supplementary fig.1 native expression relative expression ratio vs. hksrnas a relative expression...

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Supplementary Fig.1 0.0 2.0 4.0 6.0 8.0 10.0 12.0 14.0 DAOY D 458 M ed M ed8A NCB miR-182 miR-183 Native expression Relative expression ratio vs. HKsRNAs a 0 10 20 30 40 50 60 70 Relative expression ratio vs. pCMX DAOY Med8A Relative expression ratio vs. pCMX Stable overexpression b 0 20 40 60 80 100 120 140 D458 Med Relative expression ratio vs. pCMX 0 1 2 3 4 5 6 7 8 pC M X 182K 1 182K 2 183K 1 183K 2

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Page 1: Supplementary Fig.1 Native expression Relative expression ratio vs. HKsRNAs a Relative expression ratio vs. pCMX DAOY Med8A Relative expression ratio vs

Supplementary Fig.1

0.02.04.06.08.0

10.012.014.0

DAOY D458Med

Med8A NCB

miR-182

miR-183

Native expression

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s. H

KsR

NA

sa

0

10

20

30

40

50

60

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pCMX 182K1 182K2 183K1 183K2

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8AR

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exp

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ratio

vs.

pC

MX

Stable overexpression

b

0

20

40

60

80

100

120

140

pCMX 182K1 182K2 183K1 183K2

D45

8 M

ed

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pCMX 182K1 182K2 183K1 183K2

Page 2: Supplementary Fig.1 Native expression Relative expression ratio vs. HKsRNAs a Relative expression ratio vs. pCMX DAOY Med8A Relative expression ratio vs

Supplementary Fig.1

0.0

0.3

0.6

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siCtrl si182 siCtrl si183

Page 3: Supplementary Fig.1 Native expression Relative expression ratio vs. HKsRNAs a Relative expression ratio vs. pCMX DAOY Med8A Relative expression ratio vs

Supplementary Fig.2

Page 4: Supplementary Fig.1 Native expression Relative expression ratio vs. HKsRNAs a Relative expression ratio vs. pCMX DAOY Med8A Relative expression ratio vs

Supplementary Fig.3

Page 5: Supplementary Fig.1 Native expression Relative expression ratio vs. HKsRNAs a Relative expression ratio vs. pCMX DAOY Med8A Relative expression ratio vs

Molecular subgroup

miR-182 miR-183 miR-96

Supplementary Fig.4

Page 6: Supplementary Fig.1 Native expression Relative expression ratio vs. HKsRNAs a Relative expression ratio vs. pCMX DAOY Med8A Relative expression ratio vs

Supplementary Fig. 5

Page 7: Supplementary Fig.1 Native expression Relative expression ratio vs. HKsRNAs a Relative expression ratio vs. pCMX DAOY Med8A Relative expression ratio vs

Transient knockdown

0.5

1.0

1.5

2.0

2.5

3.0

3.5

1 2 3 4 5 6 7

DAOY-siCtrlDAOY-si183

DAOY-si182

0.5

1.0

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2.0

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3.0

1 2 3 4 5 6 7

M8A-siCtrl

M8A-si183

M8A-si182

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DAOY-183K1

DAOY-183K2

0.0

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DAOY-pCMX

DAOY-182K1

DAOY-182K2

0.51.01.52.02.53.03.54.04.55.0

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M8A-pCMXM8A-183K1M8A-183K2

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M8A-pCMXM8A-182K1

M8A-182K2

Stable overexpression

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Supplementary Fig. 6

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