIRECT

GO:0002224~toll-like receptor signaling pathway

1.77E-02

PELI1, CTSK, CD36, TLR1, TLR2, PELI2, TLR4, MAPK10, CTSS

2.71E+01

GOTERM_BP_DIRECT

GO:0043491~protein kinase B signaling

1.79E-02

CCL2, AXL, IGF1, IL1B, CCL5 2.73E



2 VCAM1, CD44, CTGF, ITGAV, FBLN5, SGCE, ADAMTS12, VCL

2.78E+01

GOTERM_BP_DIRECT

GO:0031175~neuron projection development

1.82E-02

FLRT3, EFHD1, IL6, STMN2, PRICKLE2, CNTN4, AREG, HDGFRP3

2.78E+01

GOTERM_BP_DIRECT


1.90E-02

STMN2, MID1IP1, MID1, HDGFRP3 2.88E



1.92E-02

SRPX2, CD44, CD93, CD2, CYFIP2, VNN1, CD24, THY1

2.91E+01

GOTERM_BP_DIRECT

GO:1902715~positive regulation of interferon-gamma secretion

2.08E-02

CD244, RASGRP1, CD2 3.11E


GO:0031622~positive regulation of fever generation

2.08E-02

PLA2G4A, IL1B, CCL5 3.11E



2.08E-02

VCAM1, SULT1C2, INMT 3.11E


GO:0050702~interleukin-1 beta secretion

2.08E-02

CD36, F2RL1, TLR4 3.11E

+01

GOTERM_BP_DIRECT

GO:0009967~positive regulation of signal transduction

2.11E-02

SH2D1A, VAV3, SOCS2, GRAP, CD80, PAG1 3.15E



2 SLC11A1, S100A8, CCL20, IL1B, DCN, NRG1, TGFB2

3.18E+01

GOTERM_BP_DIRECT

GO:0050830~defense response to Gram-positive bacterium

2.14E-02

IL6, CD36, FCN2, TLR2, ACP5, DEFB1, TNFSF8

3.18E+01

GOTERM_BP_DIRECT


2.24E-02

CD84, PIK3CG, ITK, LAIR1, CD244, SH2D1A, TXK, CTSS, PAG1, CLEC4M

3.31E+01

GOTERM_BP_DIRECT


2.27E-02


3.34E+01

GOTERM_BP_DIRECT


2.27E-02


3.34E+01

GOTERM_BP_DIRECT


2.32E-02

CXCL1, IL6, PODN, S100A11, IGF1, FRZB, SESN1, TGFB2, SFRP5, WARS, SERPINE2, BCHE, EEF1E1, IL1B, PMP22, GPNMB, BMP5, TP53INP1, CSF1R, DPT

3.40E+01

GOTERM_BP_DIRECT

GO:0042157~lipoprotein metabolic process

2.35E-02

LPL, LPA, OLR1, APOLD1, CETP 3.44E


GO:0043200~response to amino acid

2.35E-02

SLC1A2, IL6, CCL2, CTGF, EDN1 3.44E


GO:0006909~phagocytosis 2.35E-0

2 SLC11A1, CD93, PECAM1, AXL, ANXA3

3.44E+01

GOTERM_BP_DIRECT


2.35E-02

FLRT3, PODN, SOCS2, LRRC19, DCN 3.44E

+01

GOTERM_BP_DIRECT

GO:0043547~positive regulation of GTPase activity

2.37E-02

CCL2, VAV3, SIPA1L2, PSD3, NCKAP1L, CCL19, DOCK8, CCL5, CCL4, IQGAP1, THY1, DOCK2, RGS1, CCL20, RASGRP1, RGS4, RGS5, PLCB1, DOCK10, LRRK2, DOCK11, ERRFI1, ARHGDIB

3.47E+01

GOTERM_BP_DIRECT


2.44E-02

FGFR2, RET, FLT1, HCK, EFEMP1, AXL, WEE1, CSF1R, KDR

3.54E+01

GOTERM_BP_DIRECT

GO:0009617~response to bacterium

2.47E-02

SLC11A1, CCL2, VIL1, DEFB1 3.57E


GO:0071345~cellular response to cytokine stimulus

2.47E-02

IL18RAP, CXCR4, MME, CSF1R 3.57E



2.54E-02


3.66E+01

GOTERM_BP_DIRECT

GO:0006915~apoptotic process 2.57E-0

2

FGFR2, IER3, LY86, VIM, GPR65, TLR2, GJA1, TLR4, STK17A, GREM1, CXCR4, GSN, CD2, RHOB, IL1B, INPP5D, PHLDA1, PIM1, CD5L, S100A14, TNFSF8, SFRP5, EPB41L3, RNF152, GADD45G, CYFIP2, TP53INP1

3.69E+01

GOTERM_BP_DIRECT

GO:0009611~response to wounding

2.59E-02

SLC1A2, SLC1A3, CCL2, CTGF, CCR1, TGFB2 3.72E


GO:0032609~interferon-gamma production

2.63E-02

ITK, TLR4, TXK 3.76E


GO:0019934~cGMP-mediated signaling

2.63E-02

EDNRB, CD36, PRKG1 3.76E

+01 GOTERM_BP_D GO:0035556~intracellular signal 2.72E-0 FLRT3, CXCL1, FYB, ITK, CD3E, PRKCH, 3.86E

IRECT transduction 2 STK17A, CLEC4M, CD80, CTGF, PPP1R1A, TGFBR3, INPP5D, PLCB1, NRG1, LRRK2, PAG1, IGFBP5, LCP2

+01

GOTERM_BP_DIRECT

GO:0008360~regulation of cell shape

2.77E-02

GNA13, EPB41L3, IL6, CCL2, HCK, VIL1, BAMBI, CSF1R, KDR

3.92E+01

GOTERM_BP_DIRECT


2.99E-02

DUSP5, CXCR4, FPR1, IL1B, TLR4, MAPK10, LRRK2, CD74

4.16E+01

GOTERM_BP_DIRECT


3.13E-02

PELI1, CD36, TLR1, TLR2, PELI2, TLR4, MAPK10, S100A14

4.31E+01

GOTERM_BP_DIRECT

GO:0060100~positive regulation of phagocytosis, engulfment

3.23E-02

CD36, F2RL1, NCKAP1L 4.40E


GO:0042119~neutrophil activation

3.23E-02

CXCR4, F2RL1, CCL5 4.40E


GO:2000406~positive regulation of T cell migration

3.23E-02

CCL20, CCL21, CCL5 4.40E


GO:0048286~lung alveolus development

3.26E-02

FGFR2, IGF1, ERRFI1, KDR, IGFBP5 4.44E


GO:0071364~cellular response to epidermal growth factor stimulus

3.46E-02

VIL1, COL1A1, ERRFI1, IQGAP1 4.63E


GO:0001934~positive regulation of protein phosphorylation

3.53E-02

EDNRB, CCND1, RASGRP1, IL1B, PELI2, LRRK2, ANXA2, CSF1R, KDR

4.71E+01

GOTERM_BP_DIRECT

GO:0015758~glucose transport 3.55E-0

2 G6PC, SLC2A3, SLC5A1, EDN1, STXBP4, NRG1

4.72E+01

GOTERM_BP_DIRECT

GO:0002755~MyD88-dependent toll-like receptor signaling pathway

3.66E-02


4.83E+01

GOTERM_BP_DIRECT


3.80E-02

IL6, CD3E, VIM, TLR2, GJA1, TLR4, TGFB2, ACTG2, SLC11A1, CD44, CTGF, GSN, IL1B

4.96E+01

GOTERM_BP_DIRECT

GO:0030212~hyaluronan metabolic process

3.82E-02

CD44, PIM1, ITIH3, STAB2 4.99E


GO:0042327~positive regulation of phosphorylation

3.82E-02

NCKAP1L, AREG, CCL5, FZD7 4.99E


GO:0030449~regulation of complement activation

3.82E-02

C7, CR1, CD55, SUSD4 4.99E

+01

GOTERM_BP_DIRECT

GO:0042535~positive regulation of tumor necrosis factor biosynthetic process

3.87E-02

TLR1, TLR2, TLR4 5.03E

+01

GOTERM_BP_DIRECT

GO:0045060~negative thymic T cell selection

3.87E-02

DOCK2, CD3E, CD74 5.03E


GO:0016064~immunoglobulin mediated immune response

3.87E-02

INPP5D, CD74, IL13RA2 5.03E



3.98E-02

LPL, ACSM1, G6PC, FABP4, CETP, CD24 5.13E


GO:0010951~negative regulation of endopeptidase activity

4.11E-02

LPA, PZP, SERPINE2, SERPINB8, COL6A3, SERPINB1, ITIH3, TFPI2, TIMP1

5.24E+01

GOTERM_BP_DIRECT

GO:0035690~cellular response to drug

4.21E-02

CCL2, CD69, CRHBP, EDN1, IL1B, CCL4 5.33E


GO:0031100~organ regeneration 4.21E-0

2 CCND1, CCL2, LIFR, TGFBR3, ANXA3, NNMT

5.33E+01

GOTERM_BP_DIRECT


4.21E-02

VCAM1, OLR1, CCL5, CLEC4M 5.33E

+01

GOTERM_BP_DIRECT

GO:0051881~regulation of mitochondrial membrane potential

4.21E-02

SLC25A33, UCP2, SLC25A36, SPG20 5.33E

+01

GOTERM_BP_DIRECT

GO:0007154~cell communication 4.21E-0

2 ENPP5, FREM2, CCL19, NRG1

5.33E+01

GOTERM_BP_DIRECT

GO:0006518~peptide metabolic process

4.55E-02

CPXM2, MME, CPN1 5.62E



4.55E-02

TLR2, NCKAP1L, TLR4 5.62E


GO:0002003~angiotensin maturation

4.55E-02

ACE2, MME, CPA3 5.62E


GO:0045840~positive regulation of mitotic nuclear division

4.62E-02

EDN1, NUSAP1, IGF1, IL1B 5.67E


GO:0018146~keratan sulfate biosynthetic process

4.62E-02




2 FGFR2, MYO5A, AQP3, TGFB2

5.67E+01

GOTERM_BP_DIRECT

GO:0007163~establishment or maintenance of cell polarity

4.62E-02

SFRP5, CD3G, CAP2, CCL4 5.67E


GO:0045785~positive regulation of cell adhesion

4.65E-02

VAV3, ITGAV, CCL5, NRG1, APBB1IP 5.70E



4.65E-02

IL6, CD36, TLR2, IL1B, TLR4 5.70E



5.20E-02

GNA13, PLXNC1, SERPINE2, RHOB, JAG1, DOCK10

6.11E+01

GOTERM_BP_DIRECT


5.28E-02

GSN, VIL1, CAPG 6.17E


GO:0006957~complement activation, alternative pathway

5.28E-02

C7, CFHR5, VSIG4 6.17E


GO:0006000~fructose metabolic process

5.28E-02

PFKFB3, ALDOC, AKR1B1 6.17E


GO:2000484~positive regulation of interleukin-8 secretion

5.28E-02

CD244, F2RL1, CD2 6.17E



5.28E-02

CCL21, F2RL1, CCL19 6.17E

+01

GOTERM_BP_DIRECT


5.28E-02

CD80, CD3E, IL1B 6.17E

+01

GOTERM_BP_DIRECT

GO:0089711~L-glutamate transmembrane transport

5.28E-02

SLC1A2, SLC1A3, SLC1A1 6.17E


GO:0006641~triglyceride metabolic process

5.49E-02

LPL, G6PC, INSIG1, CETP 6.32E

+01

GOTERM_BP_DIRECT

GO:0043552~positive regulation of phosphatidylinositol 3-kinase activity

5.49E-02

VAV3, FLT1, CCL21, CCL19 6.32E

+01

GOTERM_BP_DIRECT


5.55E-02

FMOD, OGN, CD44, CHST9, LUM, DCN, STAB2, PRELP

6.36E+01

GOTERM_BP_DIRECT


5.55E-02

CCND1, SOCS2, CTGF, IL1B, POSTN, COL1A1, AREG, IGFBP2

6.36E+01

GOTERM_BP_DIRECT

GO:0014823~response to activity 5.62E-0

2 CCL2, EDN1, IGF1, CCL5, PCK1

6.41E+01

GOTERM_BP_DIRECT

GO:0014070~response to organic cyclic compound

5.62E-02

EDNRB, CD83, LUM, LIFR, CALU 6.41E

+01

GOTERM_BP_DIRECT

GO:0007264~small GTPase mediated signal transduction

5.64E-02

FGFR2, IQGAP1, DOCK2, RASGRP1, RHOB, IL2RG, NRG1, DOCK10, ARL5B, DOCK11, ARHGDIB, RHOH, VAV3, KLB, NCF2, NCKAP1L, DOCK8, FLNA, NCAM1, DUSP5, RND2, RAB31, MYH11, HIST1H3B, CYFIP2, MAPRE1, LRRK2, ARL4C, RASD1

6.42E+01

GOTERM_BP_DIRECT

GO:0045659~negative regulation of neutrophil differentiation

5.70E-02

INPP5D, TRIB1 6.47E


GO:0032633~interleukin-4 production

5.70E-02

ITK, TXK 6.47E


GO:0042495~detection of triacyl bacterial lipopeptide

5.70E-02

TLR1, TLR2 6.47E


GO:0043217~myelin maintenance 5.70E-0

2 EPB41L3, CXCR4

6.47E+01

GOTERM_BP_DIRECT

GO:0007497~posterior midgut development

5.70E-02

EDNRB, RET 6.47E

+01

GOTERM_BP_DIRECT

GO:0045957~negative regulation of complement activation, alternative pathway

5.70E-02

CR1, SUSD4 6.47E

+01

GOTERM_BP_DIRECT

GO:0048002~antigen processing and presentation of peptide antigen

5.70E-02

SLC11A1, CTSS 6.47E

+01

GOTERM_BP_DIRECT


5.70E-02

PROM1, CD24 6.47E


GO:0006864~pyrimidine nucleotide transport

5.70E-02

SLC25A33, SLC25A36 6.47E

+01

GOTERM_BP_DIRECT

GO:0071403~cellular response to high density lipoprotein particle stimulus

5.70E-02

CCL2, CCL5 6.47E

+01

GOTERM_BP_DIRECT

GO:0045601~regulation of endothelial cell differentiation

5.70E-02

APOLD1, KDR 6.47E

+01

GOTERM_BP_DIRECT

GO:0038096~Fc-gamma receptor signaling pathway involved in phagocytosis

5.75E-02

VAV3, CD3G, HCK, CYFIP2, NCKAP1L, FCGR2A, IGKC

6.49E+01

GOTERM_BP_DIRECT

GO:0046677~response to antibiotic

5.95E-02

ALPL, IL6, SLC1A3, CCL2 6.63E


GO:0007565~female pregnancy 5.99E-0

2 PZP, UCP2, CRHBP, IGF1, IGFBP2, HPGD, IGFBP5

6.65E+01

GOTERM_BP_DIRECT


6.05E-02

CMKLR1, TLR2, ACP5 6.68E


GO:0035815~positive regulation of renal sodium excretion

6.05E-02

EDNRB, EDN1, AVPR1A 6.68E

+01 GOTERM_BP_D GO:0001817~regulation of 6.05E-0 CD83, ACE2, IQGAP1 6.68E

IRECT cytokine production 2 +01 GOTERM_BP_DIRECT

GO:0006768~biotin metabolic process

6.05E-02

VNN1, VNN2, VNN3 6.68E

+01

GOTERM_BP_DIRECT

GO:2001241~positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

6.05E-02

RET, SRPX, TGFB2 6.68E

+01

GOTERM_BP_DIRECT


6.31E-02

GMPPB, PGM3, MVD, ST8SIA4, GFPT1, ALG3 6.85E

+01

GOTERM_BP_DIRECT

GO:0001558~regulation of cell growth

6.31E-02

EPB41L3, SOCS2, CTGF, FBLN5, IGFBP2, IGFBP5

6.85E+01

GOTERM_BP_DIRECT

GO:0010744~positive regulation of macrophage derived foam cell differentiation

6.85E-02

LPL, CD36, PRKCH 7.15E

+01

GOTERM_BP_DIRECT

GO:1990138~neuron projection extension

6.85E-02

FLRT3, POSTN, IQGAP1 7.15E


GO:0010243~response to organonitrogen compound

6.85E-02

PLA2G4A, CCND1, NNMT 7.15E


GO:0036092~phosphatidylinositol-3-phosphate biosynthetic process

6.85E-02

PIK3CG, INPP4B, PIK3R3 7.15E


GO:0002042~cell migration involved in sprouting angiogenesis

6.85E-02

EFNB2, GREM1, KDR 7.15E


GO:0042339~keratan sulfate metabolic process

6.93E-02



GO:0048662~negative regulation of smooth muscle cell proliferation

6.93E-02

OGN, APOD, TRIB1, IGFBP5 7.20E


GO:0001503~ossification 7.23E-0

2 CHRDL1, CTGF, MGP, ACP5, BMP5, CDH11

7.35E+01

GOTERM_BP_DIRECT


7.45E-02

PELI1, CLEC4G, PDE5A, VSIG4 7.46E



7.45E-02

CYP3A4, G6PC, CYP2B6, AKR1B10, AKR1B1 7.46E


GO:0016311~dephosphorylation 7.55E-0

2 PTPRB, ALPL, PTPRC, PFKFB3, ACP5, INPP4B

7.51E+01

GOTERM_BP_DIRECT

GO:0010613~positive regulation of cardiac muscle hypertrophy

7.68E-02

EDN1, PDE5A, IGF1 7.57E



7.68E-02

CCL21, CCL19, PPT1 7.57E


GO:0045579~positive regulation of B cell differentiation

7.68E-02

IKZF1, NCKAP1L, INPP5D 7.57E

+01

GOTERM_BP_DIRECT

GO:0042590~antigen processing and presentation of exogenous peptide antigen via MHC class I

7.88E-02

CD36, NCF2, ITGAV, IFI30, CTSS, SEC61G 7.66E

+01

GOTERM_BP_DIRECT

GO:0043410~positive regulation of MAPK cascade

7.88E-02

FGFR2, IL6, FLT1, IGF1, PELI2, KDR 7.66E



7.98E-02

FGFR2, TGFBR3, FLNA, TGFB2 7.70E



7.98E-02


+01

GOTERM_BP_DIRECT

GO:0006661~phosphatidylinositol biosynthetic process

8.26E-02

PIK3CG, IMPA1, INPP4B, INPP5D, PIK3R3 7.83E



2 PGM3, TIPARP, JAG1, CSF1R, TGFB2

7.83E+01

GOTERM_BP_DIRECT

GO:0061092~positive regulation of phospholipid translocation

8.43E-02

ATP8A1, ABCB4 7.90E


GO:0001766~membrane raft polarization

8.43E-02

DOCK2, CD2 7.90E

+01

GOTERM_BP_DIRECT


8.43E-02

PROM1, CD24 7.90E

+01

GOTERM_BP_DIRECT

GO:0002730~regulation of dendritic cell cytokine production

8.43E-02

TLR2, TLR4 7.90E



8.43E-02

EFEMP1, FBN1 7.90E


GO:0071727~cellular response to triacyl bacterial lipopeptide

8.43E-02

TLR1, TLR2 7.90E


GO:0070487~monocyte aggregation

8.43E-02

CD44, IL1B 7.90E


GO:0001865~NK T cell differentiation

8.43E-02

ITK, TXK 7.90E

+01

GOTERM_BP_DIRECT

GO:0007181~transforming growth factor beta receptor complex assembly

8.43E-02

FMOD, TGFBR3 7.90E

+01

GOTERM_BP_DIRECT

GO:0071307~cellular response to vitamin K

8.43E-02

POSTN, CCL5 7.90E

+01

GOTERM_BP_DIRECT


8.52E-02

LGALS3, ITGAV, IGF1, GCLM 7.93E

+01

GOTERM_BP_DIRECT


8.54E-02

CCL2, HLA-DPB1, THY1 7.94E


GO:0030193~regulation of blood coagulation

8.54E-02

F2RL1, STAB2, CLEC4M 7.94E

+01

GOTERM_BP_DIRECT

GO:0036120~cellular response to platelet-derived growth factor stimulus

8.54E-02

CCL2, ERRFI1, IQGAP1 7.94E

+01

GOTERM_BP_DIRECT

GO:0010460~positive regulation of heart rate

8.54E-02

EDN1, AVPR1A, SLC1A1 7.94E



8.54E-02

EFEMP1, ADAMTS12, GREM1 7.94E


GO:0046579~positive regulation of Ras protein signal transduction

8.54E-02

RASGRP1, IGF1, NRG1 7.94E


GO:0006959~humoral immune response

8.68E-02

CD83, IL6, SH2D1A, CCL2, LY86 8.00E



2 IL6, ITGAV, EDN1, TGFBR3, TGFB2

8.00E+01

GOTERM_BP_DIRECT

GO:0006936~muscle contraction 8.73E-0

2 ACTG2, MYH11, GJA1, LMOD1, MYOM1, ANXA2, VCL

8.01E+01

GOTERM_BP_D GO:0001974~blood vessel 9.09E-0 AXL, IGF1, JAG1, TGFB2 8.15E

IRECT remodeling 2 +01 GOTERM_BP_DIRECT

GO:0090630~activation of GTPase activity

9.09E-02

CXCL13, CCL21, RASGRP1, GPR65 8.15E

+01

GOTERM_BP_DIRECT

GO:0032720~negative regulation of tumor necrosis factor production

9.09E-02

AXL, ACP5, TLR4, GPNMB 8.15E

+01

GOTERM_BP_DIRECT


9.27E-02

VAV3, ITGAX, CTGF, ITGAV, HCK, TXK 8.21E


GO:0009615~response to virus 9.34E-0

2 CXCR4, IFITM2, DUOX2, CCL19, CCL5, MX2, CCL4

8.24E+01

GOTERM_BP_DIRECT

GO:0007263~nitric oxide mediated signal transduction

9.43E-02

CD36, FPR1, RASD1 8.27E


GO:0006885~regulation of pH 9.43E-0

2 SLC9A9, EDNRB, EDN1

8.27E+01

GOTERM_BP_DIRECT

GO:0006796~phosphate-containing compound metabolic process

9.43E-02

PTPRB, IMPA1, INPP5D 8.27E


GO:0048514~blood vessel morphogenesis

9.43E-02

COL4A1, FLT1, GJA1 8.27E



9.66E-02

SMOC2, CCDC80, ABI3BP, SPP1 8.35E


GO:1901215~negative regulation of neuron death

9.66E-02

IL6, IGF1, CCL5, LRRK2 8.35E



9.66E-02

RAB31, CD36, ADRBK2, CALCRL 8.35E


GO:0000165~MAPK cascade 9.81E-0

2 NCAM1, FGFR2, DUSP5, RET, CCL2, KLB, RASGRP1, IL1B, IL2RG, CCL5, NRG1, LRRK2

8.39E+01

GOTERM_BP_DIRECT

GO:0051216~cartilage development

1.00E-01

CD44, LUM, EDN1, BMP5, TIMP1 8.45E


GO:0006968~cellular defense response

1.00E-01

ITK, SH2D1A, KLRG1, NCF2, CD5L 8.45E


KEGG_PATHWAY


8

HLA-DQB1, IL6, CCL2, FLT1, TLR2, ACP5, TLR4, HLA-DMB, CCL5, HLA-DQA1, TGFB2, CTSK, CCL20, CD80, IL1B, HLA-DPB1, HLA-DRA

7.58E-05

KEGG_PATHWAY


6 KLRB1, VCAM1, CR1, IL6, CD36, CCL2, PECAM1, TLR2, IL1B, TLR4, THBS2, TGFB2

1.33E-03

KEGG_PATHWAY


4.54E-06

PIK3CG, IL6, CCL2, CD3G, CD3E, TLR2, TLR4, MAPK10, CCL5, C1QC, TGFB2, C1QA, C1QB, IL1B, PLCB1, PIK3R3

5.86E-03

KEGG_PATHWAY

hsa05150:Staphylococcus aureus infection

1.18E-05

HLA-DQB1, C1QA, C3AR1, C1QB, FPR1, FCGR2A, HLA-DPB1, HLA-DMB, C1QC, HLA-DQA1, HLA-DRA

1.52E-02

KEGG_PATHWAY

hsa05321:Inflammatory bowel disease (IBD)

1.61E-05

HLA-DQB1, IL6, IL18RAP, TLR2, IL1B, IL2RG, TLR4, HLA-DPB1, HLA-DMB, HLA-DQA1, TGFB2, HLA-DRA

2.08E-02

KEGG_PATHWAY


5

HLA-DQB1, CR1, IL6, TLR1, TLR2, TLR4, MAPK10, CTSS, HLA-DMB, HLA-DQA1, CD74, CLEC4M, TGFB2, ITGAX, CLEC4E, IL10RA,

2.71E-02

IL1B, FCGR2A, HLA-DPB1, HLA-DRA

KEGG_PATHWAY

hsa05140:Leishmaniasis 4.43E-0

5

HLA-DQB1, CR1, NCF2, TLR2, IL1B, TLR4, FCGR2A, HLA-DPB1, HLA-DMB, HLA-DQA1, TGFB2, HLA-DRA

5.72E-02

KEGG_PATHWAY


5.17E-05

CR1, IL6, CD3G, CD3E, MME, CD55, CD36, CD44, CD2, IL1B, CD24, HLA-DRA, CSF1R

6.68E-02

KEGG_PATHWAY


6.54E-05

COL4A2, COL4A1, ATP1B3, SLC16A10, COL6A3, ACE2, SLC7A8, MME, CPA3, COL12A1, MEP1B, COL1A1, SLC1A1

8.44E-02

KEGG_PATHWAY


8.24E-05

IL6, CCL2, FLT1, IL18RAP, CCR1, LIFR, CCL19, CCL5, CCL4, KDR, TNFSF8, TGFB2, CCL20, CXCR4, CCL21, CXCL13, IL10RA, CXCL16, IL1RAP, IL1B, IL2RG, CSF1R

1.06E-01

KEGG_PATHWAY


8.88E-05

PIK3CG, VCAM1, ITK, CLDN7, VAV3, NCF2, CXCR4, PECAM1, TXK, CLDN11, PIK3R3, MMP2, RHOH, THY1, VCL

1.15E-01

KEGG_PATHWAY


4

PIK3CG, COL4A2, IL6, COL4A1, TLR2, TLR4, VCL, TGFB2, LAMC3, IL1B, SERPINB1, COL1A1, PIK3R3, PLCB1

1.45E-01

KEGG_PATHWAY

hsa04062:Chemokine signaling pathway

1.27E-04

CXCL1, PIK3CG, ITK, CCL2, VAV3, HCK, CCR1, ADRBK2, CCL19, CCL5, CCL4, DOCK2, CCL20, CXCR4, CCL21, CXCL13, CXCL16, PLCB1, PIK3R3

1.63E-01

KEGG_PATHWAY

hsa04145:Phagosome 1.30E-0

4

HLA-DQB1, OLR1, NCF2, TLR2, TLR4, CTSS, HLA-DMB, HLA-DQA1, CLEC4M, MARCO, CD36, ITGAV, FCGR2A, HLA-DPB1, THBS2, SEC61G, HLA-DRA

1.68E-01

KEGG_PATHWAY

hsa05332:Graft-versus-host disease

1.48E-04

HLA-DQB1, IL6, CD80, IL1B, HLA-DPB1, HLA-DMB, HLA-DQA1, HLA-DRA

1.91E-01

KEGG_PATHWAY

hsa05020:Prion diseases 1.48E-0

4 NCAM1, C1QA, C7, C1QB, IL6, IL1B, CCL5, C1QC

1.91E-01

KEGG_PATHWAY


1.89E-04

HLA-DQB1, PTPRC, CLDN7, CLDN11, HLA-DMB, PDCD1LG2, HLA-DQA1, VCAM1, NCAM1, CD80, ITGAV, PECAM1, CD2, HLA-DPB1, CD226, HLA-DRA

2.43E-01

KEGG_PATHWAY


4

PIK3CG, HLA-DQB1, TLR2, TLR4, MAPK10, HLA-DMB, HLA-DQA1, TGFB2, HSPA2, LAMC3, IL10RA, HLA-DPB1, PIK3R3, HLA-DRA

4.30E-01

KEGG_PATHWAY


4.39E-04

PIK3CG, CTSK, IL6, CD80, TLR1, TLR2, IL1B, TLR4, MAPK10, CCL5, PIK3R3, CCL4, SPP1

5.65E-01

KEGG_PATHWAY


4

PIK3CG, COL4A2, VAV3, FLT1, COL4A1, IGF1, MAPK10, CAPN2, FLNA, KDR, VCL, CCND1, LAMC3, ITGAV, COL6A3, COL1A1, PIK3R3, THBS2, SPP1

6.22E-01

KEGG_PATHWAY

hsa04672:Intestinal immune network for IgA production

1.41E-03

HLA-DQB1, IL6, CD80, CXCR4, HLA-DPB1, HLA-DMB, HLA-DQA1, HLA-DRA

1.81E+00

KEGG_PATHWAY

hsa05164:Influenza A 1.62E-0

3 PIK3CG, HLA-DQB1, TMPRSS2, IL6, CCL2, TLR4, MAPK10, HLA-DMB, CCL5, HLA-DQA1,

2.08E+00

HSPA2, IL1B, HLA-DPB1, DNAJC3, PIK3R3, HLA-DRA

KEGG_PATHWAY


3.42E-03

HLA-DQB1, C1QA, C7, C1QB, HIST1H2BM, CD80, HIST1H3B, FCGR2A, HLA-DPB1, HLA-DMB, C1QC, HLA-DQA1, HLA-DRA

4.32E+00

KEGG_PATHWAY

hsa04940:Type I diabetes mellitus 3.83E-0

3 HLA-DQB1, CD80, IL1B, HLA-DPB1, HLA-DMB, HLA-DQA1, HLA-DRA

4.84E+00

KEGG_PATHWAY


4.20E-03

COL4A2, COL4A1, CD36, CD44, LAMC3, ITGAV, COL6A3, COL1A1, THBS2, SPP1

5.29E+00

KEGG_PATHWAY


3 HLA-DQB1, CD55, CCND1, CD80, HLA-DPB1, HLA-DMB, HLA-DQA1, HLA-DRA

5.49E+00

KEGG_PATHWAY

hsa04668:TNF signaling pathway 4.73E-0

3 PIK3CG, CXCL1, VCAM1, IL6, CCL2, CCL20, EDN1, IL1B, MAPK10, CCL5, PIK3R3

5.94E+00

KEGG_PATHWAY


3

PIK3CG, LUM, TLR2, IGF1, TLR4, DCN, MMP2, IQGAP1, FLNA, FZD7, KDR, TGFB2, CCND1, CD44, ITGAV, PIK3R3

6.99E+00

KEGG_PATHWAY

hsa04612:Antigen processing and presentation

6.14E-03

HLA-DQB1, HSPA2, IFI30, CTSS, HLA-DPB1, HLA-DMB, HLA-DQA1, CD74, HLA-DRA

7.65E+00

KEGG_PATHWAY

hsa05162:Measles 8.04E-0

3 PIK3CG, IL6, SH2D1A, CD3G, HSPA2, CD3E, TLR2, IL1B, IL2RG, TLR4, PIK3R3, CLEC4M

9.90E+00

KEGG_PATHWAY

hsa04750:Inflammatory mediator regulation of TRP channels

8.55E-03

PIK3CG, PLA2G4A, IL1RAP, F2RL1, PRKCH, IGF1, IL1B, MAPK10, PLCB1, PIK3R3

1.05E+01

KEGG_PATHWAY

hsa05330:Allograft rejection 1.03E-0

2 HLA-DQB1, CD80, HLA-DPB1, HLA-DMB, HLA-DQA1, HLA-DRA

1.26E+01

KEGG_PATHWAY


2 LPL, CD36, OLR1, FABP4, ACSL4, PLTP, PCK1, ANGPTL4

1.28E+01

KEGG_PATHWAY

hsa04666:Fc gamma R-mediated phagocytosis

1.11E-02

PIK3CG, PTPRC, DOCK2, VAV3, GSN, HCK, FCGR2A, INPP5D, PIK3R3

1.34E+01

KEGG_PATHWAY


1.23E-02

C1QA, C3AR1, C7, C1QB, CR1, CD55, F8, C1QC 1.48E

+01 KEGG_PATHWAY

hsa05134:Legionellosis 1.31E-0

2 CXCL1, CR1, IL6, HSPA2, TLR2, IL1B, TLR4

1.57E+01

KEGG_PATHWAY


1.40E-02

FGFR2, PIK3CG, COL4A2, IL6, COL4A1, FLT1, TLR2, IGF1, TLR4, KDR, PCK1, G6PC, CCND1, LAMC3, ITGAV, COL6A3, IL2RG, COL1A1, PIK3R3, THBS2, SPP1, CSF1R

1.67E+01

KEGG_PATHWAY


2

PIK3CG, GNA13, PLA2G4A, RASGRP1, FCGR2A, COL1A1, PRKG1, PLCB1, PIK3R3, APBB1IP, LCP2

2.09E+01

KEGG_PATHWAY


1.99E-02

PIK3CG, CTSK, NCF2, ACP5, IL1B, FCGR2A, MAPK10, PIK3R3, CSF1R, TGFB2, LCP2

2.28E+01

KEGG_PATHWAY

hsa05310:Asthma 1.99E-0

2 HLA-DQB1, HLA-DPB1, HLA-DMB, HLA-DQA1, HLA-DRA

2.29E+01

KEGG_PATHWAY

hsa04066:HIF-1 signaling pathway 2.60E-0

2 PIK3CG, IL6, FLT1, PFKFB3, EDN1, IGF1, TLR4, PIK3R3, TIMP1

2.88E+01

KEGG_PATHWAY

hsa00051:Fructose and mannose metabolism

2.77E-02

GMPPB, PFKFB3, ALDOC, AKR1B10, AKR1B1 3.04E

+01 KEGG_PATHWAY

hsa05143:African trypanosomiasis 3.07E-0

2 VCAM1, IL6, F2RL1, IL1B, PLCB1

3.31E+01

KEGG_PATHWAY

hsa04660:T cell receptor signaling pathway

3.20E-02

PIK3CG, ITK, PTPRC, VAV3, CD3G, CD3E, RASGRP1, PIK3R3, LCP2

3.43E+01

KEGG_PATHWAY

hsa04664:Fc epsilon RI signaling pathway

3.44E-02

PIK3CG, PLA2G4A, VAV3, INPP5D, MAPK10, PIK3R3, LCP2

3.64E+01

KEGG_PATHWAY

hsa05320:Autoimmune thyroid disease

3.71E-02

HLA-DQB1, CD80, HLA-DPB1, HLA-DMB, HLA-DQA1, HLA-DRA

3.86E+01

KEGG_PATHWAY


2 PIK3CG, G6PC, IL6, CCND1, GADD45G, IGF1, MAPK10, PIK3R3, TGFB2, PCK1

4.92E+01

KEGG_PATHWAY

hsa05133:Pertussis 5.48E-0

2 C1QA, C1QB, IL6, IL1B, TLR4, MAPK10, C1QC

5.17E+01

KEGG_PATHWAY

hsa04973:Carbohydrate digestion and absorption

6.53E-02

PIK3CG, G6PC, ATP1B3, SLC5A1, PIK3R3 5.82E

+01

KEGG_PATHWAY

hsa05168:Herpes simplex infection

6.79E-02

HLA-DQB1, IL6, CCL2, TLR2, IL1B, MAPK10, HLA-DPB1, HLA-DMB, CCL5, HLA-DQA1, CD74, HLA-DRA

5.97E+01

KEGG_PATHWAY


6.82E-02

GNA13, ACTG2, PLA2G4A, AVPR1A, PRKCH, CALCRL, PRKG1, PLCB1, CACNA1C

5.98E+01

KEGG_PATHWAY


2

GNA13, FGFR2, PIK3CG, COL4A2, RET, IL6, COL4A1, IGF1, MAPK10, MMP2, FZD7, TGFB2, EDNRB, CCND1, CXCR4, LAMC3, ITGAV, RASGRP1, PLCB1, PIK3R3, CSF1R

6.58E+01

KEGG_PATHWAY

hsa04015:Rap1 signaling pathway 8.12E-0

2

FYB, FGFR2, PIK3CG, FLT1, SIPA1L2, FPR1, IGF1, APBB1IP, KDR, PIK3R3, PLCB1, LCP2, CSF1R

6.65E+01

KEGG_PATHWAY


2 CXCL1, IL6, IL1B, TLR4, MAPK10, CCL4, FLNA

6.65E+01

KEGG_PATHWAY

hsa05166:HTLV-I infection 8.15E-0

2

HLA-DQB1, PIK3CG, IL6, CD3G, CD3E, HLA-DMB, FZD7, HLA-DQA1, TGFB2, VCAM1, IL2RG, HLA-DPB1, PIK3R3, TP53INP1, HLA-DRA

6.66E+01

KEGG_PATHWAY

hsa04630:Jak-STAT signaling pathway

8.20E-02

PIK3CG, IL6, CCND1, SOCS2, IL10RA, PIM1, LIFR, IL2RG, PIK3R3, IL13RA2

6.68E+01

KEGG_PATHWAY

hsa04144:Endocytosis 8.69E-0

2

FGFR2, RET, FLT1, PSD3, ADRBK2, KDR, TGFB2, RAB31, HSPA2, FOLR2, CXCR4, SPG20, IL2RG, EHD3, CSF1R

6.91E+01

KEGG_PATHWAY


2 PIK3CG, COL4A2, CCND1, COL4A1, LAMC3, ITGAV, PIK3R3

6.99E+01

KEGG_PATHWAY


9.62E-02

PIK3CG, SOCS2, MAPK10, PIK3R3, CACNA1C 7.29E

+01 KEGG_PATHWAY

hsa04931:Insulin resistance 9.84E-0

2 PIK3CG, G6PC, IL6, CD36, GFPT1, MAPK10, PIK3R3, PCK1

7.37E+01

AEBP1-FOSB repression program


GOTERM_BP_DIRECT


9.34E-15

CYP3A5, CYP3A7, SLC44A3, HMGCR, ACSS2, FDFT1, APOA4, GSTM1, GSTM3, ASPA, PTGIS, CYP7A1, SULT1A1, ELOVL2, SULT1A2, DAO, ELOVL6, NQO1, PDPR, CYP1A1, ABCB11,

1.63E-11

CA12, HAL, CYP26A1, CYP1A2, PLCE1, SULT1B1, AKR1B10, PLA2G2A, MVK, EXT1, ME1, ACADSB, GLUD1, PPP1R3C, CSAD, DHODH, B3GNT3, LPL, KCNB1, SCD, UPB1, ACACA, FDPS, ABCB1, ABCB4, CYP17A1, ABCG5, DIO1, CACNA1C, PLA2G4C, CACNA1D, IMPA2, CYP2C19, CYP3A43, GPC4, GPC3, CYP39A1, NT5E, DDC, PIK3C2G, PFKP, STXBP1, LPIN2, FOLH1, DGAT2, HAO2, PKLR, RPS4Y1, PPM1L, UROC1, OAT, GSTP1, PLA2G5, BCAT1, FMOD, LUM, AASS, DCN, SLC19A2, GLS2, TYMS, DHCR7, FASN, ENO3, PRKAA2, ACSL4, HBB, MT1H, MT1G, EBP, GSTA3, CYP21A2, FADS1, AMACR, NAT2, FADS2, ACLY, INMT, MT1X, AMPD1, AMDHD1, ACSM1, MBOAT1, LIPG, SLC5A6, GPT

GOTERM_BP_DIRECT


5.01E-12

FMOD, A2M, ADAMTSL2, LTBP3, LUM, NPNT, COL3A1, MMP7, ITGB3, DCN, MMP2, TGFB2, VCAM1, SMOC2, TNFRSF11B, ITGB8, ITGAV, TGFBI, COL6A3, COL12A1, SPP1, COL4A2, LGALS3, EFEMP1, FBN1, ITGA2, ITGA3, NID2, TMPRSS6, LAMA2, CTSK, FBLN1, LAMA3, ITGA6, COL1A2, COL1A1

8.78E-09

GOTERM_BP_DIRECT


9.28E-09

CYP3A5, GSTA3, CYP3A7, CYP2C19, CYP1A1, CYP21A2, NAT2, CYP26A1, CYP1A2, ACSS2, CYP3A43, GSTM1, CYP17A1, ACSM1, GSTM3, CYP39A1, PTGIS, SULT1B1, SULT1A1, CYP7A1, SULT1A2, NQO1, GSTP1

1.63E-05

GOTERM_BP_DIRECT


7.59E-08

ME1, CYP3A7, CYP2C19, HMGCR, UTY, GLUD1, DNAJC10, OSGIN2, AASS, FDFT1, VCAM1, CYP3A43, GPX2, FMO4, AKR1C2, CYP39A1, PTGIS, CYP7A1, ALDH1A3, DHCR7, DHODH, DAO, LOXL4, NQO1, PDPR, CYP1A1, CYP21A2, FADS1, SCD, F8, FADS2, CYP26A1, CYP1A2, MOXD1, DHRS7, CYP4X1, CYP17A1, AKR1B10, CYBRD1, ABCC4, DIO1, STEAP2

1.33E-04

GOTERM_BP_DIRECT

GO:0006695~cholesterol biosynthetic process

1.25E-06

APOA4, EBP, HMGCR, DHCR7, FDPS, ACLY, MVK, CFTR, PRKAA2, FDFT1

2.19E-03

GOTERM_BP_DIRECT


1.86E-06

COL4A2, A2M, COL3A1, FBN1, MMP7, DCN, MMP2, CTSK, LAMA3, GSN, CAPG, COL6A3, COL1A2, COL12A1, COL1A1, SPP1

3.26E-03

GOTERM_BP_DIRECT


3.16E-06

ME1, CYP1A1, HMGCR, FADS1, SCD, AMACR, ACACA, ACLY, LPIN2, FDFT1, ABCB4, DGAT2, CYP7A1, HAO2, ELOVL2, FASN, ELOVL6, PRKAA2, ACSL4

5.53E-03

GOTERM_BP_DIRECT


5

CTNNAL1, IL32, ITGB3, FER, CDH6, VCAM1, ITGB8, GP1BB, ROBO1, FAP, ITGAV, TGFBI, COL6A3, COL12A1, SSX2IP, ENTPD1, THBS2,

2.08E-02

SPP1, DPT, SVEP1, LGALS4, ITGA2, NID2, GRHL2, EPHA3, LAMA2, EPHA4, LAMA3, CX3CR1, CDH11

GOTERM_BP_DIRECT


1.53E-05

FMOD, LUM, COL3A1, COL1A2, COL12A1, COL1A1, ANXA2, TGFB2, DPT

2.68E-02

GOTERM_BP_DIRECT


2.34E-05

LPL, MOGAT1, DGAT2, SCD, ELOVL2, ACACA, FASN, ACLY, ELOVL6, ACSL4, LPIN2

4.09E-02

GOTERM_BP_DIRECT


5

KIF4A, A2M, CD244, F13A1, PDE11A, ITGB3, PRKG1, TTN, TGFB2, SERPINE2, GP1BB, ITGAV, PDE1A, FCER1G, ENTPD1, HBB, PLAT, F8, ITGA2, PDE3A, DGKH, ITGA3, ANXA5, FLNA, ITGA6, PDE5A, HIST1H3A, COL1A2, ABCC4, COL1A1, SELE, HIST1H3I

7.18E-02

GOTERM_BP_DIRECT


5

VCAM1, ITGA6, CD34, ITGB8, ITGAV, NPNT, COL3A1, ITGA2, ITGA3, NID2, ADAMTS12, ITGB3

1.29E-01

GOTERM_BP_DIRECT

GO:0007568~aging 1.07E-0

4

CYP1A1, LITAF, HMGCR, CRYAB, COL3A1, MMP7, DCN, WRN, VCAM1, EDNRA, TYMS, GSN, CCR2, ADRA1A, ENO3, NQO1

1.88E-01

GOTERM_BP_DIRECT


1.66E-04

CYP3A5, AKR1C2, CYP17A1, UGT2B17, CYP2C19, SULT1B1, CYP21A2, AKR1B10, SULT1A2

2.91E-01

GOTERM_BP_DIRECT


4

FGFR2, KIF4A, ENAH, EFNA1, COL3A1, ITGB3, MMP2, TGFB2, RASGRP3, ROBO1, ITGAV, COL6A3, CD24, TRPC1, FLRT2, COL4A2, CAP2, ROCK2, NFASC, FGF23, ITGA2, DPYSL3, SLIT2, EPHA3, LAMA2, EPHA4, PDGFRA, PDGFRB, CACNA1C, EXT1, CACNA1D

7.65E-01

GOTERM_BP_DIRECT


5.26E-04

GLS2, FOLH1, ASPA, GLUD1, GPT, OAT 9.16E-

01 GOTERM_BP_DIRECT


5.36E-04

APOA4, LPL, ACSM1, ABCG5, DGAT2, CYP7A1, LIPG, PCSK9, CD24

9.34E-01

GOTERM_BP_DIRECT


7.22E-04

GSN, CYP1A2, MT1H, MT1X, MT1G 1.26E

+00

GOTERM_BP_DIRECT

GO:0055085~transmembrane transport

1.02E-03

FXYD1, FXYD2, SLC16A14, TUSC3, GABRB3, SLC15A1, SLC44A3, SLC39A10, SLC16A10, SLC22A15, NEDD4L, SLC2A9, TRPC1, ABCA10, SLCO4C1, SLC12A2, TRPM7, SLC22A7, SLC6A12, ABCB1, CFTR, ABCB4, ATP6V1C1, ABCG5, SLC17A3, SLC17A1, SLC7A1, CYBRD1, SLC5A9, ABCC4, SLC5A6, SLC38A1, SLC25A18, ABCC6

1.76E+00

GOTERM_BP_DIRECT

GO:0031325~positive regulation of cellular metabolic process

1.20E-03

PKLR, ACACA, FASN, ACLY 2.07E



1.20E-03

VCAM1, CYP1A1, SULT1A1, INMT 2.07E


GO:0035338~long-chain fatty-acyl-CoA biosynthetic

1.21E-03

SCD, ELOVL2, ACACA, FASN, ACLY, ELOVL6, ACSL4

2.09E+00

process

GOTERM_BP_DIRECT


3

NAT8, LPL, CYP1A1, MMP7, ITGA2, PDE3A, ABCB1, ITGA3, ATR, TGFB2, ABCB4, TYMS, CYP17A1, TNFRSF11B, ABCG5, DHODH, ADRA1A, ENO3, COL1A1, ABCC6, VLDLR

2.31E+00

GOTERM_BP_DIRECT


1.39E-03

COL4A2, CTSK, COL3A1, COL6A3, COL1A2, MMP7, COL12A1, COL1A1, MMP2

2.41E+00

GOTERM_BP_DIRECT


1.52E-03

MARCO, COL4A2, COL3A1, SUSD2, COL1A2, LOXL4, COL1A1, IGKC, PLA2R1, HBB, TMPRSS3, CD163, VLDLR

2.63E+00

GOTERM_BP_DIRECT


1.98E-03

COL4A2, ROCK2, CCR2, SULF1, CX3CR1, DCN, THBS2, CXCL10

3.41E+00

GOTERM_BP_DIRECT

GO:0007584~response to nutrient 2.47E-0

3 VCAM1, TNFRSF11B, ABCG5, HMGCR, PKLR, LIPG, ACSL4, NQO1, VLDLR

4.25E+00

GOTERM_BP_DIRECT


2.67E-03

FBLN1, ITGA6, ITGB8, ITGAV, COL3A1, FCER1G, ITGA2, ITGA3, ITGB3

4.58E+00

GOTERM_BP_DIRECT


2.67E-03

A2M, F13A1, F8, STXBP1, ABCC4, ITGB3, TTN, FLNA, TGFB2

4.58E+00

GOTERM_BP_DIRECT

GO:0016125~sterol metabolic process

2.76E-03

CYP17A1, CYP39A1, LIPA, CYP21A2, CYP7A1 4.73E


GO:0006636~unsaturated fatty acid biosynthetic process

3.30E-03

FADS1, SCD, ELOVL2, FADS2 5.63E



3.30E-03

FGFR2, ITGA2, ITGA3, ITGB3 5.63E

+00

GOTERM_BP_DIRECT


3.67E-03

FGFR2, HMGCR, NPNT, CCL19, FGF23, EDNRA, CCL21, PDGFRA, PLA2G2A, PDGFRB, ADRA1A, PDGFD, PLA2G5

6.23E+00

GOTERM_BP_DIRECT

GO:0018958~phenol-containing compound metabolic process

4.79E-03

CYP17A1, SULT1B1, SULT1A2 8.06E


GO:0019557~histidine catabolic process to glutamate and formate

4.79E-03

AMDHD1, HAL, UROC1 8.06E

+00

GOTERM_BP_DIRECT

GO:0019556~histidine catabolic process to glutamate and formamide

4.79E-03


+00

GOTERM_BP_DIRECT

GO:1903825~organic acid transmembrane transport

4.79E-03


+00

GOTERM_BP_DIRECT

GO:0034765~regulation of ion transmembrane transport

5.08E-03

KCNJ16, KCNJ15, TMEM37, KCND3, CACNA2D1, KCNJ8, KCNB1, KCNK5, CLIC6, NEDD4L

8.54E+00

GOTERM_BP_DIRECT

GO:0008610~lipid biosynthetic process

5.48E-03

ACLY, PRKAA2, ACSL4, ACSS2 9.18E


GO:0006633~fatty acid biosynthetic process

5.58E-03

LPL, ACSM1, ACACA, FASN, ACLY, PRKAA2 9.33E

+00

GOTERM_BP_DIRECT


6.23E-03

BCAT1, DDC, ACADSB, GLUD1, HAL, AASS, INMT, GLS2, AMDHD1, ASPA, FOLH1, CSAD, RPS4Y1, GPT, DAO, UROC1, DIO1, NQO1, OAT

1.04E+01

GOTERM_BP_DIRECT


3 CD244, ITGA6, CD34, ITGAV, COL1A2, FCER1G, ITGA3, COL1A1, ITGB3, SELE

1.06E+01

GOTERM_BP_D GO:0006766~vitamin metabolic 6.68E-0 APOA4, GPC4, LPL, PTGIS, GPC3, AKR1B10, 1.11E

IRECT process 3 ACACA, FASN, CYP26A1, SLC5A6, SLC19A2 +01 GOTERM_BP_DIRECT


7.07E-03

COL4A2, LAMA3, ITGAV, COL12A1, MMP2 1.17E



7.18E-03

SLC17A3, SLC12A2, SLC17A4, SLC38A6, SLC5A9, SLC5A6, NEDD4L, SLC38A1

1.18E+01

GOTERM_BP_DIRECT

GO:0007507~heart development 7.47E-0

3

MRE11A, FBN1, COL3A1, ITGA3, BICC1, DNAH5, TGFB2, VCAM1, EDNRA, PLCE1, KCNJ8, ADAM19, VLDLR

1.23E+01

GOTERM_BP_DIRECT

GO:0048008~platelet-derived growth factor receptor signaling pathway

9.14E-03

PLAT, PDGFRA, PDGFRB, PDGFD, FER 1.49E

+01

GOTERM_BP_DIRECT


9.27E-03

KCNB1, PKLR, ACACA, FASN, STXBP1, ACLY, PRKAA2, CACNA1C, CACNA1D

1.51E+01

GOTERM_BP_DIRECT


2

A2M, F13A1, COL3A1, F8, DGKH, ITGB3, TTN, FLNA, TGFB2, GP1BB, COL1A2, ABCC4, FCER1G, COL1A1

1.68E+01

GOTERM_BP_DIRECT


2

PIK3C2G, USP9Y, EFNA1, ITGAV, WWC1, PDGFRB, ENPEP, ADAMTS12, CD24, ITGB3, TGFB2, EPHA3

1.73E+01

GOTERM_BP_DIRECT

GO:0009812~flavonoid metabolic process

1.15E-02

CYP1A1, SULT1B1, SULT1A1 1.84E


GO:0042737~drug catabolic process

1.15E-02

FMO4, CYP3A5, CYP1A2 1.84E



1.15E-02



GO:0060763~mammary duct terminal end bud growth

1.15E-02

SLC12A2, ROBO1, SLIT2 1.84E


GO:0006855~drug transmembrane transport

1.20E-02

EBP, SLC17A3, ABCB1, ABCB4 1.90E

+01

GOTERM_BP_DIRECT


1.31E-02

COL4A2, FBN1, CX3CR1, PDE3A, PDGFD, COL1A1

2.06E+01

GOTERM_BP_DIRECT


1.41E-02

ITGA6, ITGAV, ITGA2, ITGB3 2.20E



1.43E-02

PODN, CCR2, SULF1, CX3CR1, DPYSL3, TPM1, SLIT2, THY1

2.23E+01

GOTERM_BP_DIRECT

GO:0006749~glutathione metabolic process

1.54E-02

GSTM1, NAT8, GSTA3, GSTM3, CLIC6, GSTP1 2.38E


GO:0006548~histidine catabolic process

1.58E-02



GO:0072089~stem cell proliferation

1.58E-02

RNF43, CD34, ABCB1 2.44E



1.63E-02

GPC3, MT1H, MT1X, MT1G 2.51E



1.70E-02

EBP, TNFRSF11B, LGALS3, COL3A1, FBN1, COL1A2, COL12A1, COL1A1, EXT1, CDH11

2.60E+01

GOTERM_BP_DIRECT


1.88E-02

CKAP2, STMN2, MID1IP1, HDGFRP3 2.83E

+01 GOTERM_BP_D GO:0061337~cardiac conduction 1.99E-0 FXYD1, TRPC1, FXYD2, KCND3, CACNA2D1, 2.96E

IRECT 2 KCNE1, CACNA1C, CACNA1D +01 GOTERM_BP_DIRECT

GO:0044341~sodium-dependent phosphate transport

2.07E-02



GO:0035385~Roundabout signaling pathway

2.07E-02

FMOD, ROBO1, SLIT2 3.06E



2 COL3A1, PDGFRA, PDGFRB, DCN, ITGB3, TPM1, TGFB2

3.10E+01

GOTERM_BP_DIRECT


2.15E-02

NEDD4L, MT1H, MT1X, MT1G 3.17E


GO:0006699~bile acid biosynthetic process

2.15E-02

CYP39A1, ABCB11, CYP7A1, AMACR 3.17E



2.32E-02

HIST1H4L, HIST1H3A, S100A10, ANXA2, HIST1H3I

3.37E+01

GOTERM_BP_DIRECT

GO:0001580~detection of chemical stimulus involved in sensory perception of bitter taste

2.32E-02

RTP3, TAS2R13, TAS2R50, TAS2R4, PIGR 3.37E

+01

GOTERM_BP_DIRECT


2.53E-02

EFNA1, ITGAV, FER, ITGB3, ANTXR1 3.61E

+01

GOTERM_BP_DIRECT


2

FGFR2, COL4A2, EFNA1, ENPEP, TMPRSS6, MMP2, THY1, TGFB2, ANXA2, SRPX2, FAP, ITGAV, TGFBI

3.70E+01

GOTERM_BP_DIRECT

GO:0051923~sulfation 2.61E-0

2 SULT1B1, SULT1A1, SULT1A2

3.71E+01

GOTERM_BP_DIRECT

GO:0097267~omega-hydroxylase P450 pathway

2.61E-02

CYP1A1, CYP2C19, CYP1A2 3.71E


GO:0043589~skin morphogenesis 2.61E-0

2 COL1A2, ITGA2, COL1A1

3.71E+01

GOTERM_BP_DIRECT

GO:0006813~potassium ion transport

2.64E-02

KCNJ16, KCNJ15, KCND3, SLC12A2, KCNJ8, KCNK5, KCNN2

3.74E+01

GOTERM_BP_DIRECT

GO:0036152~phosphatidylethanolamine acyl-chain remodeling

2.75E-02

MBOAT1, PLA2G2A, PLA2G4C, PLA2G5 3.86E


GO:0072661~protein targeting to plasma membrane

2.75E-02

TESC, KCNB1, NFASC, ANXA2 3.86E


GO:0070527~platelet aggregation 2.75E-0

2 PDGFRA, STXBP1, ITGB3, HBB, FLNA

3.86E+01

GOTERM_BP_DIRECT

GO:0030324~lung development 2.78E-0

2 FGFR2, GPC3, LIPA, DHCR7, HEG1, ITGA3, CYP1A2

3.90E+01

GOTERM_BP_DIRECT

GO:0006644~phospholipid metabolic process

3.16E-02

LPL, PLCE1, PIK3C2G, SLC44A3, DGAT2, MBOAT1, PLA2G2A, PCSK9, LPIN2, PLA2G4C, PLA2G5

4.30E+01

GOTERM_BP_DIRECT


3.20E-02

ALDH1A3, EFEMP1, FBN1 4.34E


GO:0046415~urate metabolic process

3.20E-02



GO:0042416~dopamine biosynthetic process

3.20E-02

DDC, DAO, TGFB2 4.34E


GO:0045839~negative regulation of mitotic nuclear division

3.20E-02

FGFR2, TOM1L1, CHEK1 4.34E

+01

GOTERM_BP_DIRECT

GO:0006164~purine nucleotide biosynthetic process

3.20E-02

OAS1, OAS2, NT5E 4.34E



2 EDNRA, PLAT, VCAM1, CYP1A1, CRYAB, PKLR, ITGA2, CD24, MMP2, TGFB2, DDIT4

4.52E+01

GOTERM_BP_DIRECT


3.47E-02

FBLN1, PTGIS, SERPINE2, MMP2, SPP1 4.61E

+01

GOTERM_BP_DIRECT

GO:0008283~cell proliferation 3.47E-0

2

BCAT1, LIPA, CYP1A1, MRE11A, ITGA2, ENPEP, FER, GRHL2, HDGFRP3, DDIT4, TGFB2, GPC4, EDNRA, TYMS, PLCE1, CD34, TGFBI, LIPG

4.61E+01

GOTERM_BP_DIRECT


3.60E-02

EDNRA, VCAM1, TNFRSF11B, CYP1A1, KCNJ8, CCR2, FER, DCN, CYP1A2, S100A14, SELE

4.74E+01

GOTERM_BP_DIRECT


3.78E-02

ASPN, FLRT2, PODN, PPP1R1A, DCN, GSTP1, THY1

4.91E+01

GOTERM_BP_DIRECT


2 VCAM1, CCL21, PDGFRA, PDGFRB, CCL28

5.11E+01

GOTERM_BP_DIRECT


4.10E-02

IFIT3, APOBEC3B, FCN3, KCNJ8, IFI44L, OAS1, OAS2, GBP3, DDIT4, CXCL10

5.19E+01

GOTERM_BP_DIRECT


4.14E-02

LGALS3, CCL21, FCER1G, CCL19, SPP1, TGFB2

5.23E+01

GOTERM_BP_DIRECT

GO:0010976~positive regulation of neuron projection development

4.16E-02

SERPINE2, STMN2, ENC1, DPYSL3, ITGA3, GPRC5B, EPHA3

5.24E+01

GOTERM_BP_DIRECT


4.17E-02

APOA4, VCAM1, NT5E, SELE 5.26E

+01

GOTERM_BP_DIRECT


2

IL1R2, SUSD2, CCL19, IL32, IFI44L, CCL28, C1QC, PDCD1LG2, CXCL10, TNFRSF11B, CCL21, CCR2, CD4, IGKC, DEFB1, GBP2, IFI6

5.42E+01

GOTERM_BP_DIRECT


4.52E-02

SERPINE2, CD34, ANXA5 5.55E



2 EDNRA, CD34, SULF1

5.55E+01

GOTERM_BP_DIRECT

GO:0008299~isoprenoid biosynthetic process

4.52E-02

HMGCR, MVK, FDFT1 5.55E


GO:0090399~replicative senescence

4.52E-02

CHEK1, ATR, PLA2R1 5.55E


GO:0035435~phosphate ion transmembrane transport

4.52E-02



GO:0055003~cardiac myofibril assembly

4.52E-02

PDGFRA, PDGFRB, TTN 5.55E


GO:0006206~pyrimidine nucleobase metabolic process

4.57E-02

TYMS, UPB1, DHODH, NT5E 5.59E

+01

GOTERM_BP_DIRECT

GO:0006810~transport 4.95E-0

2

LAPTM4B, FXYD2, GABRE, SLC15A1, SLC12A2, GABRB3, ABCB11, SLC6A12, CFTR, ABCB1, SEC14L4, ABCB4, SLC7A1, SLC5A6, ABCC6

5.89E+01

GOTERM_BP_DIRECT

GO:0051281~positive regulation of release of sequestered calcium ion into cytosol

5.00E-02

EDNRA, TRPC1, CXCL10, THY1 5.92E

+01

GOTERM_BP_DIRECT


5.22E-02

COL3A1, COL1A2, PDGFD, COL1A1, MMP2 6.09E



5.22E-02

APOA4, GPC4, LPL, GPC3, AKR1B10 6.09E


GO:0033559~unsaturated fatty acid metabolic process

5.24E-02

FADS1, ELOVL2, FADS2 6.10E


GO:0036109~alpha-linolenic acid metabolic process

5.24E-02




5.24E-02

CCL21, PDGFRB, CCL19 6.10E


GO:0010952~positive regulation of peptidase activity

5.24E-02

FBLN1, PCOLCE, PCOLCE2 6.10E



5.38E-02

EDNRA, LPL, CCR2, PLA2G2A, ITGA2, GPRC5B

6.20E+01

GOTERM_BP_DIRECT


5.42E-02

SRPX2, CD34, PKHD1, DSG1, CD24, SLIT2, THY1

6.23E+01

GOTERM_BP_DIRECT

GO:0043552~positive regulation of phosphatidylinositol 3-kinase activity

5.44E-02

CCL21, PDGFRA, PDGFRB, CCL19 6.24E

+01

GOTERM_BP_DIRECT


5.45E-02

CRYAB, PDGFRB, CD4, COL1A1, CYP1A2, NQO1, GSTP1, RBBP8

6.25E+01

GOTERM_BP_DIRECT


2 PIK3C2G, RNASE2, CCR2, CX3CR1, FER, DEFB1, CCL28, CXCL10

6.39E+01

GOTERM_BP_DIRECT

GO:0060282~positive regulation of oocyte development

5.68E-02

PDE5A, PDE3A 6.41E


GO:0046890~regulation of lipid biosynthetic process

5.68E-02

MID1IP1, THRSP 6.41E


GO:0097156~fasciculation of motor neuron axon

5.68E-02

EPHA4, EPHA3 6.41E


GO:0050748~negative regulation of lipoprotein metabolic process

5.68E-02

ITGAV, ITGB3 6.41E



5.68E-02

PROM1, CD24 6.41E

+01

GOTERM_BP_DIRECT

GO:0021836~chemorepulsion involved in postnatal olfactory bulb interneuron migration

5.68E-02

ROBO1, SLIT2 6.41E

+01

GOTERM_BP_DIRECT

GO:2000439~positive regulation of monocyte extravasation

5.68E-02

CCR2, PDGFD 6.41E


GO:0035759~mesangial cell-matrix adhesion

5.68E-02

CD34, CCL21 6.41E


GO:0043651~linoleic acid metabolic process

6.00E-02




6.00E-02

MARCO, ITGAV, TGM2 6.62E



6.08E-02

LIPG, PDE3A, MID1IP1, ACSL4, LPIN2, THRSP, TM6SF2, ABCB4

6.67E+01

GOTERM_BP_DIRECT


6.08E-02

FGFR2, EPHA4, EFEMP1, PDGFRA, PDGFRB, FER, TTN, EPHA3

6.67E+01

GOTERM_BP_D GO:0070588~calcium ion 6.30E-0 TRPC1, TMEM37, CACNA2D1, TRPM7, ITGAV, 6.80E

IRECT transmembrane transport 2 ANXA5, CACNA1C, CACNA1D +01 GOTERM_BP_DIRECT

GO:1901687~glutathione derivative biosynthetic process

6.37E-02

GSTM1, GSTA3, GSTM3, GSTP1 6.84E

+01

GOTERM_BP_DIRECT


2

SLC15A1, SLC12A2, SLC16A10, SLC7A1, SLC22A15, SLC6A12, SLC17A1, AKAP7, SLC38A1

6.91E+01

GOTERM_BP_DIRECT


6.75E-02

EDNRA, PLCE1, CCR2, PDGFRA, ADRA1A, CD24, CACNA1C, CCL28

7.06E+01

GOTERM_BP_DIRECT

GO:0050730~regulation of peptidyl-tyrosine phosphorylation

6.80E-02

EFNA1, PDGFRB, PDGFD 7.08E



6.80E-02

CCR2, S100A14, CXCL10 7.08E



6.80E-02

CCL21, CCR2, CCL19 7.08E

+01

GOTERM_BP_DIRECT

GO:0045956~positive regulation of calcium ion-dependent exocytosis

6.80E-02

KCNB1, STXBP1, SYT7 7.08E

+01

GOTERM_BP_DIRECT

GO:1901379~regulation of potassium ion transmembrane transport

6.80E-02

KCNN2, KCNE1, CACNA1D 7.08E

+01

GOTERM_BP_DIRECT


6.86E-02

ITGA2, RAB25, ITGA3, TGFB2 7.12E


GO:0046474~glycerophospholipid biosynthetic process

6.90E-02

SLC44A3, DGAT2, MBOAT1, PLA2G2A, LPIN2, PLA2G4C, PLA2G5

7.14E+01

GOTERM_BP_DIRECT

GO:0051591~response to cAMP 6.98E-0

2 CYP17A1, PKLR, PDE3A, COL1A1, PLA2G5

7.18E+01

GOTERM_BP_DIRECT

GO:0017144~drug metabolic process

7.37E-02

FMO4, CYP1A1, CYP2C19, CYP1A2 7.38E


GO:0007585~respiratory gaseous exchange

7.37E-02

EDNRA, COX11, TAS2R4, CFTR 7.38E


GO:0050919~negative chemotaxis 7.37E-0

2 FLRT2, ITGAV, ITGB3, SLIT2

7.38E+01

GOTERM_BP_DIRECT

GO:0006865~amino acid transport

7.37E-02

SLC16A10, SLC7A1, SLC6A12, SLC38A1 7.38E


GO:0034329~cell junction assembly

7.44E-02

LAMA3, ITGA6, GRHL2, FLNA, CDH11, CDH6 7.42E


GO:0060384~innervation 7.62E-0

2 SERPINE2, GABRB3, SULF1

7.51E+01

GOTERM_BP_DIRECT

GO:0055093~response to hyperoxia

7.62E-02

CYP1A1, PDGFRB, COL1A1 7.51E


GO:0036149~phosphatidylinositol acyl-chain remodeling

7.62E-02

PLA2G2A, PLA2G4C, PLA2G5 7.51E


GO:0048545~response to steroid hormone

7.62E-02

CYP17A1, SPP1, PAQR5 7.51E


GO:0019369~arachidonic acid metabolic process

7.76E-02

PTGIS, CYP1A1, CYP2C19, CYP1A2, PLA2G4C 7.57E


GO:0045859~regulation of protein kinase activity

7.90E-02

PLCE1, TTN, ECT2, CXCL10 7.63E

+01

GOTERM_BP_DIRECT


2 APOA4, ACADSB, ACACA, ABCB4

7.63E+01

GOTERM_BP_DIRECT


7.99E-02

LITAF, GOLT1B, CCL21, UNC5CL, CCL19, MALT1, GPRC5B, ECT2, FLNA

7.68E+01

GOTERM_BP_DIRECT


8.03E-02

ASPN, FLRT2, IL1R2, PODN, OAS1, FER, DCN, OAS2, IFIT3, VCAM1, CCR2, KPNA5, IFI6, GBP2

7.69E+01

GOTERM_BP_DIRECT

GO:1901509~regulation of endothelial tube morphogenesis

8.40E-02

ADAMTS12, CXCL10 7.85E



8.40E-02

EFEMP1, FBN1 7.85E

+01

GOTERM_BP_DIRECT

GO:0070458~cellular detoxification of nitrogen compound

8.40E-02

GSTM1, GSTM3 7.85E

+01

GOTERM_BP_DIRECT

GO:0045715~negative regulation of low-density lipoprotein particle receptor biosynthetic process

8.40E-02

ITGAV, ITGB3 7.85E

+01

GOTERM_BP_DIRECT


8.40E-02

PROM1, CD24 7.85E

+01

GOTERM_BP_DIRECT

GO:0050746~regulation of lipoprotein metabolic process

8.40E-02

DGAT2, LIPG 7.85E

+01

GOTERM_BP_DIRECT

GO:0038091~positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

8.40E-02

PDGFRA, PDGFRB 7.85E

+01

GOTERM_BP_DIRECT

GO:0097195~pilomotor reflex 8.40E-0

2 NPNT, ADRA1A

7.85E+01

GOTERM_BP_DIRECT

GO:0097155~fasciculation of sensory neuron axon

8.40E-02

EPHA4, EPHA3 7.85E


GO:0072277~metanephric glomerular capillary formation

8.40E-02

PDGFRA, PDGFRB 7.85E

+01

GOTERM_BP_DIRECT


8.44E-02

ITGA6, LGALS3, ITGAV, GSTP1 7.87E

+01

GOTERM_BP_DIRECT


8.48E-02

CCR2, MALT1, THY1 7.88E


GO:0014850~response to muscle activity

8.48E-02

FNDC5, ITGA2, PRKAA2 7.88E


GO:0036150~phosphatidylserine acyl-chain remodeling

8.48E-02

MBOAT1, PLA2G2A, PLA2G5 7.88E



8.48E-02

MT1H, MT1X, MT1G 7.88E


GO:0006939~smooth muscle contraction

8.48E-02

EDNRA, ROCK2, ADRA1A 7.88E



2 TYMS, ITGAV, ADRA1A, ITGB3, TGFB2

7.92E+01

GOTERM_BP_DIRECT


9.00E-02

FGFR2, HMGCR, PDGFRB, ITGA2, PDGFD 8.08E

+01

GOTERM_BP_DIRECT


9.00E-02

ASPN, FLRT2, TESC, PODN, DCN 8.08E

+01

GOTERM_BP_DIRECT

GO:0007597~blood coagulation, intrinsic pathway

9.36E-02

A2M, GP1BB, F8 8.21E


GO:0019373~epoxygenase P450 pathway

9.36E-02

CYP1A1, CYP2C19, CYP1A2 8.21E



2 AKR1C2, CYP39A1, SLC15A1, AKR1B10, CTSE

8.24E+01

GOTERM_BP_DIRECT

GO:0007266~Rho protein signal transduction

9.44E-02

EDNRA, CTNNAL1, ROCK2, COL1A2, CDC42EP3

8.24E+01

GOTERM_BP_DIRECT


9.57E-02

ASPN, FLRT2, PODN, DCN 8.28E



9.57E-02

SMOC2, NPNT, ITGA3, SPP1 8.28E



9.85E-02

VCAM1, LAIR1, CD34, COL3A1, CLEC2D, COL1A2, COL1A1, IGKC

8.37E+01

GOTERM_BP_DIRECT


9.88E-02

APOA4, GPC4, LPL, GPC3, AKR1B10 8.38E


KEGG_PATHWAY


3.42E-07

CYP3A5, GSTA3, CYP3A7, CYP2C19, CYP1A1, NAT2, CYP1A2, CYP3A43, GSTM1, GSTM3, UGT2B17, SULT1A1, ALDH1A3, SULT1A2, UGT2A3, GSTP1

4.44E-04

KEGG_PATHWAY


1.06E-06

LAMA2, COL4A2, LAMA3, ITGA6, ITGB8, GP1BB, ITGAV, COL3A1, COL6A3, COL1A2, ITGA2, ITGA3, COL1A1, ITGB3, THBS2, SPP1

1.38E-03

KEGG_PATHWAY


4.26E-05

CACNA2D1, ITGA6, ITGB8, ITGAV, ITGA2, ITGA3, PRKAA2, ITGB3, TTN, CACNA1C, CACNA1D, TPM1, TGFB2

5.53E-02

KEGG_PATHWAY

hsa01100:Metabolic pathways 3.03E-0

4

CYP3A5, IMPA2, IMPAD1, COX11, TUSC3, CYP3A7, CYP2C19, HMGCR, ACSS2, FDFT1, ASPA, PTGIS, CYP7A1, DAO, NT5E, DDC, PIK3C2G, CYP1A1, HAL, PFKP, CYP26A1, CYP1A2, LPIN2, ATP6V1C1, FOLH1, PLCE1, UGT2B17, DGAT2, SDS, AKR1B10, PKLR, HAO2, PLA2G2A, UROC1, EXT1, OAT, PLA2G5, BCAT1, ME1, GALNT2, ACADSB, GLUD1, AASS, GLS2, TYMS, POLE2, CSAD, DHCR7, ALDH1A3, ENO3, B3GNT3, UGT2A3, ACSL4, EBP, CYP21A2, UPB1, NAT2, AMACR, FDPS, ACACA, DGKH, ACLY, AMPD1, GLYCTK, AMDHD1, CYP17A1, ACSM1, LIPG, MBOAT1, GPT, PLA2G4C

3.92E-01

KEGG_PATHWAY

hsa04976:Bile secretion 3.08E-0

4

FXYD2, ABCG5, ABCB11, HMGCR, CYP7A1, SLC22A7, KCNN2, ABCC4, ABCB1, CFTR, ABCB4

3.99E-01

KEGG_PATHWAY


3.65E-04

CYP3A5, AKR1C2, CYP17A1, UGT2B17, CYP3A7, CYP1A1, CYP21A2, CYP7A1, CYP1A2, UGT2A3

4.73E-01

KEGG_PATHWAY

hsa05414:Dilated cardiomyopathy 3.85E-0

4

CACNA2D1, ITGA6, ITGB8, ITGAV, ITGA2, ITGA3, ITGB3, TTN, CACNA1C, CACNA1D, TPM1, TGFB2

4.99E-01

KEGG_PATHWAY


4

COL4A2, ROCK2, COL3A1, ITGA2, ITGA3, ITGB3, FLNA, LAMA2, LAMA3, ITGA6, ITGB8, ITGAV, COL6A3, PDGFRA, COL1A2, PDGFRB, COL1A1, PDGFD, THBS2, SPP1

5.33E-01

KEGG_PATHWAY

hsa01212:Fatty acid metabolism 4.71E-0

4 ACADSB, FADS1, SCD, ELOVL2, ACACA, FASN, FADS2, ELOVL6, ACSL4

6.10E-01

KEGG_PATHWAY

hsa00982:Drug metabolism - cytochrome P450

5.44E-04

GSTM1, FMO4, CYP3A5, GSTA3, GSTM3, CYP2C19, ALDH1A3, CYP1A2, GSTP1

7.05E-01

KEGG_PATHWAY

hsa00980:Metabolism of xenobiotics by cytochrome P450

1.06E-03

GSTM1, CYP3A5, AKR1C2, GSTA3, GSTM3, CYP1A1, ALDH1A3, CYP1A2, GSTP1

1.37E+00

KEGG_PATHWAY


3 ABCA10, ABCG5, ABCB11, ABCC4, ABCB1, CFTR, ABCC6, ABCB4

1.82E+00

KEGG_PATHWAY

hsa00340:Histidine metabolism 1.65E-0

3 DDC, AMDHD1, ASPA, ALDH1A3, HAL, UROC1

2.12E+00

KEGG_PATHWAY


1.91E-03

GLYCTK, LPL, MOGAT1, DGAT2, AKR1B10, MBOAT1, LIPG, DGKH, LPIN2

2.45E+00

KEGG_PATHWAY


3.86E-03

BCAT1, HMGCR, FDPS, PFKP, AASS, ACLY, ACSS2, AMPD1, FDFT1, GLYCTK, PGM3, SDS, PKLR, HAO2, ENO3, DAO, MVK, OAT

4.89E+00

KEGG_PATHWAY


5.65E-03

IL1R2, CR1, ITGA6, CD34, GP1BB, ITGA2, CD4, ITGA3, CD24, ITGB3

7.09E+00

KEGG_PATHWAY


6.13E-03

CACNA2D1, ITGA6, ITGB8, ITGAV, ITGA2, ITGA3, ITGB3, CACNA1C, CACNA1D

7.68E+00

KEGG_PATHWAY


6.58E-03

FXYD2, COL4A2, SLC15A1, SLC16A10, COL3A1, KCNK5, COL6A3, COL1A2, COL12A1, COL1A1

8.21E+00

KEGG_PATHWAY


8.10E-03

PPP2R1B, FGFR2, COL4A2, EFNA1, COL3A1, ITGA2, FGF23, ITGA3, ITGB3, DDIT4, LAMA2, LAMA3, ITGA6, ITGB8, ITGAV, COL6A3, COL1A2, PDGFRA, PDGFRB, COL1A1, PRKAA2, PDGFD, THBS2, SPP1

1.00E+01

KEGG_PATHWAY

hsa04978:Mineral absorption 8.43E-0

3 FXYD2, TRPM7, CYBRD1, STEAP2, MT1H, MT1X, MT1G

1.04E+01

KEGG_PATHWAY

hsa01040:Biosynthesis of unsaturated fatty acids

1.12E-02

FADS1, SCD, ELOVL2, FADS2, ELOVL6 1.36E

+01 KEGG_PATHWAY

hsa00591:Linoleic acid metabolism

2.50E-02

CYP2C19, PLA2G2A, CYP1A2, PLA2G4C, PLA2G5

2.80E+01

KEGG_PATHWAY

hsa00830:Retinol metabolism 4.04E-0

2 CYP3A5, UGT2B17, CYP3A7, CYP1A1, CYP26A1, CYP1A2, UGT2A3

4.15E+01

KEGG_PATHWAY

hsa00100:Steroid biosynthesis 4.10E-0

2 EBP, LIPA, DHCR7, FDFT1

4.20E+01

KEGG_PATHW hsa05144:Malaria 4.11E-0 VCAM1, CR1, THBS2, HBB, SELE, TGFB2 4.20E


hsa00250:Alanine, aspartate and glutamate metabolism

4.20E-02

GLS2, FOLH1, ASPA, GLUD1, GPT 4.27E

+01 KEGG_PATHWAY


5.16E-02

PLAT, MBL2, CR1, A2M, F13A1, F8, C1QC 4.98E

+01 KEGG_PATHWAY

hsa04977:Vitamin digestion and absorption

5.24E-02

APOA4, FOLH1, SLC5A6, SLC19A2 5.03E

+01 KEGG_PATHWAY


2 ROCK2, GP1BB, COL3A1, COL1A2, FCER1G, ITGA2, COL1A1, ITGB3, PRKG1, PLA2G4C

5.66E+01

KEGG_PATHWAY

hsa04975:Fat digestion and absorption

6.41E-02

APOA4, ABCG5, DGAT2, PLA2G2A, PLA2G5 5.77E

+01

KEGG_PATHWAY

hsa04810:Regulation of actin cytoskeleton

6.93E-02

FGFR2, ENAH, ITGA6, ROCK2, GSN, ITGB8, ITGAV, PDGFRA, FGF23, PDGFRB, ITGA2, ITGA3, ITGB3, PDGFD

6.07E+01

KEGG_PATHWAY

hsa00592:alpha-Linolenic acid metabolism

7.19E-02

PLA2G2A, FADS2, PLA2G4C, PLA2G5 6.20E

+01 KEGG_PATHWAY

hsa00061:Fatty acid biosynthesis 8.92E-0

2 ACACA, FASN, ACSL4

7.03E+01

KEGG_PATHWAY


9.30E-02

EDNRA, ROCK2, PLA2G2A, ADRA1A, PRKG1, PLA2G4C, CACNA1C, CACNA1D, PLA2G5

7.19E+01

KEGG_PATHWAY

hsa00590:Arachidonic acid metabolism

9.35E-02

GPX2, PTGIS, CYP2C19, PLA2G2A, PLA2G4C, PLA2G5

7.21E+01

KEGG_PATHWAY

hsa04152:AMPK signaling pathway

9.65E-02

PPP2R1B, HMGCR, SCD, ACACA, FASN, PFKP, ADRA1A, CFTR, PRKAA2

7.32E+01

AEBP1-PBX1 program


AEBP1 PBX1 activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1


THBS2


FBLN5


COL1A1


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2


JAG1


PDE1A


RBMS3


MTHFD2


SRPX2


SERPINE2


SMOC2

AEBP1 PBX1 activati CCDC3

on


MMP2


ITGAV


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2


BAMBI


RANBP17


PMP22


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD


PODN


PLP2


CAPG


CACNA1C


CCL21


CHRDL1


KCNA3

AEBP1 PBX1 activati ENPP5

on


FAM38B


S100A14


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1


CYP39A1


GABRB3


PLCE1


GRM8

AEBP1 PBX1 repessing

SDS


CYP3A43


MT1X


IFI44L


TIMD4


OAT


VCAM1


CD163


DNAJC12


MARCO


VSIG4


CR1


PPP1R1A


FCER1G


CD4


P2RY13


C1QC


ACADSB


GPR116


SLC16A10


F8


ODZ3


KCNN2


PDCD1LG2


SLC19A2


ITIH3


CD244

AEBP1 PBX1 repessi EFHD1

ng


KCNJ8


LAIR1


LY86


SUSD4

AEBP1-PBX1 activation program


GOTERM_BP_DIRECT


1.03E-16


1.78E-13

GOTERM_BP_DIRECT


2.44E-09


3.80E-06

GOTERM_BP_DIRECT


1.27E-07


1.98E-04

GOTERM_BP_DIRECT


6


1.81E-03

GOTERM_BP_DIRECT



1.04E-02

GOTERM_BP_DIRECT


8.49E-05


1.33E-01

GOTERM_BP_DIRECT


5.21E-04


01 GOTERM_BP_DIRECT


5.44E-04


01 GOTERM_BP_DIRECT


6.49E-04





1.67E+00

GOTERM_BP_DIRECT


1.18E-03


+00

GOTERM_BP_DIRECT


3


2.12E+00

GOTERM_BP_DIRECT


3.06E-03




6.25E-03




6.90E-03


+01 GOTERM_BP_D GO:0001501~skeletal system 8.94E-0 LGALS3, FBN1, COL12A1, COL1A1, CDH11 1.31E

IRECT development 3 +01 GOTERM_BP_DIRECT



1.58E+01

GOTERM_BP_DIRECT


1.19E-02

PROM1, CD24 1.71E

+01

GOTERM_BP_DIRECT


1.38E-02


+01

GOTERM_BP_DIRECT


1.48E-02


+01

GOTERM_BP_DIRECT


1.65E-02


+01

GOTERM_BP_DIRECT


1.78E-02

EFEMP1, FBN1 2.45E

+01

GOTERM_BP_DIRECT


1.78E-02

PROM1, CD24 2.45E

+01

GOTERM_BP_DIRECT


1.85E-02





2.62E+01

GOTERM_BP_DIRECT


1.98E-02




2.16E-02


+01

GOTERM_BP_DIRECT


2.37E-02

CCL21, CCL19 3.12E

+01

GOTERM_BP_DIRECT


2.49E-02




2.72E-02





3.57E+01

GOTERM_BP_DIRECT


2.95E-02

CCL21, CCL19 3.74E



2 LAMC3, GRM8, LUM, EFEMP1, COL1A1

3.87E+01

GOTERM_BP_DIRECT


3.46E-02


+01

GOTERM_BP_DIRECT


3.46E-02


+01

GOTERM_BP_DIRECT


3.53E-02

CCL21, CCL19 4.30E



4.11E-02

CCL21, CCL19 4.81E

+01 GOTERM_BP_D GO:0072112~glomerular visceral 4.11E-0 PROM1, CD24 4.81E

IRECT epithelial cell differentiation 2 +01

GOTERM_BP_DIRECT


4.11E-02

CCL21, CCL19 4.81E

+01

GOTERM_BP_DIRECT


2 PGM3, JAG1, TGFB2

5.17E+01

GOTERM_BP_DIRECT


4.68E-02

COL1A1, MMP2 5.27E



2 CYP39A1, AKR1B10, CTSE

5.51E+01

GOTERM_BP_DIRECT


5.30E-02




5.81E-02

CCL21, CCL19 6.08E



5.81E-02




5.81E-02

FGFR2, VIM 6.08E



5.81E-02

EFEMP1, FBN1 6.08E



6.27E-02




6.94E-02

FMOD, LUM 6.75E



7.40E-02


+01

GOTERM_BP_DIRECT


7.49E-02

CCL21, TGFB2 7.04E

+01

GOTERM_BP_DIRECT


7.49E-02

CCL21, CCL19 7.04E



7.49E-02

GSN, CAPG 7.04E



8.60E-02

CCL21, CCL19 7.54E



8.60E-02

SRPX2, CD24 7.54E




7.73E+01

GOTERM_BP_DIRECT


9.14E-02

LAMC3, VIM 7.76E



9.14E-02

CCL21, CCL19 7.76E

+01

GOTERM_BP_DIRECT


9.14E-02

LGALS3, THY1 7.76E

+01

GOTERM_BP_DIRECT

GO:0060384~innervation 9.14E-0

2 SERPINE2, GABRB3

7.76E+01

GOTERM_BP_D GO:0032331~negative regulation 9.68E-0 EFEMP1, ADAMTS12 7.96E

IRECT of chondrocyte differentiation 2 +01 Category Term PValue Genes FDR

KEGG_PATHWAY


6


3.46E-03

KEGG_PATHWAY


4.86E-05


5.78E-02

KEGG_PATHWAY


4 CCND1, PLCE1, ITGAV, LUM, DCN, MMP2, FLNA, TGFB2

8.67E-01

KEGG_PATHWAY


4.47E-03


5.20E+00

KEGG_PATHWAY


1.25E-02


+01 KEGG_PATHWAY



2.81E+01

KEGG_PATHWAY


2.89E-02


+01 KEGG_PATHWAY



3.02E+01

KEGG_PATHWAY



4.41E+01

KEGG_PATHWAY



6.39E+01

KEGG_PATHWAY



6.60E+01

KEGG_PATHWAY


2 LPL, FABP4, ACSL4

6.90E+01

KEGG_PATHWAY


9.54E-02


+01 AEBP1-PBX1 repression program



4.38E-04

MARCO, CR1, CD244, LY86, FCER1G, SUSD4, CD4, C1QC

5.39E-01

GOTERM_BP_DIRECT

GO:0045957~negative regulation of complement activation, alternative pathway

3.29E-03

CR1, SUSD4 3.98E

+00

GOTERM_BP_DIRECT


3.93E-03




4.49E-03

CR1, SUSD4, C1QC 5.41E

+00

GOTERM_BP_DIRECT

GO:0045959~negative regulation of complement activation, classical pathway

6.56E-03

CR1, SUSD4 7.81E

+00

GOTERM_BP_DIRECT



2.08E+01

GOTERM_BP_DIRECT


2.27E-02

LAIR1, CD244, CD4 2.46E

+01

GOTERM_BP_DIRECT

GO:0030449~regulation of complement activation

4.19E-02

CR1, SUSD4 4.11E



6.54E-02

F8, CD163 5.66E



1.51E-02

CR1, F8, C1QC 1.36E

+01 KEGG_PATHWAY


5.74E-02


+01

AEBP1-KLF6 program


AEBP1 KLF6 activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1


THBS2


FBLN5

AEBP1 KLF6 activati COL1A1

on


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2


JAG1


PDE1A


RBMS3


MTHFD2


SRPX2


SERPINE2


SMOC2


CCDC3


MMP2


ITGAV


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2


BAMBI


RANBP17

AEBP1 KLF6 activati PMP22

on


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD


PODN


PLP2


CAPG


CACNA1C


CCL21


CHRDL1


KCNA3


ENPP5


FAM38B


S100A14


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1


PDK4


CRHBP


AADAT


APOA5


ZFAND5


SLC4A7


CALCRL


OLFML1


PLXDC2


PRELP


LOC646982


CA13


PECAM1


IYD

AEBP1 KLF6 activati PKHD1L1

on


GCLM


TP53INP1


ACE2


SLC25A33


ALG3


CD200


KCNN2


RHOB


IKZF1


ITIH3


SH3RF2

AEBP1 KLF6 repessing

SDS


CYP3A43


MT1X


IFI44L


TIMD4


OAT


VCAM1


CD163


DNAJC12


MARCO


VSIG4


CR1


PPP1R1A


FCER1G


CD4


P2RY13


C1QC


ACADSB


GPR116


SLC16A10


F8


ODZ3


KCNN2


PDCD1LG2


SLC19A2


ITIH3


CD244


EFHD1


KCNJ8


LAIR1


SLC17A4


HIST1H4B


UNC5CL


DAK


PSD3


AHI1


HIST1H4L

AEBP1 KLF6 repessi LRRC7

ng


IKZF3


PCOLCE

AEBP1-KLF6 activation program


GOTERM_BP_DIRECT


3.56E-16

FMOD, COL4A2, LGALS3, ADAMTSL2, LUM, FBN1, EFEMP1, CCDC80, DCN, MMP2, TGFB2, NCAM1, SMOC2, CTSK, LAMC3, CRISPLD2, ITGAV, FBLN5, PECAM1, COL6A3, COL12A1, COL1A1, SPP1

5.33E-13

GOTERM_BP_DIRECT


1.38E-08


2.20E-05

GOTERM_BP_DIRECT


7

SVEP1, MCAM, ITGBL1, NCAM1, LAMC3, ITGAV, PECAM1, COL6A3, RHOB, COL12A1, THBS2, CHL1, SPP1, CDH11, SPON1, DPT

4.37E-04

GOTERM_BP_DIRECT


3.63E-07


5.78E-04

GOTERM_BP_DIRECT


7

FGFR2, COL4A2, SRPX2, ITGAV, RHOB, JAG1, CALCRL, MCAM, MMP2, ANXA2, TGFB2, THY1

7.78E-04

GOTERM_BP_DIRECT


1.96E-04


3.11E-01

GOTERM_BP_DIRECT


7.42E-04




9.12E-04




1.19E-03




1.26E-03


+00

GOTERM_BP_DIRECT


3

NCAM1, FGFR2, COL4A2, CAP2, ITGAV, COL6A3, RHOB, CD24, CACNA1C, MMP2, CHL1, TGFB2

2.48E+00

GOTERM_BP_DIRECT



2.82E+00

GOTERM_BP_DIRECT


1.96E-03




2.90E-03

LGALS3, FBN1, COL12A1, COL1A1, PRELP, CDH11

4.51E+00

GOTERM_BP_DIRECT


3.17E-03

FMOD, LUM, PRELP 4.93E



4.34E-03




4.92E-03

CCL21, CRHBP, CCL19, COL1A1, ADAMTS12 7.56E

+00

GOTERM_BP_DIRECT


5.66E-03




3 SERPINE2, ITGAV, PECAM1, PDE1A, PDE5A, RHOB, COL1A1, PRKG1, FLNA, TGFB2

1.29E+01

GOTERM_BP_DIRECT


8.80E-03




1.42E-02

PROM1, CD24 2.04E


GO:0018146~keratan sulfate biosynthetic process

1.69E-02





2.47E+01

GOTERM_BP_DIRECT


1.92E-02

LPL, APOA5, FABP4 2.66E

+01

GOTERM_BP_DIRECT


1.92E-02


+01

GOTERM_BP_DIRECT


2.12E-02

EFEMP1, FBN1 2.89E

+01

GOTERM_BP_DIRECT


2.12E-02

PROM1, CD24 2.89E

+01

GOTERM_BP_DIRECT


2.30E-02


+01

GOTERM_BP_DIRECT

GO:0042339~keratan sulfate metabolic process

2.30E-02




2.36E-02




2.57E-02




2.57E-02

PODN, RHOB, TP53INP1, THY1 3.40E

+01

GOTERM_BP_DIRECT


2.71E-02

LGALS3, ITGAV, GCLM 3.54E

+01

GOTERM_BP_DIRECT


2.82E-02

CCL21, CCL19 3.66E

+01

GOTERM_BP_DIRECT


2 FGFR2, FMOD, LUM, PRELP

3.72E+01

GOTERM_BP_DIRECT


3.00E-02





4.24E+01

GOTERM_BP_DIRECT


3.45E-02




3.51E-02

PROM1, SLC4A7 4.34E

+01

GOTERM_BP_DIRECT


3.51E-02

CCL21, CCL19 4.34E



3.76E-02




4.20E-02

CCL21, CCL19 4.95E


GO:1990314~cellular response to insulin-like growth factor stimulus

4.20E-02

SLC25A33, FBN1 4.95E

+01

GOTERM_BP_DIRECT


4.77E-02


+01

GOTERM_BP_DIRECT


4.77E-02




4.89E-02

PROM1, CD24 5.49E

+01

GOTERM_BP_DIRECT


4.89E-02

CCL21, CCL19 5.49E

+01

GOTERM_BP_DIRECT


4.89E-02

CCL21, CCL19 5.49E



5.23E-02

FMOD, LUM, DCN, PRELP 5.74E




5.82E+01

GOTERM_BP_DIRECT


5.56E-02

COL1A1, MMP2 5.98E

+01

GOTERM_BP_DIRECT


5.81E-02

AADAT, FMOD, LPL, SLC44A3, CA13, LUM, PDK4, DCN, GCLM, INMT, PRELP, IYD, ABCB4, ACSM1, AKR1B10, APOA5, FABP4, ACSL4, CACNA1C

6.14E+01

GOTERM_BP_DIRECT


6.24E-02

LPL, APOA5 6.41E



2 PGM3, JAG1, TGFB2

6.41E+01

GOTERM_BP_DIRECT


6.91E-02




6.91E-02

FGFR2, VIM 6.80E



6.91E-02

EFEMP1, FBN1 6.80E



6.91E-02

CCL21, CCL19 6.80E



2 PECAM1, RHOB, COL1A1, FLNA, TGFB2

6.83E+01

GOTERM_BP_DIRECT


7.23E-02




7.34E-02

CD3E, COL1A1, IGKC, CD200 7.03E

+01 GOTERM_BP_D GO:0045723~positive regulation 7.57E-0 APOA5, MID1IP1 7.14E

IRECT of fatty acid biosynthetic process 2 +01 GOTERM_BP_DIRECT


2 LPL, CCND1, COL1A1, GCLM, TGFB2, ABCB4

7.56E+01

GOTERM_BP_DIRECT


8.88E-02

GSN, CAPG 7.73E



8.88E-02

CCL21, CCL19 7.73E


GO:0006536~glutamate metabolic process

8.88E-02

AADAT, GCLM 7.73E

+01

GOTERM_BP_DIRECT


8.88E-02

CCL21, TGFB2 7.73E

+01

GOTERM_BP_DIRECT


8.90E-02

SERPINE2, RHOB, JAG1 7.73E



9.48E-02



KEGG_PATHWAY


6


1.12E-02

KEGG_PATHWAY


9.87E-05


1.18E-01

KEGG_PATHWAY


3.49E-03


4.10E+00

KEGG_PATHWAY


6.75E-03

COL4A2, COL6A3, ACE2, COL12A1, COL1A1 7.81E

+00 KEGG_PATHWAY



8.29E+00

KEGG_PATHWAY


9.54E-03


1.09E+01

KEGG_PATHWAY


2 LPL, APOA5, FABP4, ACSL4

2.18E+01

KEGG_PATHWAY


3.46E-02

NCAM1, CLDN7, ITGAV, PECAM1, CLDN11 3.45E

+01 KEGG_PATHWAY



3.67E+01

KEGG_PATHWAY



4.81E+01

KEGG_PATHWAY



5.50E+01

KEGG_PATHWAY


2 PECAM1, THBS2, TGFB2

5.68E+01

AEBP1-KLF6 repression program



6.19E-03


+00 GOTERM_BP_D GO:0035574~histone H4-K20 3.27E-0 HIST1H4L, HIST1H4B 3.50E

IRECT demethylation 2 +01 GOTERM_BP_DIRECT


3.39E-02





3.64E+01

GOTERM_BP_DIRECT


3.48E-02

LAIR1, CD244, CD4 3.68E


GO:0045653~negative regulation of megakaryocyte differentiation

3.67E-02

HIST1H4L, HIST1H4B 3.84E

+01

GOTERM_BP_DIRECT

GO:0006336~DNA replication-independent nucleosome assembly

5.25E-02


+01

GOTERM_BP_DIRECT

GO:0032200~telomere organization

5.45E-02


+01

GOTERM_BP_DIRECT

GO:0006335~DNA replication-dependent nucleosome assembly

6.43E-02


+01

GOTERM_BP_DIRECT

GO:0032776~DNA methylation on cytosine

6.81E-02




7.59E-02



GO:0000183~chromatin silencing at rDNA

8.16E-02




8.16E-02

F8, CD163 6.68E


GO:0034080~CENP-A containing nucleosome assembly

8.35E-02




2.01E-02

CR1, F8, C1QC 1.79E

+01 KEGG_PATHWAY


6.73E-02

HIST1H4L, HIST1H4B, C1QC 4.92E

+01 KEGG_PATHWAY


7.45E-02


+01

AEBP1-IFI16 program


AEBP1 IFI16 activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1


THBS2


FBLN5


COL1A1


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2


JAG1


PDE1A

AEBP1 IFI16 activati RBMS3

on


MTHFD2


SRPX2


SERPINE2


SMOC2


CCDC3


MMP2


ITGAV


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2


BAMBI


RANBP17


PMP22


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD


PODN


PLP2

AEBP1 IFI16 activati CAPG

on


CACNA1C


CCL21


CHRDL1


KCNA3


ENPP5


FAM38B


S100A14


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1


INPP4B


ADRA1A


OLFML1


MCTP1


MAML2


CTSS


DOCK10


EPB41L2


PIK3R3


MX2


PLXNC1


PAG1


MYO5A


ARL4C


PSTPIP2


HPS3


KPNA5

AEBP1 IFI16 repessing

SDS


CYP3A43


MT1X


IFI44L


TIMD4


OAT


VCAM1


CD163


DNAJC12

AEBP1 IFI16 repessi MARCO

ng


VSIG4


CR1


PPP1R1A


FCER1G


CD4


P2RY13


C1QC


ACADSB


GPR116


SLC16A10


F8


ODZ3


KCNN2


PDCD1LG2


SLC19A2


ITIH3


CD244


EFHD1


KCNJ8


LAIR1


ACADS

AEBP1-IFI16 activation program



8.99E-17

FMOD, COL4A2, LGALS3, ADAMTSL2, LUM, FBN1, EFEMP1, CCDC80, CTSS, DCN, MMP2,

1.78E-13

TGFB2, NCAM1, SMOC2, CTSK, LAMC3, CRISPLD2, ITGAV, FBLN5, COL6A3, COL12A1, COL1A1, SPP1

GOTERM_BP_DIRECT


4.65E-10

COL4A2, CTSK, GSN, COL6A3, CAPG, FBN1, COL12A1, COL1A1, DCN, CTSS, MMP2, SPP1

7.32E-07

GOTERM_BP_DIRECT


2.52E-07


3.97E-04

GOTERM_BP_DIRECT


7

PLXNC1, SVEP1, MCAM, ITGBL1, NCAM1, LAMC3, ITGAV, COL6A3, COL12A1, THBS2, CHL1, SPP1, CDH11, SPON1, DPT

1.18E-03

GOTERM_BP_DIRECT


1.09E-05

COL4A2, CTSK, COL6A3, COL12A1, COL1A1, CTSS, MMP2

1.72E-02

GOTERM_BP_DIRECT



2.69E-02

GOTERM_BP_DIRECT


6.56E-04




7.62E-04


+00

GOTERM_BP_DIRECT


4

NCAM1, FGFR2, COL4A2, PLXNC1, CAP2, ITGAV, COL6A3, CD24, CACNA1C, MMP2, CHL1, TGFB2

1.49E+00

GOTERM_BP_DIRECT


1.00E-03


+00

GOTERM_BP_DIRECT


1.04E-03

CTSK, ADAMTS12, CTSS, CAPN2 1.63E

+00

GOTERM_BP_DIRECT



2.35E+00

GOTERM_BP_DIRECT


1.64E-03




3.84E-03




3 ITGAV, ADAMTS12, CD24, BAMBI, TGFB2, PSTPIP2

8.87E+00

GOTERM_BP_DIRECT


7.82E-03




9.47E-03




1.16E-02

PLXNC1, SERPINE2, JAG1, DOCK10 1.68E



1.32E-02




1.34E-02

PROM1, CD24 1.91E




2.11E+01

GOTERM_BP_DIRECT


2 FGFR2, MYO5A, TGFB2

2.12E+01

GOTERM_BP_D GO:2000768~positive regulation 2.00E-0 PROM1, CD24 2.72E

IRECT of nephron tubule epithelial cell differentiation

2 +01

GOTERM_BP_DIRECT


2.00E-02

EFEMP1, FBN1 2.72E



2.01E-02


+01

GOTERM_BP_DIRECT


2.05E-02


+01

GOTERM_BP_DIRECT


2.29E-02


+01

GOTERM_BP_DIRECT


2.65E-02

CCL21, CCL19 3.45E

+01

GOTERM_BP_DIRECT


2.67E-02




2.68E-02




3.08E-02




3.31E-02

CCL21, CCL19 4.11E



3.36E-02



GO:0046822~regulation of nucleocytoplasmic transport

3.96E-02

INPP4B, MX2 4.70E



3.96E-02

CCL21, CCL19 4.70E

+01

GOTERM_BP_DIRECT


4.27E-02


+01

GOTERM_BP_DIRECT


4.27E-02




2 MYO5A, LAMC3, LUM, EFEMP1, COL1A1

5.09E+01

GOTERM_BP_DIRECT


4.60E-02

PROM1, CD24 5.23E

+01

GOTERM_BP_DIRECT


4.60E-02

CCL21, CCL19 5.23E

+01

GOTERM_BP_DIRECT


4.60E-02

CCL21, CCL19 5.23E



4.61E-02

NCAM1, PLP2, PODN, KPNA5, DCN, MX2 5.24E




5.35E+01

GOTERM_BP_DIRECT


5.24E-02

COL1A1, MMP2 5.71E

+01 GOTERM_BP_D GO:0030097~hemopoiesis 5.60E-0 PGM3, JAG1, TGFB2 5.96E



2 ITGAV, ADRA1A, TGFB2

6.08E+01

GOTERM_BP_DIRECT


6.49E-02




6.51E-02




6.51E-02

CCL21, CCL19 6.53E



6.51E-02

EFEMP1, FBN1 6.53E



6.51E-02

FGFR2, VIM 6.53E


GO:0035265~organ growth 6.51E-0

2 FGFR2, ADRA1A

6.53E+01

GOTERM_BP_DIRECT


2 LPL, CCND1, ADRA1A, COL1A1, TGFB2, ABCB4

6.75E+01

GOTERM_BP_DIRECT

GO:0060402~calcium ion transport into cytosol

7.13E-02

ADRA1A, CACNA1C 6.88E



7.76E-02

FMOD, LUM 7.19E



8.21E-02

LPL, FABP4, CTSS 7.40E



8.23E-02




2 CCL21, SUSD2, CCL19, CTSS, IGKC, DEFB1

7.45E+01

GOTERM_BP_DIRECT


8.37E-02

CCL21, TGFB2 7.48E

+01

GOTERM_BP_DIRECT


8.37E-02

GSN, CAPG 7.48E



8.37E-02

CCL21, CCL19 7.48E



9.02E-02




9.60E-02

SRPX2, CD24 7.96E


GO:0036092~phosphatidylinositol-3-phosphate biosynthetic process

9.60E-02

INPP4B, PIK3R3 7.96E



9.60E-02

CCL21, CCL19 7.96E


KEGG_PATHWAY


7

COL4A2, CCND1, LAMC3, ITGAV, COL6A3, COL1A1, MAPK10, CAPN2, PIK3R3, THBS2, FLNA, SPP1

7.20E-04

KEGG_PATHWAY


6.66E-05


8.03E-02

KEGG_PATHW hsa05205:Proteoglycans in cancer 1.02E-0 CCND1, ITGAV, LUM, DCN, PIK3R3, MMP2, 1.22E

AY 3 FLNA, TGFB2 +00 KEGG_PATHWAY


1.67E-03

FGFR2, COL4A2, CCND1, LAMC3, ITGAV, COL6A3, COL1A1, PIK3R3, THBS2, SPP1

2.00E+00

KEGG_PATHWAY


2.57E-03

CLDN7, CLDN11, PIK3R3, MMP2, RHOH, THY1

3.06E+00

KEGG_PATHWAY


3 COL4A2, CCND1, LAMC3, ITGAV, PIK3R3

5.71E+00

KEGG_PATHWAY


2 COL4A2, LAMC3, COL1A1, PIK3R3, TGFB2

1.20E+01

KEGG_PATHWAY


2 FGFR2, COL4A2, CCND1, LAMC3, ITGAV, MAPK10, PIK3R3, MMP2, TGFB2

1.49E+01

KEGG_PATHWAY


2 CCND1, MAPK10, PIK3R3, TGFB2

1.53E+01

KEGG_PATHWAY



1.66E+01

KEGG_PATHWAY


3.33E-02


+01 KEGG_PATHWAY

hsa04022:cGMP-PKG signaling pathway

4.20E-02

PDE5A, ADRA1A, PRKG1, PIK3R3, CACNA1C 4.04E

+01 KEGG_PATHWAY


5.21E-02

CD3E, MAPK10, PIK3R3, TGFB2 4.75E

+01 KEGG_PATHWAY


5.45E-02

CTSK, MAPK10, PIK3R3, SPP1 4.91E

+01 KEGG_PATHWAY


5.77E-02

MAPK10, PIK3R3, CACNA1C 5.11E

+01 KEGG_PATHWAY


2 LAMC3, MAPK10, PIK3R3, TGFB2

5.86E+01

KEGG_PATHWAY


2 LAPTM4B, CTSK, CTSE, CTSS

6.08E+01

KEGG_PATHWAY


7.56E-02

FABP4, PRKG1, PIK3R3 6.12E

+01 KEGG_PATHWAY


8.85E-02

CTSK, MAPK10, PIK3R3, TGFB2 6.72E

+01 KEGG_PATHWAY

hsa05160:Hepatitis C 9.16E-0

2 CLDN7, CLDN11, MAPK10, PIK3R3

6.86E+01

KEGG_PATHWAY



6.86E+01

AEBP1-IFI16 repression program



3.65E-03




1.14E-02





1.89E+01

GOTERM_BP_D GO:0002250~adaptive immune 2.11E-0 LAIR1, CD244, CD4 2.31E

IRECT response 2 +01

GOTERM_BP_DIRECT


2.81E-02

ACADSB, ACADS 2.97E

+01

GOTERM_BP_DIRECT


2 ACADSB, ACADS

4.96E+01

GOTERM_BP_DIRECT


6.30E-02

F8, CD163 5.52E



9.23E-02

CR1, C1QC 6.98E



1.67E-02

CR1, F8, C1QC 1.50E

+01 KEGG_PATHWAY


6.29E-02


+01

AEBP1-MYBL1 program


AEBP1 MYBL1 activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2

AEBP1 MYBL1 activati DEFB1

on


THBS2


FBLN5


COL1A1


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2


JAG1


PDE1A


RBMS3


MTHFD2


SRPX2


SERPINE2


SMOC2


CCDC3


MMP2


ITGAV


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2

AEBP1 MYBL1 activati CAPN2

on


BAMBI


RANBP17


PMP22


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD


PODN


PLP2


CAPG


CACNA1C


CCL21


CHRDL1


KCNA3


ENPP5


FAM38B


S100A14


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1


NPR3


FAM102B


ADAM9


AOAH


SESN3


PALMD


LTBP1


LACTB2


TLR1


AHI1


DNAJC10

AEBP1 MYBL1 activati GPR116

on


SLC2A9


ABCG2


KLRC4


STK38L


PTPN22


COX11


LRRK2


EIF2S1


TTC21B


UFM1


FLJ10213


TAGAP

AEBP1 MYBL1 repessing

SDS


CYP3A43


MT1X


IFI44L


TIMD4


OAT


VCAM1


CD163


DNAJC12


MARCO


VSIG4


CR1


PPP1R1A


FCER1G


CD4


P2RY13


C1QC


ACADSB


GPR116


SLC16A10


F8


ODZ3


KCNN2


PDCD1LG2


SLC19A2


ITIH3


CD244


EFHD1


KCNJ8


LAIR1


SLC35C1


KCNE4


FCGR2B


RAB15


NXF1

AEBP1-MYBL1 activation program


GOTERM_BP_DIRECT


1.77E-17

FMOD, COL4A2, LTBP1, LGALS3, ADAMTSL2, LUM, FBN1, EFEMP1, CCDC80, DCN, MMP2, TGFB2, NCAM1, SMOC2, CTSK, LAMC3, CRISPLD2, ITGAV, FBLN5, COL6A3, COL12A1, COL1A1, SPP1, ADAM9

2.81E-14

GOTERM_BP_DIRECT


7.53E-10

COL4A2, CTSK, GSN, COL6A3, CAPG, FBN1, COL12A1, COL1A1, DCN, MMP2, SPP1, ADAM9

1.20E-06

GOTERM_BP_DIRECT


3.28E-07


5.23E-04

GOTERM_BP_DIRECT


6

SVEP1, MCAM, ITGBL1, NCAM1, LAMC3, ITGAV, COL6A3, COL12A1, THBS2, CHL1, SPP1, CDH11, SPON1, DPT, ADAM9

2.07E-03

GOTERM_BP_DIRECT


1.41E-05

COL4A2, CTSK, COL6A3, COL12A1, COL1A1, MMP2, ADAM9

2.25E-02

GOTERM_BP_DIRECT



3.89E-02

GOTERM_BP_DIRECT


7.17E-04




8.67E-04




1.18E-03





2.69E+00

GOTERM_BP_DIRECT


1.86E-03




2.69E-03

LGALS3, FBN1, COL12A1, COL1A1, NPR3, CDH11

4.20E+00

GOTERM_BP_DIRECT


3.61E-03

CCL21, TGFB2, ADAM9 5.60E

+00

GOTERM_BP_DIRECT


4.19E-03


+00

GOTERM_BP_DIRECT


3


6.89E+00

GOTERM_BP_DIRECT


5.48E-03

LGALS3, PTPN22, THY1 8.38E

+00

GOTERM_BP_DIRECT


8.52E-03




1.07E-02




1.40E-02

PROM1, CD24 2.01E




2.37E+01

GOTERM_BP_DIRECT


1.86E-02


+01

GOTERM_BP_DIRECT

GO:0035583~sequestering of TGFbeta in extracellular matrix

2.09E-02

LTBP1, FBN1 2.85E

+01

GOTERM_BP_DIRECT


2.09E-02

PROM1, CD24 2.85E

+01

GOTERM_BP_DIRECT


2.09E-02

EFEMP1, FBN1 2.85E


GO:0033688~regulation of osteoblast proliferation

2.09E-02

FGFR2, NPR3 2.85E

+01

GOTERM_BP_DIRECT


2.23E-02


+01

GOTERM_BP_DIRECT


2.25E-02




2.49E-02




2 ITGAV, FBLN5, ADAMTS12, ADAM9

3.59E+01

GOTERM_BP_DIRECT


2.77E-02

CCL21, CCL19 3.61E

+01

GOTERM_BP_DIRECT


2.90E-02




2.99E-02





4.07E+01

GOTERM_BP_DIRECT


3.34E-02



GO:0042908~xenobiotic transport 3.46E-0

2 ABCG2, ABCB4

4.29E+01

GOTERM_BP_DIRECT


3.46E-02

CCL21, CCL19 4.29E



3.65E-02




4.13E-02

CCL21, CCL19 4.89E



4.62E-02


+01

GOTERM_BP_DIRECT


4.62E-02


+01

GOTERM_BP_DIRECT


4.80E-02

PROM1, CD24 5.44E



4.80E-02

CCL21, CCL19 5.44E

+01

GOTERM_BP_DIRECT


4.80E-02

CCL21, CCL19 5.44E

+01

GOTERM_BP_DIRECT


5.33E-02

AOAH, MID1IP1, ACSL4, ABCB4 5.82E



5.47E-02

COL1A1, MMP2 5.92E



5.68E-02

PDE5A, CD24, LRRK2 6.06E




6.12E+01

GOTERM_BP_DIRECT

GO:0060271~cilium morphogenesis

6.05E-02

GSN, TTC21B, AHI1 6.30E



2 PGM3, JAG1, TGFB2

6.30E+01

GOTERM_BP_DIRECT

GO:0090263~positive regulation of canonical Wnt signaling pathway

6.68E-02

FGFR2, COL1A1, BAMBI, LRRK2 6.68E

+01

GOTERM_BP_DIRECT


6.79E-02

CCL21, CCL19 6.74E



6.79E-02

FGFR2, VIM 6.74E



6.79E-02

EFEMP1, FBN1 6.74E


GO:0046415~urate metabolic process

6.79E-02

SLC2A9, ABCG2 6.74E



6.79E-02


+01

GOTERM_BP_DIRECT


6.92E-02

LTBP2, BAMBI, TGFB2, ADAM9 6.81E

+01

GOTERM_BP_DIRECT


7.01E-02



GO:0010955~negative regulation of protein processing

7.45E-02

SERPINE2, LRRK2 7.08E



2 LPL, CCND1, COL1A1, TGFB2, ABCG2, ABCB4

7.35E+01

GOTERM_BP_DIRECT


8.03E-02

CD3E, GSN, VIM, PTPN22, TGFB2 7.36E



8.09E-02

FMOD, LUM 7.39E



8.74E-02

GSN, CAPG 7.67E

+01

GOTERM_BP_DIRECT

GO:0051966~regulation of synaptic transmission, glutamatergic

8.74E-02

SERPINE2, LRRK2 7.67E

+01

GOTERM_BP_DIRECT


8.74E-02

CCL21, CCL19 7.67E

+01 GOTERM_BP_D GO:0034976~response to 9.07E-0 UFM1, EIF2S1, DNAJC10 7.80E

IRECT endoplasmic reticulum stress 2 +01 GOTERM_BP_DIRECT


9.11E-02



GO:0006468~protein phosphorylation

9.43E-02

CCND1, STK17A, MAPK10, PRKG1, LRRK2, STK38L, TGFB2

7.93E+01

GOTERM_BP_DIRECT


2 CCL21, TLR1, SUSD2, CCL19, IGKC, DEFB1

8.00E+01

GOTERM_BP_DIRECT


9.72E-02



KEGG_PATHWAY


6


8.14E-03

KEGG_PATHWAY


8.14E-05


9.71E-02

KEGG_PATHWAY



7.03E+00

KEGG_PATHWAY


7.79E-03


8.90E+00

KEGG_PATHWAY


1.70E-02


+01 KEGG_PATHWAY

hsa04350:TGF-beta signaling pathway

3.24E-02

LTBP1, DCN, BAMBI, TGFB2 3.24E

+01 KEGG_PATHWAY



3.41E+01

KEGG_PATHWAY


3.65E-02


+01 KEGG_PATHWAY



4.26E+01

KEGG_PATHWAY

hsa04141:Protein processing in endoplasmic reticulum

5.14E-02

EIF2S1, HSPA4L, DNAJC10, MAPK10, CAPN2 4.67E

+01 KEGG_PATHWAY



5.18E+01

KEGG_PATHWAY


5.94E-02

CTSK, TLR1, MAPK10, SPP1 5.18E

+01 KEGG_PATHWAY



6.98E+01

KEGG_PATHWAY

hsa05160:Hepatitis C 9.93E-0

2 CLDN7, EIF2S1, CLDN11, MAPK10

7.13E+01

AEBP1-MYBL1 repression program



3 FCGR2B, IFI44L, CD4, C1QC, PDCD1LG2

4.20E+00

GOTERM_BP_DIRECT


4.84E-03




2.07E-02


+01

GOTERM_BP_DIRECT


2.55E-02

VCAM1, LAIR1, FCGR2B 2.74E



2.76E-02

LAIR1, CD244, CD4 2.94E



7.24E-02

F8, CD163 6.07E


GO:0016032~viral process 7.60E-0

2 VCAM1, FCGR2B, CD4, NXF1

6.25E+01



1.84E-02

CR1, F8, C1QC 1.68E

+01 KEGG_PATHWAY


6.86E-02


+01

AEBP1-FOSL2 program


AEBP1 FOSL2 activation

AKR1B10


SPP1


LUM


FABP4


CD24


EFEMP1


CCDC80


ITGBL1


ACSL4


CCL19


PROM1


MOXD1


SVEP1


CRISPLD2


STMN2


DEFB1

AEBP1 FOSL2 activati THBS2

on


FBLN5


COL1A1


FGFR2


DCN


VIM


DPT


CHL1


PTPN13


FBN1


COL6A3


TGFB2


JAG1


PDE1A


RBMS3


MTHFD2


SRPX2


SERPINE2


SMOC2


CCDC3


MMP2


ITGAV


ANXA2


IGKC


ACSM1


NAV3


HSPA4L


THY1


PRKG1


ABCB4


CTSK


LRRC1


FLJ36840


COL12A1


COL4A2


FLNA


PLCXD3


PGM3


GABRE


LGALS3


CDH11


PDE5A


LAPTM4B


MID1IP1


LTBP2


SPON1


INMT


CAP2


CAPN2

AEBP1 FOSL2 activati BAMBI

on


RANBP17


PMP22


BAI3


CTSE


STK17A


LPL


SLC44A3


GSN


MCAM


STXBP4


FMOD


PODN


PLP2


CAPG


CACNA1C


CCL21


CHRDL1


KCNA3


ENPP5


FAM38B


S100A14


ADAMTSL2


IKZF3


CD3E


ADAMTS12


FNDC1


NCAM1


HDGFRP3


GLT8D2


RHOH


MAPK10


LAMC3


CLDN7


CLDN11


SUSD2


CCND1


PDK4


HLA-DRA


APOA5


SLC4A7


PNPLA3


APOF


HIST1H2BM


PFKFB3


PECAM1


ALG3


CD200


RNASE2

AEBP1 FOSL2 activati ITIH3

on


SH3RF2


SUSD4


ARSK


LAIR1


CD80

AEBP1 FOSL2 repessing

SDS


CYP3A43


MT1X


IFI44L


TIMD4


OAT


VCAM1


CD163


DNAJC12


MARCO


VSIG4


CR1


PPP1R1A


FCER1G


CD4


P2RY13


C1QC


ACADSB


GPR116


SLC16A10


F8


ODZ3


KCNN2


PDCD1LG2


SLC19A2


ITIH3


CD244


EFHD1


KCNJ8


LAIR1


WSB1


PDE5A


BAI3


REPS1


LRP2

AEBP1-FOSL2 activation program


GOTERM_BP_DIRECT


1.35E-16

FMOD, COL4A2, LGALS3, ADAMTSL2, LUM, FBN1, EFEMP1, CCDC80, DCN, MMP2, TGFB2, NCAM1, SMOC2, CTSK, LAMC3, CRISPLD2, ITGAV, FBLN5, PECAM1, COL6A3, COL12A1, COL1A1, SPP1

1.78E-13

GOTERM_BP_DIRECT


9.03E-09


1.42E-05

GOTERM_BP_DIRECT


2.80E-07


4.41E-04

GOTERM_BP_DIRECT


7

SVEP1, MCAM, ITGBL1, NCAM1, LAMC3, ITGAV, PECAM1, COL6A3, COL12A1, THBS2, CHL1, SPP1, CDH11, SPON1, DPT

1.47E-03

GOTERM_BP_D GO:0001525~angiogenesis 1.97E-0 FGFR2, COL4A2, SRPX2, ITGAV, JAG1, MCAM, 3.10E-

IRECT 5 MMP2, ANXA2, TGFB2, THY1 02 GOTERM_BP_DIRECT


1.60E-04


2.51E-01

GOTERM_BP_DIRECT


4 CD80, CD3E, CCL21, CCL19, CD24, HLA-DRA

2.84E-01

GOTERM_BP_DIRECT


6.80E-04




8.03E-04




1.01E-03




1.07E-03




1.10E-03

LPL, APOA5, FABP4, PNPLA3 1.71E




2.47E+00

GOTERM_BP_DIRECT


1.73E-03


+00

GOTERM_BP_DIRECT


3


5.66E+00

GOTERM_BP_DIRECT


3.98E-03




5.20E-03




8.09E-03




1.36E-02

PROM1, CD24 1.94E



1.41E-02




1.41E-02

LAIR1, CD3E, COL1A1, IGKC, CD200 2.00E

+01

GOTERM_BP_DIRECT


1.77E-02


+01

GOTERM_BP_DIRECT


2 SERPINE2, ITGAV, PECAM1, PDE1A, PDE5A, COL1A1, PRKG1, FLNA, TGFB2

2.65E+01

GOTERM_BP_DIRECT


2.03E-02

EFEMP1, FBN1 2.76E

+01

GOTERM_BP_DIRECT


2.03E-02

PROM1, CD24 2.76E

+01

GOTERM_BP_DIRECT


2.10E-02


+01

GOTERM_BP_DIRECT


2.12E-02


+01

GOTERM_BP_DIRECT


2.37E-02


+01

GOTERM_BP_DIRECT


2.70E-02

CCL21, CCL19 3.50E

+01

GOTERM_BP_DIRECT


2.77E-02




2.80E-02





3.77E+01

GOTERM_BP_DIRECT


3.18E-02




3.37E-02

CCL21, CCL19 4.16E



3.37E-02

PROM1, SLC4A7 4.16E



3.48E-02




4.03E-02

CCL21, CCL19 4.76E


GO:0045627~positive regulation of T-helper 1 cell differentiation

4.03E-02

CD80, CCL19 4.76E

+01

GOTERM_BP_DIRECT


4.41E-02


+01

GOTERM_BP_DIRECT


4.41E-02





5.29E+01

GOTERM_BP_DIRECT


4.68E-02

PROM1, CD24 5.29E



4.68E-02

CCL21, CCL19 5.29E

+01

GOTERM_BP_DIRECT


4.68E-02

CCL21, CCL19 5.29E

+01

GOTERM_BP_DIRECT


4.99E-02

APOF, MID1IP1, ACSL4, ABCB4 5.53E



5.33E-02

COL1A1, MMP2 5.77E



2 PGM3, JAG1, TGFB2

6.08E+01

GOTERM_BP_DIRECT

GO:0046641~positive regulation of alpha-beta T cell proliferation

5.98E-02

CD80, CD3E 6.21E



5.98E-02

LPL, APOA5 6.21E



6.62E-02

CCL21, CCL19 6.59E

+01

GOTERM_BP_DIRECT


6.62E-02




6.62E-02

EFEMP1, FBN1 6.59E



6.62E-02

FGFR2, VIM 6.59E



6.70E-02



GO:0045723~positive regulation of fatty acid biosynthetic process

7.26E-02

APOA5, MID1IP1 6.94E



7.86E-02

LPL, ACSL4, PNPLA3 7.24E



7.89E-02

FMOD, LUM 7.25E



8.52E-02

GSN, CAPG 7.53E

+01

GOTERM_BP_DIRECT


8.52E-02

CD80, CD3E 7.53E

+01

GOTERM_BP_DIRECT


8.52E-02

CCL21, TGFB2 7.53E

+01

GOTERM_BP_DIRECT


8.52E-02

CCL21, CCL19 7.53E



8.58E-02




2 CCL21, SUSD2, CCL19, IGKC, DEFB1, HLA-DRA

7.66E+01

GOTERM_BP_DIRECT


9.29E-02




9.77E-02

SRPX2, CD24 8.01E



9.77E-02

CCL21, CCL19 8.01E


KEGG_PATHWAY


6


6.98E-03

KEGG_PATHWAY


7.37E-05


8.87E-02

KEGG_PATHWAY


1.05E-03

NCAM1, CLDN7, CD80, ITGAV, PECAM1, CLDN11, HLA-DRA

1.26E+00

KEGG_PATHWAY


2.78E-03


3.30E+00

KEGG_PATHWAY



6.53E+00

KEGG_PATHWAY


7.01E-03


8.12E+00

KEGG_PATHW hsa03320:PPAR signaling pathway 1.77E-0 LPL, APOA5, FABP4, ACSL4 1.93E




3.31E+01

KEGG_PATHWAY


2 CTSK, CD80, TGFB2, HLA-DRA

3.39E+01

KEGG_PATHWAY


3.49E-02


+01 KEGG_PATHWAY



4.03E+01

KEGG_PATHWAY



5.06E+01

KEGG_PATHWAY


5.69E-02

CTSK, CD80, MAPK10, SPP1 5.06E

+01 KEGG_PATHWAY


2 PECAM1, THBS2, TGFB2

5.36E+01

KEGG_PATHWAY


2 LAMC3, MAPK10, TGFB2, HLA-DRA

6.01E+01

KEGG_PATHWAY


2 CCND1, CD80, HLA-DRA

6.35E+01

KEGG_PATHWAY


8.53E-02

LPL, AKR1B10, PNPLA3 6.58E

+01 KEGG_PATHWAY



6.90E+01

KEGG_PATHWAY



7.11E+01

AEBP1-FOSL2 repression program



4.23E-03




1.56E-02





2.29E+01

GOTERM_BP_DIRECT


2.43E-02

LAIR1, CD244, CD4 2.64E



2.75E-02

MARCO, LRP2, CD163 2.95E



2 CD244, PDE5A, F8, FCER1G

4.76E+01

GOTERM_BP_DIRECT


5.65E-02

PDE5A, VSIG4 5.16E



6.77E-02

F8, CD163 5.84E



9.91E-02

CR1, C1QC 7.29E


KEGG_PATHWAY


1.84E-02

CR1, F8, C1QC 1.65E

+01 KEGG_PATHWAY


6.86E-02


+01

Supplementary Table S3: The complete co-regulator pairs in each stage of NAFLD.

Regulator1 Regulator2 Support nGRN* fisherTest& adjustedPvalue

EGR1 FOS 0.16725 862 1.36E-119 9.00E-117

JUNB ZFP36 0.01397 72 6.56E-60 2.17E-57

FOS ZFP36 0.02813 145 9.41E-38 2.08E-35

JUN MYC 0.12747 657 2.08E-33 3.45E-31

EGR1 ZFP36 0.02445 126 8.99E-30 1.19E-27

FOSB ZFP36 0.02600 134 1.59E-28 1.75E-26

JUNB NFIL3 0.00660 34 1.28E-27 1.21E-25

NFIL3 ZFP36 0.00660 34 1.72E-26 1.42E-24

CEBPA MLXIPL 0.00407 21 1.12E-25 8.21E-24

NR4A1 ZFP36 0.00718 37 1.78E-25 1.18E-23

FOSB JUN 0.12806 660 2.36E-25 1.42E-23

NR4A1 NR4A2 0.01281 66 5.87E-25 3.24E-23

EGR2 FOSB 0.04230 218 7.93E-22 4.04E-20

IFI16 MNDA 0.00272 14 1.63E-18 7.72E-17

CEBPD JUNB 0.00349 18 1.90E-16 8.38E-15

CEBPD ZFP36 0.00349 18 7.00E-16 2.90E-14

DENND4A MXD1 0.00155 8 1.01E-15 3.93E-14

DMTF1 PNN 0.00194 10 3.95E-15 1.45E-13

DBP TEF 0.00213 11 1.71E-14 5.97E-13

EGR1 JUNB 0.01940 100 2.36E-14 7.81E-13

AEBP1 PRRX1 0.00252 13 6.44E-13 2.03E-11

FOSB NR4A2 0.07722 398 8.04E-13 2.42E-11

CEBPD NFIL3 0.00233 12 1.71E-12 4.93E-11

EGR2 NOTCH3 0.00272 14 3.47E-12 9.56E-11

EGR2 NR4A2 0.02328 120 4.08E-11 1.08E-09

KLF6 NR4A1 0.00194 10 1.26E-10 3.21E-09

ASB9 NR1I3 0.00213 11 2.36E-10 5.78E-09

EEF1A1 MYC 0.00563 29 3.28E-10 7.75E-09

COPS2 MYC 0.00795 41 4.62E-10 1.06E-08

JUNB NR4A1 0.00407 21 9.29E-10 2.05E-08

JUND NR4A1 0.00136 7 1.13E-09 2.42E-08

EEF1A1 FOSB 0.00563 29 1.28E-09 2.64E-08

IRF8 ZFP36 0.00155 8 3.81E-09 7.64E-08

FOS JUNB 0.02057 106 4.23E-09 8.24E-08

JUNB SPIC 0.00485 25 6.89E-09 1.30E-07

MLXIPL TCEA2 0.00310 16 8.57E-09 1.58E-07

EGR2 NR4A1 0.00563 29 8.91E-09 1.59E-07

JUN NFIL3 0.00970 50 1.27E-08 2.21E-07

FOSB NR4A1 0.01300 67 1.68E-08 2.85E-07

NFIL3 PRDM1 0.00252 13 1.89E-08 3.12E-07

ETV5 JUNB 0.00175 9 2.18E-08 3.44E-07

SHPRH ZNF248 0.00116 6 2.15E-08 3.44E-07

SPIC ZFP36 0.00485 25 3.06E-08 4.71E-07

ETV5 ZFP36 0.00175 9 4.09E-08 6.15E-07

EGR1 KLF11 0.00504 26 9.26E-08 1.33E-06

CEBPD SPIC 0.00213 11 9.23E-08 1.33E-06

FOSL2 ZFP36 0.00194 10 1.63E-07 2.29E-06

BTG2 MYC 0.00524 27 1.83E-07 2.52E-06

FOSB NFIL3 0.01028 53 1.88E-07 2.54E-06

BTG2 ZFP36 0.00213 11 2.05E-07 2.69E-06

ARID5B NFIL3 0.00136 7 2.07E-07 2.69E-06

MLXIPL NR1I3 0.00175 9 4.12E-07 5.25E-06

KLF6 ZFP36 0.00175 9 4.92E-07 6.15E-06

RORA TSC22D3 0.00097 5 5.47E-07 6.71E-06

BTG2 FOSB 0.00524 27 5.98E-07 6.89E-06

TCF4 ZFPM2 0.00097 5 5.89E-07 6.89E-06

CEBPD ETV5 0.00097 5 6.03E-07 6.89E-06

RUNX1T1 SSBP2 0.00058 3 5.87E-07 6.89E-06

CITED2 TOB1 0.00078 4 6.22E-07 6.98E-06

COPS2 JUN 0.00679 35 7.17E-07 7.91E-06

CCRN4L ZFP36 0.00194 10 1.45E-06 1.57E-05

ETV5 NFIL3 0.00116 6 1.47E-06 1.57E-05

FOS NFIL3 0.01048 54 1.54E-06 1.62E-05

AEBP1 ZDHHC13 0.00097 5 2.40E-06 2.48E-05

EHF PBX1 0.00097 5 2.46E-06 2.50E-05

EGR2 MAFF 0.00175 9 2.91E-06 2.92E-05

DBP KLF15 0.00194 10 3.31E-06 3.27E-05

ASB9 MLXIPL 0.00233 12 3.49E-06 3.40E-05

EGR3 NR4A2 0.00175 9 3.85E-06 3.70E-05

RBM14 ZNF587 0.00058 3 4.08E-06 3.86E-05

FOS KLF11 0.00524 27 4.99E-06 4.65E-05

CCRN4L TOB1 0.00078 4 5.21E-06 4.79E-05

FOSL2 NR4A1 0.00136 7 5.30E-06 4.80E-05

ZDHHC21 ZNF83 0.00078 4 5.89E-06 5.27E-05

MLXIPL ZIC1 0.00155 8 1.08E-05 9.42E-05

RBM14 SHPRH 0.00116 6 1.08E-05 9.42E-05

DMTF1 ZNF334 0.00058 3 1.13E-05 9.74E-05

E2F1 MCM5 0.00058 3 1.27E-05 1.08E-04

EGR1 NOTCH3 0.00291 15 1.89E-05 1.58E-04

EHF MLLT3 0.00078 4 2.14E-05 1.77E-04

EGR2 FOS 0.03648 188 2.36E-05 1.93E-04

ARID5B JUNB 0.00136 7 3.03E-05 2.45E-04

IFI16 MYC 0.01358 70 3.56E-05 2.84E-04

CEBPD NR4A1 0.00136 7 3.65E-05 2.87E-04

BRIP1 STAT1 0.00078 4 4.11E-05 3.17E-04

ATF5 ZIC1 0.00058 3 4.09E-05 3.17E-04

BCL3 JUNB 0.00097 5 4.19E-05 3.19E-04

PRDM1 ZFP36 0.00272 14 4.85E-05 3.61E-04

ARID5B ZFP36 0.00136 7 4.80E-05 3.61E-04

EGR2 NR0B2 0.00446 23 5.28E-05 3.86E-04

FOSB MAFF 0.00272 14 5.31E-05 3.86E-04

FOSB TNFAIP3 0.00330 17 6.13E-05 4.41E-04

MAFF NR0B2 0.00097 5 6.51E-05 4.63E-04

FOSL2 JUN 0.00369 19 6.65E-05 4.68E-04

IFI16 JUN 0.01222 63 7.73E-05 5.38E-04

KNTC1 MCM3 0.00058 3 8.48E-05 5.85E-04

CCRN4L JUND 0.00058 3 9.24E-05 6.31E-04

MYC ZFP36 0.01785 92 9.62E-05 6.50E-04

JUNB PRDM1 0.00252 13 9.78E-05 6.54E-04

DDB2 MCM7 0.00058 3 1.16E-04 7.69E-04

RBM14 ZNF586 0.00058 3 1.17E-04 7.69E-04

PPARGC1A TSC22D3 0.00078 4 1.20E-04 7.76E-04

CEBPD PRDM1 0.00116 6 1.57E-04 1.01E-03

FOS MAFF 0.00272 14 1.73E-04 1.10E-03

TSC22D2 ZNF295 0.00039 2 1.76E-04 1.11E-03

DMTF1 SHPRH 0.00097 5 1.90E-04 1.19E-03

STAT1 TRIM25 0.00039 2 2.15E-04 1.33E-03

NFIL3 NR4A1 0.00175 9 2.40E-04 1.47E-03

MEF2C ZNF100 0.00039 2 2.47E-04 1.50E-03

MYC TNFAIP3 0.00310 16 2.91E-04 1.75E-03

MEF2C NR4A1 0.00136 7 2.99E-04 1.78E-03

LASS4 TCEA2 0.00058 3 3.30E-04 1.95E-03

JUN TNFAIP3 0.00291 15 3.53E-04 2.07E-03

AEBP1 PBX1 0.00097 5 4.76E-04 2.76E-03

AEBP1 EHF 0.00116 6 5.59E-04 3.22E-03

SHPRH ZNF566 0.00058 3 5.98E-04 3.41E-03

DAB2 MYC 0.00485 25 7.80E-04 4.34E-03

CEBPA SREBF1 0.00039 2 7.75E-04 4.34E-03

CEBPD ELF3 0.00039 2 7.75E-04 4.34E-03

SHPRH ZNF586 0.00058 3 8.42E-04 4.64E-03

JUN TSC22D2 0.00155 8 8.96E-04 4.90E-03

EGR1 MAFF 0.00233 12 9.41E-04 5.10E-03

ARID5B MYC 0.00310 16 1.03E-03 5.51E-03

ARID5B JUN 0.00291 15 1.03E-03 5.51E-03

HIF1A MXD1 0.00058 3 1.10E-03 5.83E-03

EGR2 ZFP36 0.00563 29 1.21E-03 6.38E-03

AEBP1 TAX1BP3 0.00058 3 1.30E-03 6.79E-03

JUND NR4A2 0.00136 7 1.37E-03 7.04E-03

DAB2 JUNB 0.00136 7 1.37E-03 7.04E-03

CEBPD KLF6 0.00058 3 1.42E-03 7.24E-03

NFIL3 SPIC 0.00194 10 1.51E-03 7.61E-03

BCL3 ID1 0.00078 4 1.62E-03 8.07E-03

NR1D2 PER1 0.00039 2 1.61E-03 8.07E-03

FOSB IFI16 0.01300 67 1.66E-03 8.18E-03

DBP TCEA2 0.00136 7 1.67E-03 8.18E-03

DDB2 STAT1 0.00058 3 1.69E-03 8.21E-03

FOSB MXD1 0.00388 20 1.74E-03 8.40E-03

EGR3 FOSB 0.00175 9 1.80E-03 8.64E-03

DAB2 FOSB 0.00485 25 1.83E-03 8.72E-03

FOSB NOTCH3 0.00272 14 1.85E-03 8.75E-03

CCRN4L NR4A1 0.00097 5 1.87E-03 8.80E-03

JUND KLF6 0.00039 2 1.99E-03 9.30E-03

JUN MXD1 0.00349 18 2.01E-03 9.31E-03

DAB2 ZFP36 0.00136 7 2.07E-03 9.47E-03

FOSL2 TSC22D2 0.00039 2 2.07E-03 9.47E-03

MCM2 MCM5 0.00097 5 2.10E-03 9.52E-03

KLF15 NR1I3 0.00097 5 2.17E-03 9.68E-03

MEF2C TCF4 0.00058 3 2.18E-03 9.68E-03

MAFB MCM5 0.00039 2 2.17E-03 9.68E-03

SFRS14 ZNF586 0.00039 2 2.24E-03 9.88E-03 *Support means the portion of co-regulated gene networks in which this pair is found. &nGRN means the number of times the pair was found as cooperative regulators in the

network.

supplementary table s1: primers used for detecting aebp1 ......supplementary table s2: transcription...

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