SCIENTIFIC PROGRAM

Wednesday, October 23, 2019

10:00-11:00 Welcome and Registration for Students

11:00 Opening Ceremony

12:00 Cocktail

13:00-14:00 Registration for Doctors

14:00-15:30 Session 1 : Immuno-Oncology

Moderators: Walid Rachidi, Nizar Bitar, Elie Hadchity, Hussein Kazan

14:00-14:30 Ahmad Awada - Jules Bordet Institute, Free University of Brussels, Belgium Cancer treatment based on Molecular Biology advances: A revolution ?

14:30-14:50

Roberto Accolla - University of Insubria, Italy The MHC class II transactivator: a molecule intersecting intrinsic and adaptive immunity against human retroviruses during evolution

14:50-15:10

Luigi Buonaguro - Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Napoli, Italy Road to development of cancer vaccine for liver cancer

15:10-15:30

Christophe Ferrand - Franche-Comté University, Besançon, France Target antigen epitope masking, after CAR’s lentiviral transduction of IL-1RAP-expressing tumor cells affects cytotoxicity

15:30-16:00 Coffee Break

16:00-17:00 Session 2 : Cancer and Epigenetic

Moderators: Raghida Bou Merhi, Majida Jalbout, Nader Hussein

16:00-16:20 Rabih Murr - University of Geneva, Geneva, Switzerland Super Pioneer Transcription Factors Could Use the Replication Window to Interfere with Epigenetic Inheritance

16:20-16:40

Cyril Ribeyre - University of Montpellier, Montpellier, France Identification of new factors involved in the response to chemotherapeutic treatments using mass spectrometry

16:40-17:00

Sara Fneich, Paris Sud University, Paris, France–Lebanese University, Lebanon The epigenetic mechanisms underlying the long-term effects of maternal obesity and/or maternal separation in mice

Thursday, October 24, 2019

09:00-10:25 Session 3 : Regenerative Medicine and biomaterials

Moderators: Roberto Accolla, Yolla Makhour, Walid Rachidi, Kazem Zibara

09:00-09:25 Philipe Menasché - Hôpital Européen Georges Pompidou, Paris, France Cellular or Acellular Therapies for Heart Failure

09:25-09:45

Gilles Lemaitre - Université d'Évry-Val-d'Essonne, Évry, France Cell therapy of epidermis using pluripotent stem cells and application in aging

09:45-10:05 Sophie Lerouge - University of Quebec, Quebec, Canada Injectable T-cell delivery scaffold: towards local cancer immunotherapy

10:05-10:25 Olivier Detante - Grenoble Alpes University Hospital Centre, Grenoble, France Cell therapy for stroke: Progresses and future

10:25-10:45 Coffee Break

10:50-11:50 Session 4 : Neuroscience

Moderators: Youssef Fares, Rita Azzi Nabbout, Eva Hamade

10:50-11:10 Frederic Saudou - Grenoble Institute of Neuroscience, Grenoble, France Huntingtin: Linking Fast Axonal Transport, Energy Supply and Neurotrophin Signaling to Neurodegeneration

11:10-11:30 Ahmed Shaaban - Max Planck Institute of Experimental Medicine, Goettingen, Germany Dissecting Key Mechanisms of Gut-to-Brain Signalling

11:30-11:50

Ali Shaib - Max Planck Institute of Experimental Medicine, Goettingen, Germany Human-Induced Pluripotent Stem Cells-Derived Neurons from 22q11.2DS Patients with Autism Spectrum Disorder Show Morphogenic and Fuctional Synaptic Anomalies

11:50-13:20 Session 5 : Cancer Biology I

Moderators: Luigi Buonaguro, Rabih Murr, Michella Ghassibi, Haidar Akl

11:50-12:15 Ahmad Awada - Jules Bordet Institute, Free University of Brussels, Belgium Breast cancer molecular subtyping :Implications for therapy

12:15-12:40 Patrick Mehlen - Lyon Cancer Research Center, Centre Léon Bérard, Lyon, France The Dependence Receptor Notion: From a Cell Death Pathway to Novel Targeted Anti-Cancer Therapies

12:40-13:00

Robert Barouki - Paris Descartes University, Paris, France Environment and Health: the Exposome concept

13:00-13:20

Patrice Marche - Grenoble Alpes University, Grenoble, France Immune system of the liver in chronic diseases

13:20 – 14:30 Lunch Break

Poster Session

14:30-15:50 Session 6 : Cancer Biology II

Moderators: Nada Borghol, Hala Chamiyeh, Mazen Kurdi, Mahmoud Homsi

14:30-14:50 Marie Therese Leccia - Grenoble Alpes University Hospital Centre, Grenoble, France UV and skin cancers

14:50-15:10 Ruben Varela Calvino - University of Santiago de Compostela, Spain NPPEs, auto-immunity and Diabetes

15:10-15:30

Muriel LeRomancer - Lyon Cancer Research Center, Centre Léon Bérard, Lyon, France The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast Cancer

15:30-15:50 Hiba Komati, University of Ottawa, Ottawa, Canada Preventing chemotherapy from inducing heart failure: a new cardioprotective treatment in the arena

15:50-16:15 Coffee Break

16:15-17:00 Session 7 : Cancer Biology - Young Research Session

Moderators: Rouba Hajj Sleiman, Zahraa Khamis

16:15-16:30 Farah Koubeissi - Grenoble Alpes University, Grenoble, France – Lebanese University RNAi and Chemical-Based High Content Screening for the Normalization of XPC Phenotype

16:30-16:45 Nour Fayyad - Grenoble Alpes University, Grenoble, France Xeroderma Pigmentosum C mutations increase oxidative DNA damages by inhibiting Base Excision Repair System’s expression and activity

16:45-17:00

Assil Fahs - Lebanese University – American University of Beirut Investigating the role of exosomal CD147 in paracrine signaling in pediatric rhabdomyosarcoma

Friday, October 25, 2019

09:00-10:40 Session 8 : Cancer Therapy

Moderators: Hasna Bou Haroun, Mohamad Kazan, Nabil El Zein, Bilal Hocheimi, Yolla Makhour

09:00-09:20 Gerolama Condorelli - Federico II University of Naples, Naples, Italy The discovery of RNA-aptamers affecting Glioblastoma cancer stem cells

09:20-09:40 Jean Luc Coll - Grenoble Alpes University, Grenoble, France Theranostic nanovectors for optical guided treatment of cancer

09:40-10:00

Ahcene Boumendjel - Grenoble Alpes University, Grenoble, France Drug-efflux modulators to target resistant cancer cells

10:00-10:20

Nader Nakouzi - University of British Columbia, Vancouver, Canada Targeting oncofetal glycosaminoglycans in cancer

10:20-10:40 Thierry Dubois - Institute Curie, PSL Research University, Paris, France The canonical Wnt pathway as a targetable pathway for triple-negative breast cancers

10:40-11:10 Coffee Break

11:10-12:50 Session 9 : Proteomics and Cancer

Moderators: Fadi Abdel Sater, Mona Diab Assaf, Zahraa Khamis, Ahmad Daher, Fadwa Berri

11:10-11:30 Michel Seve - Grenoble Alpes University, Grenoble, France The toxicity of Iron Oxide Nanoparticles

11:30-11:50 Guillem Pratx - Radiation Oncology & Medical Physics, Stanford University CellGPS: Whole-body tracking of single cell by positron emission tomography

11:50-12:10

Bertrand Liagre - University of Limoges, Limoges, France Photodynamic therapy activity of new silica-tetraphenylporphyrin nanoparticles in a colorectal cancer in vivo model

12:10-12:30

Ziad Ibrahim - University of Leicester, Leicester, United Kingdom Protein disorder and phase separation in NUT Midline Carcinoma

12:30-12:50 Imad Haidar Ahmad - Analytical Research and Development, Merck & Co. Inc, New Jersey, USA The Emergence of Analytical Methods in Pharmaceutical Research and Development to Meet Grand Scientific Challenges and Regulatory Expectations.

13:00 – 14:00 Lunch Break

Poster Session

14:00-16:50 Session 10 : Biologics and alternative pharmaceutical therapy: Perspectives and Path forward

Moderators: Assem El Kak, Rita Karam, Mirna Metni, Mazen Kurdi

14:00-14:25 Fernando De Mora - Universidad Autonoma de Barcelona, Spain Demonstration of Analytical Comparability for Biosimilars (CMC), non-clinical and Clinical assessment of Biosimilars

14:30-14:55

Fernando De Mora - Universidad Autonoma de Barcelona, Spain Biologics, Biosimilars, NCB and Biobetters - Manufacturing Biologicals and Biosimilars: Principles and Challenges

15:00-15:25 Susanne Ausborn - Regulatory Policy Lead EEMEA, Switzerland Regulation of Biologics and Biosimilars in the EU and US - Extrapolation of indications for Biosimilars

15:30-15:55 Susanne Ausborn - Regulatory Policy Lead EEMEA, Switzerland Interchangeability: Switching and Substitution - Post marketing Surveillance: Pharmacovigilance and Risk management plan

16:00-16:20 Coffee Break

16:20-16:50 Interactive discussion on current status and future state of biologics and biosimilars

17:00 Meeting conclusions Young Researcher Award 2019

ORGANIZING COMMITTEE

Bassam Badran (Dean of the Faculty of Science, Lebanese University) Pierre Yared (Dean of the Faculty of Medical Science, Lebanese University) Hasna Bou Haroun (Dean of the Faculty of Public Health, Lebanese University) Assem El Kak (Dean of the Faculty of Pharmacy, Lebanese University) Fawaz El Omar (Dean of the Doctoral School of Science and Technology, Lebanese University) Elie Hadchity (Director of the University Medical Center, Lebanese University) Nizar Bitar (Faculty of Medical Sciences, Lebanese University) Walid Rachidi (Faculty of Pharmacy, Grenoble Alpes University)

SCIENTIFIC COMMITTEE

Dr. Ahmad Daher, LU Dr. Bassam Badran, LU Dr. Elie Hadchity, LU Dr. Eva Hamade, LU Dr. Fadi Abdel Sater, LU Dr. Fadwa Berri, LU

Dr. Ghada Kchour, LU Dr. Haidar Akl, LU Dr. Hussein Kazan, LU Dr. Kazem Zibara, LU Dr. Mazen Kurdi, LU Dr. Michella Ghassibi, LAU Dr. Mohamad Kazan, LU Dr. Mohamad Mortada, LU Dr. Mona Diab, LU Dr. Nabil El Zein, LU Dr. Nada Borghol, LU Dr. Nader Hussein, LU Dr. Nizar Bitar, LU Dr. Raghida Bou Merhi, LU Dr. Rim El Dirani, LU Dr. Rita Azzi Nabbout, LU Dr. Rita Karam Mouawad, LU Dr. Rouba Hajj Sleiman Dr. Soulayma Chamat, LU Dr. Walid Rachidi, GAU Dr. Wissam Faour, LAU Dr. Yolla Makhour, LU Dr. Zahraa Khamis, LU