Sepsis

• Increase of 8.7% per year

– Age

– Surgery

– Immunosuppressive treatment

– Global cost 8700 € /patient (750€/day)

– 38% of the health system budget (Canada)

• Sepsis physiopathology

– Red blood membrane alteration

– O2 consumption capacity

– Increase NO

– Increase of permeability

– Increase of white cell apoptosis

• Complicated surgery

– Peritonitis

– Perforation

– Mesenteric ischemic

– Oncological

– Inmunosupression

• Dehiscence risk

– low proteins levels (diabetes, chronic process)

– Colonization

– Oncological surgery

• Other like…pancreatitis, abd. Dialysis, abd.

Hypertension, etc…

• Damage by gun

• Unique• No diffusion problem• Biggest spectrum of action• Easy storage• High thermal range of viability• Easy transport• Long time stability• Inactive storage• Easy application• Low cost of production

non ionic Silver

Alginate

Positive charge

Sphere Architecture

Negative Charge

Poli L lysine

Laminaria HyperboreaLaminaria Digitata

Azotobacter VinelandiiPseudomonas spp

Water binding/bactO-acetilo

G

G

MG

SINÉRESISMG, proporción de Ca2+Gelation timeIncrease of mol weight

SAXS

• 1. Silver effects are well known in clinicalinfection

• 2. Alginate has been used in celltransplantation in order to achieve optimalbiocompatibility

• 3. Spherical geometry and lower size

• External

• Inner gelation (CaCO3/EDTA-citrate)

– Descend pH (GLD)

– Kinetic control

– lower grad

ηo is the viscosity of the outer liquid,Vo is the outer characteristic velocity andγ is the surface or interfacial tension between the two fluid phases.

Ca is the relation between Fdrag/F γ

Ca=η0V0di/γdi Fdrag ~ η0V0di//F γ ~ γdi

Ca≈ o(1) dripping jetting

Ca< o(1) dripping

Ca≥ o(1) jetting

Ca= η0V0 /γ

Ca= η0V0 /γFracture condition Fdrag≈ Fγ

η0V0 dgout≈ γdi

Ca ≈ o(1)dgout/di ≈ 1/Ca

dgout>di // Ca<1…dripping

Fracture condition Fdrag<Fγη0V0 dgout< γdi

Ca ≥ o(1)dgout/di ≥ 1/Ca

dgout≤di // Ca≥1…jetting

ρi is the density of the inner liquid,Vi is the inner fluid velocity andd is the characteristic length (typically the tip diameter)γ is the surface or interfacial tension between the two fluid phases.

Wei is the relation between Ek/Eγ

ρiVi2/ (γ/d ) (Mi/V)*Vi

2/ (γ/d )

Wei≈ o(1) dripping jetting

Wei < o(1) dripping

Wei ≥ o(1) jetting

Wei=ρiVi2d/γ

Ca= η0V0 /γCa< o(1) dripping

Ca≥ o(1) jetting

L>2πr; // jet fracture condition λ> 2πrWei=ρiVi2d/γ

Thanks for your attention