short list of influences on efficacy of …...short list of influences on efficacy of foot-and-mouth...
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SHORT LIST OF
INFLUENCES ON EFFICACY OF
FOOT-AND-MOUTH DISEASE
VACCINES
Tom Willems
On behalf of DISCONVAC consortium
19 April 2012GFRA, Disconvac, Hazyview, SA
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Introduction
o What is Vaccine Efficacy ?
• Effectiveness of the vaccine to prevent disease,
• depending on the vaccine being potent and
• on it’s proper administration
• to animals capable to respond.
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Introduction
o What are important factors influencing the efficacy
of FMD vaccination?
• When do we measure quality• In-production control
• Post production control
• Post marketing
o What is the goal of the FMD vaccination?
• Endemic region• Primary control
• FMD Free with vaccination region• Routine & control
• Emergency control
• FMD Free region• Emergency vaccination
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In-Production
o Importance of In-production Quality Assurance:
• Good Manufacturing Practice• Product source traceability
• Purity of content
• Safety of content
• Concentration of content
• Integrity of content
• Identity of content
• Improvements in GMP• Assurance of post production efficacy
• Harmonisation of Quality Assurance • Better comparability
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Post –Production/ Marketing
What is the goal of the FMD vaccination?
oFMD Endemic region
• Risk based cost effective building of immunity barrier
• Improve quality of livestock
• Access to international market
• Influences on vaccine efficacy?
• Vaccine quality & suitability
• Cold-chain quality
• Strategic vaccination programming
• Assessing vaccine efficacy
• Seroconversion
• Virus circulation (DIVA)19/04/2012 5
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Post –Production/ Marketing
o FMD Free with vaccination region
• Maintain immunity barrier
• Prevention of outbreaks
• Influences on vaccine efficacy?
• Routine Vaccination• …
• Emergency Vaccination• Suitability & speed
• Assessing Vaccine efficacy
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Routine vaccination Emmergency vaccination
Seroconversion
Herd immunity
Suitability
Seroconversion
DIVA
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Post –Production/ Marketing
o FMD Free region
• Fast immunity barrier
• Stopping of outbreaks
• Influences on vaccine efficacy?• …
• Suitability & speed
• Increased potency
• Assessing vaccine efficacy• Higher vaccine potency
• Fast seroconversion
• Carrier state prevention
• DIVA
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Summary
o Producer
• GMP � QA
• Batch Validation � Potency (dir./indir.)
o User
• Vaccination strategy � Suitability
Cold-chain management
• Coverage � Herd immunity
o Evaluation in a Harmonized and independent way
o In perspective of vaccination policy
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THANKS
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