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Project Number: 257401

A highly integrated and sensitive POrous SIlicon based lab on a chip for multiple quantitaTIVE monitoring of food allergies at point of care.

Specific Targeted Research Project

Information Society Technologies

Deliverable D11.15: End of project roadmap for the use and dissemination of foreground – Section A (Public)

Due date of deliverable: February 28 2014

Actual submission date: May 19th 2014

Start date of project: 2010-09-01 Duration: 3 1/2 Years

Organisation name of lead contractor for this deliverable: UVEG

Revision [1.0]

Project co-funded by the European Commission within the Seventh Framework Programme

Dissemination Level

PU Public X

PP Restricted to other programme participants (including the Commission Services)

RE Restricted to a group specified by the consortium (including the Commission Services)

CO Confidential, only for members of the consortium (including the Commission Services)

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1 About this deliverable

1.1 Introduction

This report describes the end of project roadmap for the use and spread of the knowledge generated, or foreground, during the project lifetime.

For the spread of knowledge (dissemination) the strategies employed by the consortium members and the achievements in disseminating the knowledge generated during the project lifetime are reported. This includes participation in workshops, conferences, EC related events, standardisation bodies, etc. Positive members participated and shared information and resources with on-going R&D activities or entities, such as NoEs, IPs or any other horizontal network.

For the use of the knowledge, exploitable foreground technologies were identified, listed and individual exploitation plans developed for them given the interest and vision at the time. Where necessary from the IP observatory patent reviews were performed in order to identify a freedom to operate and unique selling points also identified as part of business plans.

The report therefore consists of:

Section A: describing the dissemination measures, including any scientific publications relating to foreground. Its content can be made available in the public domain thus demonstrating the

added-value and positive impact of the project on the European Community.

Section B: This section specifies the exploitable foreground and provides the plans for exploitation. This section must be kept confidential and must be treated as such by the Commission.

1.2 Scope of the deliverable

The deliverable outlines an end of project roadmap for the use and spread of the knowledge generated during the project lifetime. It consists of two parts A and B, the first public and the second confidential and therefore is delivered as two separate documents.

1.3 Structure of this deliverable

The report is laid out according to the tasks defined in WP11 as follows:

T11.3: Elaboration of roadmap for use and dissemination of foreground. (UVEG)

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2 Section A – Dissemination (for public knowledge)

This section includes a list of dissemination activities (publications, conferences, workshops, web, press releases, flyers, etc) realised throughout the project. In addition, a list of scientific (peer reviewed) publications is provided.

2.1 Setup of Positive web-site

At the start of the project an interactive webpage, www.fp7positive.eu, was designed and published to allow world-wide knowledge of the activities and results of the project as well as co-ordination between partners (file exchange, etc) by M3 (Deliverable D11.1). Later it underwent a major revision improving its style and content. Throughout the project it has been updated with information of interest to the scientific community, medical instrumentation industry as well as the general public.

2.2 Creation of promotional material

During the project we aimed to publicize the project and its results through the creation of promotional material for broader dissemination at key events and through a newsletter to a regularly updated database of contacts (= the Positive INTEREST GROUP, see section 2.4.2).

A first set of promotional material was created in M3 (D11.2), and then updated in M12 (D11.7), M27 (D11.12) before a final update was made in M45 (D11.14 and D11.17). The promotional material consists of a project leaflet/flyer, a poster, a short presentation and a newsletter. UVEG leads this work, with active assistance of all partners.

2.2.1 Project leaflet

A first leaflet was created and printed by M3 containing 4 A5 sides with general information about the project, its objectives and its partners. Changes in the second leaflet (M14) reflected the new project coordinator and some minor style changes, 500 copies were professionally printed. They were distributed at various dissemination events: Student Open Days, MNBS concertation meetings, ICT Proposers days and EC Workshop on Cross-KETs for Healthcare. The third flyer (M27) includes highlights of technical achievements to date in the project whilst the final flyer (M45) overviews the best technical achievements from the project. The leaflets can also be downloaded from the Positive website.

2.2.2 Poster

A first poster, containing general information about the project, its objectives and its partners was created, printed and used by the partners from M3. Posters generated since have contained more and more technical results as they have become available within the project. These posters were presented annually at Medica and the MNBS concertation day as well as other events such as CLEO, EuroNanoForum, FP7-IP-HELIOS and UK Silicon Photonics (UKSP) organised photonics summer school, a workshop on Nanophotonics for sensing and nonlinear optics organized by the University of Adelaide, PECS IX, MicroTAS2011, Nanotech Italy 2011, MEMs2012, Student Open Days, Europtrode 2012, Euromediag Convention…..

2.2.3 A short presentation

Updated standard presentation material was kept available for all partners on the basis for incorporation into more detailed presentations or for use ad hoc at opportunities where the partners can present their on-going work. The standard presentation was incorporated into oral presentations at various EC organized events (Biophotonics cluster meeting, Photonics open day, MNBS concertation days) as well as various scientific workshops and conferences as regular

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papers (Photonics West 2012, PSST 2012, IEEE Sensors 2012, SPIE Microtechnologies 2013,…) or invited papers (pHealth, 26th International Symposium on MicroScale Bioseparations, Advances in microarray technology, Therapeutics for personalized medicine…).

2.2.4 A newsletter

An annual newsletter was created and distributed to the Positive INTEREST GROUP (including the Europrevall, Ga2LEN and SMARTHEALTH consortia) in months M4, M14, M27 and finally M45. As well the general introduction given in the first, the next contained achievements of Year 1, UNITN and their porous silicon membrane development. The 3rd newsletter was sent to the INTEREST GROUP highlighting technical achievements from Y2, CNR and their surface functionalization developments. The final newsletter followed in M45 (see also section 2.4.2.) focused on key project progress and novel foreground as well as included a feature on CSEM and their microfluidics and optics work in Positive.

2.3 Dissemination among other FP7 RTD projects

The consortium participants have been disseminating to and cooperating with other FP7 RTD projects where possible. Contacts have been made and weblinks (http://www.fp7positive.eu/projects.html) are provided to the projects Europrevall, Ga2Len and Nanospad.

The consortium participants cooperated with other FP7 RTD projects in the area of microsystems and photonics and exchanged non-confidential information with these projects particularly through the participation in periodic concertation meetings and as partners themselves in those projects.

Table: Dissemination events to other FP7 RTD projects

Date Event Responsible Positive partner

Newsletters 1-4 The Europrevall, Ga2LEN and Nanospad consortia UVEG

M3 Biophotonics cluster meeting presentation KTH

M3 Photonics Open Day KTH

M5 Interchange with coordinator of FP7 Mash project UVEG

M8 EC MNBS Concertation meeting UVEG

M11 Silicon Photonics summer school (Poster) organized by FP7 HELIOS and UKSP.

UVEG

M18 CFBI organized meeting for Microfluidics Group UVEG

M20 Interchange with FP7 FoodMicrosystems project UVEG

M21 MNBS Concertation meeting UVEG

M21 EC MNBS Concertation meeting UVEG

M25 ICT Proposers Day UVEG

M25 COWIN Market Place, Paris. CSEM

M27 EC MNBS Concertation meeting UVEG

M37 EC MNBS Concertation meeting UVEG

M39 EC-WS on Cross Key enabling technologies for Healthcare with presentation topics

UVEG

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2.4 General publicity of the project

Further publicity has taken place through the dissemination of Positive research results to the non-scientific/technical media at large (eg. newspapers, magazines, TV, periodicals) and raising of public awareness for the project and interest in photonic technologies at "student days", "open days", "girls days".

2.4.1 Press releases

Whenever a good opportunity presented itself, Positive disseminated its results via the larger press. These opportunities were either pursued actively, e.g. when critical results were obtained, or occurred on an ad-hoc basis when the partners were contacted by the press in conjunction with the general research activities.

Table: planned press releases.

Date Press release content Responsible Positive partner

M4 Project start:

http://www.kth.se/en/aktuellt/supersnabba-allergitest-snart-har-1.74636

http://www.kth.se/en/ees/omskolan/organisation/avdelningar/mst/news/quick-food-allergy-test-just-a-drop-of-blood-1.73580

KTH, with help from all

M4 Project start in the Farfield Periodical NewsLetter, Illuminations 14: http://www.farfield-group.com/pdfs/Newsletter_Issue_14.pdf

Farfield

M5 Farfield Group Press release:

Farfield Join Forces to Detect Hypersensitivity of Allergens

http://www.farfield-group.com/readstory.asp?sid=113

Farfield

M7 Press release done through Euromediag diffusion list (http://www.eurobiomed.org/en/euromediag/) in which Phylogene is involved. Euromediag is a group of diagnostics actors inside Eurobiomed competitivity pole. Euromediag also initiated a EU meta-cluster which includes Euromediag (Eurobiomed-France), Wal-DX (Biowin-Belgium), Biocat (Barcelona, Spain), Kakow life Sciences cluster (Poland), Nexxus (Scotland- UK), OBN (Oxford, UK), Uppsala Bio (Uppsala - Sweden) and ZMDB (Berlin-Brandebourg - Germany).

Phylogene

M7 Press-release through Almanacco della Scienza

(http://www.almanacco.rm.cnr.it/reader/ ?MIval=cw_usr_view_articolo.html&id_articolo= 1753&id_rub=13&giornale=1760)

CNR

M29 A press-release in M29 highlights the major technical achievements since the project began.

UVEG + CNR

M45 A press release announcing innovation developed within the whole project will be released at the end of M45.

UVEG + CSEM

The first press-release was quickly picked up by sources in Sweden and around the world, including:

Swedish National Radio interviewed Prof. van der Wijngaart http://sverigesradio.se/sida/gruppsida.aspx?programid=406&grupp=12718&artikel=4290223

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Swedish National Television interviewed Prof. van der Wijngaart http://www.tv4play.se/nyheter_och_debatt/tv4nyheterna?title=blodchip_kan_avsloja_allergier&videoid=1215225

An enquiry came from the Aftonbladet Swedish Tablet

NYTEKNIK (the number one technology newspaper in Sweden) http://www.nyteknik.se/nyheter/innovation/forskning_utveckling/article3063070.ece

An enquiry came from two Swedish highschool (natural da Vinci in the Kattegat High School in Halmstad) girls for a school assignment.

The Illinois-Sweden Program for Educational and Research Exchange (INSPIRE) http://illinois.edu/lb/imageList/3833

http://www.righthealth.com/topic/scratch_tests_allergy/BlogPosts

Ann Göransson Nyberg, the project manager from EU project MASH ”Mass casualties and Health care following the release of toxic chemicals or radioactive material”.

Per Matsson, Chief Technology Officer of Phadia AB and Associate Professor, Uppsala University

Emelie Nyman, a freelance journalist, working for the Campus magazine that goes out to students across the country in engineering, economics and law. Contacted for article.

A local newspaper in Trento published an article on consultation.

Article in Italian national newspaper http://www.sanitaliaweb.it/index.php?option=com_content&view=article&id=542:progetto-positive-il-test-per-le-allergie-alimentari&catid=15:news-italia&Itemid=107

Article in Italian Family Church Magazine

Italian Television

A contact from communication consultant for Parliament Magazine’s Research Review.

A recent contact from a representative of Europes Leading Scientific Dissemination Portal – Research Media Ltd.

Following the second press-release of M29 follow-ups included:

7 regional and national radio, television and newspaper contacts

A contact Prof Alcocer from the U. Nottingham who is working with a similar assay

Brazilian Society of Clinical Pathology

Two members of the general public

RUVID

Chemistry & Industry - UK Magazine

Prachi Patel, Science and technology writer

We expect to receive similar if not greater interest from our 3rd and final press-release which is scheduled for the end of M45.

2.4.2 The user forum

Positive identified an INTEREST GROUP to which promotional material was distributed at M4, M14, M27 and M45 in the form of annual newsletters. The INTEREST GROUP is basically an email list that contains key players and experts from Industry (most of them from European companies), governmental agencies and academia. The INTEREST GROUP currently consists of >200 entities.

2.4.3 "Student days" and "Open days"

All partners were to identify a suitable event close to the M24 date in which they were to disseminate the Positive project and its results to the broader public. Due to the lack of opportunities however it was decided to hold events as and when they became available at each partner.

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Table: Public events targeted for Positive dissemination

Date Event Responsible Positive partner

M20 Positive open day at KTH in connection with the bi-annual Course Fair for the students

KTH

M21 Expociencia 2012 UVEG

M39 Medica 2013 Phylogene

M19 Positive Students day CNR

M7 Open day at Univ. of Trento. NL group disseminated POSITIVE related activities to undergraduate students that will visit the Nanoscience research group laboratories

UNITN

M18 Public dissemination event “Realizzazione di un sensore point-of-care in silicio poroso per analisi quantitative delle allergie alimentari”, 10 February 2012, City Hall of Levico Terme (Italy).

UNITN

M15 Nationaler Zukunftstag 2011, open day for students to visit CSEM’s facilities in Alpnach

CSEM

M18 Information day at CSEM for Executive MBA course from HSLU CSEM

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2.4.4 Other dissemination events

Table: Other dissemination events

Date Event Responsible Positive partner

M1 PECs IX KTH

M9 CLEO (Poster) UNITN

M9 Therapeutics for personalized medicine (planned, invited talk) UVEG

M9-10 EuroNanoForum UVEG

M10-11 pHEALTH 2011 (invited talk) UVEG

M11 UK FP7 ICT meeting Farfield

M11 Silicon Photonics summer school (Poster) UVEG

M12 Nanophotonics for sensing & nonlinear optics workshop UNITN

M13 Swedish Medical Technology Days KTH

M14 Medica 2011 Phylogene

M14 NanoTech Italy 2011 UVEG

M18 CFBI organised meeting for Microfluidics Group UVEG via Ikerlan

M19 European Lab-on-a-Chip Congress KTH

M19 Swedish MEMS conference (http://www.msw2012.org/), KTH

M21 MNBS UVEG/UNITN

M21 Euromediag Convention Phylogene

M25 ICT Proposers Day UVEG

M25 Information on optical packaging technology for MCCS (Micro Center Central Switzerland, organization with 17 shareholders)

CSEM

M25 Cowin Market Place, Paris 2012 CSEM

M27 Medica 2012 Phylogene

M34 DPI User Meeting Farfield

M30 Italian national conference UNITN

M34 WaferBond ‘13 KTH

M37 Italian national conference UNITN

M39 ASME UVEG/UNITN

M39 MNBS UVEG

M25 28th International Symposium on MicroScale Bioseparations and Analyses.

CNR

M31 AMT2013 CNR

M33 Nanotech 2013 CNR

M42 Swedish national conference MSW 2014 KTH

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2.5 Communications to scientific journals and conferences/workshops

The project research results obtained were either protected by patenting and/or published at international conferences, EU-workshops and refereed journals, such that dissemination activities to the scientific community and the European Diagnostics industry are as follows:

Publications in leading scientific and technical journals in the field

Publications in leading international conferences.

International exhibitions (usually co-located in major conferences).

Concertation meetings and topical clusters.

2.5.1 Conference communications

1st reporting period: Poster presented at PECS IX "Simulation of porous silicon photonic crystals for biosensing". -

UVEG, KTH

Invited talk at Advances in microarray technology, “Silicon Chips with Dual Label-Free and Fluorescence Detection for High Sensitivity Diagnostic Protein Microarrays“ – CNR

Invited talk at 26th International Symposium on MicroScale Bioseparations, “Silicon biochips for dual label-free and fluorescence detection: application to protein microarrays development.” – CNR

Invited talk at Therapeutics for personalized medicine “Microfluidic and Sensor Technologies for Lab on a Chip Applications” – UVEG

Invited talk at pHealth “The need for nutrition monitoring and Lab on a Chip based technologies as solutions” – UVEG

2nd reporting period: Poster presented at MicroTAS2011, "Low temperature "click" wafer bonding of

offstoichiometry thiol-ene(oste) polymers to silicon" - KTH Poster presented at MicroTAS2011, "Biostickers: patterned microfluidic stickers for rapid

integration with microarrays" - KTH and CNR Oral presentation at SPIE Photonics West, "Highly-Sensitive Anisotropic Porous Silicon

based Optical Sensors" - UVEG and UNITN Oral presentation at Fotonica2012 “n-Type Porous Silicon Optical Micro-Cavity”, UNITN Poster presented at Europtrode, “Mesoporous silicon for phase sensitive biosensing” - UVEG Oral presentation at PSST, “Optimization and synthesis of thin transparent free standing

ntype porous silicon membranes” - UNITN. Poster presented at MEMs 2012, "Dry transfer bonding of porous silicon membranes to

OSTE(+) polymer microfluidic devices" - UNITN and KTH Oral presentation at SSI-2012, “Photonic sensing of food allergens: integration and

miniaturization” – CSEM on behalf of the consortium Oral presentation at IEEE Sensors 2012 “A polarimetric sensor based on nanoporous

membranes“, UNITN and UVEG

3rd reporting period Oral presentation at IEEE Transducers, “Polarimetric based biosensor with targeted delivery

of analytes for real-time monitoring of molecular interactions” - UNITN, UEG, Farfield, KTH, CSEM.

Oral presentation given at Italian National Conference, “High sensitivity, free standing macroporous silicon cavities fabricated in n-type substrates” – UNITN

Oral presentation given at Italian National Conference, “A case study of the optimization of a nanoporous material for sensing applications” – UNITN

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Oral Presentation at SPIE Microtechnologies – “Real-time polarimetric biosensing using macroporous alumina membranes” – UVEG, CNR, Farfield

Poster presentation at WaferBond 2013, “Dry adhesive bonding of porous alumina membranes to microstructured silicon wafers using the OSTE(+) dual-cure polymer” – KTH

Poster presentation at Micro and Nanosystem Workshop 2014, “Dry adhesive bonding of porous membranes to microstructured silicon wafers using the OSTE(+) dual-cure polymer” – KTH

Oral presentation at ASME (Invited Talk), “Anisotropic nanoporous materials” – UVEG, UNITN

Oral presentation at 28th International Symposium on MicroScale Bioseparations and Analyses " Polymer coatings in micro-system platforms for biosensing" - CNR

Oral presentation at AMT 2013 Advances in Microarray Technology, " A Dual Label/Label Free, Highly Sensitive Protein Microarray Platform for Molecular Diagnostics" - CNR

Poster and conference proceedings at 2013 NSTI nanotechnology Conference & Expo - Nanotech 2013 " Reduction of the hydrophobicity of thiol-ene microfluidic devices using an adsorbed polymeric coating" - CNR

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2.5.2 Peer reviewed scientific publications

LIST OF SCIENTIFIC (PEER REVIEWED) PUBLICATIONS, STARTING WITH THE MOST IMPORTANT ONES

No. Title Main

author

Title of the periodical or the

series

Number, date or

frequency Publisher

Place of publication

Year of publication

Relevant

pages

1

Simulation of Surface-Modified Porous Silicon

Photonic Crystals for biosensing applications

Issac Suarez

(UVEG)

Photonics and Nanostructures - Fundamentals

and Applications

V10 Elsevier Amsterdam 2011 304-311,

Doi:10.1016/j.photonics.2011.04.014

2

Birefringent Porous Silicon Membranes for Optical

Sensing

Jesús Álvarez

(UVEG)

Optics Express V9, I27 OSA Washington 2011 26106- 26116,

10.1364/OE.19.026106

3

Advances in nanophotonic sensing technologies

during three international Label Free Lab-on-Chip

projects

Daniel Hill

(UVEG)

Journal of BioNanoScience

V1, I4 ASP Valencia, California

2011 162-172,

10.1007/s12668-011-0026-1

4

Phase sensitive detection for optical sensing with

porous silicon

Jesús Álvarez

(UVEG)

IEEE Photonics V4 I3 IEEE New Jersey 2012 986-995,

10.1109/JPHOT.2012.2201461

5

Biocompatible 'Click' Wafer Bonding for

Microfluidic Devices

Farizah Saharil

(KTH)

Lab on Chip V12 RSC London 2012 pp3032-3035,10.1039/C2L

C21098C

6

Dry adhesive bonding of nanoporous inorganic

membranes to microfluidic devices using the

OSTE(+) dual-cure

Farizah Saharil

(KTH)

Journal of Micromechanics

and Microengineering

V23 IOP London 2013 pp1-8, 10.1088/0960-

1317/23/2/025021

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polymer

7

Universal hydrophilic coating of thermoplastic

polymers currently used in microfluidics

Caterina Zilio

(CNR)

Journal of Biomedical

Microdevices

NA Springer New York 2014 pp107-114, 10.1007/s10544-

013-9810-8.

8

Real-time polarimetric optical sensor using

macroporous alumina membranes

Jesús Álvarez

(UVEG)

Journal of Optics Letters,

38 OSA Washington 2013 pp 1058-1060,

10.1364/OL.38.001058

9

Self detachment of free-standing porous silicon

membranes in moderately doped n-type silicon

Neeraj Kumar

(UNITN)

Applied Physics A NA Springer New York 2013 (online)

10.1007/s00339-013-8104-6

10

Allergen immobilization and signal amplification by quantum dots for use in a biosensor assay of IgE in

serum.

Geoff Platt

(Farfield)

Journal of Biosensors and bioelectronics

V52 Elsevier Amsterdam 2014 pp82-88

10.1016/j.bios.2013.08.019

11

Characterisation of porous alumina membranes for efficient, real-time, flow

through biosensing

Jesús Álvarez

(UVEG)

Analytica Chimica Acta

NA NA NA Under review

NA

12

Real time optical immunosensing with flow through porous alumina membranes

Jesús Álvarez

(UVEG)

Sensors and actuators B

NA NA NA Under review

NA

13

Investigation of non specific signal in nanoporous flow through and flow over sensors

Neeraj Kumar

(UNITN)

Analyst 139 Royal Soc. Of Chem.

NA 2014 pp1345-1349, 10.1039/c3an0199

6a

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2.6 Internal dissemination

Since there was a common knowledge basis on the critical issues, in order to greatly facilitate the final device integration the distribution of interdisciplinary knowledge was encouraged. This was done by taking advantage of the possibilities for internal dissemination such as introductory sessions for new PhD students and postdocs from the consortium partners at meetings and permitting short stays at one or two other partners. Most of the partners were already involved in EU networks of excellence where exchanges of students and postdocs take place. Furthermore, results can be used in educational activities such as courses, M.Sc. and Ph.D. projects. Previous participation in EU-projects has clearly shown that such participation enhances the quality of the educated candidates to world-class level.

Specifically we planned a series of 60-90 minute lectures to be held at each consortium meetings. The lectures contained a basic introduction in each of the many scientific and technical fields addressed within Positive. The target audience was the Positive partners themselves AND interested researchers at the site of the meeting.

Table: Positive internal lectures (typ. 60 - 90 minutes)

Date Lecture title Positive partners

13/09/10 Food allergies and currently available diagnostic tests

Kirsten Beyer, C-UB

2/12/10 Porous Silicon: From fundamentals to applications Paolo Bettotti, UNITN

24/3/11 Photonic and plasmonic materials and their applications

Juan Martinez Pastor, UVEG

22/3/12 Integration of Materials and functions in microfluidic devices.

Marcella Chiari, CNR

18/7/13 Introduction to DPI and Analight applications Paul Coffey, Farfield

20/6/11 OSTE in microfluidics Tommy Haraldsson, KTH

2.7 Contributions to standards

Throughout the project where necessary the consortium contributed to national and/or international standards.

2.8 Contribution to policy developments

In the eventuality that the project would have significant impacts on research or research-based policy development at regional, national or European level such details and policy process have been detailed in the dissemination section of the periodic reports. The project manager channeled any technical achievements which would have a significant impact on the Integrated Research and Industrial Roadmap for European Nanotechnology through the Nanofutures key node group of Design, Modelling and Testing of Materials in which he actively participates.

2.9 Risk assessment and related communication strategy

Any potential risks (real or perceived) for society/citizens associated with the project and the communication strategy adopted in this regard was identified during the project and communicated to the corresponding group through the appropriate means.

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3 Conclusions

Dissemination of foreground through various means took place throughout the whole of the project generating interest from all sections of society and scientific bodies for further work, collaborations, consortium formations and recognition of the high academic value of the work of the EC funded project. All of the activities and their successes have been recorded in this report.