razvitak i plastičnost kortikalnih putova
TRANSCRIPT
8/14/2019 Razvitak i plastičnost kortikalnih putova
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Razvitak i plastičnost
kortikalnih putovaSekundarna prevencija u pedijatriji
Slavonski brod, 27. veljače 2010.
Akademik Ivica Kostović
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Plan
• Razvitak puteva
• Razvitak funkcija
•
Perivenrtikularna leukomalacija istrukturna plastičnost
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NEUROGENETIC EVENTS IN THE HUMAN CORTEX I.: LAMINARAND TEMPORAL PARAMETERS (WHERE AND WHEN
NEUROGENETIC EVENTS OCCUR ?)
1. Proliferation
2. Migration
3. Cell differentiation
4. Synaptogenesis
5. Axonal outgrowth
6. Cell death
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Rakic (1995): Radial unit hypothesisand sequential ingrowth of afferents
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eurogene c even s andevelopmental windows
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Bilaminar distribution of dendrites –10,5w
Nissl Golgi
Early bilaminar circuitry -
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Accumulation Below the CP and Targetselection 22-23 PCW
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Accumulation of thalamocorticals
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in vivo MR Fibronectin AchE
22w 22w 23w
Accumulation of thalamocorticals
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Ingrowth and AddressSelection - 24-32 PCW
Synaptogenesis in the CP –
28PCW
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AchE reactivity in the prefrontal CP
28 PCW
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Vanhatalo et al inClin Neurophys (113) 2002
Neural activity:Brain waves
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Fitzgerald M (2005):
The development of nociceptive circuits.
Slater R (2006):Cortical pain responses in human
infants.
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Axonal strata andcrossroads –
guidancemolecules
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Crossroad significance –pathways, tangential
& radial migration
Judaš et al, AJNR
2 G
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Born at 27, MRI at 44 GW Born at 27, MRI at 44 GW
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Crossroad signal
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Lesion in the crossroads
l l i f h d
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Focal PVL – lesion of the PVL crossroads
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MRI – structural trias after perinatal lesion
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CP after massive destruction of WM
Ult d l li d i t i l l i
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Ultrasound – localized periventricular lesion- PVH
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Perinatal reorganization of selectively
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Kostović et al (2002):Disappearance of the SP
(Nissl – MRI – PAS-AB)and development of the corona radiata
Perinatal reorganization of selectivelyvulnerable zones
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Patterns of structuralplasticity of fiber
pathways:
1. Detouring
Structural plasticit
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TI/ Fiberracking
Courtesy of dr. M. StaDept. Of Radiology, University of Tubin
Structural plasticity
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matosensory afferent projections
24 weeks GA time
S1
S1
subplate
I. Kostovic, yesterdayrtesy of dr. M. Staudtt. Of Radiology, University of Tubingen
Corticostriatal system
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Structuralrearrangement of cortico-striatalconnections
Goldman-Rakic PS, Science1978
Corticostriatal system
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CE
P
28w.g.
Maturation of thecorticostriatal
pathway
• Corticostriatal axons
“wait” for a long time before
entering (about 20 weeks)!
• Developmental time window!
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Corticostriatalmaturation
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Reorganization of striatalmoduls
• Caudate and rostral putamen
without modular organization
• Possible reorganization of the
nigrostriatal projection system
in the caudal putamen
C
Th
AChE
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C
P
CI
Reorganization of striatal modulsrevealed by MAP-2
MAP-2 (microtubule-associated protein2):
• expressed in neurons
•synaptic plasticity