resurrection and reincarnation: giving abandoned drugs new life
TRANSCRIPT
Resurrection and reincarnation: giving abandoned drugs new life
Receptor 1 Receptor 2
Abandoned drug: a drug that is no longer supported by the pharmaceutical company; a company can stop drug development at any stage
How can an abandoned drug be given a new life?
Receptor 1 Receptor 2
Compare downstream pathways
Off-target or non-specific: all drugs have effects they are not supposed to, but the secret is balancing desired vs. undesired
Failed clinical trials: 95% of drugs fail to be effective in humans (Source: Nature journal)
Cost is insurmountable: development of one new drug can cost $350 million to $5 billion; if no chance to recoup, then it becomes a black hole expenditure
Placebo
Treatment
Cholesterol X X
Infection X
Protein Gene
Receptor 1 X ✓Receptor 2 ✓ ✓ ©2014, Created by Firhan Malik ([email protected])