precision medicine - center for cancer research · precision medicine: report of the surgeon...
TRANSCRIPT
1
Precision Medicine
2
Disease classification
3
Research strategy
4
Information commons
5
Lung cancer
6
Geographical map
7
Smoke exposure
8
Never smokers
9
Worldwide cancers
10
Early stage lung cancer
11
Exposome
12
p53
13
Chronic inflammation and infection
14
Pro-inflammatory cytokines
15
IL-6 and IL-8
16
Genome
17
Chemical agents
18
TP53 mutations
19
Mutational processes
20
NSCLC evolution
21
TP53 mutations
22
Patient prognosis
23
Transcriptome
24
MicroRNA
25
microRNA mechanisms
26
Hypothesis
27
Upregulated microRNA
28
Increased miR-21 expression
29
miR-21 expression
30
Cancer biomarkers
31
microRNA secretion
32
4-gene classifier
33
Meta-Analysis
34
Mechanistic cancer bimarkers
35
miR-21 and 4 coding genes
36
Non-coding RNA
37
Proof of Principle
38
Epigenome
39
DNA methylation
40
Prognostic epigenetic signature
41
Survival curve
42
Metabolome
43
Tumor metabolism
44
Urinalysis
45
Survival curve
46
Creatine ribose
47
Lung cancer risk
48
Creatine riboside and NANA
49
Lung cancer screening
50
Spiral CT scans
51
Low dose CT
52
Unmet needs
53
Precision medicine goals
54
Coworkers and collaborators