study of ocular transport of drugs released from a sustained release device

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 ABSTRACT Title of Dissertation / Thesis: STUDY OF OCULAR TRANSPORT OF DRUGS RELEASED FROM A SUSTAINED RELEASE DEVICE Hyuncheol Kim, Ph.D., 2004 Dissertation / Thesis Directed By: Associate Professor Nam Sun Wang, Department of Chemical Engineering Delivering ocular therapeutics to a target site with minimal side e ffects requires detailed informat ion about the dist ribution and elimination pathways. This knowledge can guide the development of new drug delivery devices. In this study, we investigated the movement of two drug surrogates, H-110, which is lipophilic, and Gd-DTPA, which is hydrophilic, released from polymer-based implants using a fluorescein technique and magnetic resonance imaging (MRI). We also st udied the  pharmacokinetics of intravitreally injected triamcinolone acetonide, a low water soluble drug used for treating sight-threatening diseases such as diabetic retinopathy and choroidal neovascularization associated with age-related macular degeneration (AMD). At 24 hour post implantation, H-110 released from an intravitreal implant

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